WO2008060368A3 - Transglutaminase-binding peptides and methods of use - Google Patents

Transglutaminase-binding peptides and methods of use Download PDF

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Publication number
WO2008060368A3
WO2008060368A3 PCT/US2007/021163 US2007021163W WO2008060368A3 WO 2008060368 A3 WO2008060368 A3 WO 2008060368A3 US 2007021163 W US2007021163 W US 2007021163W WO 2008060368 A3 WO2008060368 A3 WO 2008060368A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
transglutaminase
binding peptides
compositions
subject matter
Prior art date
Application number
PCT/US2007/021163
Other languages
French (fr)
Other versions
WO2008060368A2 (en
Inventor
Mark W Dewhirst
Zahid N Rabbani
Zeljko Vujaskovic
Charles S Greenberg
John C Kirkpatrick
Hong Yuan
Original Assignee
Univ Duke
Mark W Dewhirst
Zahid N Rabbani
Zeljko Vujaskovic
Charles S Greenberg
John C Kirkpatrick
Hong Yuan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke, Mark W Dewhirst, Zahid N Rabbani, Zeljko Vujaskovic, Charles S Greenberg, John C Kirkpatrick, Hong Yuan filed Critical Univ Duke
Publication of WO2008060368A2 publication Critical patent/WO2008060368A2/en
Publication of WO2008060368A3 publication Critical patent/WO2008060368A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The presently disclosed subject matter discloses diagnostic and prognostic techniques and compositions for the detection and evaluation of a pathologic disorder. Particularly, the presently disclosed subject matter relates to compositions and methods for evaluating the presence of transglutaminase expression in a pathologic condition compared to normal, healthy expression to diagnose, treat and effectively monitor the pathologic condition.
PCT/US2007/021163 2006-10-02 2007-10-02 Transglutaminase-binding peptides and methods of use WO2008060368A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84871006P 2006-10-02 2006-10-02
US60/848,710 2006-10-02

Publications (2)

Publication Number Publication Date
WO2008060368A2 WO2008060368A2 (en) 2008-05-22
WO2008060368A3 true WO2008060368A3 (en) 2008-09-25

Family

ID=39402167

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/021163 WO2008060368A2 (en) 2006-10-02 2007-10-02 Transglutaminase-binding peptides and methods of use

Country Status (1)

Country Link
WO (1) WO2008060368A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060052308A1 (en) * 2003-11-18 2006-03-09 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
US20060083689A1 (en) * 2001-01-05 2006-04-20 Duke University Contrast enhancement agent for magnetic resonance imaging
US7049289B1 (en) * 1998-05-15 2006-05-23 Amersham Plc Labelled glutamine and lysine analogues

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7049289B1 (en) * 1998-05-15 2006-05-23 Amersham Plc Labelled glutamine and lysine analogues
US20060083689A1 (en) * 2001-01-05 2006-04-20 Duke University Contrast enhancement agent for magnetic resonance imaging
US20060052308A1 (en) * 2003-11-18 2006-03-09 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof

Also Published As

Publication number Publication date
WO2008060368A2 (en) 2008-05-22

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