WO2008058170A2 - Recipient destine a contenir une solution temoin stabilisee, recipient pour solution temoin a usage unique comportant un indicateur d'usage anterieur - Google Patents

Recipient destine a contenir une solution temoin stabilisee, recipient pour solution temoin a usage unique comportant un indicateur d'usage anterieur Download PDF

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Publication number
WO2008058170A2
WO2008058170A2 PCT/US2007/083869 US2007083869W WO2008058170A2 WO 2008058170 A2 WO2008058170 A2 WO 2008058170A2 US 2007083869 W US2007083869 W US 2007083869W WO 2008058170 A2 WO2008058170 A2 WO 2008058170A2
Authority
WO
WIPO (PCT)
Prior art keywords
control solution
seal
containment system
liquid containment
liquid
Prior art date
Application number
PCT/US2007/083869
Other languages
English (en)
Other versions
WO2008058170A3 (fr
Inventor
Randy Bryd
Original Assignee
Bionostics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionostics, Inc. filed Critical Bionostics, Inc.
Publication of WO2008058170A2 publication Critical patent/WO2008058170A2/fr
Publication of WO2008058170A3 publication Critical patent/WO2008058170A3/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped

Definitions

  • a liquid agent such as medication, reagents, and control solutions for evaluating diagnostic systems.
  • reagents are required to be provided in very precise amounts in an assay process.
  • certain agents and reagents are provided in containers or packages which hold only a single dose of liquid or which provide for the delivery of only a single dose from a multi-dose volume of liquid.
  • reagent fluid such as glucose, cholesterol, and narcotics or the like
  • a physiological fluid such as blood, interstitial fluid, urine, and saliva.
  • Such systems typically include test strips containing a reagent material to which a physiological sample is applied, and meters configured for receiving the test strips and determining the target analyte concentration of the sample on the test strip.
  • the strips are typically quality control checked by batch sampling methods in which a monitoring agent, often called a control solution, formulated to mimic blood is used to test the accuracy and efficacy of the test strips.
  • a monitoring agent often called a control solution
  • control solution formulated to mimic blood
  • Examples of such control solutions are disclosed in U.S. Pat. Nos. 5,187,100 and 5,605,837.
  • the accuracy of test strip meters is also checked during the manufacturing process by using the meter with test strips known to meet quality control standards and having such a control solution applied to them.
  • Such quality control of test strips and meters is similarly performed directly by the patient or user of such meters and test strips as well as medical personnel treating such a patient.
  • the patient or medical worker is supplied with a control solution, such as when receiving a meter or obtaining a new package of test strips, and is typically instructed to perform a quality control check upon the occurrence of any of the following events: opening a new package of test strips; using a new meter; when training or learning to use the meter and test strips; after the meter is dropped or the like; when the analyte measurement results do not reflect how the patient is currently feeling (e.g., when a glucose measurement result indicates a substantially high level of blood glucose level but the patient is feeling quite normal); or when a glucose measurement result is normal but the patient is feeling sick.
  • a control solution such as when receiving a meter or obtaining a new package of test strips, and is typically instructed to perform a quality control check upon the occurrence of any of the following events: opening a new package of test strips; using a new
  • Control results that fall outside an expected range may indicate: user procedural error; a dirty meter or test strip container; test strip contamination, deterioration, damage or expiration; meter malfunction; control solution expiration; and/or a control solution which is outside of an acceptable temperature range, etc.
  • FIG. 1 illustrates an example of a prior art container 1 with a removable cap 2 used for containing and dispensing a control solution
  • the dispensing end of these containers is typically configured with a small opening at the end of a taper 3 through which a relatively imprecise droplet of control solution can be dispensed by squeezing the bottle.
  • the container 1 holds a volume of liquid control solution, typically having a volume of about 3 to 5 ml, which provides about 100 to 200 dosages which typically lasts about three months.
  • the cap 2 is removed and the container 1 is tilted so that that its dispensing portion 3 is held several millimeters over a test strip's reagent area. The user then applies a slight squeeze pressure to container to dispense a droplet of the control solution onto the reagent area.
  • Such containers and the steps for dispensing control solution from them have their drawbacks.
  • the container is repeatedly opened over an extended period of time, thereby repeatedly exposing the control solution to contaminants in the air and on surfaces, such as the user's fingers, which carry contaminants.
  • the users of such control solutions may often have poor dexterity (such as diabetics), a user may frequently fumble and/or drop the cap, which may further contaminate the solution.
  • contamination can cause erroneous analyte test results. If it is determined that the control solution has become contaminated the entirety of the control solution must be thrown away, and a new container opened, which can become costly. Moreover, when this happens, a new container of control solution may not be readily available to the user, possibly leaving him or her in a medically risky situation.
  • control solution containers are problematic in that, because such a relatively large volume of the control solution is provided, the efficacy of the control solution may expire well before a majority of the control solution is used, which also adds to the cost of treating the patient.
  • the shelf-life of the control solution sealed within its original containment is usually about one to two years, but once the user opens the solution container, the shelf-life quickly drops to only a few months due to the contamination problem mentioned above.
  • microneedles are now being integrated with test strips.
  • the integrated needle/test strips include a capillary channel which extends from an opening in the distal tip of the microneedle to the sensor reagent area or matrix area within the test strip.
  • the tester is partially dispensed from the meter in an automatic or semi-automatic manner for accessing and collecting the sample fluid, yet remains electrically or photometrically (as the case may be) in contact or engaged with the meter during such fluid access and collection, thereby obviating the need for the user to handle the test strip.
  • the microneedle configuration clearly saves time and reduces the risk if injury to the patient and contamination to the strip and meter.
  • physiological fluid can be accessed (by penetrating the skin with the microneedle), transferring only the minimum amount of sample necessary to the sensor (by means of the capillary channel) and determining the target analyte concentration within the sample (by means of the engaged meter).
  • the meter is equipped with "on board" diagnostic electronics and software, and a control solution is provided for testing the efficacy of the test strip's sensor.
  • control solution dispensers can be used in this case to evaluate the test strips by dispensing a droplet of control solution on to the designated sensor area of the test strip as mentioned above, there is no provision for evaluating the effectiveness of the integrated microneedle.
  • the present disclosure relates to systems, methods, and displays that address the problems noted previously for the prior art.
  • Systems and techniques according to the present disclosure are directed to containers for maintaining a stabilized control solution and/or containers for single-use control solution, including a use-status indicator.
  • aspects and embodiments of the present disclosure are directed to devices and methods for the containment and presentation of a control solution to medical devices, e.g., those that in operation draw blood via a lancet from the finger of a patient/user.
  • Such containment and presentation devices can include structures such as nested containment wells for maintaining a stabilized control solution.
  • Embodiments can include an indicator, such a prior use indicator or pH indicator, to indicate status of a seal of a container and/or a control solution within a container.
  • FIG. 1 illustrates an example of a prior art container used for containing and dispensing a control solution
  • FIG. 2 illustrates the physical attributes of one embodiment of the of the liquid containment structure of the present disclosure
  • FIG. 3 is a perspective view of the liquid containment structure embodiment of FIG. 2 with the addition of a foil laminate seal;
  • FIG. 4 is a front planar view of the liquid containment structure and foil laminate seal of FIG. 3;
  • FIG. 5 is a side planar view of the liquid containment structure and foil laminate seal of FIG. 3;
  • FIG. 6A is a top-down planar view of the liquid containment structure of FIG. 3;
  • FIG. 6B is a sectional view of the containment structure of FIG. 6A taken along cutting plane R-R;
  • FIGS. 7 A and 7B are perspective views depicting utilization of a foil barrier film, in accordance with further embodiments of the present disclosure;
  • FIG. 8 illustrates another embodiment of the liquid containment structure of the present disclosure with added tapering of the top planar surfaces to allow a smoother presentation of the foil laminate covered top surface and so, greater similarity to a finger;
  • FIG. 9 A is a top-down planar view of the liquid containment structure of FIG. 8;
  • FIG. 9B is a sectional view of the containment structure of FIG. 9A taken along cutting plane C-C;
  • FIG. 10 illustrates yet another embodiment of the liquid containment structure of the present disclosure with a smaller handle portion to reduce the cost of materials, yet reserve space for minimal identification labeling if necessary;
  • FIG. HA is a top-down planar view of the liquid containment structure of FIG. 10;
  • FIG. HB is a sectional view of the containment structure of FIG. HA taken along cutting plane S-S;
  • FIG. 12 illustrates yet another embodiment of the liquid containment structure of the present disclosure with a larger handle portion to facilitate use by persons with more limited dexterity, and to provide up to four surfaces to accommodate more extensive labeling information;
  • FIG. 13 depicts a variation of the embodiment of FIG. 12, utilizing a columnar square handle portion
  • FIG. 14 illustrates use of the liquid containment structure of the present disclosure in sheet having a relatively large number of liquid containment structures.
  • the present disclosure is directed to devices/systems and methods useful for the containment of a control solution (e.g., a liquid solution containing a controlled amount of one or more given chemical/analytes) and presentation of such a solution to a medical device, e.g., for calibration of the medical device.
  • a control solution e.g., a liquid solution containing a controlled amount of one or more given chemical/analytes
  • Such medical devices useful with embodiments of the present disclosure can include and/or contain a lancet that is intended to pierce the skin of a patient's finger when placed into an orifice on the device.
  • Embodiments of control containment devices can: (1) present a control liquid to a medical device in a manner simulating a patient's finger; (2) contain a control solution in a manner to preserve the integrity of the solution over an extended time; and/or (3) present an indication as to the state of usefulness of a container holding a control solution, e.g., "used” or "unused," or a status of a physical attribute of the control solution itself, e.g., pH.
  • control solution containers, applicators, or containment devices/systems can be configured and arranged to fit within a target area of a medical device, e.g., portable glucose measuring device. Insertion of such a containment device/system into the particular intended medical device can serve to actuate a mechanical sensor and thereby activate a spring-loaded lancet of the medical device.
  • a lancet can be directly incorporated to a sensor, and so, on penetration of the applicator, it can 'sip' the control liquid directly through the lancet to the sensor.
  • Embodiments of the present disclosure provide a system (e.g., a containment and presentation device), consisting of a body or container for containing a control solution, and a cover including a foil laminate material that is suitable for covering a portion of the container.
  • a cover can serve as a barrier to contain the liquid, and, in some applications, can simulate the skin for the 'piercing' action of the lancing device of a medical device.
  • the container system When pressed into the target area of the device, the container system has enough length and rigidity to activate the spring-loaded lancet and sensor.
  • a further functional feature of such applicators/systems is that they are not prone to leaking control solution, as pressurization of the container is not required.
  • FIG. 2 illustrates one embodiment of a liquid containment structure/system 200 according to the present disclosure.
  • System 200 has a body that includes an inner wall 201 defining an inner well 202 that is suitable for containing a control solution.
  • System 200 may, optionally, include an outer wall 203 defining an outer well, e.g., concentric with the inner wall 201.
  • the walls 201, 203 can be disposed on a platform 206.
  • Liquid containment system 200 can include a large, flat surface or base 207 to serve as a handle to facilitate use. Base 207 can also be used as space to allow for the imprint of identifying marks such as lot or batch number and product identification.
  • Structure 200 can be used to present a control solution reliably to a lancet on piercing by precise filling of the inner well of the applicator prior to sealing, e.g., using a defined combination of pressure, temperature and time, with a cover 2.08 (e.g., laminate foil) as shown in FIGS. 3-6.
  • a cover 2.08 e.g., laminate foil
  • FIG. 3 is a perspective view of the liquid containment structure embodiment of FIG. 2 with the addition of foil laminate seal/cover 208.
  • FIG. 4 is a front planar view of the liquid containment structure and foil laminate seal of FIG. 3.
  • FIG. 5 is a side planar view of the liquid containment structure and foil laminate seal of FIG. 3.
  • FIG. 6A is a top-down planar view of the liquid containment structure of FIG. 3;
  • FIG. 6B is a sectional view of the containment structure of FIG. 6A taken along cutting plane R-R.
  • containment structure 200 can further be enhanced for use by the inclusion of small tabs 205 to guide the structure 200 reliably to the target area of the intended medical device, thereby serving to ensure/facilitate a good 'strike' by the lancet of the medical device.
  • a further functional feature is that applicators/systems can have at all times (or substantially all times) a liquid available for contact to the penetrating lancet, in any direction of use.
  • This multi-directional capability is shown by the rounded feature 209 of the central portion of cover 208.
  • Aspects and embodiments of the present disclosure can provide suitable protection for the liquid (control) solutions intended for containment by addressing loss of liquid as vapor through the containment structure(s), e.g., 201.
  • Embodiments of the present disclosure can address other liquid loss, such as through the cover 208, as will be described below.
  • these two phenomena may be balanced by manipulation of factors affecting rate of evaporation (e.g., container material, flexible membrane material, fill volume) and factors affecting the rate of oxidation (e.g., like pH), to accommodate a certain control of change over time and therefore improve the useful storage life of the control solution product.
  • factors affecting rate of evaporation e.g., container material, flexible membrane material, fill volume
  • factors affecting the rate of oxidation e.g., like pH
  • Embodiments of the present disclosure can balance such above-described factors for control liquids/solutions.
  • a presentation and containment device construction as described herein can include one or more (e.g., multiple) vapor barriers to reduce water loss, and the selection of materials to further control evaporation.
  • high density polyethylene (HDPE) has roughly one third the water vapor transmission rate as low density polyethylene (LDPE) (0.4 to 1.4 g/m 2 /day).
  • LDPE low density polyethylene
  • the water loss through evaporation can be further controlled by the use of a secondary fill liquid.
  • a secondary fill liquid As seen in the drawings (e.g., inner well 202 in FIG. 2), the center portion of a device 200 of the present disclosure can be used for containment and presentment of the control solution to a lancet of a medical device for sampling.
  • a secondary compartment e.g., outer well 204 in FIG. 2 can surround this center space and may be additionally filled with liquid to provide an additional water vapor pressure within this surrounding space to significantly reduce water loss by evaporation from the center well.
  • This capability may be used in addition to the water vapor barrier provided by the materials used for the device 200 and sealing foil 208 to balance evaporation to the loss of glucose by oxidation to provide and enhanced useful life of the control solution in the device 200.
  • the material utilized for the flexible seal 208 can be altered to further adjust the water vapor loss of the device 200, but this barrier generally contributes the smallest portion of the total water loss.
  • a typical flexible foil laminate may have a water vapor transmission rate of 0.0006 g/m 2 /day, or less than 0.04% of the rate of HDPE in the walls of the device for certain embodiments/applications.
  • Devices/methods according to the present disclosure may provide (in addition or alternative to the features described previously) a status indicator, e.g., a visually obvious indication of use (status). Because exemplary embodiments can be a single-use device/method, it is preferable that such work the first time, every time. For this reason, according to embodiments of the present disclosure, a flexible foil barrier film having a paper layer may be used to seal the associated presentation and containment device.
  • FIGS. 7 A and 7B are perspective views depicting utilization of a cover having a foil barrier film or paper layer 701 acting as a status indicator, in accordance with further embodiments 700A, 700B of the present disclosure.
  • a cover can be used to seal containment structure/systems described herein, e.g., system 200 of FIG. 2.
  • the paper layer 701 shown can allow for printing of artwork or other identification, and can also serve to wick solution from within the containment device 200 through this paper layer, e.g., which can be sandwiched between aluminum foil and a protective polyester outer layer (reference all together as 701).
  • this paper layer 701 becomes wetted with the containment solution (which can contain selected/desired dyes and/or have a selected/desired pH)
  • the whole covered surface of the device (or portion thereof) can become discolored (visually obvious) as an indicator that the device has been used.
  • the paper layer (or other absorbing layer of material) 701 can indicate that the seal 701 of the device has been compromised and has already been used.
  • This effect may be further enhanced by the addition of indicator inks printed on the paper to provide bold graphics (black bars, for example) to serve as a more obvious visual indicator.
  • FIG. 8 illustrates another embodiment of a liquid containment structure/system 800 of the present disclosure.
  • System 800 is similar to system 200 of FIG. 2 in that it includes a body with inner and outer walls 801 and 803 defining inner and outer wells 802 and 804, respectively.
  • System 800 also includes, however, with tapering of the top (i.e., distal from platform 806) planar surfaces of the inner and outer walls 801 and 803 to allow a smoother presentation of the foil laminate covered top surface and so, greater similarity to a finger. While the top surfaces are shown as planar, one or both of them may also include contoured or curved portions or be entirely contoured or curved.
  • FIG. 9A is a top-down planar view of the liquid containment structure/system 800 of FIG. 8;
  • FIG. 9B is a sectional view of the containment structure of FIG. 9A taken along cutting plane C-C.
  • FIG. 10 illustrates yet another embodiment of the liquid containment structure/system 1000 of the present disclosure.
  • System 1000 is similar to system 200 of FIG. 2 in that it includes a body with inner and outer walls 1001 and 1003 defining inner and outer wells 1002 and 1004, respectively, but also includes a base with a smaller handle portion to reduce the cost of materials, yet reserve space for minimal identification labeling if necessary.
  • FIG. HA is a top-down planar view of the liquid containment structure/system 1000 of FIG. 10;
  • FIG. HB is a sectional view of the containment structure of FIG. HA taken along cutting plane S-S.
  • FIG. 12 illustrates yet another embodiment of a liquid containment structure/system 1200 in accordance with the present disclosure.
  • System 1200 is similar to system 200 of FIG. 2 in that it includes a body with inner and outer walls 1201 and 1203 defining inner and outer wells 1202 and 1204, respectively, but also includes a base with a larger handle portion 1205 to facilitate use by persons with more limited dexterity, and to provide up to four surfaces to accommodate more extensive labeling information. While handle portion 1205 is shown as having four sides, it may include any desired number of sides.
  • FIG. 13A is a top-down planar view of the liquid containment structure/system 1200 of FIG. 12;
  • FIG. 13B is a sectional view of the containment structure/system 1200 of FIG. 13A taken along cutting plane T-T.
  • FIG. 14 illustrates an embodiment 1400 utilizing multiple liquid containment systems 1401, e.g., similar to system 200 of FIG. 2, on a sheet 1402.
  • sheet 1402 may be configured and arranged in a desired size such that a desired number of containment systems are arranged on the sheet 1402, e.g., as in a M x N array.
  • the sheet 1402 may be perforated, as shown by perforations 1403(1)4403(4), to allow dispensing in units of one or more, and the sheet 1402 may be considered in any length, to allow for rolling for ease of storage or dispensing.
  • embodiments of the present disclosure can provide control solution containment structures/systems that: present very accurate and repeatable single-doses; prevent against contamination of unused control solution; minimize the risk of user contact with the dispensed solution; provide a practical number of single- dose units, for example, for a single user over a given time period or for short-term mass use by a large number of users such as in a hospital or clinic; facilitate maximizing the shelf life and efficacy of the control solution; provide quality control assessment of a plurality of aspects of integrated test systems; are easy and convenient to use and store; and, are cost effective to manufacture and store.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Des aspects et des modes de réalisation de la présente invention concernent des dispositifs et des procédés de rétention et de présentation d'une solution témoin à un dispositif médical. Ces dispositifs et procédés peuvent être destinés à des récipients (des dispositifs de rétention et de présentation, par exemple) comprenant des structures telles que des cupules de rétention alvéolaires destinées à contenir une solution témoin stabilisée. Des modes de réalisation de l'invention peuvent comprendre un indicateur, tel qu'un indicateur destiné à indiquer l'état d'un joint pour un récipient et/ou pour un liquide se trouvant à l'intérieur du récipient.
PCT/US2007/083869 2006-11-07 2007-11-07 Recipient destine a contenir une solution temoin stabilisee, recipient pour solution temoin a usage unique comportant un indicateur d'usage anterieur WO2008058170A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85739106P 2006-11-07 2006-11-07
US60/857,391 2006-11-07

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Publication Number Publication Date
WO2008058170A2 true WO2008058170A2 (fr) 2008-05-15
WO2008058170A3 WO2008058170A3 (fr) 2008-11-06

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5265745A (en) * 1992-04-08 1993-11-30 Minnesota Mining And Manufacturing Company Tamper evident top tab innerseal
US5272093A (en) * 1990-08-02 1993-12-21 Miles Inc. Reagent containment and delivery tray and method of use
US5587321A (en) * 1995-07-31 1996-12-24 University Of Kansas Moated tissue culture plate
WO1997002140A1 (fr) * 1995-07-03 1997-01-23 Tetra Laval Holding & Finance S.A. Stratifie d'emballage a base de carton et de papier
EP1024362A2 (fr) * 1999-01-30 2000-08-02 Fresenius Medical Care Deutschland GmbH Réceptacles pour solutions, en particulier pour des solutions de calibrage de capteurs pour mesurer des paramètres physiologiques pertinents
US20030021726A1 (en) * 2001-05-21 2003-01-30 John Wu Fluid-specimen collecting and testing device and method for recording chromatographic assay test results
EP1362788A2 (fr) * 2002-05-09 2003-11-19 Lifescan, Inc. Dispositifs, systèmes et méthodes permettant de contenir de d'utiliser des solutions liquides
WO2005009868A1 (fr) * 2003-07-25 2005-02-03 Kagawa, Atsuko Corps de couverture pour sceller un contenant, presentant un excellent pouvoir de retenue de descellement
WO2006118843A1 (fr) * 2005-05-04 2006-11-09 Bionostics, Inc. Dispositifs, systemes et procedes de retenue et d'utilisation de solutions liquides

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
GB1414701A (en) * 1973-09-20 1975-11-19 Standard Telephones Cables Ltd Chemical reaction vessel
ATE316916T1 (de) * 2001-05-03 2006-02-15 Allied Domecq Spirits & Wine L Originalitätsverschluss

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272093A (en) * 1990-08-02 1993-12-21 Miles Inc. Reagent containment and delivery tray and method of use
US5265745A (en) * 1992-04-08 1993-11-30 Minnesota Mining And Manufacturing Company Tamper evident top tab innerseal
WO1997002140A1 (fr) * 1995-07-03 1997-01-23 Tetra Laval Holding & Finance S.A. Stratifie d'emballage a base de carton et de papier
US5587321A (en) * 1995-07-31 1996-12-24 University Of Kansas Moated tissue culture plate
EP1024362A2 (fr) * 1999-01-30 2000-08-02 Fresenius Medical Care Deutschland GmbH Réceptacles pour solutions, en particulier pour des solutions de calibrage de capteurs pour mesurer des paramètres physiologiques pertinents
US20030021726A1 (en) * 2001-05-21 2003-01-30 John Wu Fluid-specimen collecting and testing device and method for recording chromatographic assay test results
EP1362788A2 (fr) * 2002-05-09 2003-11-19 Lifescan, Inc. Dispositifs, systèmes et méthodes permettant de contenir de d'utiliser des solutions liquides
WO2005009868A1 (fr) * 2003-07-25 2005-02-03 Kagawa, Atsuko Corps de couverture pour sceller un contenant, presentant un excellent pouvoir de retenue de descellement
WO2006118843A1 (fr) * 2005-05-04 2006-11-09 Bionostics, Inc. Dispositifs, systemes et procedes de retenue et d'utilisation de solutions liquides

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WO2008058170A3 (fr) 2008-11-06
TW200845955A (en) 2008-12-01
TWI409058B (zh) 2013-09-21

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