WO2008057543A3 - Uii-modulating compounds and their use - Google Patents

Uii-modulating compounds and their use Download PDF

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Publication number
WO2008057543A3
WO2008057543A3 PCT/US2007/023383 US2007023383W WO2008057543A3 WO 2008057543 A3 WO2008057543 A3 WO 2008057543A3 US 2007023383 W US2007023383 W US 2007023383W WO 2008057543 A3 WO2008057543 A3 WO 2008057543A3
Authority
WO
WIPO (PCT)
Prior art keywords
uii
modulating compounds
containing compounds
aromatic
urotensin
Prior art date
Application number
PCT/US2007/023383
Other languages
French (fr)
Other versions
WO2008057543A2 (en
Inventor
Ingrid Kristina Luthman
Fredrik Lehmann
Original Assignee
Acadia Pharm Inc
Ingrid Kristina Luthman
Fredrik Lehmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acadia Pharm Inc, Ingrid Kristina Luthman, Fredrik Lehmann filed Critical Acadia Pharm Inc
Publication of WO2008057543A2 publication Critical patent/WO2008057543A2/en
Publication of WO2008057543A3 publication Critical patent/WO2008057543A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton

Abstract

Disclosed herein are novel aromatic-containing compounds and methods for using various aromatic-containing compounds for treatment and prevention of diseases and disorders related to the Urotensin II receptor.
PCT/US2007/023383 2006-11-06 2007-11-06 Uii-modulating compounds and their use WO2008057543A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86459006P 2006-11-06 2006-11-06
US60/864,590 2006-11-06

Publications (2)

Publication Number Publication Date
WO2008057543A2 WO2008057543A2 (en) 2008-05-15
WO2008057543A3 true WO2008057543A3 (en) 2009-04-09

Family

ID=39365123

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023383 WO2008057543A2 (en) 2006-11-06 2007-11-06 Uii-modulating compounds and their use

Country Status (1)

Country Link
WO (1) WO2008057543A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2793212A (en) * 1953-12-09 1957-05-21 Lilly Co Eli Substituted benzamidopiperidinopropanes
US4804662A (en) * 1987-05-05 1989-02-14 Schering A.G. Substituted 4-(1H-imidazol-1-yl)benzamides as antiarrhythmic agents
US6982348B2 (en) * 2001-01-26 2006-01-03 Takeda Pharmaceutical Company Limited Aminoethanol derivatives
US20060058374A1 (en) * 2002-06-10 2006-03-16 Lehmann Per F Urotensin II receptor agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2793212A (en) * 1953-12-09 1957-05-21 Lilly Co Eli Substituted benzamidopiperidinopropanes
US4804662A (en) * 1987-05-05 1989-02-14 Schering A.G. Substituted 4-(1H-imidazol-1-yl)benzamides as antiarrhythmic agents
US6982348B2 (en) * 2001-01-26 2006-01-03 Takeda Pharmaceutical Company Limited Aminoethanol derivatives
US20060058374A1 (en) * 2002-06-10 2006-03-16 Lehmann Per F Urotensin II receptor agents

Also Published As

Publication number Publication date
WO2008057543A2 (en) 2008-05-15

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