WO2008057365A3 - Epileptic event detection systems - Google Patents

Epileptic event detection systems Download PDF

Info

Publication number
WO2008057365A3
WO2008057365A3 PCT/US2007/023032 US2007023032W WO2008057365A3 WO 2008057365 A3 WO2008057365 A3 WO 2008057365A3 US 2007023032 W US2007023032 W US 2007023032W WO 2008057365 A3 WO2008057365 A3 WO 2008057365A3
Authority
WO
WIPO (PCT)
Prior art keywords
spikes
time period
event detection
detection systems
instances
Prior art date
Application number
PCT/US2007/023032
Other languages
French (fr)
Other versions
WO2008057365A2 (en
Inventor
Abraham H Caplan
J Christopher Flaherty
Ronald G Emerson
Original Assignee
Abraham H Caplan
J Christopher Flaherty
Ronald G Emerson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abraham H Caplan, J Christopher Flaherty, Ronald G Emerson filed Critical Abraham H Caplan
Publication of WO2008057365A2 publication Critical patent/WO2008057365A2/en
Publication of WO2008057365A3 publication Critical patent/WO2008057365A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/375—Electroencephalography [EEG] using biofeedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0531—Brain cortex electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4261—Evaluating exocrine secretion production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/726—Details of waveform analysis characterised by using transforms using Wavelet transforms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Physiology (AREA)
  • Optics & Photonics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Various systems and methods for predicting occurrence of a neurological event are disclosed. In certain embodiments, a neurological event detection system may comprise a sensor configured to be placed in the body of a patient, the sensor comprising a plurality of electrodes, at least one of the electrodes being configured to detect neurological signals emanating from a portion of the brain of the patient over a plurality of time periods. The system may also include a signal analyzer configured to analyze the signals to determine a number of spikes detected by each electrode during each time period. The system may also detect a number of instances where spikes associated with at least two neurons are detected at substantially the same time during each time period, and determine a correlation between the number of spikes and the number of instances for each time period.
PCT/US2007/023032 2006-11-02 2007-11-01 Epileptic event detection systems WO2008057365A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85601006P 2006-11-02 2006-11-02
US60/856,010 2006-11-02

Publications (2)

Publication Number Publication Date
WO2008057365A2 WO2008057365A2 (en) 2008-05-15
WO2008057365A3 true WO2008057365A3 (en) 2008-08-21

Family

ID=39365039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023032 WO2008057365A2 (en) 2006-11-02 2007-11-01 Epileptic event detection systems

Country Status (1)

Country Link
WO (1) WO2008057365A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8702629B2 (en) * 2005-03-17 2014-04-22 Great Lakes Neuro Technologies Inc. Movement disorder recovery system and method for continuous monitoring
DE102009024866A1 (en) * 2009-06-09 2010-12-16 Abb Research Ltd. Method and device for monitoring the brain activity of a human
US10226209B2 (en) 2010-10-15 2019-03-12 Brain Sentinel, Inc. Method and apparatus for classification of seizure type and severity using electromyography
EP2627244B1 (en) 2010-10-15 2018-07-18 Brain Sentinel, Inc. Apparatus with emg sensors for detecting seizures
JP6158799B2 (en) 2011-07-05 2017-07-05 ブレイン センティネル インコーポレイテッドＢｒａｉｎ Ｓｅｎｔｉｎｅｌ，Ｉｎｃ． Convulsion detection device and method of operating the same
US20130072809A1 (en) * 2011-09-19 2013-03-21 Persyst Development Corporation Method And System For Analyzing An EEG Recording
EP3047475B1 (en) * 2013-09-19 2021-08-18 Tata Consultancy Services Ltd. System and method for evaluating a cognitive load on a user corresponding to a stimulus
US20160045127A1 (en) * 2014-08-15 2016-02-18 The Regents Of The University Of Michigan Automated detector and classifier of high frequency oscillations and indicator seizure onset
AU2017253093A1 (en) 2016-04-19 2018-11-15 Brain Sentinel, Inc. Systems and methods for characterization of seizures
EP3463062A4 (en) 2016-06-07 2020-02-19 Neurosteer Ltd. Systems and methods for analyzing brain activity and applications thereof
BR102016016259A2 (en) 2016-07-13 2018-02-06 Gomez & Gomez Ltda Epileptic Outbreak Prediction Method and Device Configured for Epileptic Outbreak Prediction
EP3582069A4 (en) * 2017-02-10 2020-11-25 Nihon Kohden Corporation Brain-machine interface system capable of changing amount of communication data from internal device, and control method therefor
EP3415085B1 (en) * 2017-06-14 2024-03-20 IMEC vzw A method for processing sensor data in a neuroprobe
WO2020069084A1 (en) * 2018-09-28 2020-04-02 The Board Of Trustees Of The Leland Stanford Junior University Detection, localization, and/or suppression of neural activity using acoustic waves and/or ultrasound
MX2021007033A (en) * 2018-12-13 2021-10-22 Liminal Sciences Inc Systems and methods for a wearable device for substantially non-destructive acoustic stimulation.
WO2020236001A1 (en) * 2019-05-22 2020-11-26 Universiteit Leiden Analyzing brain functioning using behavioral event markers from portable electronic device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050203366A1 (en) * 2004-03-12 2005-09-15 Donoghue John P. Neurological event monitoring and therapy systems and related methods
US20060167371A1 (en) * 2005-01-10 2006-07-27 Flaherty J Christopher Biological interface system with patient training apparatus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050203366A1 (en) * 2004-03-12 2005-09-15 Donoghue John P. Neurological event monitoring and therapy systems and related methods
US20060167371A1 (en) * 2005-01-10 2006-07-27 Flaherty J Christopher Biological interface system with patient training apparatus

Also Published As

Publication number Publication date
WO2008057365A2 (en) 2008-05-15

Similar Documents

Publication Publication Date Title
WO2008057365A3 (en) Epileptic event detection systems
EP1758714A4 (en) Question and control paradigms for detecting deception by measuring brain activity
EP1755447A4 (en) Systems and methods for detecting deception by measuring brain activity
EP1755448A4 (en) Systems and methods for detecting deception by measuring brain activity
WO2007093819A3 (en) Dna conformation (loop structures) in normal and abnormal gene expression
WO2005062267A3 (en) Activity monitoring
WO2007047854A3 (en) Methods and systems for establishing parameters for neural stimulation
WO2011062769A3 (en) Methods and apparatus for performing capacitive touch sensing and proximity detection
WO2007117826A3 (en) Implantable medical device system and method with signal quality monitoring and response
WO2008092133A3 (en) Methods and systems for measuring a subject's susceptibility to a seizure
WO2013028680A3 (en) Method and apparatus for detecting a biomarker in the presence of electrical stimulation
WO2009102613A3 (en) Methods of monitoring hemodynamic status for ryhthm discrimination within the heart
WO2010099190A3 (en) Methods and apparatus for measuring physiological conditions
WO2008017055A3 (en) Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems
WO2004034882A3 (en) Measuring a neurological event using clustering
WO2010045481A3 (en) Methods, devices and systems for programming neurostimulation
WO2006135846A3 (en) Methods and systems for neural maintenance and regeneration
WO2012044699A3 (en) Systems and methods for detecting intrathecal penetration
WO2010001231A3 (en) Processing and detecting baseline changes in signals
WO2008005270A8 (en) Local and non-local sensing for cardiac pacing
WO2007124194A3 (en) Method and apparatus for detection of nervous system disorders
EP2573367A3 (en) Sensor system
WO2006131850A3 (en) Method and apparatus for distinguishing between clinically significant changes and artifacts in patient physiological information
WO2008004010A3 (en) Multielectrode array and method of manufacturing the same
WO2006093699A3 (en) Detecting atrial fibrillation, method of and apparatus for

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07861620

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07861620

Country of ref document: EP

Kind code of ref document: A2