WO2008049401A2

WO2008049401A2 - Nail varnish for cosmetic and medical applications

Info

Publication number: WO2008049401A2
Application number: PCT/DE2007/001888
Authority: WO
Inventors: Rudy Susilo
Original assignee: Rudy Susilo
Priority date: 2006-10-22
Filing date: 2007-10-22
Publication date: 2008-05-02
Also published as: WO2008049401A3; DE112007003183A5; DE102006049585A1

Abstract

The invention relates to a cosmetic and medical nail varnish containing urea, dexpanthenol, a solvent and at least one oil having a weight proportion of more than 20% by wt. of fatty acids containing 10 - 25 carbon atoms. Other components can be added to said composition, such as substances with an anti-mycotic, anti-viral, anti-bacterial, anti-septic, anti-microbial, anti-infectious, anti-psoriatic and/or antiparasitic action. The invention also relates to the use of said type of nail varnish for treating nail diseases and nail infections.

Description

Nail polish for cosmetic and medical applications

description

The invention relates to a cosmetic and / or medical nail polish and its use for the treatment of nail diseases and nail infections and for the cosmetic application and prevention of brittle or brittle nails. In particular, the invention relates to nail varnishes containing dexpanthenol, urea and oils and / or fatty acids.

Diseases or infections of the fingernails and fingernails are preferably treated by nail plasters containing antimicrobial or antifungal agents, or by medical nail polishes containing antimicrobial or antifungal agents.

US 5,993,790 discloses a water-based nail varnish containing from 0.5 to 10% by weight of urea, from 0.5 to 1.5% by weight of preservative, from 0.1 to 0.6% by weight of natural additives and from 1 to 0 10% by weight of deionized water.

European patent EP 0 913 154 B1 describes an antipsoriatic nail polish consisting of one or more glucocorticoids, one or more film formers and one or more physiologically acceptable solvents.

Despite a variety of nail patches and known nail varnishes they are able to combat only a part of the nail diseases and nail infections effectively, so that there is a need for other compositions that can be used to treat damaged foot and fingernails.

The object of the present invention is to provide nail varnishes which can be used for the treatment of nail diseases and nail infections as well as for the protection and regeneration of the nails.

This object is achieved by the technical teaching of the independent claims. Advantageous embodiments of the invention are specified in the dependent claims, the description and the examples. Surprisingly, it has been found that a nail varnish is particularly suitable for the prophylaxis and treatment of nail diseases and nail infections containing a combination of urea, dexpanthenol and fatty acids or fatty acid-containing oils such as evening primrose oil, sea buckthorn oil, linseed oil and / or γ-linolenic acid.

Such an active ingredient combination may also be incorporated into nail plasters and is also effective when applied via a nail patch.

However, the administration of this combination of active ingredients in the form of nail varnish has proven to be preferred. A nail varnish is obtained when the combination of urea, dexpanthenol and fatty acid and / or oil, e.g. Evening primrose oil, linseed oil or sea buckthorn oil is taken up in a solvent.

Thus, the present invention relates to a nail varnish comprising or containing the following constituents: a) urea, b) fatty acids containing 10 to 25 carbon atoms or oils having a weight fraction of more than 20% by weight of 10-25

Carbon atoms containing fatty acids or mixtures of said fatty acids and oils, c) dexpanthenol and d) at least one solvent.

Furthermore, it is preferred if the composition according to the invention contains at least one polymer-forming or film-forming substance.

The polymer-forming or film-forming substances which can be used according to the invention are described in detail below, with preferred polymer-forming or film-forming substances being natural as well as synthetic polymers and in particular acrylate polymers, methacrylate polymers, acrylic polymers and methacrylic polymers.

Examples of acrylic polymers are polyacrylic acid, polymethacrylic acid,

Polyacrylamide, polymethacrylamide, polyacrylimide, polymethacrylimide,

Polyacrylates, polymethacrylates, polymethylacrylate, polymethyl methacrylate (PMMA), polyacrylonitrile, polymethacrylonitrile. An essential ingredient of the cosmetic or pharmaceutical nail polish formulation is dexpanthenol. Dexpanthenol (pantothenol, panthenol, D-panthenol) is an active ingredient in the vitamin B series and is converted in the body to pantothenic acid (vitamin B5). It supports the regeneration of skin cells, increases the moisture retention and improves the elasticity of the skin. Furthermore, dexpanthenol supports wound healing, has antipruritic and anti-inflammatory properties. Dexpanthenol can penetrate the nail and protect it from brittleness and dehydration.

Although the positive properties of dexpanthenol for the protection and regeneration of the skin and the nail were known, the present invention can prove that the combination of dexpanthenol and urea and an oil surprisingly better properties than the individual components or the mixture of only two aforementioned substances. Only the combination of oil, urea and dexpanthenol gave a very good result while only dexpanthenol or dexpanthenol provided sub-optimal results with oil or with urea. It thus appears to exist a synergistic effect between the components of the invention. The test results are discussed in detail below.

The nail varnish of the invention preferably contains dexpanthenol in an amount of from 0.1 to 10% by weight, preferably from 0.2% by weight to 8% by weight, more preferably in an amount of from 0.4% by weight to 6 Wt .-% and particularly preferably in an amount of 0.5 wt .-% to 5 wt .-%.

Another essential ingredient is urea (H ₂ N-CO-NH ₂ ). Urea is used in an amount of from 0.1% to 10.0% by weight of the nail varnish, preferably in an amount of from 0.4% to 7% by weight of the nail varnish and most preferably in an amount from 0.5% to 5% by weight of the nail varnish.

The percentages by weight (% by weight) always refer to the mass (weight) of the total nail varnish formulation, so that 10% by weight of component a) means that 100 g of nail polish (formulation) contains 10 g of urea.

As further optional ingredients, the nail varnish may contain allantoin or hyaluronic acid or a wax or at least one permeation enhancer or at least one antimicrobial substance or at least one Antipsoriatic or at least one substance against eczema or at least one additive or mixtures of the aforementioned substances. The waxes used in the nail varnish according to the invention can be selected from a group consisting of beeswax, carnauba wax, candelilla wax and / or mixtures thereof.

The waxes used in the nail varnish according to the invention can in a concentration of 0.1 to 20 wt .-%, preferably in a concentration of 0.5 to 15 wt .-%, more preferably 1 to 10 wt .-% and particularly preferably in a concentration be contained from 2 to 5 wt .-%.

However, the presence of allantoin / allantoin derivative and / or hyaluronic acid is preferably not essential. The nail varnish may contain allantoin / allantoin derivative or hyaluronic acid or allantoin / allantoin derivative and hyaluronic acid in an amount of from 0.1% to 20% by weight, preferably from 0.5% to 15% by weight and most preferably in from 1% to 10% by weight of the nail polish in the nail polish formulation. The imidazolidinyl derivative allantoin causes the acceleration of cell formation, cell formation and / or cell regeneration.

Additives are customary pharmacologically acceptable auxiliaries and solvents which are customarily used in liquid cosmetic or medicinal formulations, for example preservatives, cosolvents, such as ethanol, dyes, odorants, brighteners, binders, amino acids, chitosan, chitosan salts, chitosan derivatives, glucosamine, glycerol, Diglycerin, triglycerol, uric acid, honey, creatinine, collagen hydrolysis products, lactitol, polyols and polyol derivatives (such as butylene glycol, erythritol, propylene glycol, 1, 2,6-hexanetriol, polyethylene glycols such as PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20), pyrrolidonecarboxylic acid, sugars and sugar derivatives (such as fructose, glucose, maltose, maltitol, mannitol , Inositol, sorbitol, sorbitylsilanediol, sucrose, trehalose, xylose, xylitol, glucuronic acid and salts thereof), ethoxylated sorbitol (sorbeth-6, sorbeth-20, sorbeth-30, sorbitol) 40), hardened starch hydrolysates, PEG-20 acetate copolymer and preferably panthenol. In addition, polyethylene glycol, sulfur-containing amino acids, sulfur-containing imino acids, lipids, phospholipids, keratolytic agents, antioxidants, plasticizers and mixtures of the abovementioned substances can be contained in the nail polish. The nail varnish may contain the at least one sulfur-containing amino acid, at least one sulfur-containing imino acid, at least one lipid or the at least one phospholipid or mixtures of the abovementioned substances together in an amount of from 0.1% by weight to 20% by weight, preferably 0, 5 wt .-% to 15 wt .-% and particularly preferably in an amount of 1 wt .-% to 10 wt .-% of the nail polish.

In addition, the presence of at least one permeation enhancer is particularly preferred in medical nail varnishes. Permeation enhancers are substances which promote the passage of drugs through the nail, e.g. to provide a pharmacologically effective amount of an antimycotic in the nail bed. Examples of permeation enhancers are fatty acid esters,

Fatty alcohols, propylene glycol, polyethylene glycol, unsaturated polyglycolated glycerides, salicylic acid, lactic acid, pyrrolidone, DMSO and sodium dodecylsulfate.

Each of the aforementioned substances may be present in an amount of from 0.1% to 10% by weight, preferably from 0.5% to 8% by weight, more preferably from 1% to 6% by weight, still further preferably from 1% to 4% by weight, and more preferably from 1% to 2% by weight, in nail polish. Preferably, in addition to the essential constituents [urea, dexpanthenol, oil / fatty acid and solvent (mixture)] and possibly the active ingredient, not more than 5, preferably not more than 4 and especially preferably not more than 3 further constituents are contained in the nail polish formulation.

In addition, it is preferred that the total amount of further ingredients other than the solvent or other than the solvent mixture, i. of non-essential constituents is not more than 14% by weight, preferably not more than 11% by weight, more preferably not more than 8% by weight and especially preferably not more than 5% by weight.

In the case of medical nail varnishes, the presence of at least one active substance is furthermore preferred. For example, at least one antimicrobial substance, at least one antiviral substance, at least one anti-infective substance, at least one antiparasitic substance, at least one antipsoriatic, at least one antimycotic or at least one substance against eczema or mixtures of the aforementioned substances can be added to the nail varnish according to the invention , In particular, water, purified water, deionized water and alcohols have proved very suitable as solvents. Suitable alcohols may for example be selected from the group consisting of or consisting of methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, tert-butanol, isobutanol, ethylene glycol, ethylene glycol monomethyl ether, (methoxyethanol), ethylene glycol monoethyl ether , Ethylene glycol monopropyl ether, propane-1,2-diol (propylene glycol), propane-1,3-diol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 1-methoxy-4-hydroxybutane, 1, 3,5-pentanetriol, 1-ethoxy-3,5-dihydroxy-pentane, glycerol (1, 2,3-trihydroxypropane) and mixtures of the aforementioned solvents as well as mixtures with water.

Additional solvent cosolvents may be added to the solvent or solvent mixture. Suitable cosolvents are, for example, acetone, dimethyl sulfoxide (DMSO), ethyl acetate (ethyl acetate, AcEt), propyl acetate, butyl acetate, dimethylformamide (DMF) or tetrahydrofuran (THF).

Furthermore, the addition of polypropylene glycol (PPG) and / or polyethylene glycol (PEG) and in particular of polyethylene glycol has proved to be preferred. In addition, in particular average molecular weights of PEG and PPG of 200 to 600 are suitable and more preferably from 300 to 500 and particularly preferably from about 400 (PPG 400, PEG 400).

Particularly preferred is PEG and in particular PEG 400, wherein the 400 denotes, as stated, an average molecular weight of 400. PEG is very suitable for the removal of toxins from the skin and as a solubilizer.

PEG 400 is a colorless to yellowish-brownish, odorless substance, which is well soluble in alcohols, acetone, ethyl acetate and water and is also known under the following synonyms: Carbowax Compound 400, Cremolan, Lutrol E 400, Pagol, polyethylene glycol 400, Syntharesin.

PEG may be present in an amount of from 0.1% to 10.0% by weight of the nail varnish, preferably in an amount of from 0.4% to 6% by weight of the nail varnish and most preferably in an amount from 0.5% to 3% by weight of the nail polish formulation. The solvent or the solvent mixture including the cosolvents is contained in an amount of from 60% by weight to 95% by weight, based on the total mass of the nail varnish, in the nail varnish.

In the amount of from 60% to 95% by weight of solvent, up to 10% by weight, preferably up to 5% by weight, of cosolvents may be present.

The third essential component of the nail polish formulation is at least one oil containing more than 20% by weight of fatty acids containing 10-25 carbon atoms, or instead of the oil, the fatty acids containing 10 to 25 carbon atoms may also be used directly, with the use of an oil being preferred is. Of course, mixtures of oils and mixtures of fatty acids as well as mixtures of oils with fatty acids can be used.

Should an oil of natural or synthetic origin contain less than 20% by weight of fatty acids containing 10 to 25 carbon atoms, then as much fatty acids of 10 to 25 carbon atoms may be added to this oil until an amount of 20% by weight is reached.

The 10-25 carbon atoms containing saturated or unsaturated, branched or unbranched fatty acids or a mixture of these substances in an amount of 0.1 wt .-% to 40 wt .-% of the nail polish, preferably in an amount of 0.5 wt. -% to 20.0 wt .-% of the nail polish, and particularly preferably used in an amount of 1, 0 wt .-% to 10.0 wt .-% of the nail polish, if no oil is used.

Examples of preferred fatty acids are those having 10 to 18 carbon atoms, more preferably those having 12-16 carbon atoms, with saturated or monounsaturated ones being again preferred, and in particular omega fatty acids being preferred. Particularly preferred are linoleic acid and α-linolenic acid.

Examples of the most preferred omega-3 fatty acids are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and examples of the most preferred omega-6 fatty acids are gamma-linolenic acid (GLS), dihomo-gamma-linolenic acid (DGLA) and arachidonic acid (AA ). Ricinoleic acid (12-hydroxy-9-octadecenoic acid) is an example of an unsaturated, linearly-built omega-9 fatty acid with the molecular formula C ₁₈ H ₃ ^. Be oils In particular, those oils are preferred which contain omega fatty acids in a proportion of at least 10 wt .-%, preferably at least 15 wt .-% and particularly preferably of at least 20 wt .-%, wherein the aforementioned omega-3 and omega-6 fatty acids are in turn preferred.

In particular, since sand dome seed oil, seabuckthorn seed oil, sea buckthorn pulp oil, evening primrose oil and linseed oil have proven particularly useful in the experiments described herein, it is preferred that one of the oils described herein be used as a component of component b) and such fatty acids are added to that oil contained in the preferred aforementioned oils such as omega fatty acids, eicosapentaenoic acid, docosahexaenoic acid, linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid and / or α-linolenic acid.

The following tables list the preferred fatty acids.

Table 2: linear saturated carboxylic acids

Table 3: Polyunsaturated fatty acids

Table 4: Acetylenic fatty acids

Instead of the pure fatty acids having 10 to 25 carbon atoms or mixtures of these fatty acids, it is also possible to use oils, waxes or fats which contain these fatty acids, preferably in an amount of at least 20% by weight, more preferably of at least 30% by weight, even more preferably of at least 40% by weight and more preferably of at least 50% by weight. The particularly preferred oils used according to the invention additionally preferably contain at least 5% by weight, more preferably at least 10% by weight, even more preferably at least 15% by weight and especially preferably at least 20% by weight of unsaturated fatty acids and preferably omega fatty acids ,

It should be emphasized here that the nail varnish of the invention can be used effectively even without the presence of pharmacological agents for the treatment of nail diseases and nail infections. The presence of pharmaceutical agents is optional but not mandatory, since the drug combination of urea, dexpanthenol and oil such as sea buckthorn oil itself already has good activity against nail diseases and nail infections and also protects healthy nails from brittleness and brittleness. For the nail polish formulation according to the invention is not primarily a medical formulation but a cosmetic and nourishing formulation which is suitable even without a pharmacological agent for the prophylaxis and treatment of some nail diseases and optionally can be added to a pharmacological agent.

The fatty acids preferably used in the nail varnish according to the invention can be selected from a group comprising or consisting of oleic acid, eicosapentaenoic acid, timnodonic acid, docosahexaenoic acid, arachidonic acid, linoleic acid, α-linolenic acid, γ-linolenic acid, dihomo-γ-linolenic acid and mixtures of the abovementioned fatty acids, more preferably is γ-linolenic acid.

The oils used in the nail varnish according to the invention may be selected from a group consisting of linseed oil, hemp oil, echium oil, trichodesma oil, currant seed oil, corn oil, walnut oil, rapeseed oil, soybean oil, sunflower oil, poppy oil, safflower oil, wheat germ oil, safflower oil, grapeseed oil, evening primrose oil, borage oil, black cumin oil , Algae oil, fish oil, cod liver oil, evening primrose oil, sea buckthorn oil, Sanddomfruchtfleischöl and / or mixtures of the aforementioned substances are selected. Evening primrose oil is preferred, and sea buckthorn oil, sea buckthorn seed oil, sandorn seed oil, and sand dipper flake oil are particularly preferred, and oils very similar to sea buckthorn oil, such as, for example, linseed oil.

The oils and / or the fatty acids having 10 to 25 carbon atoms, i. the component b) can in the nail varnish of the invention in a concentration of 0.1 to 40 wt .-%, preferably in a concentration of 0.5 to 30 wt .-%, more preferably 1 to 20 wt .-% and particularly preferably in be contained in a concentration of 1 - 10 wt .-%.

In addition, it is preferred if the oils together with the optionally added 10 to 25 carbon atoms containing fatty acids together in a concentration of 1-40 wt .-%, preferably in a concentration of 5 to 30 wt .-%, more preferably 5 to 20 wt .-% and particularly preferably in a concentration of 5-15 wt .-% are contained in the nail polish.

Further constituents which may optionally be present in the nail varnish according to the invention are described below. Antiseptics may be included in the nail polish in amounts up to 10% by weight, based on the nail polish formulation. Preference is given to antiseptic substances such as, for example, alcohols and phenols, with antiseptic oils being particularly preferred. Examples of antiseptic oils are oils from the group of Angelica fine and Angelica archangelica, aniseed (Pimpinella anisum), benzoin siam (Styrax tokinensis), cabreuva (myrocarpus fastigiatus), cajeput (melaleuca leucadendron), cistus (Cistrus ladaniferus), copaiba balm (Copaifera reticulata), Costus root (Saussurea discolor), Edeltann needle (Abies alba), Elemi (Canarium luzonicum), Fennel (Foeniculum dulce), Spruce needle (Picea abies), Geranium (Pelargonium graveolens), Ho leaves (Cinnamonum camphora), Immortelle (Straw flower), ginger extra (Zingiber officinalis), St. John's wort (Hypericum perforatum), jojoba, chamomile German (Matricaria recutita), chamomile blue fine (Matricaria chamomilla), chamomile rom. (Anthemis nobilis), chamomile wild (Ormensis multicaulis), carrot (Daucus carota), Dwarf Pine (Pinus mugho), Lavandin (Lavendula hybrida), Litsea Cubeba (May Chang), Manuka (Leptospermum scoparium), Melissa (Melissa officinalis), Sea Pine (Pinus pinaster), Myrrh (Comm iphora molmol), myrtle (Myrtus communis), neem (Azadirachta), niaouli (MQV: Melaleuca quin, viridiflora), palmarosa (Cymbopogom martini), patchouli (Pogostemon patchouli), Peru balsam (Myroxylon balsamum var. pereirae), Raventsara aromatica, rosemary Rosmarinus officinalis, Rosewood (Aniba rosae odora), Sage (Salvia officinalis), Horsetail (Equisetaceae), Yarrow extra (Achillea millefolia), Ribwort plantain (Plantago lanceolata), Styrax (Liquidambar orientalis), Tagetes (Marigold, Tagetes patula), Tea tree ( Melaleuca altemifolia), Tolu balsam (Myroxylon balsamum L.), Virginia cedar (Juniperus virginiana), Frankincense (Olibanum: Boswellia carteri), Silver fir (Abies alba).

Skin-protecting oils can be added to the essential oils and fatty acids used in accordance with the invention in an amount of up to 20% by weight, based on the nail polish formulation. The skin-protecting oils are preferably algae oil (Oleum Phaeophyceae), aloe vera oil (Aloe vera brasiliana), apricot kernel oil (Prunus armeniaca), arnica oil (Arnica montana), avocado oil (Persea americana), calendula oil (Calendula officinalis), camellia oil (Camellia oleifera). , Safflower oil (Carthamus tinctorius), peanut oil (Arachis hypogaea), hazelnut oil (Corylus avellana), St. John's wort oil (Hypericum perforatum), jojoba oil (Simondsia chinensis), carrot oil (Daucus carota), coconut oil (Cocos nucifera), pumpkin oil (Curcubita pepo), kukui nut oil (Aleurites moluccana), Macadamia nut oil (Macadamia ternifolia), almond oil (Prunus dulcis), meadowfoam oil (Limnanthes alba), olive oil (Olea europaea), peach kernel oil (Prunus persica), rapeseed oil (Brassica oleifera), castor oil (Ricinus communis), sesame oil (Sesamium indicum), sunflower oil ( Helianthus annus), grape seed oil (Vitis vinifera), walnut oil (Juglans regia), wheat germ oil (Triticum sativum), Gold Of Pleasure Camelina Sativa, Kemiri oil (Aleurites moluccana), passion flower oil (Passiflora incarnata) and rice germ oil (Oryza sativa).

Preservatives are preferably used in an amount of 0.5 to 10 wt .-% based on the total nail varnish formulation.

Examples of preservatives are Germaben (Sutton Labs of Chatham), formic acid, propylene glycol, methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, diazolylidinylurea, p-hydroxybenzoate, o-cymene-5-ol, 2-bromo-2-nitropropane-1, 3-diol, chlorphenesin, methyldibromo-glutaronitrile, iodopropynyl-butylcarbamate, methylisothiazolinone, butylene glycol, DMDM hydantoin, imidazolidinylurea, triclosan, 5-bromo-5-nitro-1,3-dioxane, sodium methylparaben, sodium benzoate and sorbic acid.

Perfumes can also be used in amounts of from 0.01 to 1.0% by weight, and dyes also in an amount of from 0.01 to 1.0% by weight, based on the total amount of the nail polish formulation. Examples of agents are vanillin, lemon extract, orange extract, benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinylacetate, phenylethylacetate, linalylbenzoate, benzylformate, ethylmethylphenylglycinate, allylcyclohexylpropionate, styrallylpropionate, benzylsalicylate, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde , Hydroxycitronellal, lilial, bourgeonal, ionone, isomethylionone, methyl cedryl ketone, anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol, terpineol, terpenes such as limonene and pinene, dehydrating oils such as pine oil, muscatel, clove oil, cinnamon oil, lime blossom oil, juniper berry oil, Vetiver oil, galbanum oil, labdanum oil, orange blossom oil, orange peel oil. Preferred perfumes are St. John's wort, lavandin, melissa, frankincense, benzoin, eucalyptus, thyme, lime, mint, grapefruit, lemon, petitgrain, bergamot, citronella, mountain pine, peppermint, hyssop or lavender, chamomile, lavender, melissa, neroli, sandalwood, rose , Geranium, frankincense, vanilla, ylang-ylang, jasmine, musk, sandalwood, tonka bean, cinnamon bark, mustard oil, gaultheria, laurel oil, rosemary oil, camphor, thyme, arnica. As dyes, for example, color pigments and pearlescing agents are used.

Antioxidants such as butylhydroxytoluene (BHT), cysteine, sulfur-containing amino / imino acids, polyphenols, grape seed extract, oligomeric

Procyanidin, coenzyme Q ₁₀ , vitamin C and / or carotenoids such as β-carotene, α-

Carotene, lycopene, β-cryptoxanthin, lutein and zeaxanthin may be added to the nail varnish in amounts of 0.01 to 8% by weight, more preferably in an amount of 0.05 to

10 wt .-% and particularly preferably in an amount of 0.1 to 5 wt .-% are added.

Antioxidants may be selected from the group consisting of amino acids (eg, glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg, urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-camosine, L-carnosine, and the like Derivatives (eg anserine), carotenoids, carotenes and their derivatives, chlorogenic acid and its derivatives, aurothioglucose, propylthiouracil and other thiols (eg thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl) , Propyl, amyl, butyl and lauryl, palmitoyl, oleyl, gamma-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, Nucleotides, nucleosides and salts) as well as sulfoximine compounds (eg buthionine sulfoximines, homocysteine sulfoximine, buthionine sulfones, penta, hexa, heptathionine sulfoximine), furthermore (metal) chelators (eg [alpha] hydroxy fatty acids, palmitins acid, phytic acid, lactoferrin), [alpha] -hydroxy acids (eg citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg gamma-linolenic acid, linoleic acid , Oleic acid), folic acid and its derivatives, furfurylidene sorbitol and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (eg ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), vitamin E (tocopherols and derivatives, eg vitaminin E acetate) , and koniferyl benzoate of benzoin, ferulic acid, furfurylidenglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, Nordihydroguajakharzsäure, Nordihydroguajaretsäure, trihydroxybutyrophenone, uric acid and its derivatives, mannose and derivatives thereof, zinc and its derivatives (eg ZnO, ZnSO ₄ ) selenium and its derivatives (eg selenium methionine ) as well as stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide). Permeation enhancers can be added in amounts of from 0.1 to 10% by weight, preferably from 0.1 to 5% by weight, based on the total amount of nail varnish.

Permeation enhancers promote the permeation of substances, in particular active ingredients through the skin and through the nail, so that an active ingredient gets under the fingernail or toenail where the nail disease has its origin, for example due to viruses, bacteria, fungi, parasites or infections. Thus, permeation enhancers increase the rate of passage of drugs through biological membranes or biological barriers. The permeation promotion, for example, by the method of Merrit et al. (Diffusion Apparatus for Skin Penetration, J. Controlled Release, 1984, 1, 161-162).

Suitable permeation enhancers include, for example, fatty acid esters, fatty acid alcohols, 2- (2-ethoxyethoxy) ethanol, glycerol esters, glycerol monolaurate,

Propylene glycol, polyethylene glycol, unsaturated polyglycolated glycerides (Labrafil

M1944CS ^®, Gattefosse), saturated polyglycerides (Labrasol ^®, Gattefosse),

^(® Softigen, sleeve) partial glyceride of ricinoleic acid, Labrafac Hydra WL1219 ^®

(Gattefosse), Estasan ^® (Gattefosse), α-hydroxy acids, dimethylsulfoxide, decylmethylsulfoxide, pyrrolidone, salicylic acid, lactic acid, myristol,

Isopropyl myristate, dimethylformamide, dimethylacetamide, sodium dodecylsulfate,

Phospholipids, Transcutol ^® (Gattefosse), Eutanol ^® (Henkel), as well as mixtures comprising oleic acid / 2- (2-ethoxyethoxy) -ethanol, oleic acid / Labrafil ^®, and oleic acid /

Labrafac ^® (Gattefosse), preferably in a ratio of 1: 1. As a permeation enhancer, certain enzymes can also be used which promote the permeation of chemicals through a hard nail or Keratinewebe.

Hyaluronic acid is a naturally occurring biopolymer that has the ability to bind very large amounts of water relative to its own mass. In the body it comes u. a. in synovial fluid. Hyaluronic acid may be added in an amount of from 0.1 to 10% by weight, and preferably from 0.5 to 5% by weight, based on the total amount of the nail polish.

The one or more keratolytic agents are preferably used in an amount of 1 to 10 wt .-% based on the total weight of the nail polish. Keratolytic means "horn-releasing" or "shuddering". This term refers to the property of such agents to dissolve the horny layer of the skin. Examples of keratolytic agents are salicylic acid, acetic acid, glycolic acid, ammonium sulfite and combinations thereof.

Binders or film formers for thickening the nail polish and for forming a uniform film can also be used in amounts of from 0.1% by weight to 10% by weight, based on the total mass.

Suitable binders or film formers are preferably cellulose-based materials such as cellulose nitrate or ethylcellulose or physiologically acceptable polymers thereof, polyvinyl acetate, partially saponified polyvinyl acetate, copolymers of vinyl acetate and acrylic acid or crotonic acid or monoalkyl maleate, ternary copolymers of vinyl acetate and crotonic acid and vinyl neodecanoate, or crotonic acid and vinyl propionate, Copolymers of methyl vinyl ether and

Maleic acid monoalkyl esters, in particular as monobutyl maleate, copolymers of fatty acid vinyl ester and acrylic acid or methacrylic acid, copolymers of N-vinylpyrrolidone, methacrylic acid and methacrylic acid alkyl esters, copolymers of acrylic acid and methacrylic acid or alkyl acrylates or methacrylates, in particular containing quaternary ammonium groups, or polymers, copolymers or mixtures containing Ethyl acrylate, methyl methacrylate or trimethylammonioethyl methacrylate chloride, or polyvinyl acetals and polyvinyl butyrals, alkyl-substituted poly-N-vinylpyrrolidone, alkyl esters of copolymers of olefins and maleic anhydride, reaction products of rosin with acrylic acid and benzoic resins, chitosan and Luvimer 100 ^® . In the esters, the alkyl radicals are usually short chain and usually have no more than four carbon atoms. Such materials are also referred to herein as polymer-forming or film-forming substances.

The binders or film formers include water-soluble polymers such as ionic polyamides, polyurethanes and polyesters and homo- and copolymers of ethylenically unsaturated monomers. Such materials are, for example, under the trade names Acronal ^®, Acudyne ^®, Amerhold ^®, Amphome ^®, Eastman AQ ^®, Lovocryl ^®, Luviflex VBM ^®, Luvimer ^®, Luviset PUR ^®, Luviskol ^®, Luviskol ^® Plus, Stepanhold ^®, Ultrahold ^® , Ultrahold Strand ^® or Versatylr ^® . In Luvimer ^® is developed by the company BASF AG is a polyacrylate as a hair styling polymer. In particular, chitosan may be mentioned here, a naturally occurring biopolymer and derivative of chitin, which can be obtained by alkaline hydrolysis of chitin, for example with potassium hydroxide solution. In the present invention, it serves to make fat-like substances more water-soluble. Chitosan may be added in an amount of from 1 to 10% by weight, and preferably from 3 to 6% by weight, based on the total amount of nail varnish.

Thiolated polymers, i. Polymers with thiol side chains, so-called "thiomers", can also be present in the nail varnish according to the invention. [0101] Active substances have a better adhesion to this substance group and can thus be better transported to the site of action.

In addition, the nail polish may also contain lipids of mono- or / and polyunsaturated fatty acids, preferably with a chain length of 10 to

25 carbon atoms or phospholipids. Examples of such phospholipids are:

Phosphatidylcholine, phosphatidylserine, phosphatidylglycerol,

Dipalmitoylphosphatidylserine, dipalmitoylphosphatidylcholine and / or

Dimyristoylphosphatidylcholine, with phosphatidylcholine and phosphatidylserine being particularly preferred.

If the amino acid serine is bound to the phosphate group, one arrives at serine-cephalin, which is also called phosphatidylserine and has the following structure:

phosphatidylserine

The phosphatidylserine contains any two fatty acid residues which are esterified with the glycerol residue. For example, if there are two palmitoyl fatty acid residues, dipalmitoyl phosphatidyl serine of the following structure is obtained

Dipalmitoylserinkephalin

Choline is used in particular as a neurotransmitter precursor and has the following structure

Θ HO-CH ₂ -CH ₂ -N (CH ₃ ) ₃

choline

In addition to the at least one lipid or at least one phospholipid, the formulation of the nail polish remover may also contain at least one sulfur-containing amino acid and / or at least one sulfur-containing imino acid or mixtures of these acids and lipids. These substances or mixtures are contained in an amount of up to 10% by weight in the nail polish remover.

Examples of sulfur-containing amino acids or imino acids are cysteine, cystine, methionine, thioproline, 4-hydroxythioproline, thiazolidinecarboxylic acid and the tripeptide glutathione as well as all possible chiral isoforms and racemic mixtures of the abovementioned compounds, wherein the racemic individual components can occur in any ratios, additionally comprising all possible D / L forms and R / S forms of the aforementioned compounds.

Odorants and dyes, if present, preferably together account for only one part by weight, preferably less than 2% by weight and more preferably less than 1% by weight.

Preservatives, permeation enhancers, keratolytic agents and binders, if any, preferably with respect to the nail polish formulation not more than 20% by weight, more preferably not more than 15% by weight, and particularly preferably not more than 10% by weight.

In the nail varnish formulation of the present invention, the ingredients are preservative, odorant, permeation enhancer, dye and / or binder preferably in an amount of 0.01% by weight to 30% by weight, and particularly preferably in an amount of 0.1% by weight. contain up to 10% by weight of the nail polish.

In addition, the nail varnish may still contain substances in a total amount of up to 10 wt .-%, preferably up to 5 wt .-%, selected from the group consisting of or comprising phthalate or camphor based plasticizers, Sedimentationsverzögerer, sulfonamide resins, silicates, lanolin derivatives , Sunscreens such as 2-hydroxy-4-methoxybenzophenone, esters and salts of thioglycolic acid, allantoin and / or enzymes.

In addition to these other constituents of the nail polish formulation, the nail polish may of course also contain one or more antimycotic or antiviral or antibacterial or antimicrobial or anti-infective or antipsoriatic or antiparasitic substances.

The at least one active substance or the combination of active substances may be added to the nail varnish preferably in an amount of from 0.01 to 8% by weight, more preferably in an amount of from 0.05 to 6% by weight, and most preferably in an amount of 0 , 1 to 4 wt .-% are added.

Examples of the at least one antimycotically active or at least one antiviral or at least one antibacterial or at least one antimicrobial or at least one anti-infective or at least one antipsoriatic or at least one antiparasitic acting substance can be selected from the group comprising or consisting of

- (+) - cis-2,6-dimethyl4- [2-methyl-3- (p-tert-pentylphenyl) propyl] morpholine (amorolfin)

- Amphotericin

- 6-cyclohexyl-1 -hydroxy-4-methyl-2 (1 H) -pyridinone (Ciclopirox, Batrafen ^®, Aventis Pharma)

Bis-phenyl (2-chlorophenyl) -1-imidazolylmethane (clotrimazole) - 1 - [2- (2,4-dichlorophenyl) -2- (4-chlorobenzyloxy) ethyl] imidazole (econazole)

- 2,4-difluoro-α, α-bis (1 H-1, 2,4-triazol-1-ylmethyl) benzyl alcohol (fluconazole .Diflucan ^®)

- 5-fluorocytosine (flucytosine) - y-chloro-trimethoxy-methyl-spiro-tbenzofuran-cyclohexene-dione (griseofulvin)

- 1 - [2,4-dichloro-ss (2,6-dichlorobenzyloxy) -phenethyl] imidazole (isoconazole)

- (±) -1-sec-butyl-4- {4- [4- (4 - {[(2R *, 4S *) -2- (2,4-dichlorophenyl) -2- (1, 2,4 -triazol-1-ylmethyl) -1,3-dioxolan-4-yl] methoxy} phenyl) -1-piperazinyl] phenyl} 4,5-dihydro-1,2,4-triazol-5-one (itraconazole) - (±) -cis-1-Acetyl-4- {4 - ([2- (2,4-dichlorophenyl) -2- (1 H -imidazol-1-ylmethyl) -1, 3-dioxolan-4-yl] methoxy) phenyl piperazine (ketoconazole)

- 1 - [2,4-dichloro-β- (2,4-dichlorobenzyloxyl) -phenethyl] imidazole (miconazole)

- (E) -N-cinnamyl-N-methyl-1-naphthylnethylamine (naftifine)

- Nystatin - (E) -N- (6,6-dimethyl-2-hepten-4-ynyl) -N-methyl-1-naphthylmethylamine

(Terbinafine)

- 1 [2 - {(2-chloro-3-thienyl) methoxy} -2- (2,4-dichlorophenyl) ethyl] -1H-imidazole (Tioconazole)

O-2-naphthyl-N-methyl-N- (3-tolyl) -thiocarbamate (tolnaftate) -α- (2,4-difluorophenyl) -5-fluoro-ss-methyl-α- (1H-1, 2,4-triazol-1-ylmethyl) 4-pyrimidineethanol (voriconazole)

- pentamycin

- Sertaconazole

Preference is given to the following antimycotics and their physiologically acceptable

salts:

2,4-difluoro-α, α-bis (1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol (fluconazole)

- (±) -1-sec-butyl-4- {4- [4- (4 - {[(2R *, 4S *) -2- (2,4-dichlorophenyl) -2- (1, 2,4 -triazol-1-ylmethyl) -1,3-dioxolan-4-yl] methoxy} phenyl) -1-piperazinyl] phenyl} -4,5-dihydro-l, 2,4-triazol-5-one (itraconazole)

6-Cyclohexyl-1 -hydroxy-4-methyl-2 (1 H) -pyridinone (Ciclopirox, Batrafen ^®, Aventis Pharma)

Bis-phenyl (2-chlorophenyl) -1-imidazolylmethane (clotrimazole)

- 1 - [2- (2,4-dichlorophenyl) -2- (4-chlorobenzyloxy) ethyl] imidazole (econazole)

- pentamycin - (+) - cis-1-Acetyl-4- {4 - ([2- (2,4-dichlorophenyl) -2- (1 H -imidazol-1-ylmethyl) -1,3-dioxolan-4-yl] methoxy) phenyl piperazine (ketoconazole)

- 1 - [2,4-dichloro-sis (2,4-dichlorobenzyloxyl) -phenethyl] imidazole (miconazole)

- (E) -N- (6,6-dimethyl-2-hepten-4-ynyl) -N-methyl-1-naphthylmethylamine (terbinafine)

α- (2,4-Difluorophenyl) -5-fluoro-β-methyl-α- (1H-1,2,4-triazol-1-ylmethyl) -4-pyrimidinethanol (voriconazole)

- Sertaconazole

Suitable active ingredients are, for example, the following antibiotics and their physiologically tolerated salts:

α-amino-4-hydroxybenzylpenicillin (amoxicillin)

- D - (-) - α-aminobenzylpenicillin (ampicillin) - S.S-dimethyl ^ -oxo-θ-phenylacetamido-thia-i-azabicyclo-tS-o-heptane-carboxylic acid (benzylpenicillin)

Benzylpenicillin benzathine

3-chloro-7-D (2-phenylglycinamido) cephalosporanic acid (cefaclor)

7ß- [D-2-amino- (4-hydroxyphenyl) -acetylamino] -3-methyl-cephalosporanic acid (cefadroxil)

- Amino-phenylacetamido-methyl-cephalosporanic acid (cefalexin)

- D (-) - threo-2-dichloroacetamido-1 - (4-nitrophenyl) -1,3-propanediol (chloramphenicol)

1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl) -3-quinolinecarboxylic acid (ciprofloxacin)

(Z) - (2R, 5R) -3- (2-hydroxyethylidene) -7-oxo4-oxa-1-azabicyclo [3.2.0] heptane-2-carboxylic acid (clavulanic acid)

7-chloro-7-deoxy-1-incomycin (clindamycin)

6-deoxy-5-hydroxytetracycline (doxycycline) -1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl) -1,8-naphthyridine-3-carboxylic acid (enoxacin)

- Erythromycin

3- (2-chloro-6-fluorophenyl) -5-methyl-4-isoxazolyl penicillin (flucloxacillin)

- kanamycin - lincomycin

7-dimethylamino-6-desoxy-6-demethyltetracycline (minocycline)

6- (2-ethoxy-1-naphthamido) -penicillin (nafcillin)

1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (nalidixic acid) - Neomycin

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl) -3-quinolinecarboxylic acid (norfloxacin)

- (±) -9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido [1,2,3-de] [1,4 ] benzoxazine-6-carboxylic acid (ofloxacin)

6- (5-methyl-3-phenyl-4-isoxazolecarboxamido) penicillanic acid (oxacillin)

6-phenoxyacetylamino-penicillanic acid (phenoxymethylpenicillin)

4-Dimethylamino-octahydro-pentahydroxy-1,11-dioxo-6-methyl-naphthacene-2-carbamide (tetracycline) -pentamycin

- Levolfoxacin

- Tobramycin

Preference is given to the following antibiotics and their physiologically acceptable salts:

- (±) -9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido [1,2,3-de] [1,4 ] benzoxazine-6-carboxylic acid (ofloxacin) - pentamycin

- Levofloxacin

- Tobramycin

Suitable active ingredients are, for example, the following antiseptics:

Alkylbenzyldimethylammonium chloride (benzalkonium chloride)

N-Benzyl-N, N-dimethyl-2- {2- [p- (1,1,3,3-tetramethylbuthyl) phenoxyethoxy) -ethylammonium hydroxide (benzethonium chloride)

Cetyltrimethylammonium hydroxide (cetrimonium bromide) - 1, 1'-hexamethylene-bis- [5- (p-chlorophenyl) -biguanide] (chlorhexidine)

N ', N'-decamethylene-bis- (4-amino-quinaldinium hydroxide) (dequalinium chloride)

N- (4-chlorophenyl) -N "- (3,4-dichlorophenyl) urea (triclocarban)

5-chloro-2- (2,4-dichlorophenoxy) phenol (triclosan)

The following antiseptic is preferred:

1,1-hexamethylene-bis- [5- (p-chlorophenyl) biguanide] (chlorhexidine) Suitable active ingredients are, for example, the following corticosteroids and their physiologically tolerated salts:

9α-chloro-16β-methylprednisolone (beclomethasone) - 9-fluoro-11β, 17,21-trihydroxy-16ss-methyl-1,4-pregnadiene-3,20-dione

(Betamethasone)

21-chloro-9-fluoro-11β, 17-dihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione (clobetasol)

- 17,21-dihydroxy-pregn-4-ene-3,11,20-trione (cortisone) - 11β, 16α, 17α, 21-tetrahydroxy-1,4-pregnadiene-3,20-dione-16,17 -acetonacetal

(Desonide)

9-fluoro-11β-17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (dexamethasone)

- 9α, 11β-dichloro-6α-fluoro-21-hydroxy-16α, 17α- (isopropylidenedioxy) -pregna-1, 4-diene-3,20-dione (flucloronide)

6α, 9α-difluoro-16α, 17α-isopropylidenedioxy-corticosterone (fluocinolone acetonide)

6α, 9α-difluoro-16α, 17α-isopropylidenedioxy-corticosterone acetate (fluocinonide)

6α-fluoro-11ss, 21-dihydroxy-16α, 17-isopropylidenedioxy-4-pregnene-3,20-dione (fludroxycortide)

3- (2-chloroethoxy) -9α-fluoro-6-formyl-11ss, 21-dihydroxy-16α, 17α-isopropylidenedioxypregna-3,5-dien-20-one (formocortal)

21-chloro-9α-fluoro-11 ss-hydroxy-16α, 17α-isopropylidenedioxy-4-pregnene-3,20-dione (halcinonide) - 17α-hydroxycorticosterone (hydrocortisone)

11β, 17,21-trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione (methylprednisolone)

11β, 17,21-trihydroxy-pregna-1,4-diene-3,20-dione (prednisolone)

- 17α, 21-dihydroxy-pregna-1,4-diene-3,11,20-trione (prednisone) - 9-fluoro-16α-hydroxyprednisolone (triamcinolone)

Triamcinolone-16α, 17α-acetonide (triamcinolone acetonide)

- Prednicarbate

The following corticosteroids and their physiologically acceptable salts are preferred:

- 11β, 16α, 17α, 21-tetrahydroxy-1,4-pregnadiene-3,20-dione-16,17-acetone acetal (desonide) 9a, 11β-dichloro-6α-fluoro-21-hydroxy-16α, 17α- (isopropylidenedioxy) -pregna 1, 4-diene-3,20-dione (flucloronide)

5 - θα.θα-difluoro-iαα-α-isopropylidenedioxy-corticosterone acetate (fluocinonide)

6α-fluoro-11β, 21-dihydroxy-16α, 17-isopropylidenedioxy-4-pregnene-3,20-dione (fludroxycortide)

3- (2-chloroethoxy) -9α-fluoro-6-formyl-11β, 21 -dihydroxy-16α, 17α-isopropylidenedioxypregna-3,5-dien-20-one (formocortal)

10-21-chloro-9α-fluoro-11β-hydroxy-16α, 17α-isopropylenedioxy-4-pregnene

3,20-dione (halcinonide)

Triamcinolone-16α, 17α-acetonide (triamcinolone acetonide)

- Prednicarbate

Also suitable drug combinations of corticosteroids with

Antifungals, antibiotics or antiseptics. A preferred example of this is:

- (±) -cis-1-acetyl-4- {4 - ([2- (2,4-dichlorophenyl) -2- (1H-imidazol-1-ylmethyl) -1,3-dioxolan-4-yl ] methoxy) phenyl piperazine (ketoconazole)

ZΛJ together with

11β, 16α, 17α, 21-tetrahydroxy-1,4-pregnadiene-3,20-dione-1,6,17-acetone acetal (desonide).

25

As further active ingredients can be contained:

Butoconazole, enilconazole, fenticonazole, sulconazole, iodoquinol, rimoprogin, griseofulvin, tioconazole, isoconazole, terconazole, oxiconazole, salicylic acid, glucocorticoids such as alclometasone dipropionate, amcinonide,

30 beclomethasone dipropionate, Bendacort, betamethasone benzoate,

Betamethasone dipropionate, betamethasone valerate, budesonide, chlorquinaldol, clioquinol, clobetasol propionate, clobetasone butyrate, desoximetasone, dichloroethane, diflorasone diacetate, diflucortolone valerate, difluprednate, dimethyl fumarate, dithranol, psoralens, acitretin, tazarotene, methotrexate, ciclosporin, fluazacort,

35 flucinolone acetonide, fluclorolone acetonide, flumathasone pivalate,

Fluocinolone acetonide, fluocortolone, fluorometholone, flupamesone, flupredniden, flupredniden acetate, flurandrenolide, halometasone, hydrocortamate, hydrocortisone butyrate, methylprednisolone aceponate, mometasone furoate, tixocortol, triamcinolone acetonide, neomycin, kanamycin, gentamycin, amantadine, acyclovir,

40 penciclovir, brivudine, idoxuridine, trifluridine, vidarabine, tromantadine, ganciclovir, Cidofovir, foscarnet, 5-fluorouracil, cytarabine, gemcitabine and salts of the aforementioned substances. The glucocorticosteroids can be present both as free alcohols and in the form of their esters.

The nail varnish according to the invention can be prepared in the consistency of a liquid varnish or a more viscous varnish as well as a viscous formulation, an ointment or a cream, depending on the nature and amount of the solvent (s) and the additives.

The nail polish according to the invention can be applied by means of a dispenser, tube, pen, atomizer, brush, brush, puff, sponge, pulp, tissue, sticker, nail plaster, spray bottle or drop dispenser.

Accordingly, the nail varnish can be bottled in bottles, tubes, dispensers, cans or applied or marketed introduced into pulp or tissue in the form of nail patches.

The nail varnish according to the invention with or without a phamacological active ingredient is outstandingly suitable for the treatment of diseases and infections of toenails and fingernails as well as of hair and skin. This results in an inevitably topical application of the nail varnish according to the invention.

The addressed diseases are often caused by viruses, bacteria, parasites and in particular by fungi, but can also be caused by chemicals, for example from detergents or paints or by drug intolerances to antibiotics, anticoagulants, ACE inhibitors, beta-blockers, thiazides or cytostatics.

Among the most important fungi which cause fungal nail infections (onychomycosis) include yeasts of, for example, the Candida species as well as dermatophytes such as e.g. Trichophyton, Microsporum and Epidermophyton.

Dermatophytes are a special group of fungi that specialize in growth in the foot and fingernails, skin and hair. They form enzymes such as keratinases, elastases and collagenases, which enable them to dissolve the proteins and structures in the nail, the skin and the hair, to settle and thus trigger infections. An infection by dermatophytes is medically referred to as "tinea" Body regions are z. As tinea pedis (foot, tinea pedum), tinea manuum (hand, tinea manum), tinea capitis (head), tinea corporis (upper body), tinea barbae (beard) and tinea faciei (face).

Diseases of the nails as well as the hair and the skin can be caused by endogenous causes such. As eczema (atopic eczema) or psoriasis, but also by exogenous causes such. As caused by fungal infections, bacterial (staphylococci) or viral infections.

Furthermore, diseases of the nails are also caused by malfunction of the kidney, heart failure and avitaminosis as well as by idiopathic causes. Also, contact with chemicals such as acids and bases or oxidants as well as burns and chemical burns or physical effects due to mechanical stress can lead to nail diseases or changes in nails.

Examples of such diseases and infections of the nails are viral nail infections, bacterial nail infections, parasitic nail infections, nail fungus infections, (onychomycosis), onychocryptosis, onychodystrophy, nails psoriasis, melanonychia striata, white-line disease, eczema, chronic onychia, onychitis, paronychia, discolored nails, thickened nails, discoloration of nail bed, onycholysis (detachment of nail plate from nail bed), subungual keratosis, nail plate anomalies.

Paronychia or "circulatory" refers to inflammations of the nail wall which are most commonly caused by infection with staphylococci.The nail wall is the portion of the skin that encompasses the fingernails and toenails on the side and at the root.

It is further preferred to use the nail varnish according to the invention in combination with a systemic treatment. Systemic administration may be in the form of oral administration of antibiotics, antimycotics, antiviral agents, antipsoriatic agents or antiparasitic agents, such as in an oral dose of itraconazole, fluconazole, retinoids or the immunosuppressant ciclosporin A. The cosmetic variant of the nail polish preferably contains none of the aforementioned pharmacological agents. The cosmetic nail polish supports the regeneration of the nails, leads to hard, non-brittle nails and protects nails and nail bed from the aforementioned diseases. In addition, the cosmetic nail polish nail bed and adjacent skin protects against drying, has an antiseptic and supports wound treatment, reduces skin and nail bed irritation and protects against itching.

Examples

Example 1 (100 g) Example 2 (100 g)

Urea 2g urea 5g

Dexpanthenol 8g Dexpanthenol 5g

Evening Primrose Oil 1 g Sanddom Oil 3g

DMSO i g p-hydroxybenzoate i g

Glycerol i g salicylic acid 1 g

Acetone 2g fluconazole 1g

PEG 200 i g ethylene glycol 4g

Chitosan 3g Chitosan 5g

Ethanol ad 100 g isopropanol ad 100 g

Example 3 (100 g) Example 4 (100 g)

Urea 3g urea i g γ-linolenic acid 5g palmitoleic acid 2g

Dexpanthenol 0.3 g of cysteine i g

Ethylene glycol 3g Dexpanthenol 2g

Dimethyl fumarate 2g pentamycin i g

Hydroxypropylmethyl cellulose 4g PEG 400 4g

Ethanol-isopropanol (1: 1) ad 100 g acrylic polymer 5 g

Isopropanol 20 g

Ethanol ad 100 g

Example 5 (100 g) Example 6 (100 g)

Urea 3.5 g urea 3g

Allantoin 2g evening primrose oil Qg

Oleic Acid 2g DMSO 1.5g

Ethyl cellulose i Luvimer 100 2g

Lactic Acid i g Myristol 5g

Propylene glycol 2g Dexpanthenol 1,5g

Methionine 1 g 5-fluorouracil 0.5 g

Ciclopirox i g ethanol ad 100 g

Dexpanthenol 3.5 g

Acetone 5g

Acrylic polymer 6g

Isopropanol ad 100 g Example 7 (100 g) Example 8 (100 g)

Urea i g urea 4g

Dexpanthenol 10g folic acid i g

Linoleic acid 3g Dexpanthenol 2.5g

PEG 400 2g ethylene glycol 3g

Acetone 11 g Linseed Oil 5g

Prednicarbate 2g polyacrylamide 7.5g

Terbinafine 1 g lavender 0.5 g

Ethanol ad 100 g ethanol ad 100 g

Example 9 (100 g) Example 10 (100 g)

Urea 2.5 g dexpanthenol 2g

Dexpanthenol 3.5 g Allantoin 2g

Gamma-linolenic acid 6.0 g linoleic acid 8.5 g

Luvimer 100 6.0 g Chitosan 4g

Tazarotene 0.05 g PEG 400 3g

PEG 400 2.5 g acetone 0.5 g

Ethanol ad 100 g clotrimazole 2g

Betamethasone 0.1 g

Isopropanol ad 100 g

Example 11 (100 g) Example 12 (100 g)

Urea 4g urea 4g

Sea Buckthorn Seed Oil 8g Sea Buckthorn Fruit Oil 9g

Dexpanthenol 5g Dexpanthenol 3g

Glycerol 1 g phenol 0.5 g

Stilbenoxid 2g Aloe-Vera 2g

Polymethacrylate 8g 1, 4-dihydroxybutanol 1 g

Acetone ad 100 g lemon balm 1 g

Ethanol ad 100 g Example 13 (100 g) Example 14 (100 g)

Urea 5g urea 6.5g

Sea buckthorn oil 25 g Sandornseed oil 5.5 g

Dexpanthenol 4g Dexpanthenol 3.5g

Ethylparaben 3g oleic acid 5.5 g

Selenomethionine 2g diazolylidinyl urea 1.5g

Polymethylmethacrylate 7g Arnica tincture 3g

Acetone ad 100 g peach kernel oil 2g

Propanol 3g

Polyacrylic acid 4g

Acetone ad 100 g

Example 15 (100 g) Example 16 (100 g)

Urea 3g Urea 3.0g

Sea buckthorn seed oil 11 g α-linolenic acid 7.8 g

Dexpanthenol 1 g Dexpanthenol 2.5 g

Glycerol 2g arachidonic acid 0.6 g

Methylparaben Sand gum oil 1.2 g

Polymethacrylate 8.8 g Luvimer 100 3.3 g

Acetone ad 100 g of ethanol ad 100 g

Example 17 (100g) Example 18 (10g)

Urea 2g urea 4.0g

Sea buckthorn seed oil 2g γ-linolenic acid 5.8 g

Dexpanthenol 2g Dexpanthenol 1.8g

Crotonic acid 2g soybean oil 0.4g

N-vinylpyrrolidone 1 g evening primrose oil 2.2 g

Polymethacrylate 8.8 g Acronal 2.8 g

Acetone ad 100 g of ethanol ad 100 g

The term "ad 100 g" means that the solvent constitutes the remaining weight fraction up to 100 g. Nail preparations - application observation

application

Preparations 1 to 8 as listed below are applied thinly to the dry and clean nail plate every 2 days. Before application, the nails are cleaned with a 70% isopropanol solution.

Duration of application: 2 months.

1st patient

10 patients (female, 20-45 years old) with fungal diseases of the fingernails. The affected area of the nail plate may amount to a maximum of 30%. measurement parameters

The overall impression of the effects (A), the effect on the elasticity (B) and the effect on the brittleness (C) of the nails are evaluated before and after two months of treatment by a subjective satisfaction scale by the patients:

- very good (5)

- good (4)

- medium (3)

- sufficient (2)

- not sufficient (1)

Preparation score /% judgment

1 14/93% very good 2 13/86% very good 3 11/73% good

4 8/53% average 5 6/40% sufficient

6 12/77% good

7 9/58% medium

8 7/47% medium

9 13/83% very good 10 13/89% very good Bewertunqsergebnisse

Maximum achievable score: 15 = 100%

Areas: very good = 100-80%, good = 80-60%, medium 60-40%, sufficient 40-20%, insufficient = 20-0%.

Summary

The best results were obtained by using Preparation 1 with urea, seabuckthorn oil, dexpanthenol, and antifungal clotrimazole

Acrylate polymer can be achieved. The concentration of clotrimazole used is in the suboptimal range (0.5%). Usually, concentrations between 1-2% clotrimazole are used. The suboptimal concentration of

Antifungal was deliberately used to show the additional effectiveness of the other ingredients in the preparation ("very good", 93% of the total)

Maximum score has been reached).

Preparation 2 has the same composition as Preparation 1, i. all important ingredients as mentioned in the patent application, but without the antifungal. Similarly, very good results similar to preparation 1 could be found. A comparable result could also be achieved with Preparation 9, which contained linseed oil instead of seabuckthorn oil. Preparation 10 is probably still slightly more effective than Preparation 2 and 9 because of the higher concentration of component b).

The results demonstrate that the essential, important preparation components such as urea, oil with a high content of fatty acids such as omega fatty acids together with the example of seabuckthorn oil and linseed oil and dexpanthenol together have a better effect than the individual components. The antimycotic has an additional effect but only minimally, since the dose used was suboptimal. It is to be expected that the antifungal in an optimal dosage in combination with the other essential components of the solution acts synergistically ("very good", 86% score was achieved in preparation 2 without antifungal).

Preparation 3 contains urea, sea buckthorn seed oil, but polymer without dexpanthenol. A good effectiveness of the preparation could be observed. The assessment "very good efficacy" as in Preparation 1, 2, 9 and 10 was not reached. The same applies to the preparations 6 and 7, which contain only a part of the essential components. Obviously, dexpanthenol and urea as well as the oil used are essential components of the solution in order to achieve high efficacy. If one component is missing, no "very good" results were achieved ("good", 73% score preparation 3 without dexpanthenol; "good", 77% score preparation 6 without urea; "medium", 58% score preparation 7 without oil).

Preparation 4 contains urea, polymer and castor oil to replace sea buckthorn seed oil. Here only a mediocre improvement could be achieved. Seabuckthorn oil and linseed oil are obviously better suited than castor oil for these purposes ("medium", 53% score was achieved).

Preparation 5 contains only urea and polymer. Here, a decrease in the brittleness of the nail plate, but little improvement in the elasticity and overall appearance of the nails were observed. Of all preparations, preparation 5 showed the lowest achievable score.

Preparation 8 contains only a sub-optimal amount of the antimycotic clotrimazole with dexpanthenol and efficacy may be due to clotrimazole. Overall, however, only a "mediocre" efficacy was achieved (47%).

These results show that: The components of the nail solution as a whole system are necessary for the effect of the preparation in the treatment of nail changes

these ingredients include urea as a hydration agent, dexpanthenol as an anti-inflammatory and cell regeneration enhancer, and an oil (e.g., seabuckthorn oil or linseed oil) to help restore the lipid barrier. It is believed that restoring the lipid barrier is the key to maintaining the effects of urea and dexpanthenol.

- The acrylate polymer serves as a drug carrier and as a physical protection of the nails and is preferably not essential - Antimycotic agent in a suitable dosage / concentration can enhance the effect of the solution / preparation even more, especially in medical applications.

Claims

claims

1. nail polish containing the following constituents: a) urea, b) fatty acids containing 10 to 25 carbon atoms, or

Oils containing more than 20% by weight of fatty acids containing 10 to 25 carbon atoms or mixtures of said fatty acids and oils, c) dexpanthenol and d) at least one solvent.

2. Nail varnish according to claim 1, further comprising at least one polymer-forming or film-forming substance.

3. Nail varnish according to claim 1 or 2, further containing allantoin or hyaluronic acid or a wax or at least one permeation enhancer or at least one antimicrobial substance or at least one antipsoriatic or at least one substance against eczema or at least one additive or mixtures of the aforementioned substances.

4. Nail varnish according to claim 1 or 2, further comprising polyethylene glycol, at least one sulfur-containing amino acid, at least one sulfur-containing imino acid, at least one lipid or at least one

Phospholipid or mixtures of the aforementioned substances, at least one preservative, at least one odorant, at least one keratolytic agent, at least one dye, at least one binder, at least one antioxidant, at least one plasticizer or mixtures of the aforementioned substances.

5. nail polish according to claim 1 or 2, further comprising at least one antimycotic or antiviral or antibacterial or antimicrobial or anti-infective or antipsoriatic or antiseptic or antiparasitic substance.

6. Nail varnish according to one of the preceding claims, wherein the fatty acids containing 10 to 25 carbon atoms selected from a group include oleic acid, eicosapentaenoic acid, timnodonic acid, docosahexaenoic acid, arachidonic acid, linoleic acid, α-linolenic acid, γ-linolenic acid, dihomo-γ-linolenic acid and mixtures of the abovementioned fatty acids.

7. Nail varnish according to one of the preceding claims, wherein the oils are selected from the group comprising linseed oil, hemp oil, Echiumöl, Trichodesmaöl, currant seed oil, corn oil, walnut oil, rapeseed oil, soybean oil, sunflower oil, poppy oil, safflower oil (Färberdistelöl), wheat germ oil, thistle oil, grape seed oil , Evening primrose oil, Borage oil, Black cumin oil, Algae oil,

Fish oil, cod liver oil, evening primrose oil, sea buckthorn oil, sea buckthorn oil, sea buckthorn pulp oil or mixtures of the aforementioned oils.

8. Nail varnish according to claim 1, wherein the oils contain at least 15 wt .-% of unsaturated fatty acids.

9. Nail varnish according to claim 3, wherein the waxes are selected from a group consisting of beeswax, carnauba wax, candelilla wax or mixtures thereof.

10. Nail varnish according to one of the preceding claims, wherein the fatty acids containing 10 to 25 carbon atoms and the oils are contained together in a concentration of 5 - 15 wt .-% in the nail polish.

11. Nail varnish according to claim 5, wherein the at least selected one antifungal or antiviral or antibacterial or antimicrobial or anti-infective or antipsoriatic or antiseptic or antiparasitic active substances from the group including amorolfine, amphotericin, ciclopirox, Batrafen ^®, clotrimazole, econazole, fluconazole / Diflucan ^® , flucytosine, griseofulvin, isoconazole, itraconazole, ketoconazole, miconazole,

Naftifine, nystatin, terbinafine, tioconazole, tolnaftate, voriconazole, butoconazole, enilconazole, fenticonazole, sulconazole, terconazole, oxiconazole, voriconazole, sertaconazole, amphotericin B, tolciclate, sulbentin, bifonazole, amoxicillin, ampicillin, benzylpenicillin, cefaclor, cefadroxil, cefalexin, chloramphenicol , Ciprofloxacin, clavulanic acid, clindamycin, doxycycline, enoxacin,

Erythromycin, flucloxacillin, kanamycin, lincomycin, minocycline, nafcillin, nalidixic acid, neomycin, norfloxacin, ofloxacin, oxacillin, phenoxymethylpenicillin, tetracycline, norfloxacin, ofloxacin, levofloxacin, Pentamycin, alkylbenzyldimethylammonium chloride, benzalkonium chloride, benzethonium chloride, cetyltrimethylammonium hydroxide, cetrimonium bromide, chlorhexidine, dequalinium chloride, triclocarban, triclosan, beclomethasone, betamethasone, clobetasol, cortisone, desonide, dexamethasone, flucloronide, fluocinolone acetonide, fluocinonide, fludroxycortide, formocortal, halcinonide,

Hydrocortisone, methylprednisolone, prednisolone, prednisone, 9-fluoro-16α-hydroxyprednisolone, triamcinolone, triamcinolone-16α, 17α-acetonide, triamcinolone acetonide, alclometasone dipropionate, amcinonide,

Beclomethasone dipropionate, Bendacort, betamethasone benzoate, betamethasone dipropionate, budesonide, chlorquinaldol, clioquinol,

Clobetasol propionate, clobetasone butyrate, desoximetasone, dichloroison, diflorasone diacetate, diflucortolone valerate, difluprednate, fluazacort, flucinolone acetonide, fluclorolone acetonide, flumathasone pivalate,

Fluocinolone acetonides, fluocortolone, fluorometholone, flupamesone, flupredniden, flupredniden acetate, flurandrenolide, halometasone,

Hydrocortamate, hydrocortisone butyrate, methylprednisolone aceponate, mometasone furoate, prednicarbate, tixocortol, triamcinolone acetonide, iodoquinol, rimoprogin, sodium pyrithione, salicylic acid, dimethyl fumarate, dithranol, psoralens, acitretin, tazarotene, methotrexate, ciclosporin, neomycin, kanamycin, gentamycin, amantadine, acyclovir, penciclovir,

Brivudine, idoxuridine, trifluridine, 5-fluorouracil, vidarabine, tromantadine, ganciclovir, cidofovir and salts of the aforementioned substances.

12. Nail varnish according to claim 2, wherein the at least one polymer-forming or film-forming substance is selected from the group comprising

Polymers, acrylate polymers, methacrylate polymers, acrylic polymers, methacrylic polymers, polysaccharides, chitin, chitosan, Acronal ^®, Acudyne ^®, Amerhold ^®, Amphome ^®, Eastman AQ ^®, Lovocryl ^®, Luviflex VBM ^®, Luvimer ^®, Luviset PUR ^®, Luviskol ^®, Luviskol plus ^®, Stepanhold ^®, Ultra Hold ^®, Ultra Hold strand ^® and Versatylr ^®.

13. A nail varnish according to claim 4, wherein the at least one phospholipid is selected from the group comprising phosphatidylcholine, phosphatidylserine, phosphatidylglycerol, dipalmitoylphosphatidylserine, dipalmitoylphosphatidylcholine and dimyristoylphosphatidylcholine.

14. Nail varnish according to one of the preceding claims, wherein the urea is used in an amount of 0.1 wt .-% to 10 wt .-% of the nail varnish.

15. Nail varnish according to one of the preceding claims, wherein the oils with a weight proportion of more than 20 wt .-% of 10 to 25 carbon atoms containing fatty acids in an amount of 0.1 wt .-% to 40 wt .-% of the nail varnish used becomes.

16. Nail varnish according to one of the preceding claims, wherein the at least one solvent is selected from the group comprising purified water, methanol, ethanol, isopropanol, n-butanol, sec-butanol, isobutanol, ethylene glycol, propane-1, 2-diol, propane -1, 3-diol, glycerol or a mixture of the aforementioned solvents.

17. Nail varnish according to one of the preceding claims, wherein the solvent or the solvent mixture in an amount of 60 wt .-% to 95 wt .-% of the nail varnish is used.

18. Nail varnish according to one of the preceding claims, wherein the at least one permeation enhancer in an amount of 0.3 to 9 wt .-% are added to the nail polish.

19. Nail varnish according to one of the preceding claims, wherein the nail varnish contains dexpanthenol in an amount of 0.1 wt .-% to 10 wt .-% of the nail polish.

Nail varnish according to one of the preceding claims, wherein the nail varnish contains allantoin or hyaluronic acid or allantoin and hyaluronic acid in an amount of 0.1% by weight to 10% by weight of the nail varnish.

21. Nail varnish according to one of the preceding claims, wherein the nail varnish at least one sulfur-containing amino acid, at least one sulfur-containing imino acid, at least one lipid or at least one

Phospholipid or mixtures of the aforementioned substances in an amount of

0.1 wt .-% to 10 wt .-% of the nail polish.

22. Use of the nail polish according to one of the claims 1 - 21 for the treatment of damage and diseases and infections of the toenails and fingernails.

23. Use according to claim 22, wherein the diseases and infections of the toenails, fingernails, psoriatic nail damage, bacterial nail infections, parasitic nail infections,

Fungal nail infections / onychomycosis, onychocryptosis, onychodystrophy, nails psoriasis, melanonychia striata, white-line disease, eczema, chronic onychia, onychitis, paronychia, discolored nails, thickened and deformed nails, discoloration of the nail bed, onycholysis, subungual keratosis, nail plate abnormalities ,