WO2008046584A3 - Lepa as a target for antibacterial agents - Google Patents
Lepa as a target for antibacterial agents Download PDFInfo
- Publication number
- WO2008046584A3 WO2008046584A3 PCT/EP2007/008961 EP2007008961W WO2008046584A3 WO 2008046584 A3 WO2008046584 A3 WO 2008046584A3 EP 2007008961 W EP2007008961 W EP 2007008961W WO 2008046584 A3 WO2008046584 A3 WO 2008046584A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lepa
- target
- antibacterial agents
- methods
- substances
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
Abstract
The present invention relates to methods, substances and compositions for retarding or inhibiting cell growth by inhibiting the activity of ribosomal factor LepA. Further, methods and kits for identifying antibacterial substances are disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06021666 | 2006-10-16 | ||
EP06021666.0 | 2006-10-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008046584A2 WO2008046584A2 (en) | 2008-04-24 |
WO2008046584A3 true WO2008046584A3 (en) | 2008-07-03 |
Family
ID=39271689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/008961 WO2008046584A2 (en) | 2006-10-16 | 2007-10-16 | Lepa as a target for antibacterial agents |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008046584A2 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1351059A (en) * | 2000-10-26 | 2002-05-29 | 上海博德基因开发有限公司 | Polypeptide-human LepA protein 12.32 and polynucleotide for coding it |
WO2002056013A2 (en) * | 2000-12-15 | 2002-07-18 | Upjohn Co | Oxazolidinone photoaffinity probes, uses and compounds |
WO2007003410A1 (en) * | 2005-07-04 | 2007-01-11 | Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. | Use of lepa for improving the accuracy of protein synthesis in vitro |
-
2007
- 2007-10-16 WO PCT/EP2007/008961 patent/WO2008046584A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1351059A (en) * | 2000-10-26 | 2002-05-29 | 上海博德基因开发有限公司 | Polypeptide-human LepA protein 12.32 and polynucleotide for coding it |
WO2002056013A2 (en) * | 2000-12-15 | 2002-07-18 | Upjohn Co | Oxazolidinone photoaffinity probes, uses and compounds |
WO2007003410A1 (en) * | 2005-07-04 | 2007-01-11 | Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. | Use of lepa for improving the accuracy of protein synthesis in vitro |
Non-Patent Citations (9)
Title |
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CALDON C E ET AL: "Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function.", MOLECULAR MICROBIOLOGY JUL 2001, vol. 41, no. 2, July 2001 (2001-07-01), pages 289 - 297, XP002477430, ISSN: 0950-382X * |
COLCA JERRY R ET AL: "Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 13 JUN 2003, vol. 278, no. 24, 13 June 2003 (2003-06-13), pages 21972 - 21979, XP002476765, ISSN: 0021-9258 * |
DATABASE WPI Week 200271, Derwent World Patents Index; AN 2002-658656, XP002476769 * |
DIBB N J ET AL: "lep operon proximal gene is not required for growth or secretion by Escherichia coli.", JOURNAL OF BACTERIOLOGY APR 1986, vol. 166, no. 1, April 1986 (1986-04-01), pages 83 - 87, XP002476767, ISSN: 0021-9193 * |
MARCH P E ET AL: "Characterization of the lep operon of Escherichia coli. Identification of the promoter and the gene upstream of the signal peptidase I gene.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 25 JUN 1985, vol. 260, no. 12, 25 June 1985 (1985-06-25), pages 7206 - 7213, XP002476764, ISSN: 0021-9258 * |
QIN YAN ET AL: "The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome.", CELL 17 NOV 2006, vol. 127, no. 4, 17 November 2006 (2006-11-17), pages 721 - 733, XP002477431, ISSN: 0092-8674 * |
QIN: "The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome and is essential for viability at high ionic strength", 3 March 2006, QIN, BERLIN, XP002476768 * |
XU JIANHUA ET AL: "Protected nucleotide G2608 in 23S rRNA confers resistance to oxazolidinones in E. coli.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 11 MAR 2005, vol. 328, no. 2, 11 March 2005 (2005-03-11), pages 471 - 476, XP004734330, ISSN: 0006-291X * |
YOUNGMAN ELAINE M ET AL: "Ribosomal translocation: LepA does it backwards.", CURRENT BIOLOGY : CB 20 FEB 2007, vol. 17, no. 4, 20 February 2007 (2007-02-20), pages R136 - R139, XP002477432, ISSN: 0960-9822 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008046584A2 (en) | 2008-04-24 |
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