WO2008045535A3 - Convertible nucleoside derivatives - Google Patents

Convertible nucleoside derivatives Download PDF

Info

Publication number
WO2008045535A3
WO2008045535A3 PCT/US2007/021808 US2007021808W WO2008045535A3 WO 2008045535 A3 WO2008045535 A3 WO 2008045535A3 US 2007021808 W US2007021808 W US 2007021808W WO 2008045535 A3 WO2008045535 A3 WO 2008045535A3
Authority
WO
WIPO (PCT)
Prior art keywords
convertible
nucleoside derivatives
convertible nucleoside
convertible nucleosides
nucleosides
Prior art date
Application number
PCT/US2007/021808
Other languages
French (fr)
Other versions
WO2008045535A2 (en
Inventor
Mahesh K Lakshman
Suyeal Bae
Original Assignee
Univ City
Mahesh K Lakshman
Suyeal Bae
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ City, Mahesh K Lakshman, Suyeal Bae filed Critical Univ City
Priority to US12/444,873 priority Critical patent/US8501931B2/en
Publication of WO2008045535A2 publication Critical patent/WO2008045535A2/en
Publication of WO2008045535A3 publication Critical patent/WO2008045535A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention is directed to convertible nucleosides and polymer supported convertible nucleosides for use in SNAΓ displacement reactions. The convertible nucleosides can be used to synthesize numerous substituted purine and pyrimidine derivatives.
PCT/US2007/021808 2006-10-12 2007-10-12 Convertible nucleoside derivatives WO2008045535A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/444,873 US8501931B2 (en) 2006-10-12 2007-10-12 Convertible nucleoside derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82916806P 2006-10-12 2006-10-12
US60/829,168 2006-10-12
US89576107P 2007-03-20 2007-03-20
US60/895,761 2007-03-20

Publications (2)

Publication Number Publication Date
WO2008045535A2 WO2008045535A2 (en) 2008-04-17
WO2008045535A3 true WO2008045535A3 (en) 2008-06-19

Family

ID=39283468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/021808 WO2008045535A2 (en) 2006-10-12 2007-10-12 Convertible nucleoside derivatives

Country Status (2)

Country Link
US (1) US8501931B2 (en)
WO (1) WO2008045535A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916218A (en) * 1988-06-09 1990-04-10 Almond Merrick R 1-(β-D-xylofuranosyl)thymine derivatives
US5705621A (en) * 1995-11-17 1998-01-06 Isis Pharmaceuticals, Inc. Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
US6166198A (en) * 1995-06-07 2000-12-26 La Jolla Pharmaceutical Company Methods for oligonucleotide synthesis
US20020107398A1 (en) * 1995-06-28 2002-08-08 Lutz Assmann Benzotriazoles
US20060165655A1 (en) * 2004-10-29 2006-07-27 Babu Yarlagadda S Therapeutic furopyrimidines and thienopyrimidines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916218A (en) * 1988-06-09 1990-04-10 Almond Merrick R 1-(β-D-xylofuranosyl)thymine derivatives
US6166198A (en) * 1995-06-07 2000-12-26 La Jolla Pharmaceutical Company Methods for oligonucleotide synthesis
US20020107398A1 (en) * 1995-06-28 2002-08-08 Lutz Assmann Benzotriazoles
US5705621A (en) * 1995-11-17 1998-01-06 Isis Pharmaceuticals, Inc. Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
US20060165655A1 (en) * 2004-10-29 2006-07-27 Babu Yarlagadda S Therapeutic furopyrimidines and thienopyrimidines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BILLER ET AL.: "US Statutory Invention Registration H1729", 5 May 1998 (1998-05-05) *
LAKSHMAN: "Synthesis of Biologically Important Nucleoside Analogs by Palladium-Catalyzed C-N Bond-Formation", CURRENT ORGANIC SYNTHESIS, vol. 2, 2005, pages 85 *

Also Published As

Publication number Publication date
US20100179312A1 (en) 2010-07-15
WO2008045535A2 (en) 2008-04-17
US8501931B2 (en) 2013-08-06

Similar Documents

Publication Publication Date Title
IL198086A0 (en) Preparation of nucleosides ribofuranosyl pyrimidines
IL184149A0 (en) Purine derivatives acting as a2a receptor agonists
ZA200901036B (en) Adenosine derivatives as A2A receptor agonists
IL181716A0 (en) Purine derivatives as a3 and a1 adenosine receptor agonists
IL194396A0 (en) Purine derivatives for use as adenosin a2a receptor agonists
HK1203488A1 (en) Pyrimidine substituted purine derivatives
ZA200901814B (en) Use of 2-6- (3-amino-piperidin-1-yl) -3-methyl-2, 4-dioxo-3, 4-dihydro-2H-pyrimidin-1-yl methyl-4-fluoro-benzonitrile
IL188725A0 (en) Pyrazine derivatives useful as adenosine receptor antagonists
PL2018388T3 (en) Bisadenosine compounds as adenosine a2a receptor agonists
IL195006A0 (en) Thiazolo-pyramidine/pyridine urea derivatives as adenosine a2b receptor antagonists
EP2511283A4 (en) N6-substituted adenosine derivatives, n6-substituted adenine derivatives and uses thereof
PT2227482T (en) 2',4'-substituted nucleosides as antiviral agents
PL2272517T5 (en) Ortho-condensed pyridine and pyrimidine derivatives ( e.g. purines ) as protein kinases inhibitors
MY145447A (en) Use of 2-6(3-amino-piperidin-1-yl)-3-methyl-2, 4-dioxo-3, 4-dihydrp-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile
IL174771A0 (en) Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists
ZA200703229B (en) Use of A2A adenosine receptor agonists
IL186939A0 (en) Pyrimidine derivatives and their use as
IL192348A (en) Crystalline pyrimidine nucleoside derivatives as suspensions in capsules
IL207452A0 (en) Pyrrolo pyrimidine derivatives, compositions comprising the same and uses thereof
WO2009058800A3 (en) Synthesis of nucleosides
ZA200610532B (en) Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
WO2008045535A3 (en) Convertible nucleoside derivatives
SI1758596T1 (en) Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
ZA200603486B (en) Arylindenopyridines and arylindenopyridines and their use as adenosine A2a receptor antagonist
GB0624643D0 (en) Improvements in or relating to the methods used to authenticate maunufactured items

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07852693

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07852693

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 12444873

Country of ref document: US