WO2008039579A3 - Inorganic nanotubes and devices fabricated therefrom - Google Patents

Inorganic nanotubes and devices fabricated therefrom Download PDF

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Publication number
WO2008039579A3
WO2008039579A3 PCT/US2007/071300 US2007071300W WO2008039579A3 WO 2008039579 A3 WO2008039579 A3 WO 2008039579A3 US 2007071300 W US2007071300 W US 2007071300W WO 2008039579 A3 WO2008039579 A3 WO 2008039579A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanotube
electrodes
passage
fluid
channels
Prior art date
Application number
PCT/US2007/071300
Other languages
French (fr)
Other versions
WO2008039579A2 (en
Inventor
Peidong Yang
Arunava Majumdar
Rong Fan
Rohit Karnik
Kenneth Castelino
Original Assignee
Univ California
Peidong Yang
Arunava Majumdar
Rong Fan
Rohit Karnik
Kenneth Castelino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Peidong Yang, Arunava Majumdar, Rong Fan, Rohit Karnik, Kenneth Castelino filed Critical Univ California
Publication of WO2008039579A2 publication Critical patent/WO2008039579A2/en
Publication of WO2008039579A3 publication Critical patent/WO2008039579A3/en
Priority to US12/335,430 priority Critical patent/US7898005B2/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Electrochemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

Nanofluidic devices are taught incorporating inorganic nanotubes fluidly coupled to channels or nanopores for supplying a fluid containing chemical or biochemical species. In one aspect, two channels are fluidly interconnected with a nanotube. Electrodes on opposing sides of the nanotube establish electrical contact with the fluid therein. A bias current is passed between the electrodes through the fluid, and current changes are detected to ascertain the passage of select molecules, such as DNA, through the nanotube. In another inventive aspect, a gate electrode is located proximal the nanotube between the two electrodes thus forming a nanofluidic transistor. The voltage applied to the gate controls the passage of ionic species through the nanotube selected as either or both ionic polarities. In either of these aspects the nanotube can be modified, or functionalized, to control the selectivity of detection or passage.
PCT/US2007/071300 2002-12-09 2007-06-15 Inorganic nanotubes and devices fabricated therefrom WO2008039579A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/335,430 US7898005B2 (en) 2002-12-09 2008-12-15 Inorganic nanotubes and electro-fluidic devices fabricated therefrom

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81426406P 2006-06-15 2006-06-15
US60/814,264 2006-06-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/969,010 Continuation-In-Part US8440453B2 (en) 2002-12-09 2008-01-03 Functionalization of nanofluidic channels

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/335,430 Continuation US7898005B2 (en) 2002-12-09 2008-12-15 Inorganic nanotubes and electro-fluidic devices fabricated therefrom

Publications (2)

Publication Number Publication Date
WO2008039579A2 WO2008039579A2 (en) 2008-04-03
WO2008039579A3 true WO2008039579A3 (en) 2008-08-07

Family

ID=39230846

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/071300 WO2008039579A2 (en) 2002-12-09 2007-06-15 Inorganic nanotubes and devices fabricated therefrom

Country Status (1)

Country Link
WO (1) WO2008039579A2 (en)

Families Citing this family (18)

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US8906609B1 (en) 2005-09-26 2014-12-09 Arrowhead Center, Inc. Label-free biomolecule sensor based on surface charge modulated ionic conductance
WO2009046094A1 (en) 2007-10-01 2009-04-09 Nabsys, Inc. Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment
FR2928093B1 (en) * 2008-02-28 2010-12-31 Commissariat Energie Atomique DEVICE FOR SEPARATING MOLECULES AND METHOD FOR MANUFACTURING THE SAME.
US10670559B2 (en) * 2008-07-11 2020-06-02 Cornell University Nanofluidic channels with integrated charge sensors and methods based thereon
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8882980B2 (en) 2008-09-03 2014-11-11 Nabsys, Inc. Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
US9816086B2 (en) 2010-07-06 2017-11-14 The Ohio State University Dose and location controlled drug/gene/particle delivery to individual cells by nanoelectroporation
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
WO2012067911A1 (en) 2010-11-16 2012-05-24 Nabsys, Inc. Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
US11274341B2 (en) 2011-02-11 2022-03-15 NABsys, 2.0 LLC Assay methods using DNA binding proteins
EP2909601B1 (en) 2012-10-16 2019-09-11 Abbott Laboratories Method of increasing the debye length on a sensor surface within a sample solution and corresponding computer readable strorage medium
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
EP2956550B1 (en) 2013-01-18 2020-04-08 Nabsys 2.0 LLC Enhanced probe binding
WO2015130874A1 (en) * 2014-02-26 2015-09-03 University Of Central Florida Research Foundation, Inc. Capillary ionic transistor
CN104328037A (en) * 2014-10-09 2015-02-04 中国科学院物理研究所 Compensation method for transient current in nanopore and compensation circuit
WO2017184790A1 (en) * 2016-04-19 2017-10-26 Takulapalli Bharath Nanopore sensor, structure and device including the sensor, and methods of forming and using same
JP2022015499A (en) 2020-07-09 2022-01-21 キオクシア株式会社 Storage device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040124084A1 (en) * 2002-12-31 2004-07-01 Lee James W. Separation and counting of single molecules through nanofluidics, programmable electrophoresis, and nanoelectrode-gated tunneling and dielectric detection
US20040262636A1 (en) * 2002-12-09 2004-12-30 The Regents Of The University Of California Fluidic nanotubes and devices

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040262636A1 (en) * 2002-12-09 2004-12-30 The Regents Of The University Of California Fluidic nanotubes and devices
US20040124084A1 (en) * 2002-12-31 2004-07-01 Lee James W. Separation and counting of single molecules through nanofluidics, programmable electrophoresis, and nanoelectrode-gated tunneling and dielectric detection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FAN ET AL.: "DNA Translocation in Inorganic Nanotubes", NANO LETTERS, vol. 5, 2005, pages 1633 - 1637, XP055169528, DOI: doi:10.1021/nl0509677 *
KARNIK ET AL.: "Effects of Biological Reactions and Modifications on Conductance of Nanofluidic Channels", NANO LETTERS, vol. 5, 2005, pages 1638 - 1642 *
YANG: "Inorganic Nanotubes, Nanofuidic Transistors and DNA Translocation", ABSTRACT FOR THE MARCH 2006 MEETING OF THE AMERICAN PHYSICAL SOCIETY, BALTIMORE, MD, 13 March 2006 (2006-03-13) - 17 March 2006 (2006-03-17) *

Also Published As

Publication number Publication date
WO2008039579A2 (en) 2008-04-03

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