WO2008036333A3 - Hypermethylation of cd44 promoter in head and neck squamous cell carcinoma - Google Patents

Hypermethylation of cd44 promoter in head and neck squamous cell carcinoma Download PDF

Info

Publication number
WO2008036333A3
WO2008036333A3 PCT/US2007/020339 US2007020339W WO2008036333A3 WO 2008036333 A3 WO2008036333 A3 WO 2008036333A3 US 2007020339 W US2007020339 W US 2007020339W WO 2008036333 A3 WO2008036333 A3 WO 2008036333A3
Authority
WO
WIPO (PCT)
Prior art keywords
promoter
hypermethylation
head
cell carcinoma
squamous cell
Prior art date
Application number
PCT/US2007/020339
Other languages
French (fr)
Other versions
WO2008036333A2 (en
Inventor
Elizabeth Franzmann
Rakesh Singal
Original Assignee
Univ Miami
Elizabeth Franzmann
Rakesh Singal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Miami, Elizabeth Franzmann, Rakesh Singal filed Critical Univ Miami
Publication of WO2008036333A2 publication Critical patent/WO2008036333A2/en
Publication of WO2008036333A3 publication Critical patent/WO2008036333A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Use of methylated CD44 promoter and a panel of biomarkers including methylated CD44 promoter for the diagnosis and prognosis of head and neck squamous cell carcinoma (HNSCC). In particular, methods and kits are provided that measure hypermethylation of CD44 promoter for the diagnosis and prognosis of HNSCC.
PCT/US2007/020339 2006-09-19 2007-09-19 Hypermethylation of cd44 promoter in head and neck squamous cell carcinoma WO2008036333A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84552806P 2006-09-19 2006-09-19
US60/845,528 2006-09-19

Publications (2)

Publication Number Publication Date
WO2008036333A2 WO2008036333A2 (en) 2008-03-27
WO2008036333A3 true WO2008036333A3 (en) 2008-08-07

Family

ID=39201083

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/020339 WO2008036333A2 (en) 2006-09-19 2007-09-19 Hypermethylation of cd44 promoter in head and neck squamous cell carcinoma

Country Status (1)

Country Link
WO (1) WO2008036333A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105556312A (en) * 2013-07-31 2016-05-04 迈阿密大学 Compositions and methods for identifying a risk of cancer in a subject

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014198843A1 (en) * 2013-06-12 2014-12-18 F. Hoffmann-La Roche Ag Markers for responsiveness to anti-cd44 antibodies
JP6655243B2 (en) * 2015-09-01 2020-02-26 国立大学法人 鹿児島大学 Method for detecting oral precancerous lesions
US11150246B2 (en) 2015-09-11 2021-10-19 Vigilant Biosciences, Inc. Device for early detection of disease states

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRANZMANN E.J. ET AL.: "Salivary soluble CD44: a potential molecular marker for head and neck cancer", CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, vol. 14, no. 3, March 2005 (2005-03-01), pages 735 - 739, XP008053829, DOI: doi:10.1158/1055-9965.EPI-04-0546 *
HU Y.C. ET AL.: "Molecular detection approaches for smoking associated tumors", ONCOGENE, vol. 21, 2002, pages 7289 - 7297 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105556312A (en) * 2013-07-31 2016-05-04 迈阿密大学 Compositions and methods for identifying a risk of cancer in a subject

Also Published As

Publication number Publication date
WO2008036333A2 (en) 2008-03-27

Similar Documents

Publication Publication Date Title
WO2008061104A3 (en) Methods and kits for detecting prostate cancer biomarkers
WO2009037572A3 (en) Biomarker combinations for colorectal cancer
EP2032716A4 (en) Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma
MX2009006378A (en) Cancer biomarkers.
WO2007082154A3 (en) B7-h1 and b7-h4 in cancer
WO2004061410A3 (en) Serum biomarkers in lung cancer
WO2008097908A3 (en) Methods of diagnosing and prognosing lung cancer
EP2436782B8 (en) Mir-106a for diagnosing poor survival prognosis colon adenocarcinoma.
EP1922326A4 (en) Biomarkers useful for diagnosing prostate cancer, and methods thereof
WO2007082144A3 (en) B7-h1 and survivin in cancer
WO2009036427A3 (en) Prostate cancer biomarkers
WO2007047408A3 (en) Promac signature application
WO2007076439A3 (en) Methods and marker combinations for screening for predisposition to lung cancer
WO2006007980A3 (en) Esr1 and cervical cancer
WO2009111595A9 (en) Diagnosing and monitoring depression disorders based on multiple biomarker panels
WO2007039290A3 (en) Methods and nucleic acids for the analysis of gene expression associated with the prognosis of cell proliferative disorders
WO2009115615A3 (en) Detection and prognosis of cervical cancer
WO2009048530A3 (en) Highly multiplexed particle-based assays
WO2010019566A3 (en) Methods for determining levels of 1,25 dihydroxy vitamin d2 and d3
WO2011128357A3 (en) Biomarkers for hypertensive disorders of pregnancy
WO2012076553A3 (en) Biomarkers and parameters for hypertensive disorders of pregnancy
WO2007146385A3 (en) Albumin-bound protein/peptide complex as a biomarker for disease
PT2208070E (en) Diagnostic, predictive and prognostic testing for cancer
WO2010033371A3 (en) Molecular markers for lung and colorectal carcinomas
WO2008002672A3 (en) Targets for use in diagnosis, prognosis and therapy of cancer

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07861343

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07861343

Country of ref document: EP

Kind code of ref document: A2