WO2008035381A3 - Process for the preparation of amine derivatives as calcimimetics - Google Patents

Process for the preparation of amine derivatives as calcimimetics Download PDF

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Publication number
WO2008035381A3
WO2008035381A3 PCT/IN2007/000416 IN2007000416W WO2008035381A3 WO 2008035381 A3 WO2008035381 A3 WO 2008035381A3 IN 2007000416 W IN2007000416 W IN 2007000416W WO 2008035381 A3 WO2008035381 A3 WO 2008035381A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
preparation
amine derivatives
relates
present
Prior art date
Application number
PCT/IN2007/000416
Other languages
French (fr)
Other versions
WO2008035381A2 (en
Inventor
Chidambaram Venkate Srinivasan
Perminder Singh Johar
Lalit Wadhwa
Original Assignee
Ind Swift Lab Ltd
Chidambaram Venkate Srinivasan
Perminder Singh Johar
Lalit Wadhwa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Swift Lab Ltd, Chidambaram Venkate Srinivasan, Perminder Singh Johar, Lalit Wadhwa filed Critical Ind Swift Lab Ltd
Publication of WO2008035381A2 publication Critical patent/WO2008035381A2/en
Publication of WO2008035381A3 publication Critical patent/WO2008035381A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides

Abstract

The present invention relates to a novel process for preparing amine derivatives of formula (I), and pharmaceutically acceptable salts and complexes thereof, wherein Ar1or Ar2 is either naphthyl or phenyl optionally substituted with 0 to 5 subslituents each independently selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower thioalkyl, methylene dioxy, lower haloalkyl, lower haloalkoxy, OH, CH2OH, CONH2, CN, acetoxy; q is 0-2; and R is H, by reducing novel amide intermediates of formula (II) wherein Ar1, Ar2 and q are same as described above. Particularly the present invention relates to an industrially advantageous process for the preparation of cinacalcet hydrochloride of formula (III) using novel amide intermediate of formula (VIII), wherein X is H, halo like chloro, bromo or iodo.
PCT/IN2007/000416 2006-09-22 2007-09-18 Process for the preparation of amine derivatives as calcimimetics WO2008035381A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2104DE2006 2006-09-22
IN2104/DEL/2006 2006-09-22
IN2458DE2006 2006-11-15
IN2458/DEL/2006 2006-11-15

Publications (2)

Publication Number Publication Date
WO2008035381A2 WO2008035381A2 (en) 2008-03-27
WO2008035381A3 true WO2008035381A3 (en) 2008-08-07

Family

ID=39200980

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000416 WO2008035381A2 (en) 2006-09-22 2007-09-18 Process for the preparation of amine derivatives as calcimimetics

Country Status (1)

Country Link
WO (1) WO2008035381A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009003981A (en) 2006-10-26 2009-04-27 Amgen Inc Calcium receptor modulating agents.
WO2009002427A2 (en) * 2007-06-21 2008-12-31 Amgen Inc. Methods of synthesizing cinacalcet and salts thereof
WO2009051718A2 (en) 2007-10-15 2009-04-23 Amgen Inc. Calcium receptor modulating agents
WO2010042642A1 (en) 2008-10-08 2010-04-15 Amgen Inc. Calcium receptor modulating agents
EP2358659B1 (en) * 2008-10-28 2012-12-26 ZaCh System S.p.A. Process for preparing cinacalcet
WO2010103531A2 (en) 2009-03-09 2010-09-16 Megafine Pharma (P) Ltd. A new method for the preparation of cinacalcet and new intermediates thereof
WO2012007954A1 (en) 2010-07-16 2012-01-19 Hetero Research Foundation Process for cinacalcet hydrochloride
CN102718662A (en) * 2012-07-12 2012-10-10 杭州新博思生物医药有限公司 Method for preparing cinacalcet hydrochloride
CN103193655B (en) * 2013-04-15 2015-06-24 山东新华制药股份有限公司 Method for preparing cinacalcet hydrochloride crystal form I
CN103274948A (en) * 2013-05-27 2013-09-04 上海医药工业研究院 Preparation method of cinacalcet
CN104478736B (en) * 2014-12-16 2016-07-13 成都启泰医药技术有限公司 A kind of preparation method of cinacalcet hydrochloride
CN104926799B (en) * 2015-04-16 2017-08-29 中国科学技术大学 A kind of method for synthesizing piribedil
CN104926665B (en) * 2015-04-16 2017-01-11 中国科学技术大学 Method for synthesizing cinacalcet
CN111704551B (en) * 2020-08-20 2020-11-20 天津汉一医药科技有限公司 Preparation method of cinacalcet hydrochloride
CN117550621B (en) * 2024-01-11 2024-03-22 恒泰军航高分子材料(山东)有限公司 Method and device for preparing high-purity BN ceramic precursor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070259964A1 (en) * 2006-04-27 2007-11-08 Revital Lifshitz-Liron Process for the preparation of cinacalcet base

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070259964A1 (en) * 2006-04-27 2007-11-08 Revital Lifshitz-Liron Process for the preparation of cinacalcet base

Also Published As

Publication number Publication date
WO2008035381A2 (en) 2008-03-27

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