WO2008031035A3 - Engineering shape of polymeric micro-and nanoparticles - Google Patents

Engineering shape of polymeric micro-and nanoparticles Download PDF

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Publication number
WO2008031035A3
WO2008031035A3 PCT/US2007/077889 US2007077889W WO2008031035A3 WO 2008031035 A3 WO2008031035 A3 WO 2008031035A3 US 2007077889 W US2007077889 W US 2007077889W WO 2008031035 A3 WO2008031035 A3 WO 2008031035A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
spherical
shapes
resulting
nanoparticles
Prior art date
Application number
PCT/US2007/077889
Other languages
French (fr)
Other versions
WO2008031035A2 (en
Inventor
Samir Mitragotri
Julie A Champion
Yogesh K Katare
Original Assignee
Univ California
Samir Mitragotri
Julie A Champion
Yogesh K Katare
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Samir Mitragotri, Julie A Champion, Yogesh K Katare filed Critical Univ California
Priority to EP07842057A priority Critical patent/EP2061434A2/en
Publication of WO2008031035A2 publication Critical patent/WO2008031035A2/en
Publication of WO2008031035A3 publication Critical patent/WO2008031035A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

Compositions containing polymeric micro- and nanopartioles with non- spherical shapes and methods for making and using such particles are described herein. The particles have one or more dimensions ranging from about 5 nm to about 100 μm, preferably about 100 nm to 10 μm. The particles can have any of a wide variety of non-spherical shapes. The particles are generally formed by manipulation of spherical particles embedded in a polymeric film. A wide variety of resulting shapes can be made, The resulting shape is a function of whether the films are manipulated in a first and/or second dimension, and the processes used to liquefy the microparticles. Variations of the method of manufacture may be used to generate particles having the desired shapes in large, reproducible quantities. The resulting non-spherical shaped particles can be used to alter uptake by phagocytic cells and thereby clearance by the reticuloendothelial system.
PCT/US2007/077889 2006-09-08 2007-09-07 Engineering shape of polymeric micro-and nanoparticles WO2008031035A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07842057A EP2061434A2 (en) 2006-09-08 2007-09-07 Engineering shape of polymeric micro-and nanoparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82508506P 2006-09-08 2006-09-08
US60/825,085 2006-09-08

Publications (2)

Publication Number Publication Date
WO2008031035A2 WO2008031035A2 (en) 2008-03-13
WO2008031035A3 true WO2008031035A3 (en) 2008-07-31

Family

ID=39027500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/077889 WO2008031035A2 (en) 2006-09-08 2007-09-07 Engineering shape of polymeric micro-and nanoparticles

Country Status (3)

Country Link
US (1) US20080112886A1 (en)
EP (1) EP2061434A2 (en)
WO (1) WO2008031035A2 (en)

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US7520951B1 (en) 2008-04-17 2009-04-21 International Business Machines (Ibm) Corporation Method of transferring nanoparticles to a surface
CA2726634C (en) * 2008-06-13 2015-04-07 Arkema Inc. Biodegradable impact-modified polymer compositions
WO2010096828A1 (en) * 2009-02-23 2010-08-26 The Regents Of The University Of California Multi-modality nanoparticles having optically responsive shape
WO2010101626A1 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Techniques and devices associated with blood sampling
US20110288389A9 (en) 2009-03-02 2011-11-24 Seventh Sense Biosystems, Inc. Oxygen sensor
US9119578B2 (en) 2011-04-29 2015-09-01 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
US20110105951A1 (en) 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin
WO2010110916A2 (en) 2009-03-26 2010-09-30 Seventh Sense Biosystems, Inc. Determination of tracers within subjects
WO2010110919A1 (en) 2009-03-26 2010-09-30 Seventh Sense Biosystems, Inc. Monitoring of implants and other devices
WO2010124212A2 (en) 2009-04-23 2010-10-28 The University Of Chicago Materials and methods for the preparation of nanocomposites
WO2010151329A1 (en) 2009-06-24 2010-12-29 Seventh Sense Biosystems, Inc. Assays involving colorimetric signaling
WO2011053787A2 (en) 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for application to skin and control of actuation, delivery and/or perception thereof
EP2493536B1 (en) 2009-10-30 2017-09-20 Seventh Sense Biosystems, Inc. Relatively small devices applied to the skin, modular systems, and methods of use thereof
WO2011065972A2 (en) 2009-11-24 2011-06-03 Seventh Sense Biosystems, Inc. Patient-enacted sampling technique
EP3243435A1 (en) 2010-01-13 2017-11-15 Seventh Sense Biosystems, Inc. Sampling device interfaces
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
WO2011163347A2 (en) 2010-06-23 2011-12-29 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
US8808202B2 (en) 2010-11-09 2014-08-19 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
US20120271125A1 (en) 2011-04-11 2012-10-25 Seventh Sense Biosystems, Inc. Devices and methods for delivery and/or withdrawal of fluids and preservation of withdrawn fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP3106092A3 (en) 2011-04-29 2017-03-08 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
KR102237667B1 (en) 2011-04-29 2021-04-12 세븐쓰 센스 바이오시스템즈, 인크. Delivering and/or receiving fluids
US10758487B2 (en) * 2011-12-09 2020-09-01 The Johns Hopkins University Artificial antigen presenting cells having a defined and dynamic shape
ITTO20130284A1 (en) 2013-04-09 2014-10-10 Fond Istituto Italiano Di Tecnologia PROCEDURE FOR THE PRODUCTION OF SHAPED POLYMERIC MICROPARTELS
US9950002B2 (en) * 2013-09-16 2018-04-24 Regents Of The University Of Minnesota Nanoparticles/theranostic vehicles
EP3296326A4 (en) * 2015-05-08 2018-12-19 Nisshinbo Holdings Inc. Flat elliptical polymer particles, and use thereof
BG112154A (en) 2015-11-19 2017-05-31 СОФИЙСКИ УНИВЕРСИТЕТ "Св. Кл. Охридски" Method for obtaining liquid, semi-solid and solid organic particles of controlled form and / or size
KR101811513B1 (en) * 2015-11-25 2017-12-20 주식회사 파이안에스테틱스 Micro spicule, Mold for Producing the Same and Method for Producing the Same

Citations (2)

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WO1996041236A1 (en) * 1995-06-07 1996-12-19 The Regents Of The University Of California Therapeutic microdevices and methods of making and using same

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US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
US20040180094A1 (en) * 2003-03-11 2004-09-16 Hemolytics, Inc. Activation agents on the surface of encapsulation vesicles
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US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US4743507A (en) * 1986-09-12 1988-05-10 Franses Elias I Nonspherical microparticles and method therefor
WO1996041236A1 (en) * 1995-06-07 1996-12-19 The Regents Of The University Of California Therapeutic microdevices and methods of making and using same

Also Published As

Publication number Publication date
US20080112886A1 (en) 2008-05-15
WO2008031035A2 (en) 2008-03-13
EP2061434A2 (en) 2009-05-27

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