WO2008030803A3 - Hiv inhibitors - Google Patents

Hiv inhibitors Download PDF

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Publication number
WO2008030803A3
WO2008030803A3 PCT/US2007/077527 US2007077527W WO2008030803A3 WO 2008030803 A3 WO2008030803 A3 WO 2008030803A3 US 2007077527 W US2007077527 W US 2007077527W WO 2008030803 A3 WO2008030803 A3 WO 2008030803A3
Authority
WO
WIPO (PCT)
Prior art keywords
small molecule
molecule inhibitors
inhibitors
hiv fusion
fusion
Prior art date
Application number
PCT/US2007/077527
Other languages
French (fr)
Other versions
WO2008030803A2 (en
Inventor
Bing Chen
Gary Frey
Stephen C Harrison
Original Assignee
Harvard College
Bing Chen
Gary Frey
Stephen C Harrison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Bing Chen, Gary Frey, Stephen C Harrison filed Critical Harvard College
Publication of WO2008030803A2 publication Critical patent/WO2008030803A2/en
Publication of WO2008030803A3 publication Critical patent/WO2008030803A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present invention provides a system for identifying HIV fusion inhibitors, and particularly for identifying small molecule inhibitors compounds that inhibit HIV fusion. The present invention further provides small molecule inhibitors of HIV fusion. In some embodiments, the invention provides small molecule inhibitors that bind to gp41. In some embodiments, inventive small molecule inhibitors block the gp41 conformational change associated with fusion. In some embodiments, inventive small molecule inhibitors inhibit binding of a peptide that corresponds to a portion of the gp41 outer layer with its site on the gp41 inner core.
PCT/US2007/077527 2006-09-03 2007-09-04 Hiv inhibitors WO2008030803A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84221906P 2006-09-03 2006-09-03
US60/842,219 2006-09-03

Publications (2)

Publication Number Publication Date
WO2008030803A2 WO2008030803A2 (en) 2008-03-13
WO2008030803A3 true WO2008030803A3 (en) 2008-11-06

Family

ID=39157975

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/077527 WO2008030803A2 (en) 2006-09-03 2007-09-04 Hiv inhibitors

Country Status (1)

Country Link
WO (1) WO2008030803A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455516B2 (en) 2010-01-15 2013-06-04 Touro University HIV-1 fusion inhibitors and methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIU S. ET AL.: "Identification of Inhibitors of the HIV-1 gp41 Six-helix bundle Formation from Extracts of Chinese Medicanal Herbs Prunella Vulgaris and Rhizoma cibotte", LIFE SCIENCES, vol. 71, 2002, pages 1779 - 1791 *
ZHAO ET AL.: "XTT Formazan Widely used to Detect Cell Viability Inhibits HIV Type 1 Infection in Vitro by Targeting gp41", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 18, no. 14, 2002 *

Also Published As

Publication number Publication date
WO2008030803A2 (en) 2008-03-13

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