WO2008030201A1 - manipulation d'OSTÉOGENÈSE en distraction au moyen d'une unité de libération de médicament contenant un distracteur - Google Patents

manipulation d'OSTÉOGENÈSE en distraction au moyen d'une unité de libération de médicament contenant un distracteur Download PDF

Info

Publication number
WO2008030201A1
WO2008030201A1 PCT/TR2006/000042 TR2006000042W WO2008030201A1 WO 2008030201 A1 WO2008030201 A1 WO 2008030201A1 TR 2006000042 W TR2006000042 W TR 2006000042W WO 2008030201 A1 WO2008030201 A1 WO 2008030201A1
Authority
WO
WIPO (PCT)
Prior art keywords
distraction
distractor
piston
container
drug
Prior art date
Application number
PCT/TR2006/000042
Other languages
English (en)
Inventor
Ersoy Konas
Mehmet Emin Mavili
Halil Ibrahim Canter
Original Assignee
Ersoy Konas
Mehmet Emin Mavili
Halil Ibrahim Canter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ersoy Konas, Mehmet Emin Mavili, Halil Ibrahim Canter filed Critical Ersoy Konas
Priority to PCT/TR2006/000042 priority Critical patent/WO2008030201A1/fr
Priority to TR2009/04307T priority patent/TR200904307T2/xx
Publication of WO2008030201A1 publication Critical patent/WO2008030201A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/60—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like for external osteosynthesis, e.g. distractors, contractors
    • A61B17/66—Alignment, compression or distraction mechanisms

Definitions

  • the invention concerns a distractor, used for distraction osteogenesis.
  • the distractor has the capability of drug releasing at the application site while the distraction process going on after surgical intervention.
  • Distraction osteogenesis involves creation of new bone by the gradual distraction of two bony fragments following their surgical division.
  • the technique is well-established and widely accepted for bone lengthening and defect filling. It has widespread clinical applications in hypoplastic skeleton, cancer surgery, craniofacial anomalies, trauma treatment, traumatic growth disturbances, limb deformities, and nonunion.
  • Distraction osteogenesis has several advantages over conventional techniques, including less invasive intervention, easier control of infection and minimal donor site morbidity. However, long period of rigid fixation is the most important disadvantage of this technique. Any decrease of the distraction period would improve patient comfort and compliance. Previous attempts to shorten the distraction osteogenesis time, by increasing the rate of distraction have been unsuccessful and associated with high incidence of bony non-union. Control of the infection is another important factor on the success of the distraction osteogenesis. Performance of effective distraction osteogenesis can be enhanced by application of different kind of drugs. These substances have been delivered localized areas or specific bones in the body, thus avoiding systemic toxicity and the need for higher quantities of the desired drug to achieve therapeutic levels at the site of action.
  • the invention is composed of two major parts, integrated each other called distraction and drug delivery units.
  • the drug delivery unit is consists of injection piston 4 and container 5.
  • the distractor is composed of geared rod 1, outer body 2, main body 3 and fixation plates 6, 7 ( Figure 1,2,3). Part list:
  • a geared rod 1 transfers the movement through the main body 3 to the distal segment of the distractor (elongation of the main body 3). This movement causes the separation of proximal and distal parts of the distractor and also bony segments, fixated on the distractor.
  • the long head of the piston 4 of the drug delivery unit is attached to the distal part of the distractor 3 and short head is inserted into the container 5. As the distraction continues, movement of the distal part of the distractor 3 is transferred to the piston 4 and short head of the piston causes the injection of the drug from the container 5 to the distraction gap.

Abstract

La présente invention concerne un distracteur qui contient une unité de libération de médicament et peut libérer un type quelconque de médicaments après une intervention chirurgicale tandis que le procédé de distraction est en cours. Alors que la tige à engrenage tourne pour la distraction, le mouvement est transmis au piston de l'unité de libération. La longue tête du piston est fixée à la partie mobile distale du distracteur et la tête courte du piston est insérée dans l'orifice postérieur du contenant qui peut avoir une quelconque forme géométrique ou un quelconque volume. L'orifice antérieur du récipient est situé au niveau de la zone de distraction. On a démontré que la libération continue d'un agent ostéoinducteur lors de la distraction facilite l'ossification. Un type quelconque de médicament peut être utilisé pour la manipulation d'ostéogenèse en distraction avec le présent dispositif.
PCT/TR2006/000042 2006-09-07 2006-09-07 manipulation d'OSTÉOGENÈSE en distraction au moyen d'une unité de libération de médicament contenant un distracteur WO2008030201A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/TR2006/000042 WO2008030201A1 (fr) 2006-09-07 2006-09-07 manipulation d'OSTÉOGENÈSE en distraction au moyen d'une unité de libération de médicament contenant un distracteur
TR2009/04307T TR200904307T2 (tr) 2006-09-07 2006-09-07 Distraksiyon osteogenezini manupile edebilen ilaç salabilen üniteli distraktör.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/TR2006/000042 WO2008030201A1 (fr) 2006-09-07 2006-09-07 manipulation d'OSTÉOGENÈSE en distraction au moyen d'une unité de libération de médicament contenant un distracteur

Publications (1)

Publication Number Publication Date
WO2008030201A1 true WO2008030201A1 (fr) 2008-03-13

Family

ID=37989120

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2006/000042 WO2008030201A1 (fr) 2006-09-07 2006-09-07 manipulation d'OSTÉOGENÈSE en distraction au moyen d'une unité de libération de médicament contenant un distracteur

Country Status (2)

Country Link
TR (1) TR200904307T2 (fr)
WO (1) WO2008030201A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9615864B2 (en) 2013-05-31 2017-04-11 Rehabilitation Institute Of Chicago Limb lengthening system for residual limb

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2713837B1 (de) * 1977-03-25 1978-03-02 Westerhoff Erhard Antriebsvorrichtung fuer ein Distraktionsgeraet
US20050234448A1 (en) * 2004-03-19 2005-10-20 Mccarthy James Implantable bone-lengthening device
WO2005120203A2 (fr) * 2004-06-07 2005-12-22 Synthes (U.S.A.) Implant orthopedique presentant des capteurs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2713837B1 (de) * 1977-03-25 1978-03-02 Westerhoff Erhard Antriebsvorrichtung fuer ein Distraktionsgeraet
US20050234448A1 (en) * 2004-03-19 2005-10-20 Mccarthy James Implantable bone-lengthening device
WO2005120203A2 (fr) * 2004-06-07 2005-12-22 Synthes (U.S.A.) Implant orthopedique presentant des capteurs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9615864B2 (en) 2013-05-31 2017-04-11 Rehabilitation Institute Of Chicago Limb lengthening system for residual limb

Also Published As

Publication number Publication date
TR200904307T2 (tr) 2009-12-21

Similar Documents

Publication Publication Date Title
US8043299B2 (en) Internal bone transport
US9125706B2 (en) Devices and methods for bone alignment, stabilization and distraction
US20080108995A1 (en) Internal bone transport
Schmidmaier et al. Use of bone morphogenetic proteins for treatment of non-unions and future perspectives
US7923432B2 (en) Implant depots to deliver growth factors to treat avascular necrosis
US8617585B2 (en) Intramedullary drug delivery device and method of treating bone fractures
JP5384614B2 (ja) 拡張可能な椎体切除術脊椎融合ケージ用器具
US20090062914A1 (en) Devices and methods for intervertebral therapy
Marais et al. Bone transport through an induced membrane in the management of tibial bone defects resulting from chronic osteomyelitis
US5653760A (en) Method and apparatus for managing macromolecular distribution
EP1586337A3 (fr) Administration locale d'une combinaison de rapamycine et 17 beta-estradiol pour le traitement de plaque vulnérable
Seenappa et al. Management of complex long bone nonunions using limb reconstruction system
US8147495B2 (en) Methods and kits for treating fractures with a biological agent
Hegde et al. Use of bone graft substitute in the treatment for distal radius fractures in elderly
WO2008030201A1 (fr) manipulation d'OSTÉOGENÈSE en distraction au moyen d'une unité de libération de médicament contenant un distracteur
US9480828B2 (en) Treatment method for the inferior turbinate
Trueta Nonunion of fractures.
Bartkiw et al. Diagnosis and management of nasal fractures
CN110623717A (zh) 一种可撑开固定的髓内钉
Pomares et al. An articular spacer for metacarpophalangeal fracture: the story of a crocodile bite
Gallucci et al. Infected nonunion of the humerus treated with an antibiotic cement rod. Case report
CN110693590B (zh) 一种多功能髓内钉
RU2315570C1 (ru) Способ оптимизации репаративного остеогенеза в трубчатых костях
RU2645955C1 (ru) Способ профилактики и борьбы с воспалением тканей вокруг несущего элемента аппарата внешней фиксации
Kiani Nisha, I. u

Legal Events

Date Code Title Description
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06799886

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2009/04307

Country of ref document: TR

122 Ep: pct application non-entry in european phase

Ref document number: 06799886

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2010/03063

Country of ref document: TR