WO2008028624A1 - Fungicides - Google Patents

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Publication number
WO2008028624A1
WO2008028624A1 PCT/EP2007/007700 EP2007007700W WO2008028624A1 WO 2008028624 A1 WO2008028624 A1 WO 2008028624A1 EP 2007007700 W EP2007007700 W EP 2007007700W WO 2008028624 A1 WO2008028624 A1 WO 2008028624A1
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WIPO (PCT)
Prior art keywords
optionally substituted
alkyl
alkoxy
hydrogen
methyl
Prior art date
Application number
PCT/EP2007/007700
Other languages
French (fr)
Inventor
Fiona Murphy Kessabi
Renaud Beaudegnies
Laura Quaranta
Hans-Georg Brunner
Fredrik Cederbaum
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Priority to JP2009527047A priority Critical patent/JP2010502661A/en
Priority to AU2007294156A priority patent/AU2007294156A1/en
Priority to CN2007800368897A priority patent/CN101522030B/en
Priority to EP07802112A priority patent/EP2068632A1/en
Priority to BRPI0716197-2A2A priority patent/BRPI0716197A2/en
Priority to CA002662259A priority patent/CA2662259A1/en
Priority to MX2009002012A priority patent/MX2009002012A/en
Priority to US12/439,834 priority patent/US20100056570A1/en
Publication of WO2008028624A1 publication Critical patent/WO2008028624A1/en
Priority to IL197147A priority patent/IL197147A0/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Definitions

  • This invention relates to novel quinolinyloxyalkanoic acid amides, processes for preparing them, to compositions containing them and to methods of using them to combat fungi, especially fungal infections of plants.
  • the present invention is concerned with the provision of particular substituted quinoline- 6-yloxyalkanoic acid amides for use mainly as plant fungicides.
  • Q 1 , Q 2 and Q 3 independently of each other, are halogen, cyano, nitro, azido, optionally substituted Ci- 6 alkyl, optionally substituted C 3 . 6 cycloalkyl, optionally substituted C 3 . 6 - heterocyclyl, which contains at least one heteroatom selected from sulphur, oxygen or NR 0 , where R 0 is hydrogen or optionally substituted Ci.
  • R u and R v independently of each other, are hydrogen or C 1 ⁇ alkyl optionally substituted with halogen, or, in the case of -CONR U R V or -SO 2 NR U R V , R U R V may join to form a 5- or 6-membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulfur, oxygen and NR 0 , wherein R 0 is hydrogen or optionally substituted Ci.
  • R v is hydroxy or optionally substituted C ⁇ alkoxy, optionally substituted aryloxy or optionally substituted heteroaryloxy, or Q 1 and Q 2 , independently of each other, additionally denote hydrogen,
  • R 1 is optionally substituted C 1-4 alkyl, optionally substituted C 2 . 4 alkenyl, optionally substituted C 2 . 4 alkynyl or optionally substituted C 3 . 4 cycloalkyl
  • R 2 is hydrogen, C 1-8 alkyl, C 3 . 4 cycloalkyl, C 2 .
  • R 3 is -(CR a R b ) p (CR c R d ) q (X) r (CR e R f ) s R 4 , wherein
  • R a , R b , R c , R d , R e and R f independently of each other, are hydrogen, C 1-4 alkyl, halogen, cyano, hydroxy, C 1-4 alkoxy or C 1 ⁇ alkoxycarbonyl, or R a R b , R c R d or R e R f may join to form a 3 to 8 membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulfur, oxygen and NR 0 , wherein R 0 is hydrogen or optionally substituted C h alky!,
  • R w is hydroxy or optionally substituted Ci_ 6 alkoxy, optionally substituted aryloxy or optionally substituted heteroaryloxy, or - CH 2 -C ⁇ C-R 5 , wherein R 5 is hydrogen, C v8 alkyl optionally substituted with halogen, hydroxy, Ci -6 alkoxy, d. 3 alkoxy(C 1 . 3 )alkoxy, cyano, C 1-4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(d.
  • R 5 is C 3 - 6 cycloalkyl(Ci_ 4 )alkyl, wherein the alkyl and/or cycloalkyl moiety is optionally substituted with halogen, hydroxy, C 1 ⁇ alkoxy, d. 3 alkoxy(d. 3 )alkoxy, cyano, C 1 ⁇ alkyl- carbonyloxy, aminocarbonyloxy, mono- or di(Ci ⁇ )alkylaminocarbonyloxy, tri(C 1 _ 4 )alkyl- silyloxy or -S(O) g (Ci. 6 )alkyl, wherein g is 0, 1 or 2, or
  • R 5 is optionally substituted aryl, optionally substituted aryl(Ci- 4 )alkyl, optionally substituted aryloxy(Ci ⁇ )alkyl, optionally substituted heteroaryl or optionally substituted heteroaryKC ⁇ alkyl or optionally substituted heteroaryloxy(C 1 _ 4 )alkyl, or
  • R 4 is optionally substituted C 3 . 6 cycloalkyl, optionally substituted C 5 . 6 cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl or an optionally substituted 5- to 8-membered ring optionally containing a heteroatom selected from sulfur, oxygen or NR 0 , wherein R 0 is hydrogen or optionally substituted Ci.
  • R 3 may join to form a 5- or 6- membered ring optionally substituted with halogen, C 1-4 alkyl, mono- or di- (C 1 _ 4 )alkylaminocarbonyl, and optionally containing a heteroatom selected from sulphur, oxygen and NR 00 , wherein R 00 is C 1-4 alkyl optionally substituted with halogen, C 1-6 alkoxy or cyano, or R 00 is phenyl optionally substituted with nitro, CY 4 alkyl, halo(Ci ⁇ )- alkyl, Ci -4 alkylcarbonyl or heteroaryl, or R 2 and R 3 may join to form an optionally substituted 6,6-membered bicycle, R 3 is -(CR 30 R 40 )C ⁇
  • R 30 and R 40 independently of each other, are hydrogen, C 1 . 6 alkyl, halo(C 1 ⁇ )alkyl, C 1 - 4 alkoxy(d. 3 )alkyl, C 2 - 3 alkenyl or C 2 -3alkynyl, or R 30 and R 40 join with the carbon atom to which they are attached to form a 3 to 6 membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulfur, oxygen or NR 000 , wherein R 000 is hydrogen or C 1-4 alkyl, where the carbocyclic or heterocyclic ring is optionally substituted with halo or C 1 -4 alkyl, R 50 is hydrogen, optionally substituted CV 4 alkyl, optionally substituted C 3 .
  • the compounds of the invention contain at least one asymmetric carbon atom and may exist as enantiomers (or as pairs of diastereoisomers) or as mixtures of such. Further, when n is 1 , the compounds of the invention are sulphoxides, which can exists in two enantiomeric forms, and the adjacent carbon can also exists in two enantiomeric forms. Compounds of general formula (I) can therefore exist as racemates, diastereoisomers, or single enantiomers, and the invention includes all possible isomers or isomer mixtures in all proportions. It is to be expected that for any given compound, one isomer may be more fungicidally active than another.
  • N-oxides of the compounds of the formula I preferably denote the N-oxides formed by the quinoline moiety.
  • the salts which the compounds of the formula I can form are preferably those formed by interaction of these compounds with acids.
  • the term "acid” comprises mineral acids such as hydrogen halides, sulphuric acid, phosphoric acid etc. as well as organic acids, preferably the commonly used alkanoic acids, for example formic acid, acetic acid and propionic acid.
  • alkyl groups and alkyl moieties of alkoxy, alkylthio, etc. suitably contain from 1 to 6, typically from 1 to 4, carbon atoms in the form of straight or branched chains. Examples are methyl, ethyl, ⁇ -and /so-propyl and n-, sec-, iso- and fe/t-butyl. Where alkyl moieties contain 5 or 6 carbon atoms, examples are n-pentyl and n-hexyl.
  • Suitable optional substituents of alkyl groups and moieties include halo, hydroxy, C 1 - 4 alkoxy and C ⁇ 4 alkoxy(C 1-4 )alkoxy, cyano, optionally substituted aryl and optionally substituted heteroaryl.
  • the optional substituent is halo
  • the haloalkyl group or moiety is typically monochloromethyl, monofluoromethyl, dichloromethyl, difluoromethyl, trichloromethyl or trifluoromethyl.
  • alkenyl and alkynyl moieties also suitably contain from 2 to 6, typically from 2 to 4, carbon atoms in the form of straight or branched chains. Examples are allyl, ethynyl and propargyl.
  • Optional substituents include halo, alkoxy, optionally substituted aryl and optionally substituted heteroaryl.
  • Halo includes fluoro, chloro, bromo and iodo.
  • Aryl is usually phenyl but also includes naphthyl, anthryl and phenanthryl.
  • Heteroaryl is typically a 5- or 6-membered aromatic ring containing one or more sulphur, oxygen or NR moieties as heteroatoms, which may be fused to one or more other aromatic or heteroaromatic rings, such as a benzene ring.
  • Examples are thienyl, furyl, pyrrolyl, isoxazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, imidazolyl, triazolyl, isothiazolyl, tetrazolyl, thiadiazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, benzofuranyl, benzothienyl, dibenzofuranyl, dibenzothienyl, benzothiazolyl, benzoxazolyl, benzimidazolyl, indolyl, quinolyl, isoquinolyl, quinazolinyl and quinoxalinyl groups and, where appropriate, N-oxides and salts thereof.
  • substituents which may be present include one or more of the following: halo, hydroxy, mercapto, C 1 ⁇ alkyl (especially methyl and ethyl), C 2 . 6 alkenyl (especially allyl), C 2 - 6 alkynyl (especially propargyl), C 1-6 alkoxy (especially methoxy), C 2 - 6 alkenyloxy (especially allyloxy), C 2 - 6 alkynyloxy (especially propargyloxy), halo(d ⁇ )alkyl (especially trifluoromethyl), halo(C 1 .
  • -S(O) m aryl wherein m is 0, 1 or 2 (especially optionally substituted phenylthio), optionally substituted -S(O) m heteroaryl wherein m is 0, 1 or 2 (especially optionally substituted pyridylthio or pyrimidinylthio), optionally substituted aryl(C 1 _ 4 )alkyl (especially optionally substituted benzyl, optionally substituted phenethyl and optionally substituted phenyl n-propyl) in which the alkyl moiety is optionally substituted with hydroxy, optionally substituted heteroaryl(Ci ⁇ ,)alkyl (especially optionally substituted pyridyl- or pyrimidinyl- (C 1-4 )alkyl), optionally substituted aryl(C 2 .
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is halogen, aryl or heteroaryl, Q 2 is hydrogen and Q 3 is as above.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is aryl, Q 2 is hydrogen and Q 3 is as defined above.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is heteroaryl, Q 2 is hydrogen and Q 3 is as defined above.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 and Q 3 are halogen and Q 2 is hydrogen.
  • Another group of preferred compounds of the formula (I) are those, wherein, Q 1 is aryl or heteroaryl, Q 2 is hydrogen and Q 3 is halogen.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 and Q 2 are hydrogen and Q 3 is halogen or optionally substituted alkyl.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is halogen, Q 2 is hydrogen and Q 3 is optionally substituted alkyl.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 and Q 2 are halogen and Q 3 is optionally substituted alkyl.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is bromo.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is iodo.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is chloro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is fluoro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 3 is halogen.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 3 is fluorine.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is bromo, Q 2 is hydrogen and Q 3 is fluoro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is bromo, Q 2 is hydrogen and Q 3 is chloro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is iodo, Q 2 is hydrogen and Q 3 is fluoro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is iodo, Q 2 is hydrogen and Q 3 is chloro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is hydrogen, halogen, aryl or heteroaryl.
  • R 1 is C 1 _ 4 alkyl or halo(C 1 _ 4 )alkyl.
  • Another group of preferred compounds of the formula (I) are those, wherein R 1 is methyl.
  • Another group of preferred compounds of the formula (I) are those, wherein R 1 is ethyl.
  • Another group of preferred compounds of the formula (I) are those, wherein R 2 is hydrogen or methyl.
  • Another group of preferred compounds of the formula (I) are those, wherein R 2 is hydrogen.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 , Q 2 and Q 3 are halogen.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is halogen, Q 2 is d ⁇ alkyl and Q 3 is halogen.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is halogen, Q 2 is d ⁇ alkyl and Q 3 is chloro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is halogen, Q 2 is Ci- 4 alkyl and Q 3 is fluoro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is halogen, Q 2 is methyl and Q 3 is halogen.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is halogen, Q 2 is methyl and Q 3 is chloro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is halogen, Q 2 is methyl and Q 3 is fluoro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is bromo, Q 2 is methyl and Q 3 is chloro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is bromo, Q 2 is methyl and Q 3 is fluoro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is iodo, Q 2 is methyl and Q 3 is chloro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is iodo, Q 2 is methyl and Q 3 is fluoro.
  • Another group of preferred compounds of the formula (I) are those, wherein Q 1 is halogen, Q 2 and Q 3 are d- 4 alkyl.
  • R 3 is tert- butyl, 1 -halo-2-methylprop-2-yl, 1 ,1-dihalo-2-methylprop-2-yl, 1 ,1 ,1 -trihalo-2-methylprop- 2-yl, 1 -alkoxy-2-methylprop-2-yl, 1 -alkenyloxy-2-methylprop-2-yl, 1 -alkynyloxy-2- methylprop-2-yl, 1 -cyano-2-methyl-prop-2-yl, 1-alkoxyalkoxy-2-methyl-prop-2-yl, 1 -halo- 3-methylbut-3-yl, 1 ,1-dihalo-3-methylbut-3-yl, 1 ,1 ,1 -trihalo-3-methylbut-3-yl, 1 -alkoxy-3-methylbut-3-yl, 1 -alkenyloxy-3-methylbut-3-yl, 1 -alkynyl,
  • R 4 is C 1-6 alkyl optionally substituted with Ci- 4 alkoxy-(d. 4 )alkoxy(C 1 _ 4 )alkyl, wherein the alkyl group optionally substituted with halo, mono- or di-(d. 6 )alkylamino or tri(C 1 _ 4 )alkylsilyl, or R 4 is Ci-6 alkyl optionally substituted with benzyloxy(d- 4 )alkyl, wherein the alkyl group is optionally substituted with halo, mono- or di-(d.
  • R 4 is Ci- 6 alkyl optionally substituted with C 2 . 6 alkenyloxy or -S(O) x (C 1 . 6 )alkyl, wherein x is 0, 1 or 2 and the alkyl group is optionally substituted with halo, mono- or di-(C 1 .
  • Another group of preferred compounds of the formula (I) are those, wherein the optionally substituted aryl and optionally substituted heteroaryl rings or moieties of the R 5 values are optionally substituted with halogen, cyano, nitro, azido, C 1-6 alkyl, halo(Ci- 6 )alkyl, C 3-6 cycloalkyl, C 3 . 6 cycloalkyl(C 1 _ 4 )alkyl, C 2 . 6 alkenyl, halo(C 2 - 6 )alkenyl, C 2 -6 alkynyl, halo(C 2 . 6 )alkynyl, C V 6 alkoxy, halo(C 1 .
  • R 9 R h may join to form a 5- or 6-membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulphur, oxygen or NR 0 , wherein R 0 is hydrogen or optionally substituted C 1-6 alkyl.
  • Another group of preferred compounds of the formula (I) are those, wherein the optionally substituted aryl, optionally substituted heteroaryl or optionally substituted 5- to 8-membered ring R 4 is optionally substituted with halogen, cyano, nitro, azido, C 1 ⁇ alkyl, halo(C 1 . 6 )alkyl, C 3 . 6 cycloalkyl, C 3-6 cycloalkyl(C 1 _ 4 )alkyl, C 2 - 6 alkenyl, halo(C 2 . 6 )alkenyl, C 2 . 6 alkynyl, halo(C 2 .
  • R 50 is C 1-4 alkyl optionally substituted with halogen, hydroxy, Ci -6 alkoxy, C 2 - 6 alkenyl (especially allyl), C- 2 - 6 alkynyl (especially propargyl), C 1 _ 4 alkoxy(C 1 _ 4 )alkoxy, cyano, C 1 ⁇ alkylcarbonyloxy, aminocarbonyloxy, mono- or di(C 1 _ 4 )alkylamino-carbonyloxy, S(O) p (Ci.
  • R 50 is C 3 . 6 cycloalkyl optionally substituted with halogen, hydroxy, C 1 ⁇ aIkOXy, C 1 _ 4 alkoxy(Ci. 4)alkoxy, cyano, C 1 _ 4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(d. 4 )alkylamino- carbonyloxy, S(O) p (C 1 .
  • Another group of preferred compounds of the formula (I) are those, wherein the optionally substituted aryl orthe optionally substituted heteroaryl R 50 is optionally substituted with halogen, hydroxy, mercapto, C ⁇ alkyl, C 2-4 alkenyl, C 2 - 4 alkynyl, C 1 ⁇ alkoxy, C 2 .
  • Another group of preferred compounds of the formula (I) are those, wherein L is oxygen.
  • Another group of preferred compounds of the formula (I) are those, wherein n is 0.
  • Another group of preferred compounds of the formula (I) are the N-oxides formed by the quinoline moiety in the compounds of the formula I.
  • Compounds that form part of the invention are illustrated in Tables 1 to 192 below. Melting points (mp) and/or diagnostic molecular ion (eg M + , [M+1 ] + ) values and/or spectroscopic (1 H NMR) data are provided in Examples 1 -5 while biological activities are provided in Example 6.
  • the compounds in Table 3 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 3 is the same as compound 1 of Table 1 except that in compound 1 of Table 3 Q1 is iodo, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 3 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 3 Q1 is iodo, Q2 is hydrogen, Q3 is chloro.
  • Table 4
  • the compounds in Table 4 are of the general formula (I) where Q1 is flouro, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 4 is the same as compound 1 of Table 1 except that in compound 1 of Table 4 Q1 is fluoro, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 4 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 3 Q1 is fluoro, Q2 is hydrogen, Q3 is chloro.
  • Table 5 The compounds in Table 5 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 5 is the same as compound 1 of Table 1 except that in compound 1 of Table 5 Q1 is chloro, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 5 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 5 Q1 is chloro, Q2 is hydrogen, Q3 is fluoro.
  • Table 6 The compounds in Table 5 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 5 is the same as compound 1 of Table 1 except that in compound 1 of Table 5 Q1 is chloro, Q2 is hydrogen, Q3 is
  • the compounds in Table 6 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 6 is the same as compound 1 of Table 1 except that in compound 1 of Table 5 Q1 is bromo, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 6 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 6 Q1 is bromo, Q2 is hydrogen, Q3 is fluoro.
  • Table 7
  • the compounds in Table 7 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 7 is the same as compound 1 of Table 1 except that in compound 1 of Table 7 Q1 is iodo, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 7 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 7 Q1 is iodo, Q2 is hydrogen, Q3 is fluoro.
  • Table 8 The compounds in Table 8 are of the general formula (I) where Q1 is fluoro, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 8 is the same as compound 1 of Table 1 except that in compound 1 of Table 8 Q1 is fluoro, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 8 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 8 Q1 is fluoro, Q2 is hydrogen, Q3 is fluoro.
  • Table 9 The compounds in Table 8 are of the general formula (I) where Q1 is fluoro, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 8 is the same as compound 1 of Table 1 except that in compound 1 of Table 8 Q1 is fluoro, Q2 is
  • Table 9 The compounds in Table 9 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 9 is the same as compound 1 of Table 1 except that in compound 1 of Table 9 Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 9 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 9 Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro.
  • Table 10
  • the compounds in Table 10 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 10 is the same as compound 1 of Table 1 except that in compound 1 of Table 10 Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 10 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 10 Q1 is hydrogen, Q2 is hydrogen,
  • Q3 is fluoro
  • the compounds in Table 11 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is brorno, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 1 1 is the same as compound 1 of Table 1 except that in compound 1 of Table 1 1 Q1 is hydrogen, Q2 is hydrogen, Q3 is bromo.
  • compounds 2 to 323 of Table 1 1 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 11 Q1 is hydrogen, Q2 is hydrogen, Q3 is bromo.
  • the compounds in Table 12 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 12 is the same as compound 1 of Table 1 except that in compound 1 of Table 12 Q1 is chloro, Q2 is hydrogen, Q3 is methyl.
  • compounds 2 to 323 of Table 12 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 12 Q1 is chloro, Q2 is hydrogen, Q3 is methyl.
  • the compounds in Table 13 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 13 is the same as compound 1 of Table 1 except that in compound 1 of Table 13 Q1 is bromo, Q2 is hydrogen, Q3 is methyl.
  • compounds 2 to 323 of Table 13 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 13 Q1 is bromo, Q2 is hydrogen, Q3 is methyl.
  • the compounds in Table 14 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 14 is the same as compound 1 of Table 1 except that in compound 1 of Table 14 Q1 is iodo, Q2 is hydrogen, Q3 is methyl.
  • compounds 2 to 323 of Table 14 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 14 Q1 is iodo, Q2 is hydrogen, Q3 is methyl.
  • Table 15 The compounds in Table 15 are of the general formula (I) where Q1 is flouro, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 15 is the same as compound 1 of Table 1 except that in compound 1 of Table 15 Q1 is fluoro, Q2 is hydrogen, Q3 is methyl.
  • compounds 2 to 323 of Table 15 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 15 Q1 is fluoro, Q2 is hydrogen, Q3 is methyl.
  • Table 16 The compounds in Table 15 are of the general formula (I) where Q1 is flouro, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 15 is the same as compound 1 of Table 1 except that in compound 1 of Table 15 Q1 is fluoro, Q2 is hydrogen, Q3 is
  • the compounds in Table 16 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 16 is the same as compound 1 of Table 1 except that in compound 1 of Table 16 Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl.
  • compounds 2 to 323 of Table 16 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 16 Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl.
  • Table 17 The compounds in Table 17 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 17 is the same as compound 1 of Table 1 except that in compound 1 of Table 17 R 1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 17 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 17 R 1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is chloro.
  • Table 18
  • the compounds in Table 18 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 18 is the same as compound 1 of Table 1 except that in compound 1 of Table 18 R 1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 18 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 18 R 1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is chloro.
  • Table 19
  • the compounds in Table 19 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 19 is the same as compound 1 of Table 1 except that in compound 1 of Table 19 R 1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 19 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 19 R 1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is chloro.
  • Table 20 The compounds in Table 20 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 20 is the same as compound 1 of Table 1 except that in compound 1 of Table 20 R 1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 20 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 20 R 1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is fluoro.
  • Table 21 The compounds in Table 20 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 20 is the same as compound 1 of
  • the compounds in Table 21 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 21 is the same as compound 1 of Table 1 except that in compound 1 of Table 21 R 1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 21 are the same as compounds 2 to 323 of
  • Q2 is hydrogen
  • Q3 is fluoro
  • the compounds in Table 22 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 22 is the same as compound 1 of Table 1 except that in compound 1 of Table 22 R 1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 22 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 22 R 1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is fluoro.
  • Table 23
  • the compounds in Table 23 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 23 is the same as compound 1 of Table 1 except that in compound 1 of Table 23 R 1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 23 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 23 R 1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro.
  • Table 24 The compounds in Table 24 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 24 is the same as compound 1 of Table 1 except that in compound 1 of Table 24 R 1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 24 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 24 R 1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro.
  • Table 25 The compounds in Table 24 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 24 is the same as compound 1 of Table 1 except that
  • the compounds in Table 25 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 25 is the same as compound 1 of Table 1 except that in compound 1 of Table 25 R 1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is methyl.
  • compounds 2 to 323 of Table 25 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 25 R 1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is methyl.
  • Table 26 The compounds in Table 26 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 26 is the same as compound 1 of Table 1 except that in compound 1 of Table 26 R 1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is methyl.
  • compounds 2 to 323 of Table 26 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 26 R 1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is methyl.
  • Table 27 The compounds in Table 26 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 26 is the same as compound 1 of
  • the compounds in Table 27 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 27 is the same as compound 1 of Table 1 except that in compound 1 of Table 27 R 1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is methyl.
  • compounds 2 to 323 of Table 27 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 27 R 1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is methyl.
  • Table 28
  • the compounds in Table 28 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 28 is the same as compound 1 of Table 1 except that in compound 1 of Table 28 R 1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl.
  • compounds 2 to 323 of Table 28 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 28 R 1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl.
  • Table 29 The compounds in Table 29 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 29 is the same as compound 1 of Table 1 except that in compound 1 of Table 29 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 29 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 29 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro.
  • Table 30 The compounds in Table 29 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 29 is the same as compound 1 of Table 1 except that
  • the compounds in Table 30 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 30 is the same as compound 1 of Table 1 except that in compound 1 of Table 30 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 30 are the same as compounds 2 to 323 of
  • the compounds in Table 31 are of the general formula (I) where Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 31 is the same as compound 1 of Table 1 except that in compound 1 of Table 31 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 31 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 31 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro.
  • Table 32
  • the compounds in Table 32 are of the general formula (I) where Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 32 is the same as compound 1 of Table 1 except that in compound 1 of Table 32 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 32 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 32 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro.
  • Table 33 The compounds in Table 33 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 33 is the same as compound 1 of Table 1 except that in compound 1 of Table 33 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 33 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 33 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro.
  • Table 34 The compounds in Table 33 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 33 is the same as compound
  • the compounds in Table 34 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 34 is the same as compound 1 of Table 1 except that in compound 1 of Table 34 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 34 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 34 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro.
  • Table 35 The compounds in Table 35 are of the general formula (I) where Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 35 is the same as compound 1 of Table 1 except that in compound 1 of Table 35 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro.
  • compounds 2 to 323 of Table 35 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 35 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro.
  • Table 36 The compounds in Table 35 are of the general formula (I) where Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 35 is the same as compound
  • the compounds in Table 36 are of the general formula (I) where Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R 1 is ethyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 36 is the same as compound 1 of Table 1 except that in compound 1 of Table 36 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro.
  • compounds 2 to 323 of Table 36 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 36 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro.
  • Table 37
  • the compounds in Table 37 are of the general formula (I) where Q1 is chloro, Q2 is methyl, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 37 is the same as compound 1 of Table 1 except that in compound 1 of Table 37 Q1 is chloro, Q2 is methyl, Q3 is chloro.
  • compounds 2 to 323 of Table 37 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 37 Q1 is chloro, Q2 is methyl, Q3 is chloro.
  • the compounds in Table 38 are of the general formula (I) where Q1 is bromo, Q2 is methyl, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 38 is the same as compound 1 of Table 1 except that in compound 1 of Table 38 Q1 is bromo, Q2 is methyl, Q3 is chloro.
  • compounds 2 to 323 of Table 38 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 38 Q1 is bromo, Q2 is methyl, Q3 is chloro.
  • Table 39
  • the compounds in Table 39 are of the general formula (I) where Q1 is iodo, Q2 is methyl, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 39 is the same as compound 1 of Table 1 except that in compound 1 of Table 39 Q1 is iodo, Q2 is methyl, Q3 is chloro.
  • compounds 2 to 323 of Table 39 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 39 Q1 is iodo, Q2 is methyl, Q3 is chloro.
  • Table 40 The compounds in Table 40 are of the general formula (I) where Q1 is fluoro, Q2 is methyl, Q3 is chloro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 40 is the same as compound 1 of Table 1 except that in compound 1 of Table 40 Q1 is fluoro, Q2 is methyl, Q3 is chloro.
  • compounds 2 to 323 of Table 40 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 40 Q1 is fluoro, Q2 is methyl, Q3 is chloro.
  • Table 41
  • the compounds in Table 41 are of the general formula (I) where Q1 is chloro, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 41 is the same as compound 1 of Table 1 except that in compound 1 of Table 41 Q1 is chloro, Q2 is methyl, Q3 is fluoro.
  • compounds 2 to 323 of Table 41 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 41 Q1 is chloro, Q2 is methyl, Q3 is fluoro.
  • Table 42 The compounds in Table 42 are of the general formula (I) where Q1 is bromo, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 42 is the same as compound 1 of Table 1 except that in compound 1 of Table 42 Q1 is bromo, Q2 is methyl, Q3 is fluoro.
  • compounds 2 to 323 of Table 42 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 42 Q1 is bromo, Q2 is methyl, Q3 is fluoro.
  • Table 43 The compounds in Table 42 are of the general formula (I) where Q1 is bromo, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 42 is the same as compound 1 of Table 1 except that in compound 1 of Table 42 Q1 is bromo
  • the compounds in Table 43 are of the general formula (I) where Q1 is iodo, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 43 is the same as compound 1 of Table 1 except that in compound 1 of Table 43 Q1 is iodo, Q2 is methyl, Q3 is fluoro.
  • compounds 2 to 323 of Table 43 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 43 Q1 is iodo, Q2 is methyl, Q3 is fluoro.
  • Table 44 The compounds in Table 44 are of the general formula (I) where Q1 is fluoro, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 44 is the same as compound 1 of Table 1 except that in compound 1 of Table 44 Q1 is fluoro, Q2 is methyl, Q3 is fluoro.
  • compounds 2 to 323 of Table 44 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 44 Q1 is fluoro, Q2 is methyl, Q3 is fluoro.
  • Table 45 The compounds in Table 44 are of the general formula (I) where Q1 is fluoro, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 44 is the same as compound 1 of Table 1 except that in compound 1 of Table 44 Q1 is fluoro
  • the compounds in Table 45 are of the general formula (I) where Q1 is chloro, Q2 is methyl, Q3 is bromo, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1 .
  • compound 1 of Table 45 is the same as compound 1 of Table 1 except that in compound 1 of Table 45 Q1 is chloro, Q2 is methyl, Q3 is bromo.
  • compounds 2 to 323 of Table 45 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 45 Q1 is chloro, Q2 is methyl, Q3 is bromo.
  • Table 46
  • the compounds in Table 46 are of the general formula (I) where Q1 is bromo, Q2 is methyl, Q3 is bromo, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 46 is the same as compound 1 of Table 1 except that in compound 1 of Table 46 Q1 is bromo, Q2 is methyl, Q3 is bromo.
  • compounds 2 to 323 of Table 46 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 46 Q1 is bromo, Q2 is methyl, Q3 is bromo.
  • the compounds in Table 47 are of the general formula (I) where Q1 is iodo, Q2 is methyl, Q3 is bromo, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 47 is the same as compound 1 of Table 1 except that in compound 1 of Table 47 Q1 is iodo, Q2 is methyl, Q3 is bromo.
  • compounds 2 to 323 of Table 47 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 47 Q1 is iodo, Q2 is methyl, Q3 is bromo.
  • Table 48
  • the compounds in Table 48 are of the general formula (I) where Q1 is fluoro, Q2 is methyl, Q3 is bromo, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 48 is the same as compound 1 of Table 1 except that in compound 1 of Table 48 Q1 is fluoro, Q2 is methyl, Q3 is bromo.
  • compounds 2 to 323 of Table 48 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 48 Q1 is fluoro, Q2 is methyl, Q3 is bromo.
  • the compounds in Table 49 are of the general formula (I) where Q1 is chloro, Q2 is chloro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 49 is the same as compound 1 of Table 1 except that in compound 1 of Table 49 Q1 is chloro, Q2 is chloro, Q3 is fluoro.
  • compounds 2 to 323 of Table 49 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 49 Q1 is Q1 is chloro, Q2 is chloro, Q3 is fluoro.
  • Table 50
  • the compounds in Table 50 are of the general formula (I) where Q1 is bromo, Q2 is chloro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 50 is the same as compound 1 of Table 1 except that in compound 1 of Table 50 Q1 is bromo, Q2 is chloro, Q3 is fluoro.
  • compounds 2 to 323 of Table 50 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 50 Q 1 is Q1 is bromo, Q2 is chloro, Q3 is fluoro.
  • Table 51
  • the compounds in Table 51 are of the general formula (I) where Q1 is flouro, Q2 is chloro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 51 is the same as compound 1 of Table 1 except that in compound 1 of Table 51 Q1 is flouro, Q2 is chloro, Q3 is fluoro.
  • compounds 2 to 323 of Table 51 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 51 Q1 is Q1 is flouro, Q2 is chloro, Q3 is fluoro.
  • Table 52 The compounds in Table 52 are of the general formula (I) where Q1 is iodo, Q2 is chloro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 52 is the same as compound 1 of Table 1 except that in compound 1 of Table 52 Q1 is iodo, Q2 is chloro, Q3 is fluoro.
  • compounds 2 to 323 of Table 52 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 52 Q1 is Q1 is iodo, Q2 is chloro, Q3 is fluoro.
  • Table 53 The compounds in Table 52 are of the general formula (I) where Q1 is iodo, Q2 is chloro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 52 is the same as compound 1 of Table 1 except that in
  • the compounds in Table 53 are of the general formula (I) where Q1 is chloro, Q2 is bromo, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 53 is the same as compound 1 of Table 1 except that in compound 1 of Table 53 Q1 is chloro, Q2 is bromo, Q3 is fluoro.
  • compounds 2 to 323 of Table 53 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 53 Q1 is Q1 is chloro, Q2 is bromo, Q3 is fluoro.
  • Table 54
  • the compounds in Table 54 are of the general formula (I) where Q1 is bromo, Q2 is bromo, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 54 is the same as compound 1 of Table 1 except that in compound 1 of Table 54 Q1 is bromo, Q2 is bromo, Q3 is fluoro.
  • compounds 2 to 323 of Table 54 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 54 Q1 is Q1 is bromo, Q2 is bromo, Q3 is fluoro.
  • Table 55 The compounds in Table 55 are of the general formula (I) where Q1 is flouro, Q2 is bromo, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 55 is the same as compound 1 of Table 1 except that in compound 1 of Table 55 Q1 is flouro, Q2 is bromo, Q3 is fluoro.
  • compounds 2 to 323 of Table 55 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 55 Q1 is Q1 is flouro, Q2 is bromo, Q3 is fluoro.
  • Table 56 The compounds in Table 55 are of the general formula (I) where Q1 is flouro, Q2 is bromo, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 55 is the same as compound 1 of Table 1 except that in compound 1 of Table 55 Q1 is
  • the compounds in Table 56 are of the general formula (I) where Q1 is iodo, Q2 is bromo, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 56 is the same as compound 1 of Table 1 except that in compound 1 of Table 56 Q1 is iodo, Q2 is bromo, Q3 is fluoro.
  • compounds 2 to 323 of Table 56 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 56 Q1 is Q1 is iodo, Q2 is bromo, Q3 is fluoro.
  • Table 57 The compounds in Table 57 are of the general formula (I) where Q1 is chloro, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 57 is the same as compound 1 of Table 1 except that in compound 1 of Table 57 Q1 is chloro, Q2 is fluoro, Q3 is fluoro.
  • compounds 2 to 323 of Table 57 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 57 Q1 is Q1 is chloro, Q2 is fluoro, Q3 is fluoro.
  • Table 58 The compounds in Table 58 are of the general formula (I) where Q1 is bromo, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 58 is the same as compound 1 of Table 1 except that in compound 1 of Table 58 Q1 is bromo, Q2 is fluoro, Q3 is fluoro.
  • compounds 2 to 323 of Table 58 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 58 Q1 is Q1 is bromo, Q2 is fluoro, Q3 is fluoro.
  • Table 59 The compounds in Table 58 are of the general formula (I) where Q1 is bromo, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 58 is the same as compound 1 of
  • the compounds in Table 59 are of the general formula (I) where Q1 is fluoro, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 59 is the same as compound 1 of Table 1 except that in compound 1 of Table 59 Q1 is fluoro, Q2 is fluoro, Q3 is fluoro.
  • compounds 2 to 323 of Table 59 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 59 Q1 is Q1 is fluoro, Q2 is fluoro, Q3 is fluoro.
  • Table 60 The compounds in Table 60 are of the general formula (I) where Q1 is iodo, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 60 is the same as compound 1 of Table 1 except that in compound 1 of Table 60 Q1 is iodo, Q2 is fluoro, Q3 is fluoro.
  • compounds 2 to 323 of Table 60 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 60 Q1 is Q1 is iodo, Q2 is fluoro, Q3 is fluoro.
  • Table 61 The compounds in Table 60 are of the general formula (I) where Q1 is iodo, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 60 is the same as compound 1 of
  • the compounds in Table 61 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R 1 is methyl, R 2 and R 3 have the values listed in Table 1.
  • compound 1 of Table 61 is the same as compound 1 of Table 1 except that in compound 1 of Table 61 Q1 is thiophen-3-yl, Q2 is fluoro, Q3 is fluoro.
  • compounds 2 to 323 of Table 61 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 61 Q1 is Q1 is thiophen-3-yl, Q2 is fluoro, Q3 is fluoro.
  • Tables 62 to 121 correspond exactly to Tables 1 to 61 (i.e. Table 62 corresponds exactly to Table 1 , Table 63 corresponds exactly to Table 2, and so on) the only difference being that in each of Tables 62 to 121 , L is S instead of O.
  • Tables 122 to 181 correspond exactly to Tables 1 to 61 (i.e. Table 122 corresponds exactly to Table 1 , Table 123 corresponds exactly to Table 2, and so on) the only difference being that in each of Tables 122 to 181 , n is 1 instead of 0. Tables 182 to 241
  • Tables 182 to 241 correspond exactly to Tables 1 to 61 (i.e. Table 182 corresponds exactly to Table 1 , Table 183 corresponds exactly to Table 2, and so on) the only difference being that in each of Tables 182 to 241 , n is 2 instead of 0.
  • the compounds of general formula (I) may be prepared as outlined in Schemes 1 to 8 below, in which Q1 , Q2, Q3, R 1 , R 2 and R 3 have the meanings given above, R 14 is H or Ci- 4 alkyl, as indicated, R 10 is Ci. 6 alkyl, optionally substituted benzyl, optionally substituted C 2 . 6 alkenyl, optionally substituted C 2 ⁇ alkynyl, R 6 , R 7 , R 8 , R 9 , R 12 and R 13 are independently H or Ci -4 alkyl, R 9 is H or C 1 .
  • R h is H or C 1 ⁇ alkyl
  • R' is C 1-6 alkyl
  • optionally substituted benzyl optionally substituted C 2 - 6 alkenyl, optionally substituted C 2 - A alkynyl
  • m is 0, 1 or 2
  • DMF is ⁇ /, ⁇ /-dimethylformamide
  • NBS is N- bromosuccinimide
  • NCS is ⁇ /-chlorosuccinimide
  • MCPBA is m-chloroperbenzoic acid.
  • Other abbreviations are defined in the text.
  • reaction temperature reaction temperature, time, solvent, mole ratios of reactants
  • reaction temperature reaction temperature, time, solvent, mole ratios of reactants
  • solvent solvent, mole ratios of reactants
  • optimum reaction conditions may vary with the particular reactants or solvents used, such conditions can be determined by routine optimisation procedures by one skilled in the art.
  • Esters of formula (2), where R 5 is C ⁇ 4 alkyl may be halogenated to give haloesters of formula (3), where Hal is a halogen atom such as bromine, chlorine or iodine, by reaction with a halogenating agent such as ⁇ /-bromosuccinimide, in a suitable solvent such as carbon tetrachloride or acetonitrile, in the presence of a radical initiator such as AIBN (azo-/sobutyronitrile), and a light source, at between ambient temperature and the reflux temperature of the solvent.
  • a halogenating agent such as ⁇ /-bromosuccinimide
  • esters of general formula (4) are halogenated to give haloesters of formula (5), where Hal is a halogen atom such as bromine, chlorine or iodine, by reaction with a halogenating agent such as ⁇ /-chlorosuccinimide or ⁇ /-bromosuccinimide, in a suitable solvent such as carbon tetrachloride or acetonitrile, at between O°C and the reflux temperature of the solvent.
  • Hal is a halogen atom such as bromine, chlorine or iodine
  • Haloesters of formula (5) are reacted with 6-hydroxy quinolines, where Q1 , Q2 and Q3 are as defined above, in the presence of a base such as potassium f-butoxide, potassium carbonate, or sodium hydride in a suitable solvent such as f-butanol, 1 ,4-dioxane or DMF, at between ambient temperature and the reflux temperature of the solvent, to give compounds of formula (6).
  • a base such as potassium f-butoxide, potassium carbonate, or sodium hydride
  • a suitable solvent such as f-butanol, 1 ,4-dioxane or DMF
  • Acids of formula (7) can be condensed with amines of formula (8), using suitable activating agents such as HOBT (1 -hydroxybenzotriazole) and EDC (1 -ethyl-3- ⁇ /, ⁇ /-dimethylaminopropylcarbodiimide hydrochloride), at between O°C and ambient temperature in a suitable solvent such as DMF, to give compounds of general formula (1 ) where n is 0 and L is O.
  • suitable activating agents such as HOBT (1 -hydroxybenzotriazole) and EDC (1 -ethyl-3- ⁇ /, ⁇ /-dimethylaminopropylcarbodiimide hydrochloride
  • esters of the general formula (6) where R 5 is Ci- 4 alkyl can be oxidised to sulphoxides of formula (9) with an oxidising agent such as sodium periodate in a suitable solvent such ethanol, between O°C and ambient temperature.
  • Sulphones of formula (10) can be made either directly from compounds of formula (6) with two or more equivalents of an oxidising agent such as m-chloro- perbenzoic acid (MCPBA), in a suitable solvent such as dichloromethane between O°C and the reflux temperature of the solvent, or from sulphoxides of formula (9) with one or more equivalents of m-chloroperbenzoic acid.
  • MCPBA m-chloro- perbenzoic acid
  • Sulphides of formula (6), sulphoxides of formula (9) or sulphones of formula (10) can be hydrolysed to the corresponding acids (7), (1 1 ) or (12) by reaction with an alkali metal hydroxide in a suitable solvent such as ethanol at between O°C and the reflux temperature of the solvent followed by acidification.
  • the acids of formula (7), (1 1 ) or (12) can be condensed with amines of formula (8), using suitable activating agents such as HOBT and EDC, at between O°C and ambient temperature, to give compounds of general formula (1 ) where n is 0, 1 or 2.
  • sulphoxides of formula (1 1 ) and of formula (1 ) where n is 1 can be prepared from sulphides of formula (7) and of formula (1 ) where n is 0 respectively, using oxidising agents such as sodium metaperiodate or m-chloroperbenzoic acid as described above.
  • Sulphones of formula (12) and of formula (1 ) where n is 2 can be prepared either from sulphides of formula (7) and of formula (1 ) where n is 0, by using at least two equivalents of oxidising agents such as m-chloroperbenzoic acid, or from sulphoxides of formula (1 1 ) and of formula (1 ) where n is 1 , using one or more equivalents of oxidising agents such as m-chloroperbenzoic acid, as described above.
  • Compounds of formula (1 ) can also be prepared as shown in Scheme 3. Acids of formula (13) can be condensed with amines of formula (8), using suitable activating agents such as HOBT and EDC, at between O°C and ambient temperature, to give compounds of formula (14). Compounds of formula (14) can be halogenated to compounds of formula (16) using a halogenating agent such as ⁇ /-chlorosuccinimide, in a suitable solvent such as carbon tetrachloride or acetonitrile, at between O°C and ambient temperature.
  • a halogenating agent such as ⁇ /-chlorosuccinimide
  • Amides of formula (16) can also be prepared from acid halides of formula (15) by reaction with amines of formula (8) in the presence of a base such as triethylamine in a suitable solvent such as dichloromethane, at between O°C and ambient temperature.
  • a base such as triethylamine
  • a suitable solvent such as dichloromethane
  • Halosulphides of formula (16) can be reacted with substituted 6-hydroxy quinolines, in the presence of a base such as potassium carbonate or sodium hydride, in a suitable solvent such as DMF, at between O°C and 8O°C, to give compounds of formula (1 ) where n is 0.
  • a base such as potassium carbonate or sodium hydride
  • a suitable solvent such as DMF
  • amines of the general formula (18) or (20) which are examples of amines of the general formula (8) wherein R 2 is H, may be prepared by alkylation of an aminoalcohol of the general formula (17) or (19) using a suitable base, such as n- butyl lithium or sodium hydride, followed by reaction with a suitable alkylating reagent R 10 LG, such as an alkyl iodide, for example, methyl iodide, to form an alkylated compound of the general formula (18) or (20), respectively.
  • a suitable base such as n- butyl lithium or sodium hydride
  • R 10 LG such as an alkyl iodide, for example, methyl iodide
  • ammonia usually in form of ammonium chloride
  • cyanide conveniently in form of an aqueous solution sodium cyanide
  • silyl-protected aminoalkynes of the general formula (24) may be obtained by reacting amines of general formula (23) with 1 ,2-/?/s-(chlorodimethylsilyl)- ethane in the presence of a suitable base, such as a tertiary organic amine base, for example, triethylamine.
  • a suitable base such as a tertiary organic amine base, for example, triethylamine.
  • Amines of the general formula (26), which are examples of amines of the general formula (8) wherein R 2 is H and R 3 is -(CR 30 R 40 )C ⁇ CR 50 , may be prepared by alkylation of a silyl-protected aminoalkyne of the general formula (24) using a suitable base, such as n-butyl lithium, followed by reaction with a suitable alkylating reagent R 50 LG, such as an alkyl iodide, for example, methyl iodide, to form an alkylated compound of the general formula (25).
  • the silyl protecting group may then be removed from a compound of the general formula (25) with, for example, an aqueous acid to form an aminoalkyne of the general formula (26).
  • a silyl-protected aminoalkyne of the general formula (24) may be reacted with a carbonyl derivative R a COR b , for example formaldehyde, using a suitable base, such as n-butyl lithium, to provide an aminoalkyne (27) containing a hydroxyalkyl moiety.
  • a compound of the general formula (27) may either first be treated with a base, such as sodium hydride or potassium fc>/s(trimethylsilyl)amide followed by a compound R 0 LG, where LG represents a leaving group such as a halogen, or sulphonate ester such as OSO 2 Me, or OSO 2 -4-tolyl, for example ethyl iodide, to give a compound of the general formula (29). After removal of the silyl protecting group, compounds of general formula (30) are obtained. Alternatively, the silyl protecting group can first be removed to yield compounds of the general formula (28).
  • a base such as sodium hydride or potassium fc>/s(trimethylsilyl)amide
  • LG represents a leaving group such as a halogen, or sulphonate ester such as OSO 2 Me, or OSO 2 -4-tolyl, for example ethyl iodide
  • Aminoalkynes of the general formula (28) may be further derivatised by reacting with a silylating agent, for example f-butyl- dimethylsilyl chloride, to give a derivative silylated on oxygen of the general formula (31 ).
  • a silylating agent for example f-butyl- dimethylsilyl chloride
  • silyl-protected aminoalkynes of the general formula (32) may be obtained by reacting silyl-protected amines of general formula (24) with chloroalkanes bearing a suitable leaving group, for example bromide or iodide, in the presence of a suitable base, such as asodium or lithium amide base, for example, sodium bis(trimethylsilyl)amide or sodium amide.
  • a suitable base such as asodium or lithium amide base, for example, sodium bis(trimethylsilyl)amide or sodium amide.
  • Amines of the general formula (34), which are examples of amines of the general formula (8) wherein R 2 is H and and R 3 is - (CR 30 R 40 )C ⁇ CR 50 may be prepared by displacement of chloride anion by cyanide, followed by removal of the silyl protecting group with, for example, an aqueous acid, to form a cyano compound of the general formula (34).
  • an amide of the general formula (35) can be reacted with, for example, potassium cyanide yielding a cyano amidoalkyne of the general formula (36).
  • compounds of the general formula (1 ), wherein R 50 is H may be reacted under Sonogashira conditions with, for example, optionally substituted aryl or heteroaryl chlorides, bromides, iodides or triflates to form substituted aryl or heteroaryl compounds of general formula (1 ), wherein R 50 is an optionally substituted aryl or heteroaryl group.
  • a suitable palladium catalyst is bis(triphenylphosphine)palladium (II) chloride.
  • compounds of the general formula (1 ), wherein Q1 is bromine or iodine may be reacted under Suzuki conditions with, for example, optionally substituted aryl or heteroaryl boronic acids to form substituted aryl or heteroaryl compounds of general formula (1), wherein Q1 is an optionally substituted aryl or heteroaryl group.
  • a suitable palladium catalyst is tetrakis(triphenylphosphine)palladium(0).
  • substituted 6-hydroxy quinolines are available, or may be prepared using straightforward techniques of organic chemistry. When the compounds are not commercially available, they may be prepared from available precursors using straightforward transformations that are well known in the art that are well described in standard textbooks of heterocyclic chemistry. For example, substituted aromatic amines may be readily converted into substituted quinolin-6-ols with appropriate electrophiles, such as 2,2,3 tribromopropanal. Examples of such reactions are provided in Examples 1 -3.
  • the compounds of formula (I) are active fungicides and may be used to control one or more of the following pathogens: Pyricularia oryzae (Magnaporthe grisea) on rice and wheat and other Pyric ⁇ laria spp. on other hosts; P ⁇ ccinia triticina (or recondita), Puccinia striiformis and other rusts on wheat, Puccinia hordei, Puccinia striiformis and other rusts on barley, and rusts on other hosts (for example turf, rye, coffee, pears, apples, peanuts, sugar beet, vegetables and ornamental plants); Erysiphe cichoracearum on cucurbits (for example melon); Blumeria (or Erysiphe) graminis
  • powdery mildew on barley, wheat, rye and turf and other powdery mildews on various hosts, such as Sphaerotheca macularis on hops, Sphaerotheca fusca (Sphaerotheca fuliginea) on cucurbits (for example cucumber), Leveillula taurica on tomatoes, aubergine and green pepper, Podosphaera leucotricha on apples and Uncinula necator on vines; Cochliobolus spp., Helminthosporium spp., Drechslera spp.
  • Botrytis cinerea grey mould
  • Botrytis cinerea grey mould
  • Alternaria spp. on vegetables (for example carrots), oil-seed rape, apples, tomatoes, potatoes, cereals (for example wheat) and other hosts
  • Venturia spp. including Venturia inaequalis (scab)) on apples, pears, stone fruit, tree nuts and other hosts
  • Cladosporium spp. on a range of hosts including cereals (for example wheat) and tomatoes
  • Stemphylium spp. (Pleospora spp.) on apples, pears, onions and other hosts; summer diseases (for example bitter rot (Glomerella cingulata), black rot or frogeye leaf spot (Botryosphaeria obtusa), Brooks fruit spot (Mycosphaerella pomi), Cedar apple rust (Gymnosporangium juniperi-virginianae), sooty blotch (Gloeodes pomigena), flyspeck (Schizothyrium pomi) and white rot (Botryosphaeria dothidea)) on apples and pears;
  • summer diseases for example bitter rot (Glomerella cingulata), black rot or frogeye leaf spot (Botryosphaeria obtusa), Brooks fruit spot (Mycosphaerella pomi), Cedar apple rust (Gymnosporangium juniperi-virginiana
  • Plasmopara viticola on vines other downy mildews, such as Bremia lactucae on lettuce, Peronospora spp. on soybeans, tobacco, onions and other hosts, Pseudoperonospora humuli on hops and Pseudoperonospora cubensis on cucurbits; Pythium spp. (including Pythium ultimum) on turf and other hosts; Phytophthora infestans on potatoes and tomatoes and other Phytophthora spp. on vegetables, strawberries, avocado, pepper, ornamentals, tobacco, cocoa and other hosts; Thanatephorus cucumeris on rice and turf and other Rhizoctonia spp.
  • downy mildews such as Bremia lactucae on lettuce, Peronospora spp. on soybeans, tobacco, onions and other hosts, Pseudoperonospora humuli on hops and Pseudoperonospora cub
  • mice such as wheat and barley, peanuts, vegetables, cotton and turf; Sclerotinia spp. on turf, peanuts, potatoes, oil-seed rape and other hosts; Sclerotium spp. on turf, peanuts and other hosts; Gibberella fujikuroi on rice; Colletotrichum spp. on a range of hosts including turf, coffee and vegetables; Laetisaria fuciformis on turf; Mycosphaerella spp. on bananas, peanuts, citrus, pecans, papaya and other hosts; Diaporthe spp. on citrus, soybean, melon, pears, lupin and other hosts; Elsinoe spp.
  • Verticillium spp. on a range of hosts including hops, potatoes and tomatoes; Pyrenopeziza spp. on oil-seed rape and other hosts; Oncobasidium theobromae on cocoa causing vascular streak dieback; Fusarium spp., Typhula spp., Microdochium nivale, Ustilago spp., Urocystis spp., Tilletia spp. and Claviceps purpurea on a variety of hosts but particularly wheat, barley, turf and maize; Ramularia spp.
  • a compound of formula (I) may move acropetally, basipetally or locally in plant tissue to be active against one or more fungi. Moreover, a compound of formula (I) may be volatile enough to be active in the vapour phase against one or more fungi on the plant.
  • the invention therefore provides a method of combating or controlling phytopathogenic fungi which comprises applying a fungicidally effective amount of a compound of formula (I), or a composition containing a compound of formula (I), to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or any other plant growth medium, e.g. nutrient solution.
  • plant as used herein includes seedlings, bushes and trees.
  • the fungicidal method of the invention includes protectant, curative, systemic, eradicant and antisporulant treatments.
  • the compounds of formula (I) are preferably used for agricultural, horticultural and turfgrass purposes in the form of a composition.
  • a compound of formula (I) is usually formulated into a composition which includes, in addition to the compound of formula (I), a suitable inert diluent or carrier and, optionally, a surface active agent (SFA).
  • SFAs are chemicals that are able to modify the properties of an interface (for example, liquid/solid, liquid/air or liquid/liquid interfaces) by lowering the interfacial tension and thereby leading to changes in other properties (for example dispersion, emulsification and wetting).
  • compositions both solid and liquid formulations
  • the composition is generally used for the control of fungi such that a compound of formula (I) is applied at a rate of from 0.1 g to 10kg per hectare, preferably from 1 g to 6kg per hectare, more preferably from 1 g to 1 kg per hectare.
  • a compound of formula (I) When used in a seed dressing, a compound of formula (I) is used at a rate of 0.0001 g to 10g (for example 0.001 g or 0.05g), preferably 0.005g to 10g, more preferably 0.005g to 4g, per kilogram of seed.
  • the present invention provides a fungicidal composition
  • a fungicidal composition comprising a fungicidally effective amount of a compound of formula (I) and a suitable carrier or diluent therefor.
  • the invention provides a method of combating and controlling fungi at a locus, which comprises treating the fungi, or the locus of the fungi with a fungicidally effective amount of a composition comprising a compound of formula (I).
  • compositions can be chosen from a number of formulation types, including dustable powders (DP), soluble powders (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules (GR) (slow or fast release), soluble concentrates (SL), oil miscible liquids (OL), ultra low volume liquids (UL), emulsifiable concentrates (EC), dispersible concentrates (DC), emulsions (both oil in water (EW) and water in oil (EO)), micro-emulsions (ME), suspension concentrates (SC), aerosols, fogging/smoke formulations, capsule suspensions (CS) and seed treatment formulations.
  • the formulation type chosen in any instance will depend upon the particular purpose envisaged and the physical, chemical and biological properties of the compound of formula (I).
  • Dustable powders may be prepared by mixing a compound of formula (I) with one or more solid diluents (for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and magnesium carbonates, sulphur, lime, flours, talc and other organic and inorganic solid carriers) and mechanically grinding the mixture to a fine powder.
  • solid diluents for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and magnesium carbonates, sulphur, lime, flours, talc and other organic and inorganic solid carriers
  • Soluble powders may be prepared by mixing a compound of formula (I) with one or more water-soluble inorganic salts (such as sodium bicarbonate, sodium carbonate or magnesium sulphate) or one or more water-soluble organic solids (such as a polysaccharide) and, optionally, one or more wetting agents, one or more dispersing agents or a mixture of said agents to improve water dispersibility/solubility. The mixture is then ground to a fine powder. Similar compositions may also be granulated to form water soluble granules (SG).
  • water-soluble inorganic salts such as sodium bicarbonate, sodium carbonate or magnesium sulphate
  • water-soluble organic solids such as a polysaccharide
  • WP Wettable powders
  • WG Water dispersible granules
  • Granules may be formed either by granulating a mixture of a compound of formula (I) and one or more powdered solid diluents or carriers, or from pre-formed blank granules by absorbing a compound of formula (I) (or a solution thereof, in a suitable agent) in a porous granular material (such as pumice, attapulgite clays, fuller's earth, kieselguhr, diatomaceous earths or ground corn cobs) or by adsorbing a compound of formula (I) (or a solution thereof, in a suitable agent) on to a hard core material (such as sands, silicates, mineral carbonates, sulphates or phosphates) and drying if necessary.
  • a hard core material such as sands, silicates, mineral carbonates, sulphates or phosphates
  • Agents which are commonly used to aid absorption or adsorption include solvents (such as aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones and esters) and sticking agents (such as polyvinyl acetates, polyvinyl alcohols, dextrins, sugars and vegetable oils).
  • solvents such as aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones and esters
  • sticking agents such as polyvinyl acetates, polyvinyl alcohols, dextrins, sugars and vegetable oils.
  • One or more other additives may also be included in granules (for example an emulsifying agent, wetting agent or dispersing agent).
  • DC Dispersible Concentrates
  • a compound of formula (I) may be prepared by dissolving a compound of formula (I) in water or an organic solvent, such as a ketone, alcohol or glycol ether.
  • organic solvent such as a ketone, alcohol or glycol ether.
  • surface active agent for example to improve water dilution or prevent crystallisation in a spray tank.
  • Emulsifiable concentrates or oil-in-water emulsions (EW) may be prepared by dissolving a compound of formula (I) in an organic solvent (optionally containing one or more wetting agents, one or more emulsifying agents or a mixture of said agents).
  • Suitable organic solvents for use in ECs include aromatic hydrocarbons (such as alkylbenzenes or alkylnaphthalenes, exemplified by SOLVESSO 100, SOLVESSO 150 and SOLVESSO 200; SOLVESSO is a Registered Trade Mark), ketones (such as cyclohexanone or methylcyclohexanone), alcohols (such as benzyl alcohol, furfuryl alcohol or butanol), ⁇ /-alkylpyrrolidones (such as ⁇ /-methylpyrrolidone or ⁇ /-octyl- pyrrolidone), dimethyl amides of fatty acids (such as C 8 -Ci 0 fatty acid dimethylamide) and chlorinated hydrocarbons.
  • aromatic hydrocarbons such as alkylbenzenes or alkylnaphthalenes, exemplified by SOLVESSO 100, SOLVESSO 150 and SOLVESSO 200; SOLVESSO is a Registered Trade
  • An EC product may spontaneously emulsify on addition to water, to produce an emulsion with sufficient stability to allow spray application through appropriate equipment.
  • Preparation of an EW involves obtaining a compound of formula (I) either as a liquid (if it is not a liquid at ambient temperature, it may be melted at a reasonable temperature, typically below 70°C) or in solution (by dissolving it in an appropriate solvent) and then emulsifying the resultant liquid or solution into water containing one or more SFAs, under high shear, to produce an emulsion.
  • Suitable solvents for use in EWs include vegetable oils, chlorinated hydrocarbons (such as chlorobenzenes), aromatic solvents (such as alkylbenzenes or alkylnaphthalenes) and other appropriate organic solvents that have a low solubility in water.
  • Microemulsions may be prepared by mixing water with a blend of one or more solvents with one or more SFAs, to produce spontaneously a thermodynamically stable isotropic liquid formulation.
  • a compound of formula (I) is present initially in either the water or the solvent/SFA blend.
  • Suitable solvents for use in MEs include those hereinbefore described for use in ECs or in EWs.
  • An ME may be either an oil-in-water or a water-in-oil system (which system is present may be determined by conductivity measurements) and may be suitable for mixing water-soluble and oil-soluble pesticides in the same formulation.
  • An ME is suitable for dilution into water, either remaining as a microemulsion or forming a conventional oil-in-water emulsion.
  • SC Suspension concentrates
  • SCs may comprise aqueous or non-aqueous suspensions of finely divided insoluble solid particles of a compound of formula (I).
  • SCs may be prepared by ball or bead milling the solid compound of formula (I) in a suitable medium, optionally with one or more dispersing agents, to produce a fine particle suspension of the compound.
  • One or more wetting agents may be included in the composition and a suspending agent may be included to reduce the rate at which the particles settle.
  • a compound of formula (I) may be dry milled and added to water, containing agents hereinbefore described, to produce the desired end product.
  • Aerosol formulations comprise a compound of formula (I) and a suitable propellant (for example n-butane).
  • a compound of formula (I) may also be dissolved or dispersed in a suitable medium (for example water or a water miscible liquid, such as ⁇ -propanol) to provide compositions for use in non-pressurised, hand-actuated spray pumps.
  • a compound of formula (I) may be mixed in the dry state with a pyrotechnic mixture to form a composition suitable for generating, in an enclosed space, a smoke containing the compound.
  • Capsule suspensions may be prepared in a manner similar to the preparation of EW formulations but with an additional polymerisation stage such that an aqueous dispersion of oil droplets is obtained, in which each oil droplet is encapsulated by a polymeric shell and contains a compound of formula (I) and, optionally, a carrier or diluent therefor.
  • the polymeric shell may be produced by either an interfacial polycondensation reaction or by a coacervation procedure.
  • the compositions may provide for controlled release of the compound of formula (I) and they may be used for seed treatment.
  • a compound of formula (I) may also be formulated in a biodegradable polymeric matrix to provide a slow, controlled release of the compound.
  • a composition may include one or more additives to improve the biological performance of the composition (for example by improving wetting, retention or distribution on surfaces; resistance to rain on treated surfaces; or uptake or mobility of a compound of formula (I)).
  • additives include surface active agents, spray additives based on oils, for example certain mineral oils or natural plant oils (such as soy bean and rape seed oil), and blends of these with other bio-enhancing adjuvants (ingredients which may aid or modify the action of a compound of formula (I)).
  • a compound of formula (I) may also be formulated for use as a seed treatment, for example as a powder composition, including a powder for dry seed treatment (DS), a water soluble powder (SS) or a water dispersible powder for slurry treatment (WS), or as a liquid composition, including a flowable concentrate (FS), a solution (LS) or a capsule suspension (CS).
  • DS powder for dry seed treatment
  • SS water soluble powder
  • WS water dispersible powder for slurry treatment
  • CS capsule suspension
  • compositions for treating seed may include an agent for assisting the adhesion of the composition to the seed (for example a mineral oil or a film-forming barrier).
  • Wetting agents, dispersing agents and emulsifying agents may be SFAs of the cationic, anionic, amphoteric or non-ionic type.
  • Suitable SFAs of the cationic type include quaternary ammonium compounds (for example cetyltrimethyl ammonium bromide), imidazolines and amine salts.
  • Suitable anionic SFAs include alkali metals salts of fatty acids, salts of aliphatic monoesters of sulphuric acid (for example sodium lauryl sulphate), salts of sulphonated aromatic compounds (for example sodium dodecylbenzenesulphonate, calcium dodecylbenzenesulphonate, butylnaphthalene sulphonate and mixtures of sodium di- /sopropyl- and tri-/sopropyl-naphthalene sulphonates), ether sulphates, alcohol ether sulphates (for example sodium laureth-3-sulphate), ether carboxylates (for example sodium laureth-3-carboxylate), phosphate esters (products from the reaction between one or more fatty alcohols and
  • Suitable SFAs of the amphoteric type include betaines, propionates and glycinates.
  • Suitable SFAs of the non-ionic type include condensation products of alkylene oxides, such as ethylene oxide, propylene oxide, butylene oxide or mixtures thereof, with fatty alcohols (such as oleyl alcohol or cetyl alcohol) or with alkylphenols (such as octylphenol, nonylphenol or octylcresol); partial esters derived from long chain fatty acids or hexitol anhydrides; condensation products of said partial esters with ethylene oxide; block polymers (comprising ethylene oxide and propylene oxide); alkanolamides; simple esters (for example fatty acid polyethylene glycol esters); amine oxides (for example lauryl dimethyl amine oxide); and lecithins.
  • Suitable suspending agents include hydrophilic colloids (such as polysaccharides, polyvinylpyrrolidone or sodium carb
  • a compound of formula (I) may be applied by any of the known means of applying fungicidal compounds. For example, it may be applied, formulated or unformulated, to any part of the plant, including the foliage, stems, branches or roots, to the seed before it is planted or to other media in which plants are growing or are to be planted (such as soil surrounding the roots, the soil generally, paddy water or hydroponic culture systems), directly or it may be sprayed on, dusted on, applied by dipping, applied as a cream or paste formulation, applied as a vapour or applied through distribution or incorporation of a composition (such as a granular composition or a composition packed in a water- soluble bag) in soil or an aqueous environment.
  • a composition such as a granular composition or a composition packed in a water- soluble bag
  • a compound of formula (I) may also be injected into plants or sprayed onto vegetation using electrodynamic spraying techniques or other low volume methods, or applied by land or aerial irrigation systems.
  • compositions for use as aqueous preparations are generally supplied in the form of a concentrate containing a high proportion of the active ingredient, the concentrate being added to water before use.
  • These concentrates which may include DCs, SCs, ECs, EWs, MEs, SGs, SPs, WPs, WGs and CSs, are often required to withstand storage for prolonged periods and, after such storage, to be capable of addition to water to form aqueous preparations which remain homogeneous for a sufficient time to enable them to be applied by conventional spray equipment.
  • Such aqueous preparations may contain varying amounts of a compound of formula (I) (for example 0.0001 to 10%, by weight) depending upon the purpose for which they are to be used.
  • a compound of formula (I) may be used in mixtures with fertilisers (for example nitrogen-, potassium- or phosphorus-containing fertilisers).
  • Suitable formulation types include granules of fertiliser.
  • the mixtures suitably contain up to 25% by weight of the compound of formula (I).
  • the invention therefore also provides a fertiliser composition comprising a fertiliser and a compound of formula (I).
  • compositions of this invention may contain other compounds having biological activity, for example micronutrients or compounds having similar or complementary fungicidal activity or which possess plant growth regulating, herbicidal, insecticidal, nematicidal or acaricidal activity.
  • the resulting composition may have a broader spectrum of activity or a greater level of intrinsic activity than the compound of formula (I) alone. Further the other fungicide may have a synergistic effect on the fungicidal activity of the compound of formula (I).
  • the compound of formula (I) may be the sole active ingredient of the composition or it may be admixed with one or more additional active ingredients such as a pesticide, fungicide, synergist, herbicide or plant growth regulator where appropriate.
  • An additional active ingredient may: provide a composition having a broader spectrum of activity or increased persistence at a locus; synergise the activity or complement the activity (for example by increasing the speed of effect or overcoming repellency) of the compound of formula (I); or help to overcome or prevent the development of resistance to individual components.
  • the particular additional active ingredient will depend upon the intended utility of the composition.
  • fungicidal compounds which may be included in the composition of the invention are AC 382042 ( ⁇ /-(1 -cyano-1 ,2-dimethylpropyl)-2-(2,4-dichlorophenoxy) pro- pionamide), acibenzolar-S-methyl, alanycarb, aldimorph, anilazine, azaconazole, azafenidin, azoxystrobin, benalaxyl, benomyl, benthiavalicarb, biloxazol, bitertanol, blasticidin S, boscalid (new name for nicobifen), bromuconazole, bupirimate, captafol, captan, carbendazim, carbendazim chlorhydrate, carboxin, carpropamid, carvone, CGA 41396, CGA 41397, chinomethionate, chlorbenzthiazone, chlorothalonil, chlorozolinate, clozylacon, copper containing AC
  • the compounds of formula (I) may be mixed with soil, peat or other rooting media for the protection of plants against seed-borne, soil-borne or foliar fungal diseases.
  • Some mixtures may comprise active ingredients, which have significantly different physical, chemical or biological properties such that they do not easily lend themselves to the same conventional formulation type.
  • other formulation types may be prepared.
  • one active ingredient is a water insoluble solid and the other a water insoluble liquid
  • the resultant composition is a suspoemulsion (SE) formulation.
  • SE suspoemulsion
  • HOBT 1 -hydroxybenzotriazole
  • HOAT 7-aza-1 -hydroxybenzotriazole
  • bs broad singlet
  • NMR nuclear magnetic resonance
  • t triplet
  • HPLC high performance liquid chromatography
  • q quartet
  • TLC thin layer chromatography
  • m multiplet
  • glc gas-liquid chromatography
  • ppm parts per million
  • EDC 1 -ethyl-3- ⁇ /, ⁇ /-dimethylamino
  • Step 2 A mixture of the product from Step 1 (1.4g) and hydrobromic acid (48 wt% solution in water) (100 ml x2) was refluxed for 62 hours. The mixture was cooled to ambient temperature, diluted with water, treated with sodium hydrogen carbonate and extracted with ethyl acetate. The extract was dried over magnesium sulfate, filtered and evaporated under reduced pressure to give the required product, 3-bromo-7-chloro- quinolin-6-ol (M+ 260).
  • Stage 2 Preparation of (S-Bromo ⁇ -chloro-quinolin- ⁇ -yloxyJ-methylsulfanyl-acetic acid methyl ester Step 1 To a stirred solution of methyl (methylthio)acetate (10.8 ml) in dichloromethane (300ml) cooled to -15°C was added dropwise sulphuryl chloride (8.1ml). The mixture was allowed to warm to room temperature over two hours and then concentrated under reduced pressure to give crude chloro-methylsulfanyl-acetic acid methyl ester as a colourless liquid. The product was used in the next step without further purification. 1 H NMR (CDCI 3 ) ⁇ ppm: 2.33 (3H, s); 3.83 (3H, s); 5.49 (1 H 1 S). Step 2
  • Step 2 To a stirred solution of 3-bromo-7-chloro-quinolin-6-ol from Stage 1 , Step 2 (1.1 g) in dry DMF (17ml) containing anhydrous potassium carbonate (3.1g) at ambient temperature was added chloro-methylsulfanyl-acetic acid methyl ester (0.79g) dropwise. The mixture was heated for 1 hour at 60-65°C then cooled to ambient temperature, diluted with water and extracted with ethyl acetate. The extracts were combined, washed with brine, dried over magnesium sulfate, filtered and evaporated under reduced pressure.
  • Stage 3 Preparation of (3-Bromo-7-chloro-quinolin-6-yloxy)-methylsulfanyl-acetic acid
  • Step 2 1.1 g
  • 2N sodium hydroxide in water 2.2ml
  • the mixture was stirred at room temperature for 1 hour and then poured into ice-water and acidified with 2M hydrochloric acid.
  • the resulting precipitate was filtered from solution, washed with cold water and dried in vacuo to give (3-bromo-7-chloro-quinolin-6-yloxy)- methylsulfanyl-acetic acid (M+ 364).
  • the mixture was poured into water, extracted with ethyl acetate (three times) and the extracts combined, washed with saturated aqueous sodium carbonate solution, water (three times) then dried over magnesium sulfate, filtered and evaporated under reduced pressure to give an oil.
  • the oil was fractionated by chromatography (silica; hexane/ ethyl acetate, 3:1 by volume) to give the required product as a white solid (m.p. 172-174°C, M+ 419).
  • Stage 2 Preparation of methyl 3-bromo-7-methyl-quinolinyl-6-oxy-2-methylthioacetate
  • 3-bromo-7-methyl-quinolin-6-ol was reacted with methyl 2-bromo-2-methylthioacetate to give methyl 3-bromo-7-methyl- quinolinyl-6-oxy-2-methylthio-acetate (M + 358).
  • Stage 3 Preparation of (3-Bromo-7-methyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid
  • methyl 3-bromo-7-methyl-quinolinyl-6- oxy-2-methylthio-acetate was hydrolysed to give (3-bromo-7-methyl-quinolin-6-yloxy)- methylsulfanyl-acetic acid (M + 344).
  • Stage 3 Preparation of (3-bromo-7-fluoro-quinolin-6-yloxy)-methylsulfanyl-acetic acid
  • methyl 3-bromo-7-fluoro-quinolinyl-6- oxy-2-methylthio-acetate was hydrolysed to give (3-bromo-7-fluoro-quinolin-6-yloxy)- methylsulfanyl-acetic acid (M + 348).
  • Stage 4 Preparation of 2-(3-bromo-7-fluoro-quinolin-6-yloxy)-N-fert-butyl-2- methylsulfanyl-acetamide
  • 2-(3-bromo-7-fluoro-quinolinyl-6-oxy)-2- methylthioacetic acid was condensed with t-butylamine to give 2-(3-bromo-7-fluoro- quinolin-6-yloxy)-N-tert-butyl-2-methylsulfanyl-acetamide (m.p. 144-145°C, M + 403).
  • Stage 1 A stirred mixture of 2-(3-bromo-7-fluoro-quino!in-6-yloxy)-N-tert-butyl-2- methylsulfanyl-acetamide from Example 3, Stage 4 (160mg), bis(triphenylphosphine)palladium (II) chloride (1.4 mg), 3-thiophene boronic acid (56mg) and sodium hydrogen carbonate (101 mg)) in dioxane/water (1 :1 mixture, 4.8ml) was heated to 7O°C for 14h. Upon cooling, the reaction mixture was treated with saturated aqueous sodium hydrogen carbonate (5ml).
  • This Example illustrates the fungicidal properties of compounds of formula (I).
  • the compounds were tested in a leaf disk assay, with methods described below.
  • the test compounds were dissolved in DMSO and diluted into water to 200 ppm.
  • Pythium ⁇ ltimum they were dissolved in DMSO and diluted into water to 20 ppm.
  • Erysiphe graminis f.sp. tritici (wheat powdery mildew): Wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
  • Puccinia recondita f.sp. tritici (wheat brown rust): Wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed nine days after inoculation as preventive fungicidal activity.
  • Septo ⁇ a nodor ⁇ m (wheat glume blotch): Wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
  • Pyrenophora teres Barley net blotch: Barley leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
  • Pyricularia oryzae rice blast
  • Rice leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
  • Botrytis cinerea grey mould: Bean leaf disks were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
  • Phytophthora infestans (late blight of potato on tomato): Tomato leaf disks were placed on water agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
  • Plasmopara viticola downy mildew of grapevine: Grapevine leaf disks were placed on agar in a 24-well plate and sprayed a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed seven days after inoculation as preventive fungicidal activity.
  • Septoria tritici (leaf blotch): Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of the test compounds into a microtiter plate (96-well format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 C and the inhibition of growth was determined photometrically after 72 hrs.
  • Fusarium culmorum (root rot): Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of the test compounds into a microtiter plate (96-well format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 C and the inhibition of growth was determined photometrically after 48 hrs. Pythium ultimum (Damping off): Mycelial fragments of the fungus, prepared from a fresh liquid culture, were mixed into potato dextrose broth.
  • test compound in dimethyl sulphoxide was diluted with water to 20ppm then placed into a 96-well microtiter plate and the nutrient broth containing the fungal spores was added. The test plate was incubated at 24°C and the inhibition of growth was determined photometrically after 48 hours.

Abstract

Compounds of the general formula wherein the substituents are as defined in claim (1), are useful as fungicides.

Description

FUNGICIDES
This invention relates to novel quinolinyloxyalkanoic acid amides, processes for preparing them, to compositions containing them and to methods of using them to combat fungi, especially fungal infections of plants.
Certain quinolinyloxyalkanoic acid amide derivatives and their use as agricultural and horticultural bactericides are disclosed, for example, in WO 04/047538 and JP 2001 - 89453.
The present invention is concerned with the provision of particular substituted quinoline- 6-yloxyalkanoic acid amides for use mainly as plant fungicides.
Thus according to the present invention there is provided a compound of the general formula I
Figure imgf000002_0001
wherein
Q1, Q2 and Q3, independently of each other, are halogen, cyano, nitro, azido, optionally substituted Ci-6 alkyl, optionally substituted C3.6 cycloalkyl, optionally substituted C3.6 - heterocyclyl, which contains at least one heteroatom selected from sulphur, oxygen or NR0, where R0 is hydrogen or optionally substituted Ci.6alkyl, optionally substituted C3-6 cycloalky^C^alkyl, optionally substituted C2-β alkenyl, optionally substituted C2-e alkynyl, optionally substituted C1-6 alkoxy, optionally substituted C2-6 alkenyloxy, optionally substituted C2-6 alkynyloxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted aryl(Ci.6)alkyl, optionally substituted aryl(C1.6)alkoxy, optionally substituted heteroaryl, optionally substituted heteroaryloxy, optionally substituted heteroaryl(Ci-6)alkyl, optionally substituted heteroary^d-^alkoxy, -SF5 or -S(O)u(C1.6)alkyl, wherein u is 0, 1 or 2 and the alkyl group is optionally substituted with halogen, or Q1, Q2 and Q3, independently of each other, are -OSO2(C1_4)alkyl, wherein the alkyl group is optionally substituted with halogen, or Q1, Q2 and Q3, independently of each other, are -CONRUR\ -CORU, -CO2R", -CRU=NRV, -NRURV, -NRUCORV, -NRUCO2RV, -SO2NRURV or -NRUSO2RW, wherein Rw is optionally substituted C1.6 alkyl and Ru and Rv , independently of each other, are hydrogen or C1^ alkyl optionally substituted with halogen, or, in the case of -CONRURV or -SO2NRURV, RURV may join to form a 5- or 6-membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulfur, oxygen and NR0, wherein R0 is hydrogen or optionally substituted Ci.6alkyl, or, in the case of -CRU=NRV, Rv is hydroxy or optionally substituted C^alkoxy, optionally substituted aryloxy or optionally substituted heteroaryloxy, or Q1 and Q2, independently of each other, additionally denote hydrogen,
R1 is optionally substituted C1-4 alkyl, optionally substituted C2.4 alkenyl, optionally substituted C2.4 alkynyl or optionally substituted C3.4 cycloalkyl, R2 is hydrogen, C1-8 alkyl, C3.4 cycloalkyl, C2.8 alkenyl, cyano, hydroxy, alkoxy, cyano(C1_4)alkyl, C1-4 alkoxy(C1_4)alkyl, C1-4 alkoxy(C1_4)alkoxy(C1_4)alkyl or benzyloxy(Ci_4)alkyl, wherein the phenyl ring is optionally substituted with C1-4 alkoxy, R3 is -(CRaRb)p(CRcRd)q(X)r(CReRf)sR4, wherein
Ra, Rb, Rc, Rd, Re and Rf, independently of each other, are hydrogen, C1-4 alkyl, halogen, cyano, hydroxy, C1-4 alkoxy or C1^ alkoxycarbonyl, or RaRb, RcRd or ReRf may join to form a 3 to 8 membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulfur, oxygen and NR0, wherein R0 is hydrogen or optionally substituted Chalky!,
X is (CO), (CO)O, O(CO), O, S(O),, wherein t is 0, 1 or 2, or X is NH or N(d.6)alkyl, p, r and s, independently of each other, are 0 or 1 , q is 0, 1 or 2, R4 is optionally substituted C1-6 alkyl, optionally substituted C2.6 alkenyl, -CRUU=NRW, wherein Ruu is hydrogen or Ci.6 alkyl and Rw is hydroxy or optionally substituted Ci_6alkoxy, optionally substituted aryloxy or optionally substituted heteroaryloxy, or - CH2-C≡C-R5, wherein R5 is hydrogen, Cv8 alkyl optionally substituted with halogen, hydroxy, Ci-6 alkoxy, d.3 alkoxy(C1.3)alkoxy, cyano, C1-4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(d.4)- alkylaminocarbonyloxy, tri(C1-4)alkylsilyloxy or -S(O)g(C1-6)alkyl, wherein g is 0, 1 or 2, or R5 is C3-6 cycloalkyl optionally substituted with halogen, hydroxy, C1^ alkoxy, C1^ alkoxy- (Ci-3)alkoxy, cyano, d.4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(d-4)alkyl- aminocarbonyloxy, tri(d.4)alkylsilyloxy or -S(O)g(Ci-6)alkyl, wherein g is 0, 1 or 2, or R5 is C3-6 cycloalkyl(Ci_4)alkyl, wherein the alkyl and/or cycloalkyl moiety is optionally substituted with halogen, hydroxy, C1^ alkoxy, d.3 alkoxy(d.3)alkoxy, cyano, C1^ alkyl- carbonyloxy, aminocarbonyloxy, mono- or di(Ci^)alkylaminocarbonyloxy, tri(C1_4)alkyl- silyloxy or -S(O)g(Ci.6)alkyl, wherein g is 0, 1 or 2, or
R5 is optionally substituted aryl, optionally substituted aryl(Ci-4)alkyl, optionally substituted aryloxy(Ci^)alkyl, optionally substituted heteroaryl or optionally substituted heteroaryKC^alkyl or optionally substituted heteroaryloxy(C1_4)alkyl, or
R4 is optionally substituted C3.6 cycloalkyl, optionally substituted C5.6 cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl or an optionally substituted 5- to 8-membered ring optionally containing a heteroatom selected from sulfur, oxygen or NR0, wherein R0 is hydrogen or optionally substituted Ci.6alkyl, or when R3 is -(CRaRb)p(CRcRd)q(X)r(CReRf)sR4, R2 and R3 may join to form a 5- or 6- membered ring optionally substituted with halogen, C1-4 alkyl, mono- or di- (C1_4)alkylaminocarbonyl, and optionally containing a heteroatom selected from sulphur, oxygen and NR00, wherein R00 is C1-4 alkyl optionally substituted with halogen, C1-6 alkoxy or cyano, or R00 is phenyl optionally substituted with nitro, CY4 alkyl, halo(Ci^)- alkyl, Ci-4 alkylcarbonyl or heteroaryl, or R2 and R3 may join to form an optionally substituted 6,6-membered bicycle, R3 is -(CR30R40)C≡CR50, wherein
R30 and R40, independently of each other, are hydrogen, C1.6 alkyl, halo(C1^)alkyl, C1-4 alkoxy(d.3)alkyl, C2-3 alkenyl or C2-3alkynyl, or R30 and R40 join with the carbon atom to which they are attached to form a 3 to 6 membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulfur, oxygen or NR000, wherein R000 is hydrogen or C1-4 alkyl, where the carbocyclic or heterocyclic ring is optionally substituted with halo or C1 -4 alkyl, R50 is hydrogen, optionally substituted CV4 alkyl, optionally substituted C3.6 cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl containing a heteroatom selected from sulphur, oxygen or NR000, wherein R000 is hydrogen or C^alkyl, L is sulfur or oxygen, and n is 0, 1 or 2, and salts and N-oxides of the compounds of the formula I.
The compounds of the invention contain at least one asymmetric carbon atom and may exist as enantiomers (or as pairs of diastereoisomers) or as mixtures of such. Further, when n is 1 , the compounds of the invention are sulphoxides, which can exists in two enantiomeric forms, and the adjacent carbon can also exists in two enantiomeric forms. Compounds of general formula (I) can therefore exist as racemates, diastereoisomers, or single enantiomers, and the invention includes all possible isomers or isomer mixtures in all proportions. It is to be expected that for any given compound, one isomer may be more fungicidally active than another.
N-oxides of the compounds of the formula I preferably denote the N-oxides formed by the quinoline moiety.
The salts which the compounds of the formula I can form are preferably those formed by interaction of these compounds with acids. The term "acid" comprises mineral acids such as hydrogen halides, sulphuric acid, phosphoric acid etc. as well as organic acids, preferably the commonly used alkanoic acids, for example formic acid, acetic acid and propionic acid.
Except where otherwise stated, alkyl groups and alkyl moieties of alkoxy, alkylthio, etc., suitably contain from 1 to 6, typically from 1 to 4, carbon atoms in the form of straight or branched chains. Examples are methyl, ethyl, π-and /so-propyl and n-, sec-, iso- and fe/t-butyl. Where alkyl moieties contain 5 or 6 carbon atoms, examples are n-pentyl and n-hexyl. Examples of suitable optional substituents of alkyl groups and moieties include halo, hydroxy, C1-4 alkoxy and C^4 alkoxy(C1-4)alkoxy, cyano, optionally substituted aryl and optionally substituted heteroaryl. Where the optional substituent is halo, the haloalkyl group or moiety is typically monochloromethyl, monofluoromethyl, dichloromethyl, difluoromethyl, trichloromethyl or trifluoromethyl.
Except where otherwise stated, alkenyl and alkynyl moieties also suitably contain from 2 to 6, typically from 2 to 4, carbon atoms in the form of straight or branched chains. Examples are allyl, ethynyl and propargyl. Optional substituents include halo, alkoxy, optionally substituted aryl and optionally substituted heteroaryl.
Halo includes fluoro, chloro, bromo and iodo.
Aryl is usually phenyl but also includes naphthyl, anthryl and phenanthryl.
Heteroaryl is typically a 5- or 6-membered aromatic ring containing one or more sulphur, oxygen or NR moieties as heteroatoms, which may be fused to one or more other aromatic or heteroaromatic rings, such as a benzene ring. Examples are thienyl, furyl, pyrrolyl, isoxazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, imidazolyl, triazolyl, isothiazolyl, tetrazolyl, thiadiazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, benzofuranyl, benzothienyl, dibenzofuranyl, dibenzothienyl, benzothiazolyl, benzoxazolyl, benzimidazolyl, indolyl, quinolyl, isoquinolyl, quinazolinyl and quinoxalinyl groups and, where appropriate, N-oxides and salts thereof. Any of the aryl or heteroaryl values are optionally substituted. Except where otherwise stated, substituents which may be present include one or more of the following: halo, hydroxy, mercapto, C1^ alkyl (especially methyl and ethyl), C2.6 alkenyl (especially allyl), C2-6 alkynyl (especially propargyl), C1-6 alkoxy (especially methoxy), C2-6 alkenyloxy (especially allyloxy), C2-6 alkynyloxy (especially propargyloxy), halo(d^)alkyl (especially trifluoromethyl), halo(C1. 6)alkoxy (especially trifluoromethoxy), -S(O)m(Ci^)alkyl wherein m is 0, 1 or 2 and the alkyl is optionally substituted with halo, hydroxy(C1-6)alkyl, Ci^alkoxy(C1_4)alkyl,
C1_4alkoxy(CiJl)alkoxy, C3.6 cycloalkyl, C3.6 cycloalkyKd^alkyl, optionally substituted aryl (especially optionally substituted phenyl), optionally substituted heteroaryl (especially optionally substituted pyridyl or pyrimidinyl), optionally substituted aryloxy (especially optionally substituted phenoxy), optionally substituted heteroaryloxy (especially optionally substituted pyridyloxy or pyrimidinyloxy), optionally substituted
-S(O)maryl wherein m is 0, 1 or 2 (especially optionally substituted phenylthio), optionally substituted -S(O)mheteroaryl wherein m is 0, 1 or 2 (especially optionally substituted pyridylthio or pyrimidinylthio), optionally substituted aryl(C1_4)alkyl (especially optionally substituted benzyl, optionally substituted phenethyl and optionally substituted phenyl n-propyl) in which the alkyl moiety is optionally substituted with hydroxy, optionally substituted heteroaryl(Ci^,)alkyl (especially optionally substituted pyridyl- or pyrimidinyl- (C1-4)alkyl), optionally substituted aryl(C2.4)alkenyl (especially optionally substituted phenylethenyl), optionally substituted heteroaryl(C2-4)alkenyl (especially optionally substituted pyridylethenyl or pyrimidinylethenyl), optionally substituted aryl(C1_4)alkoxy (especially optionally substituted benzyloxy and phenethyloxy), optionally substituted heteroaryl(C-ι_4)alkoxy (especially optionally substituted pyridyl(C1_4)alkoxy or pyrimi- dinyl(Ci-4)alkoxy), optionally substituted aryloxy(d-4)alkyl (especially phenoxymethyl), optionally substituted heteroaryloxy-(C1_4)alkyl (especially optionally substituted pyridyloxy or pyrimidinyloxy(C1_4)alkyl), optionally substituted -S(O)m(C1_4)alkylaryl wherein m is 0, 1 or 2 (especially optionally substituted benzylthio and phenethylthio), optionally substituted -S(O)m(Ci_4)alkylheteroaryl wherein m is 0, 1 or 2 (especially optionally substituted pyridyl(Ci_4)alkylthio or pyrimidiny^d^alkylthio), optionally substituted -(C1_4)alkylS(O)maryl wherein m is 0, 1 or 2 (especially phenylthiomethyl), optionally substituted -(C1-4)alkyl S(O)mheteroaryl wherein m is 0, 1 or 2 (especially optionally substituted pyridylthio(d.4)alkyl or pyrimidinylthio(C1_4)alkyl), acyloxy, including d-4 alkanoyloxy (especially acetyloxy) and benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, NR9Rh, -NHCOR9, -NHCONR9Rh, -CONR9Rh, -CO2R9, -SO2R', -OSO2R', -COR9, -CR9=NRh or -N=CR9Rh in which R1 is C1-4 alkyl, halo(C^)alkyl, C1-4 alkoxy, halo(C1^,)alkoxy, C1-4 alkylthio, C3.6 cycloalkyl, C3.6 cycloalkyl(d^)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or CL4 alkoxy and R9 and Rh are independently hydrogen, Ci_4 alkyl, halo(Ci-4)alkyl, Ci-4 alkoxy, halo(Ci-4)alkoxy, C1^ alkylthio, C3-6 cycloalkyl, C3.6 cyclo- alkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1_4 alkyl or C1^ alkoxy.
Of particular interest are those compounds of the formula (I), wherein Q2 is hydrogen, Q1 and Q3 are as above.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is halogen, aryl or heteroaryl, Q2 is hydrogen and Q3 is as above.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is aryl, Q2 is hydrogen and Q3 is as defined above.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is heteroaryl, Q2 is hydrogen and Q3 is as defined above.
Another group of preferred compounds of the formula (I) are those, wherein Q1 and Q3 are halogen and Q2 is hydrogen.
Another group of preferred compounds of the formula (I) are those, wherein, Q1 is aryl or heteroaryl, Q2 is hydrogen and Q3 is halogen.
Another group of preferred compounds of the formula (I) are those, wherein Q1 and Q2 are hydrogen and Q3 is halogen or optionally substituted alkyl.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is halogen, Q2 is hydrogen and Q3 is optionally substituted alkyl.
Another group of preferred compounds of the formula (I) are those, wherein Q1 and Q2 are halogen and Q3 is optionally substituted alkyl. Another group of preferred compounds of the formula (I) are those, wherein Q1 is bromo.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is iodo.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is chloro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is fluoro.
Another group of preferred compounds of the formula (I) are those, wherein Q3 is halogen.
Another group of preferred compounds of the formula (I) are those, wherein Q3 is fluorine.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is bromo, Q2 is hydrogen and Q3 is fluoro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is bromo, Q2 is hydrogen and Q3 is chloro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is iodo, Q2 is hydrogen and Q3 is fluoro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is iodo, Q2 is hydrogen and Q3 is chloro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is hydrogen, halogen, aryl or heteroaryl.
Another group of preferred compounds of the formula (I) are those, wherein R1 is C1_4 alkyl or halo(C1_4)alkyl.
Another group of preferred compounds of the formula (I) are those, wherein R1 is methyl.
Another group of preferred compounds of the formula (I) are those, wherein R1 is ethyl. Another group of preferred compounds of the formula (I) are those, wherein R2 is hydrogen or methyl.
Another group of preferred compounds of the formula (I) are those, wherein R2 is hydrogen.
Another group of preferred compounds of the formula (I) are those, wherein Q1 , Q2 and Q3 are halogen.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is halogen, Q2 is d^alkyl and Q3 is halogen.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is halogen, Q2 is d^alkyl and Q3 is chloro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is halogen, Q2 is Ci-4alkyl and Q3 is fluoro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is halogen, Q2 is methyl and Q3 is halogen.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is halogen, Q2 is methyl and Q3 is chloro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is halogen, Q2 is methyl and Q3 is fluoro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is bromo, Q2 is methyl and Q3 is chloro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is bromo, Q2 is methyl and Q3 is fluoro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is iodo, Q2 is methyl and Q3 is chloro. Another group of preferred compounds of the formula (I) are those, wherein Q1 is iodo, Q2 is methyl and Q3 is fluoro.
Another group of preferred compounds of the formula (I) are those, wherein Q1 is halogen, Q2 and Q3 are d-4alkyl.
Another group of preferred compounds of the formula (I) are those, wherein R3 is tert- butyl, 1 -halo-2-methylprop-2-yl, 1 ,1-dihalo-2-methylprop-2-yl, 1 ,1 ,1 -trihalo-2-methylprop- 2-yl, 1 -alkoxy-2-methylprop-2-yl, 1 -alkenyloxy-2-methylprop-2-yl, 1 -alkynyloxy-2- methylprop-2-yl, 1 -cyano-2-methyl-prop-2-yl, 1-alkoxyalkoxy-2-methyl-prop-2-yl, 1 -halo- 3-methylbut-3-yl, 1 ,1-dihalo-3-methylbut-3-yl, 1 ,1 ,1 -trihalo-3-methylbut-3-yl, 1 -alkoxy-3-methylbut-3-yl, 1 -alkenyloxy-3-methylbut-3-yl, 1 -alkynyloxy-3-methylbut-3-yl, 1 -cyano-3-methylbut-3-yl, 2-cyanoprop-2-yl, 2-methoxycarbonylprop-2-yl or 2- methylaminocarbonylprop-2-yl, 1 -alkylthio-2-methylprop-2-yl, 1 -alkylsulphinyl-2- methylprop-2-yl, 1-alkylsulphonyl-2-methylprop-2-yl, 2-cyano-1 -alkoxyprop-2-yl, 2- methyl-1 -[(E and/or Z)-hydroxyimino]-prop-2-yl, 2-methyl-1-[(E and/or Z)-alkoxyimino]- prop-2-yl, 2-methyl-1 -[(E and/or Z)-aryloxyimino]-prop-2-yl, 2-methyl-1 -[(E and/or Z)- heteroaryloxyimino]-prop-2-yl, 1 -alkoxy-prop-2-yl, 1 -halo-prop-2-yl, 3-methyl-but-1 -yn-3- yl, 1 -alkyl-3-methyl-but-1-yn-3-yl, 4-methyl-pent-2-yn-4-yl, 1 -hydroxy^-methyl-pent^-yn- 4-yl, 1-alkoxy-4-methyl-pent-2-yn-4-yl, 1 -alkoxyalkoxy-4-methyl-pent-2-yn-4-yl, 1 - alkoxyalkoxyalkyl-4-methyl-pent-2-yn-4-yl,1 -cyanoalkyl-3-methylbut-3-yl, 1 -haloalkyl-3- methy Ibut- 3-yl, and more preferably, wherein R3 is tert-butyl, 1-halo-2-methylprop-2-yl, 1-fluoro-2-methylprop-2-yl, 1 -methoxy-2-methylprop-2-yl, 1 -ethoxy-2-methylprop-2-yl, 1- allyloxy-2-methylprop-2-yl, 1 -(prop-2-ynyloxy)-2-methylprop-2-yl, 2-cyano-1 -ethoxy-prop- 2-yl, 2-cyano-1-methoxyprop-2-yl, 1-halo-3-methylbut-3-yl, 1-fluoro-3-methylbut-3-yl, 3- methylbuM -yn-3-yl, 4-methylpent-2-yn-4-yl, 5-methyl-hex-3-yn-5-yl, 1 -methoxy-4- methyl-pent-2-yn-4-yl, 1 -allyloxy^-methyl-pent^-yn^-yl, 1 -propargyloxy-4-methyl-pent- 2-yn-4-yl,1 -ethoxy^-methyl-pent^-yn^-yl.
Another group of preferred compounds of the formula (I) are those, wherein R4 is C1-6 alkyl optionally substituted with Ci-4alkoxy-(d.4)alkoxy(C1_4)alkyl, wherein the alkyl group optionally substituted with halo, mono- or di-(d.6)alkylamino or tri(C1_4)alkylsilyl, or R4 is Ci-6 alkyl optionally substituted with benzyloxy(d-4)alkyl, wherein the alkyl group is optionally substituted with halo, mono- or di-(d.6)alkylamino or tri(Ci-4)alkylsilyl, or R4 is Ci-6 alkyl optionally substituted with C2.6 alkenyloxy or -S(O)x(C1.6)alkyl, wherein x is 0, 1 or 2 and the alkyl group is optionally substituted with halo, mono- or di-(C1.6)alkylamino, - NH(Ci-4)alkyl=NOR, wherein R is hydrogen or C1-4alkyl, or wherein the alkyl group is optionally substituted with tri(C1_4)alkylsilyl, or R4 is -CRUU=NRW, wherein Ruu is hydrogen or Ci-6 alkyl and Rw is hydroxy or optionally substituted d.6alkoxy.
Another group of preferred compounds of the formula (I) are those, wherein the optionally substituted aryl and optionally substituted heteroaryl rings or moieties of the R5 values are optionally substituted with halogen, cyano, nitro, azido, C1-6 alkyl, halo(Ci-6)alkyl, C3-6 cycloalkyl, C3.6 cycloalkyl(C1_4)alkyl, C2.6 alkenyl, halo(C2-6)alkenyl, C2-6 alkynyl, halo(C2.6)alkynyl, CV6 alkoxy, halo(C1.6)alkoxy, C2.6 alkenyloxy, halo(C2.6)- alkenyloxy, C2.6 alkynyloxy, halo(C2-6)alkynyloxy, aryl, aryloxy, aryl(C1.6)alkyl, aryl- (d-βjalkoxy, heteroaryl, heteroaryloxy, heteroaryl(C1.6)alkyl, heteroaryl(C1.6)alkoxy, -SF5, -S(O)g(Ci-4)alkyl wherein g is 0, 1 or 2 and the alkyl is optionally substituted with halo, or R5 is optionally substituted with -OSO2(Ci^t)alkyl, wherein the alkyl group is optionally substituted with halo, or R5 is optionally substituted with -CONR9Rh, -COR9, -CO2R9, - R9=NRh, -NR9Rh, -NR9CORh, -NR9CO2R", -SO2NR9Rh Or -NR9SO2R', wherein R1 is C1-6 alkyl optionally substituted with halogen and R9 and Rh, independently of each other, are hydrogen or C1.6 alkyl optionally substituted with halogen, or, in the case of -CONR9Rh or -SO2NR9R11, R9Rh may join to form a 5- or 6-membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulphur, oxygen or NR0, wherein R0 is hydrogen or optionally substituted C1-6alkyl.
Another group of preferred compounds of the formula (I) are those, wherein the optionally substituted aryl, optionally substituted heteroaryl or optionally substituted 5- to 8-membered ring R4 is optionally substituted with halogen, cyano, nitro, azido, C1^ alkyl, halo(C1.6)alkyl, C3.6 cycloalkyl, C3-6 cycloalkyl(C1_4)alkyl, C2-6 alkenyl, halo(C2.6)alkenyl, C2.6 alkynyl, halo(C2.6)alkynyl, C1^ alkoxy, halo(C1.6)a'koxy, C2.6 alkenyloxy, halo(C2.6)- alkenyloxy, C2.6 alkynyloxy, halo(C2.6)alkynyloxy, -SF5, -S(O)x(C1.6)alkyl, wherein x is 0, 1 or 2 and the alkyl group is optionally substituted with halo, or R4 is optionally substituted with -OSO2(C1_4)alkyl, wherein the alkyl group is optionally substituted with halogen, -C0NRxRy, -CON(ORx)Ry, -CORX, -CO2RX, -CRx=NRy, -NRxRy, -NRxC0Ry, -NRxCO2Ry, -SO2NRxRy or -NRXSO2RZ, wherein Rz is Ci-8 alkyl optionally substituted with halogen and Rx and Ry, independently of each other, are hydrogen or C1^ alkyl optionally substituted with halogen. Another group of preferred compounds of the formula (I) are those, wherein R50 is C1-4alkyl optionally substituted with halogen, hydroxy, Ci-6 alkoxy, C2-6 alkenyl (especially allyl), C-2-6 alkynyl (especially propargyl), C1_4 alkoxy(C1_4)alkoxy, cyano, C1^ alkylcarbonyloxy, aminocarbonyloxy, mono- or di(C1_4)alkylamino-carbonyloxy, S(O)p(Ci. 6)-alkyl, wherein p is 0, 1 or 2, triazolyl, pyrazolyl, imidazolyl, tri(C1_4)-alkylsilyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienylmethoxy.
Another group of preferred compounds of the formula (I) are those, wherein R50 is C3. 6cycloalkyl optionally substituted with halogen, hydroxy, C1^ aIkOXy, C1_4 alkoxy(Ci. 4)alkoxy, cyano, C1_4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(d.4)alkylamino- carbonyloxy, S(O)p(C1.6)-alkyl, wherein p is 0, 1 or 2, triazolyl, pyrazolyl, imidazolyl, tri(Ci-4)-alkylsilyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienylmethoxy.
Another group of preferred compounds of the formula (I) are those, wherein the optionally substituted aryl orthe optionally substituted heteroaryl R50 is optionally substituted with halogen, hydroxy, mercapto, C^alkyl, C2-4 alkenyl, C2-4 alkynyl, C1^ alkoxy, C2.4 alkenyloxy, C2-4 alkynyloxy, halo(C1_4)alkyl, halo(C1^l)alkoxy, C^4 alkylthio, halo(Ci-4)-alkylthio, hydroxy(C1_4)alkyl, CiJtalkoxy(C1-4)alkyl, C3.6cycloalkyl, C3.6 cycloalkyl-(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, NRpRq, NHCORP, -NHCONRpRq, CONRpRq, -SO2R0, OSO2R0, CORP, CRp=NRq or N=CRpRq, wherein R0 is C^alkyl, halo(C1_4)alkyl, d.4 alkoxy, halo(C1_4)alkoxy, C1_4alkylthio, C3.6 cycloalkyl, C3-GCyClOaIkYl(C1 -4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, Ci_4alkyl or C1_4 alkoxy, and Rp and Rq are independently hydrogen, d^alkyl, halo(d-4)alkyl, d.4 alkoxy, halo(Ci ^alkoxy, Ci^alkylthio, C3-6 cycloalkyl, Cs-δ CycloalkyKd ^alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, Ci_4 alkyl or C1_4 alkoxy.
Another group of preferred compounds of the formula (I) are those, wherein L is oxygen.
Another group of preferred compounds of the formula (I) are those, wherein n is 0.
Another group of preferred compounds of the formula (I) are the N-oxides formed by the quinoline moiety in the compounds of the formula I. Compounds that form part of the invention are illustrated in Tables 1 to 192 below. Melting points (mp) and/or diagnostic molecular ion (eg M+, [M+1 ]+) values and/or spectroscopic (1 H NMR) data are provided in Examples 1 -5 while biological activities are provided in Example 6.
Figure imgf000013_0001
Figure imgf000014_0001
Figure imgf000015_0001
Figure imgf000016_0001
Figure imgf000017_0001
Figure imgf000018_0001
Figure imgf000019_0001
Figure imgf000020_0001
Figure imgf000021_0001
h
t c
Figure imgf000022_0001
respectively, except that in the compounds of Table 2 Q1 is bromo, Q2 is hydrogen, Q3 is chloro. Table 3
The compounds in Table 3 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 3 is the same as compound 1 of Table 1 except that in compound 1 of Table 3 Q1 is iodo, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 3 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 3 Q1 is iodo, Q2 is hydrogen, Q3 is chloro. Table 4
The compounds in Table 4 are of the general formula (I) where Q1 is flouro, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 4 is the same as compound 1 of Table 1 except that in compound 1 of Table 4 Q1 is fluoro, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 4 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 3 Q1 is fluoro, Q2 is hydrogen, Q3 is chloro. Table 5 The compounds in Table 5 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 5 is the same as compound 1 of Table 1 except that in compound 1 of Table 5 Q1 is chloro, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 5 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 5 Q1 is chloro, Q2 is hydrogen, Q3 is fluoro. Table 6
The compounds in Table 6 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 6 is the same as compound 1 of Table 1 except that in compound 1 of Table 5 Q1 is bromo, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 6 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 6 Q1 is bromo, Q2 is hydrogen, Q3 is fluoro. Table 7
The compounds in Table 7 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 7 is the same as compound 1 of Table 1 except that in compound 1 of Table 7 Q1 is iodo, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 7 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 7 Q1 is iodo, Q2 is hydrogen, Q3 is fluoro. Table 8 The compounds in Table 8 are of the general formula (I) where Q1 is fluoro, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 8 is the same as compound 1 of Table 1 except that in compound 1 of Table 8 Q1 is fluoro, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 8 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 8 Q1 is fluoro, Q2 is hydrogen, Q3 is fluoro. Table 9
The compounds in Table 9 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 9 is the same as compound 1 of Table 1 except that in compound 1 of Table 9 Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 9 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 9 Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro. Table 10
The compounds in Table 10 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 10 is the same as compound 1 of Table 1 except that in compound 1 of Table 10 Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 10 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 10 Q1 is hydrogen, Q2 is hydrogen,
Q3 is fluoro.
Table 1 1
The compounds in Table 11 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is brorno, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 1 1 is the same as compound 1 of Table 1 except that in compound 1 of Table 1 1 Q1 is hydrogen, Q2 is hydrogen, Q3 is bromo. Similarly, compounds 2 to 323 of Table 1 1 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 11 Q1 is hydrogen, Q2 is hydrogen, Q3 is bromo. Table 12
The compounds in Table 12 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 12 is the same as compound 1 of Table 1 except that in compound 1 of Table 12 Q1 is chloro, Q2 is hydrogen, Q3 is methyl. Similarly, compounds 2 to 323 of Table 12 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 12 Q1 is chloro, Q2 is hydrogen, Q3 is methyl.
Table 13
The compounds in Table 13 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 13 is the same as compound 1 of Table 1 except that in compound 1 of Table 13 Q1 is bromo, Q2 is hydrogen, Q3 is methyl. Similarly, compounds 2 to 323 of Table 13 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 13 Q1 is bromo, Q2 is hydrogen, Q3 is methyl. Table 14
The compounds in Table 14 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 14 is the same as compound 1 of Table 1 except that in compound 1 of Table 14 Q1 is iodo, Q2 is hydrogen, Q3 is methyl. Similarly, compounds 2 to 323 of Table 14 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 14 Q1 is iodo, Q2 is hydrogen, Q3 is methyl. Table 15 The compounds in Table 15 are of the general formula (I) where Q1 is flouro, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 15 is the same as compound 1 of Table 1 except that in compound 1 of Table 15 Q1 is fluoro, Q2 is hydrogen, Q3 is methyl. Similarly, compounds 2 to 323 of Table 15 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 15 Q1 is fluoro, Q2 is hydrogen, Q3 is methyl. Table 16
The compounds in Table 16 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 16 is the same as compound 1 of Table 1 except that in compound 1 of Table 16 Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl. Similarly, compounds 2 to 323 of Table 16 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 16 Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl. Table 17 The compounds in Table 17 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 17 is the same as compound 1 of Table 1 except that in compound 1 of Table 17 R1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 17 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 17 R1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is chloro. Table 18
The compounds in Table 18 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 18 is the same as compound 1 of Table 1 except that in compound 1 of Table 18 R1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 18 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 18 R1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is chloro. Table 19
The compounds in Table 19 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 19 is the same as compound 1 of Table 1 except that in compound 1 of Table 19 R1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 19 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 19 R1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is chloro. Table 20 The compounds in Table 20 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 20 is the same as compound 1 of Table 1 except that in compound 1 of Table 20 R1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 20 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 20 R1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is fluoro. Table 21
The compounds in Table 21 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 21 is the same as compound 1 of Table 1 except that in compound 1 of Table 21 R1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 21 are the same as compounds 2 to 323 of
Table 1 , respectively, except that in the compounds of Table 21 R1 is ethyl, Q1 is bromo,
Q2 is hydrogen, Q3 is fluoro.
Table 22
The compounds in Table 22 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 22 is the same as compound 1 of Table 1 except that in compound 1 of Table 22 R1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 22 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 22 R1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is fluoro. Table 23
The compounds in Table 23 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 23 is the same as compound 1 of Table 1 except that in compound 1 of Table 23 R1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 23 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 23 R1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is chloro. Table 24 The compounds in Table 24 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 24 is the same as compound 1 of Table 1 except that in compound 1 of Table 24 R1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 24 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 24 R1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is fluoro. Table 25
The compounds in Table 25 are of the general formula (I) where Q1 is chloro, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 25 is the same as compound 1 of Table 1 except that in compound 1 of Table 25 R1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is methyl. Similarly, compounds 2 to 323 of Table 25 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 25 R1 is ethyl, Q1 is chloro, Q2 is hydrogen, Q3 is methyl. Table 26 The compounds in Table 26 are of the general formula (I) where Q1 is bromo, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 26 is the same as compound 1 of Table 1 except that in compound 1 of Table 26 R1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is methyl. Similarly, compounds 2 to 323 of Table 26 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 26 R1 is ethyl, Q1 is bromo, Q2 is hydrogen, Q3 is methyl. Table 27
The compounds in Table 27 are of the general formula (I) where Q1 is iodo, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 27 is the same as compound 1 of Table 1 except that in compound 1 of Table 27 R1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is methyl. Similarly, compounds 2 to 323 of Table 27 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 27 R1 is ethyl, Q1 is iodo, Q2 is hydrogen, Q3 is methyl. Table 28
The compounds in Table 28 are of the general formula (I) where Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 28 is the same as compound 1 of Table 1 except that in compound 1 of Table 28 R1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl. Similarly, compounds 2 to 323 of Table 28 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 28 R1 is ethyl, Q1 is hydrogen, Q2 is hydrogen, Q3 is methyl. Table 29 The compounds in Table 29 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 29 is the same as compound 1 of Table 1 except that in compound 1 of Table 29 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 29 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 29 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro. Table 30
The compounds in Table 30 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 30 is the same as compound 1 of Table 1 except that in compound 1 of Table 30 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 30 are the same as compounds 2 to 323 of
Table 1 , respectively, except that in the compounds of Table 30 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro.
Table 31
The compounds in Table 31 are of the general formula (I) where Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 31 is the same as compound 1 of Table 1 except that in compound 1 of Table 31 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 31 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 31 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro. Table 32
The compounds in Table 32 are of the general formula (I) where Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 32 is the same as compound 1 of Table 1 except that in compound 1 of Table 32 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 32 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 32 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro. Table 33 The compounds in Table 33 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 33 is the same as compound 1 of Table 1 except that in compound 1 of Table 33 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 33 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 33 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is chloro. Table 34
The compounds in Table 34 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 34 is the same as compound 1 of Table 1 except that in compound 1 of Table 34 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 34 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 34 Q1 is thiophen-3-yl, Q2 is hydrogen, Q3 is fluoro. Table 35 The compounds in Table 35 are of the general formula (I) where Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 35 is the same as compound 1 of Table 1 except that in compound 1 of Table 35 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro. Similarly, compounds 2 to 323 of Table 35 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 35 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is chloro. Table 36
The compounds in Table 36 are of the general formula (I) where Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro, n is 0, L is O, R1 is ethyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 36 is the same as compound 1 of Table 1 except that in compound 1 of Table 36 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 36 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 36 Q1 is thiophen-2-yl, Q2 is hydrogen, Q3 is fluoro. Table 37
The compounds in Table 37 are of the general formula (I) where Q1 is chloro, Q2 is methyl, Q3 is chloro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 37 is the same as compound 1 of Table 1 except that in compound 1 of Table 37 Q1 is chloro, Q2 is methyl, Q3 is chloro. Similarly, compounds 2 to 323 of Table 37 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 37 Q1 is chloro, Q2 is methyl, Q3 is chloro.
Table 38
The compounds in Table 38 are of the general formula (I) where Q1 is bromo, Q2 is methyl, Q3 is chloro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 38 is the same as compound 1 of Table 1 except that in compound 1 of Table 38 Q1 is bromo, Q2 is methyl, Q3 is chloro. Similarly, compounds 2 to 323 of Table 38 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 38 Q1 is bromo, Q2 is methyl, Q3 is chloro. Table 39
The compounds in Table 39 are of the general formula (I) where Q1 is iodo, Q2 is methyl, Q3 is chloro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 39 is the same as compound 1 of Table 1 except that in compound 1 of Table 39 Q1 is iodo, Q2 is methyl, Q3 is chloro. Similarly, compounds 2 to 323 of Table 39 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 39 Q1 is iodo, Q2 is methyl, Q3 is chloro. Table 40 The compounds in Table 40 are of the general formula (I) where Q1 is fluoro, Q2 is methyl, Q3 is chloro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 40 is the same as compound 1 of Table 1 except that in compound 1 of Table 40 Q1 is fluoro, Q2 is methyl, Q3 is chloro. Similarly, compounds 2 to 323 of Table 40 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 40 Q1 is fluoro, Q2 is methyl, Q3 is chloro. Table 41
The compounds in Table 41 are of the general formula (I) where Q1 is chloro, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 41 is the same as compound 1 of Table 1 except that in compound 1 of Table 41 Q1 is chloro, Q2 is methyl, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 41 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 41 Q1 is chloro, Q2 is methyl, Q3 is fluoro. Table 42 The compounds in Table 42 are of the general formula (I) where Q1 is bromo, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 42 is the same as compound 1 of Table 1 except that in compound 1 of Table 42 Q1 is bromo, Q2 is methyl, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 42 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 42 Q1 is bromo, Q2 is methyl, Q3 is fluoro. Table 43
The compounds in Table 43 are of the general formula (I) where Q1 is iodo, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 43 is the same as compound 1 of Table 1 except that in compound 1 of Table 43 Q1 is iodo, Q2 is methyl, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 43 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 43 Q1 is iodo, Q2 is methyl, Q3 is fluoro. Table 44 The compounds in Table 44 are of the general formula (I) where Q1 is fluoro, Q2 is methyl, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 44 is the same as compound 1 of Table 1 except that in compound 1 of Table 44 Q1 is fluoro, Q2 is methyl, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 44 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 44 Q1 is fluoro, Q2 is methyl, Q3 is fluoro. Table 45
The compounds in Table 45 are of the general formula (I) where Q1 is chloro, Q2 is methyl, Q3 is bromo, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1 . Thus, compound 1 of Table 45 is the same as compound 1 of Table 1 except that in compound 1 of Table 45 Q1 is chloro, Q2 is methyl, Q3 is bromo. Similarly, compounds 2 to 323 of Table 45 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 45 Q1 is chloro, Q2 is methyl, Q3 is bromo. Table 46
The compounds in Table 46 are of the general formula (I) where Q1 is bromo, Q2 is methyl, Q3 is bromo, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 46 is the same as compound 1 of Table 1 except that in compound 1 of Table 46 Q1 is bromo, Q2 is methyl, Q3 is bromo. Similarly, compounds 2 to 323 of Table 46 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 46 Q1 is bromo, Q2 is methyl, Q3 is bromo.
Table 47
The compounds in Table 47 are of the general formula (I) where Q1 is iodo, Q2 is methyl, Q3 is bromo, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 47 is the same as compound 1 of Table 1 except that in compound 1 of Table 47 Q1 is iodo, Q2 is methyl, Q3 is bromo. Similarly, compounds 2 to 323 of Table 47 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 47 Q1 is iodo, Q2 is methyl, Q3 is bromo. Table 48
The compounds in Table 48 are of the general formula (I) where Q1 is fluoro, Q2 is methyl, Q3 is bromo, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 48 is the same as compound 1 of Table 1 except that in compound 1 of Table 48 Q1 is fluoro, Q2 is methyl, Q3 is bromo. Similarly, compounds 2 to 323 of Table 48 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 48 Q1 is fluoro, Q2 is methyl, Q3 is bromo.
Table 49
The compounds in Table 49 are of the general formula (I) where Q1 is chloro, Q2 is chloro, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 49 is the same as compound 1 of Table 1 except that in compound 1 of Table 49 Q1 is chloro, Q2 is chloro, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 49 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 49 Q1 is Q1 is chloro, Q2 is chloro, Q3 is fluoro. Table 50
The compounds in Table 50 are of the general formula (I) where Q1 is bromo, Q2 is chloro, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 50 is the same as compound 1 of Table 1 except that in compound 1 of Table 50 Q1 is bromo, Q2 is chloro, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 50 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 50 Q 1 is Q1 is bromo, Q2 is chloro, Q3 is fluoro. Table 51
The compounds in Table 51 are of the general formula (I) where Q1 is flouro, Q2 is chloro, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 51 is the same as compound 1 of Table 1 except that in compound 1 of Table 51 Q1 is flouro, Q2 is chloro, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 51 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 51 Q1 is Q1 is flouro, Q2 is chloro, Q3 is fluoro. Table 52 The compounds in Table 52 are of the general formula (I) where Q1 is iodo, Q2 is chloro, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 52 is the same as compound 1 of Table 1 except that in compound 1 of Table 52 Q1 is iodo, Q2 is chloro, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 52 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 52 Q1 is Q1 is iodo, Q2 is chloro, Q3 is fluoro. Table 53
The compounds in Table 53 are of the general formula (I) where Q1 is chloro, Q2 is bromo, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 53 is the same as compound 1 of Table 1 except that in compound 1 of Table 53 Q1 is chloro, Q2 is bromo, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 53 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 53 Q1 is Q1 is chloro, Q2 is bromo, Q3 is fluoro. Table 54
The compounds in Table 54 are of the general formula (I) where Q1 is bromo, Q2 is bromo, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 54 is the same as compound 1 of Table 1 except that in compound 1 of Table 54 Q1 is bromo, Q2 is bromo, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 54 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 54 Q1 is Q1 is bromo, Q2 is bromo, Q3 is fluoro. Table 55 The compounds in Table 55 are of the general formula (I) where Q1 is flouro, Q2 is bromo, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 55 is the same as compound 1 of Table 1 except that in compound 1 of Table 55 Q1 is flouro, Q2 is bromo, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 55 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 55 Q1 is Q1 is flouro, Q2 is bromo, Q3 is fluoro. Table 56
The compounds in Table 56 are of the general formula (I) where Q1 is iodo, Q2 is bromo, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 56 is the same as compound 1 of Table 1 except that in compound 1 of Table 56 Q1 is iodo, Q2 is bromo, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 56 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 56 Q1 is Q1 is iodo, Q2 is bromo, Q3 is fluoro. Table 57 The compounds in Table 57 are of the general formula (I) where Q1 is chloro, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 57 is the same as compound 1 of Table 1 except that in compound 1 of Table 57 Q1 is chloro, Q2 is fluoro, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 57 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 57 Q1 is Q1 is chloro, Q2 is fluoro, Q3 is fluoro. Table 58 The compounds in Table 58 are of the general formula (I) where Q1 is bromo, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 58 is the same as compound 1 of Table 1 except that in compound 1 of Table 58 Q1 is bromo, Q2 is fluoro, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 58 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 58 Q1 is Q1 is bromo, Q2 is fluoro, Q3 is fluoro. Table 59
The compounds in Table 59 are of the general formula (I) where Q1 is fluoro, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 59 is the same as compound 1 of Table 1 except that in compound 1 of Table 59 Q1 is fluoro, Q2 is fluoro, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 59 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 59 Q1 is Q1 is fluoro, Q2 is fluoro, Q3 is fluoro. Table 60 The compounds in Table 60 are of the general formula (I) where Q1 is iodo, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 60 is the same as compound 1 of Table 1 except that in compound 1 of Table 60 Q1 is iodo, Q2 is fluoro, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 60 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 60 Q1 is Q1 is iodo, Q2 is fluoro, Q3 is fluoro. Table 61
The compounds in Table 61 are of the general formula (I) where Q1 is thiophen-3-yl, Q2 is fluoro, Q3 is fluoro, n is 0, L is O, R1 is methyl, R2 and R3 have the values listed in Table 1. Thus, compound 1 of Table 61 is the same as compound 1 of Table 1 except that in compound 1 of Table 61 Q1 is thiophen-3-yl, Q2 is fluoro, Q3 is fluoro. Similarly, compounds 2 to 323 of Table 61 are the same as compounds 2 to 323 of Table 1 , respectively, except that in the compounds of Table 61 Q1 is Q1 is thiophen-3-yl, Q2 is fluoro, Q3 is fluoro. Tables 62 to 121
Tables 62 to 121 correspond exactly to Tables 1 to 61 (i.e. Table 62 corresponds exactly to Table 1 , Table 63 corresponds exactly to Table 2, and so on) the only difference being that in each of Tables 62 to 121 , L is S instead of O. Tables 122 to 181
Tables 122 to 181 correspond exactly to Tables 1 to 61 (i.e. Table 122 corresponds exactly to Table 1 , Table 123 corresponds exactly to Table 2, and so on) the only difference being that in each of Tables 122 to 181 , n is 1 instead of 0. Tables 182 to 241
Tables 182 to 241 correspond exactly to Tables 1 to 61 (i.e. Table 182 corresponds exactly to Table 1 , Table 183 corresponds exactly to Table 2, and so on) the only difference being that in each of Tables 182 to 241 , n is 2 instead of 0.
The compounds of general formula (I) may be prepared as outlined in Schemes 1 to 8 below, in which Q1 , Q2, Q3, R1, R2 and R3 have the meanings given above, R14 is H or Ci-4 alkyl, as indicated, R10 is Ci.6 alkyl, optionally substituted benzyl, optionally substituted C2.6 alkenyl, optionally substituted C2^ alkynyl, R6, R7, R8, R9, R12 and R13 are independently H or Ci-4 alkyl, R9 is H or C1.3 alkyl, Rh is H or C1^ alkyl, R' is C1-6 alkyl, optionally substituted benzyl, optionally substituted C2-6 alkenyl, optionally substituted C2-A alkynyl, m is 0, 1 or 2, DMF is Λ/,Λ/-dimethylformamide, NBS is N- bromosuccinimide, NCS is Λ/-chlorosuccinimide and MCPBA is m-chloroperbenzoic acid. Other abbreviations are defined in the text.
Where typical or preferred process conditions (reaction temperature, time, solvent, mole ratios of reactants) are given, unless otherwise stated other process conditions can also be used. While optimum reaction conditions may vary with the particular reactants or solvents used, such conditions can be determined by routine optimisation procedures by one skilled in the art.
Compounds of formula (1 ), where n is 0 and L is O, may be prepared as shown in Scheme 1. Esters of formula (2), where R5 is C^4 alkyl, may be halogenated to give haloesters of formula (3), where Hal is a halogen atom such as bromine, chlorine or iodine, by reaction with a halogenating agent such as Λ/-bromosuccinimide, in a suitable solvent such as carbon tetrachloride or acetonitrile, in the presence of a radical initiator such as AIBN (azo-/sobutyronitrile), and a light source, at between ambient temperature and the reflux temperature of the solvent. Compounds of general formula (3) are then reacted with alkanethiols of general formula R1SH, in the presence of a base such as sodium hydride, in a suitable solvent such as DMF, to give compounds of general formula (6), or are reacted with alkanethiol salts R1S M+, where M is a metal such as sodium or lithium, in a suitable solvent such as DMF, to give compounds of general formula (6).
Figure imgf000037_0001
(7) ere n = 0
Alternatively esters of general formula (4) are halogenated to give haloesters of formula (5), where Hal is a halogen atom such as bromine, chlorine or iodine, by reaction with a halogenating agent such as Λ/-chlorosuccinimide or Λ/-bromosuccinimide, in a suitable solvent such as carbon tetrachloride or acetonitrile, at between O°C and the reflux temperature of the solvent. Haloesters of formula (5) are reacted with 6-hydroxy quinolines, where Q1 , Q2 and Q3 are as defined above, in the presence of a base such as potassium f-butoxide, potassium carbonate, or sodium hydride in a suitable solvent such as f-butanol, 1 ,4-dioxane or DMF, at between ambient temperature and the reflux temperature of the solvent, to give compounds of formula (6). Compounds of formula (6) are hydrolysed to acids of formula (7) by reaction with an alkali metal hydroxide M+OH", in a suitable solvent such as aqueous methanol, ethanol, or THF (tetrahydrofuran) at between ambient temperature and the reflux temperature of the solvent followed by acidification. Acids of formula (7) can be condensed with amines of formula (8), using suitable activating agents such as HOBT (1 -hydroxybenzotriazole) and EDC (1 -ethyl-3- Λ/,Λ/-dimethylaminopropylcarbodiimide hydrochloride), at between O°C and ambient temperature in a suitable solvent such as DMF, to give compounds of general formula (1 ) where n is 0 and L is O.
Compounds of general formula (1 ), where n is 1 or 2, are prepared by oxidation of compounds (1 ) where n = 0 to the sulphoxide (n is 1 ) or sulphone (n is 2) oxidation state, as shown in Scheme 2. For example, esters of the general formula (6) where R5 is Ci-4 alkyl can be oxidised to sulphoxides of formula (9) with an oxidising agent such as sodium periodate in a suitable solvent such ethanol, between O°C and ambient temperature. Sulphones of formula (10) can be made either directly from compounds of formula (6) with two or more equivalents of an oxidising agent such as m-chloro- perbenzoic acid (MCPBA), in a suitable solvent such as dichloromethane between O°C and the reflux temperature of the solvent, or from sulphoxides of formula (9) with one or more equivalents of m-chloroperbenzoic acid. Sulphides of formula (6), sulphoxides of formula (9) or sulphones of formula (10) can be hydrolysed to the corresponding acids (7), (1 1 ) or (12) by reaction with an alkali metal hydroxide in a suitable solvent such as ethanol at between O°C and the reflux temperature of the solvent followed by acidification. The acids of formula (7), (1 1 ) or (12) can be condensed with amines of formula (8), using suitable activating agents such as HOBT and EDC, at between O°C and ambient temperature, to give compounds of general formula (1 ) where n is 0, 1 or 2.
2
Figure imgf000038_0001
Similarly, sulphoxides of formula (1 1 ) and of formula (1 ) where n is 1 can be prepared from sulphides of formula (7) and of formula (1 ) where n is 0 respectively, using oxidising agents such as sodium metaperiodate or m-chloroperbenzoic acid as described above. Sulphones of formula (12) and of formula (1 ) where n is 2, can be prepared either from sulphides of formula (7) and of formula (1 ) where n is 0, by using at least two equivalents of oxidising agents such as m-chloroperbenzoic acid, or from sulphoxides of formula (1 1 ) and of formula (1 ) where n is 1 , using one or more equivalents of oxidising agents such as m-chloroperbenzoic acid, as described above.
Compounds of formula (1 ) can also be prepared as shown in Scheme 3. Acids of formula (13) can be condensed with amines of formula (8), using suitable activating agents such as HOBT and EDC, at between O°C and ambient temperature, to give compounds of formula (14). Compounds of formula (14) can be halogenated to compounds of formula (16) using a halogenating agent such as Λ/-chlorosuccinimide, in a suitable solvent such as carbon tetrachloride or acetonitrile, at between O°C and ambient temperature. Amides of formula (16) can also be prepared from acid halides of formula (15) by reaction with amines of formula (8) in the presence of a base such as triethylamine in a suitable solvent such as dichloromethane, at between O°C and ambient temperature.
Figure imgf000039_0001
(8) (16) (1 ) where n = 0
Halosulphides of formula (16) can be reacted with substituted 6-hydroxy quinolines, in the presence of a base such as potassium carbonate or sodium hydride, in a suitable solvent such as DMF, at between O°C and 8O°C, to give compounds of formula (1 ) where n is 0.
As shown in Scheme 4, amines of the general formula (18) or (20), which are examples of amines of the general formula (8) wherein R2 is H, may be prepared by alkylation of an aminoalcohol of the general formula (17) or (19) using a suitable base, such as n- butyl lithium or sodium hydride, followed by reaction with a suitable alkylating reagent R10LG, such as an alkyl iodide, for example, methyl iodide, to form an alkylated compound of the general formula (18) or (20), respectively. A carbonyl derivative R12COR13 (21 ), for example formaldehyde, can be reacted with ammonia, usually in form of ammonium chloride, and cyanide, conveniently in form of an aqueous solution sodium cyanide, to provide an α-aminoalkyne (22) (Strecker synthesis).
Figure imgf000040_0001
As shown in Scheme 5, silyl-protected aminoalkynes of the general formula (24) may be obtained by reacting amines of general formula (23) with 1 ,2-/?/s-(chlorodimethylsilyl)- ethane in the presence of a suitable base, such as a tertiary organic amine base, for example, triethylamine. Amines of the general formula (26), which are examples of amines of the general formula (8) wherein R2 is H and R3 is -(CR30R40)C≡CR50, may be prepared by alkylation of a silyl-protected aminoalkyne of the general formula (24) using a suitable base, such as n-butyl lithium, followed by reaction with a suitable alkylating reagent R50LG, such as an alkyl iodide, for example, methyl iodide, to form an alkylated compound of the general formula (25). The silyl protecting group may then be removed from a compound of the general formula (25) with, for example, an aqueous acid to form an aminoalkyne of the general formula (26). (3 (33) N KCN
Figure imgf000041_0001
In a similar procedure, a silyl-protected aminoalkyne of the general formula (24) may be reacted with a carbonyl derivative RaCORb, for example formaldehyde, using a suitable base, such as n-butyl lithium, to provide an aminoalkyne (27) containing a hydroxyalkyl moiety. A compound of the general formula (27) may either first be treated with a base, such as sodium hydride or potassium fc>/s(trimethylsilyl)amide followed by a compound R0LG, where LG represents a leaving group such as a halogen, or sulphonate ester such as OSO2Me, or OSO2-4-tolyl, for example ethyl iodide, to give a compound of the general formula (29). After removal of the silyl protecting group, compounds of general formula (30) are obtained. Alternatively, the silyl protecting group can first be removed to yield compounds of the general formula (28). Aminoalkynes of the general formula (28) may be further derivatised by reacting with a silylating agent, for example f-butyl- dimethylsilyl chloride, to give a derivative silylated on oxygen of the general formula (31 ). e 6
Figure imgf000042_0001
As shown in Scheme 6, silyl-protected aminoalkynes of the general formula (32) may be obtained by reacting silyl-protected amines of general formula (24) with chloroalkanes bearing a suitable leaving group, for example bromide or iodide, in the presence of a suitable base, such as asodium or lithium amide base, for example, sodium bis(trimethylsilyl)amide or sodium amide. Amines of the general formula (34), which are examples of amines of the general formula (8) wherein R2 is H and and R3 is - (CR30R40)C≡CR50 may be prepared by displacement of chloride anion by cyanide, followed by removal of the silyl protecting group with, for example, an aqueous acid, to form a cyano compound of the general formula (34).
In a similar procedure, an amide of the general formula (35) can be reacted with, for example, potassium cyanide yielding a cyano amidoalkyne of the general formula (36). As shown in Scheme 7, compounds of the general formula (1 ), wherein R50 is H, may be reacted under Sonogashira conditions with, for example, optionally substituted aryl or heteroaryl chlorides, bromides, iodides or triflates to form substituted aryl or heteroaryl compounds of general formula (1 ), wherein R50 is an optionally substituted aryl or heteroaryl group. A suitable palladium catalyst is bis(triphenylphosphine)palladium (II) chloride. (1) w H and
Figure imgf000043_0001
R3 ( 0R40ICCR^ R50 = H)
Other amines of the general formula (8) are either commercially available or may be prepared by standard literature methods or standard modifications.
As shown in Scheme 8, compounds of the general formula (1 ), wherein Q1 is bromine or iodine, may be reacted under Suzuki conditions with, for example, optionally substituted aryl or heteroaryl boronic acids to form substituted aryl or heteroaryl compounds of general formula (1), wherein Q1 is an optionally substituted aryl or heteroaryl group. A suitable palladium catalyst is tetrakis(triphenylphosphine)palladium(0).
or lyst
(1) where Q Br1 11 n = 1
Figure imgf000043_0002
Thioamides (Compounds of the general formula (1 ) where L = S) may be prepared from the corresponding amides using thionating agents such as phosphous pentasulphide, Lawesson's or Davy's reagents or prepared from the corresponding thionoacids or thionoesters using standard literature methods or standard modifications.
The substituted 6-hydroxy quinolines are available, or may be prepared using straightforward techniques of organic chemistry. When the compounds are not commercially available, they may be prepared from available precursors using straightforward transformations that are well known in the art that are well described in standard textbooks of heterocyclic chemistry. For example, substituted aromatic amines may be readily converted into substituted quinolin-6-ols with appropriate electrophiles, such as 2,2,3 tribromopropanal. Examples of such reactions are provided in Examples 1 -3.
The compounds of formula (I) are active fungicides and may be used to control one or more of the following pathogens: Pyricularia oryzae (Magnaporthe grisea) on rice and wheat and other Pyricυlaria spp. on other hosts; Pυccinia triticina (or recondita), Puccinia striiformis and other rusts on wheat, Puccinia hordei, Puccinia striiformis and other rusts on barley, and rusts on other hosts (for example turf, rye, coffee, pears, apples, peanuts, sugar beet, vegetables and ornamental plants); Erysiphe cichoracearum on cucurbits (for example melon); Blumeria (or Erysiphe) graminis
(powdery mildew) on barley, wheat, rye and turf and other powdery mildews on various hosts, such as Sphaerotheca macularis on hops, Sphaerotheca fusca (Sphaerotheca fuliginea) on cucurbits (for example cucumber), Leveillula taurica on tomatoes, aubergine and green pepper, Podosphaera leucotricha on apples and Uncinula necator on vines; Cochliobolus spp., Helminthosporium spp., Drechslera spp. (Pyrenophora spp.), Rhynchosporium spp., Mycosphaerella graminicola (Septoria tritici) and Phaeosphaeria nodorum (Stagonospora nodorum or Septoria nodorυm), Pseudocercosporella herpotrichoides and Gaeumannomyces graminis on cereals (for example wheat, barley, rye), turf and other hosts; Cercospora arachidicola and Cercosporidium personatum on peanuts and other Cercospora spp. on other hosts, for example sugar beet, bananas, soya beans and rice; Botrytis cinerea (grey mould) on tomatoes, strawberries, vegetables, vines and other hosts and other Botrytis spp. on other hosts; Alternaria spp. on vegetables (for example carrots), oil-seed rape, apples, tomatoes, potatoes, cereals (for example wheat) and other hosts; Venturia spp. (including Venturia inaequalis (scab)) on apples, pears, stone fruit, tree nuts and other hosts; Cladosporium spp. on a range of hosts including cereals (for example wheat) and tomatoes; Monilinia spp. on stone fruit, tree nuts and other hosts; Didymella spp. on tomatoes, turf, wheat, cucurbits and other hosts; Phoma spp. on oil-seed rape, turf, rice, potatoes, wheat and other hosts; Aspergillus spp. and Aureobasidium spp. on wheat, lumber and other hosts; Ascochyta spp. on peas, wheat, barley and other hosts;
Stemphylium spp. (Pleospora spp.) on apples, pears, onions and other hosts; summer diseases (for example bitter rot (Glomerella cingulata), black rot or frogeye leaf spot (Botryosphaeria obtusa), Brooks fruit spot (Mycosphaerella pomi), Cedar apple rust (Gymnosporangium juniperi-virginianae), sooty blotch (Gloeodes pomigena), flyspeck (Schizothyrium pomi) and white rot (Botryosphaeria dothidea)) on apples and pears;
Plasmopara viticola on vines; other downy mildews, such as Bremia lactucae on lettuce, Peronospora spp. on soybeans, tobacco, onions and other hosts, Pseudoperonospora humuli on hops and Pseudoperonospora cubensis on cucurbits; Pythium spp. (including Pythium ultimum) on turf and other hosts; Phytophthora infestans on potatoes and tomatoes and other Phytophthora spp. on vegetables, strawberries, avocado, pepper, ornamentals, tobacco, cocoa and other hosts; Thanatephorus cucumeris on rice and turf and other Rhizoctonia spp. on various hosts such as wheat and barley, peanuts, vegetables, cotton and turf; Sclerotinia spp. on turf, peanuts, potatoes, oil-seed rape and other hosts; Sclerotium spp. on turf, peanuts and other hosts; Gibberella fujikuroi on rice; Colletotrichum spp. on a range of hosts including turf, coffee and vegetables; Laetisaria fuciformis on turf; Mycosphaerella spp. on bananas, peanuts, citrus, pecans, papaya and other hosts; Diaporthe spp. on citrus, soybean, melon, pears, lupin and other hosts; Elsinoe spp. on citrus, vines, olives, pecans, roses and other hosts; Verticillium spp. on a range of hosts including hops, potatoes and tomatoes; Pyrenopeziza spp. on oil-seed rape and other hosts; Oncobasidium theobromae on cocoa causing vascular streak dieback; Fusarium spp., Typhula spp., Microdochium nivale, Ustilago spp., Urocystis spp., Tilletia spp. and Claviceps purpurea on a variety of hosts but particularly wheat, barley, turf and maize; Ramularia spp. on sugar beet, barley and other hosts; post-harvest diseases particularly of fruit (for example Penicillium digitatum, Penicillium italicum and Trichoderma viride on oranges, Colletotrichum musae and Gloeosporium musarum on bananas and Botrytis cinerea on grapes); other pathogens on vines, notably Eutypa lata, Guignardia bidwellii, Phellinus igniarus, Phomopsis viticola, Pseudopeziza tracheiphila and Stereum hirsutum; other pathogens on trees (for example Lophodermium seditiosum) or lumber, notably Cephaloascus fragrans, Ceratocystis spp., Ophiostoma piceae, Penicillium spp., Trichoderma pseudokoningii, Trichoderma viride, Trichoderma harzianum, Aspergillus niger, Leptographium lindbergi and Aureobasidium pullulans; and fungal vectors of viral diseases (for example Polymyxa graminis on cereals as the vector of barley yellow mosaic virus (BYMV) and Polymyxa betae on sugar beet as the vector of rhizomania).
A compound of formula (I) may move acropetally, basipetally or locally in plant tissue to be active against one or more fungi. Moreover, a compound of formula (I) may be volatile enough to be active in the vapour phase against one or more fungi on the plant.
The invention therefore provides a method of combating or controlling phytopathogenic fungi which comprises applying a fungicidally effective amount of a compound of formula (I), or a composition containing a compound of formula (I), to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or any other plant growth medium, e.g. nutrient solution. The term "plant" as used herein includes seedlings, bushes and trees. Furthermore, the fungicidal method of the invention includes protectant, curative, systemic, eradicant and antisporulant treatments.
The compounds of formula (I) are preferably used for agricultural, horticultural and turfgrass purposes in the form of a composition.
In order to apply a compound of formula (I) to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or any other growth medium, a compound of formula (I) is usually formulated into a composition which includes, in addition to the compound of formula (I), a suitable inert diluent or carrier and, optionally, a surface active agent (SFA). SFAs are chemicals that are able to modify the properties of an interface (for example, liquid/solid, liquid/air or liquid/liquid interfaces) by lowering the interfacial tension and thereby leading to changes in other properties (for example dispersion, emulsification and wetting). It is preferred that all compositions (both solid and liquid formulations) comprise, by weight, 0.0001 to 95%, more preferably 1 to 85%, for example 5 to 60%, of a compound of formula (I). The composition is generally used for the control of fungi such that a compound of formula (I) is applied at a rate of from 0.1 g to 10kg per hectare, preferably from 1 g to 6kg per hectare, more preferably from 1 g to 1 kg per hectare.
When used in a seed dressing, a compound of formula (I) is used at a rate of 0.0001 g to 10g (for example 0.001 g or 0.05g), preferably 0.005g to 10g, more preferably 0.005g to 4g, per kilogram of seed.
In another aspect the present invention provides a fungicidal composition comprising a fungicidally effective amount of a compound of formula (I) and a suitable carrier or diluent therefor.
In a still further aspect the invention provides a method of combating and controlling fungi at a locus, which comprises treating the fungi, or the locus of the fungi with a fungicidally effective amount of a composition comprising a compound of formula (I). The compositions can be chosen from a number of formulation types, including dustable powders (DP), soluble powders (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules (GR) (slow or fast release), soluble concentrates (SL), oil miscible liquids (OL), ultra low volume liquids (UL), emulsifiable concentrates (EC), dispersible concentrates (DC), emulsions (both oil in water (EW) and water in oil (EO)), micro-emulsions (ME), suspension concentrates (SC), aerosols, fogging/smoke formulations, capsule suspensions (CS) and seed treatment formulations. The formulation type chosen in any instance will depend upon the particular purpose envisaged and the physical, chemical and biological properties of the compound of formula (I).
Dustable powders (DP) may be prepared by mixing a compound of formula (I) with one or more solid diluents (for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and magnesium carbonates, sulphur, lime, flours, talc and other organic and inorganic solid carriers) and mechanically grinding the mixture to a fine powder.
Soluble powders (SP) may be prepared by mixing a compound of formula (I) with one or more water-soluble inorganic salts (such as sodium bicarbonate, sodium carbonate or magnesium sulphate) or one or more water-soluble organic solids (such as a polysaccharide) and, optionally, one or more wetting agents, one or more dispersing agents or a mixture of said agents to improve water dispersibility/solubility. The mixture is then ground to a fine powder. Similar compositions may also be granulated to form water soluble granules (SG).
Wettable powders (WP) may be prepared by mixing a compound of formula (I) with one or more solid diluents or carriers, one or more wetting agents and, preferably, one or more dispersing agents and, optionally, one or more suspending agents to facilitate the dispersion in liquids. The mixture is then ground to a fine powder. Similar compositions may also be granulated to form water dispersible granules (WG).
Granules (GR) may be formed either by granulating a mixture of a compound of formula (I) and one or more powdered solid diluents or carriers, or from pre-formed blank granules by absorbing a compound of formula (I) (or a solution thereof, in a suitable agent) in a porous granular material (such as pumice, attapulgite clays, fuller's earth, kieselguhr, diatomaceous earths or ground corn cobs) or by adsorbing a compound of formula (I) (or a solution thereof, in a suitable agent) on to a hard core material (such as sands, silicates, mineral carbonates, sulphates or phosphates) and drying if necessary. Agents which are commonly used to aid absorption or adsorption include solvents (such as aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones and esters) and sticking agents (such as polyvinyl acetates, polyvinyl alcohols, dextrins, sugars and vegetable oils). One or more other additives may also be included in granules (for example an emulsifying agent, wetting agent or dispersing agent).
Dispersible Concentrates (DC) may be prepared by dissolving a compound of formula (I) in water or an organic solvent, such as a ketone, alcohol or glycol ether. These solutions may contain a surface active agent (for example to improve water dilution or prevent crystallisation in a spray tank).
Emulsifiable concentrates (EC) or oil-in-water emulsions (EW) may be prepared by dissolving a compound of formula (I) in an organic solvent (optionally containing one or more wetting agents, one or more emulsifying agents or a mixture of said agents). Suitable organic solvents for use in ECs include aromatic hydrocarbons (such as alkylbenzenes or alkylnaphthalenes, exemplified by SOLVESSO 100, SOLVESSO 150 and SOLVESSO 200; SOLVESSO is a Registered Trade Mark), ketones (such as cyclohexanone or methylcyclohexanone), alcohols (such as benzyl alcohol, furfuryl alcohol or butanol), Λ/-alkylpyrrolidones (such as Λ/-methylpyrrolidone or Λ/-octyl- pyrrolidone), dimethyl amides of fatty acids (such as C8-Ci0 fatty acid dimethylamide) and chlorinated hydrocarbons. An EC product may spontaneously emulsify on addition to water, to produce an emulsion with sufficient stability to allow spray application through appropriate equipment. Preparation of an EW involves obtaining a compound of formula (I) either as a liquid (if it is not a liquid at ambient temperature, it may be melted at a reasonable temperature, typically below 70°C) or in solution (by dissolving it in an appropriate solvent) and then emulsifying the resultant liquid or solution into water containing one or more SFAs, under high shear, to produce an emulsion. Suitable solvents for use in EWs include vegetable oils, chlorinated hydrocarbons (such as chlorobenzenes), aromatic solvents (such as alkylbenzenes or alkylnaphthalenes) and other appropriate organic solvents that have a low solubility in water.
Microemulsions (ME) may be prepared by mixing water with a blend of one or more solvents with one or more SFAs, to produce spontaneously a thermodynamically stable isotropic liquid formulation. A compound of formula (I) is present initially in either the water or the solvent/SFA blend. Suitable solvents for use in MEs include those hereinbefore described for use in ECs or in EWs. An ME may be either an oil-in-water or a water-in-oil system (which system is present may be determined by conductivity measurements) and may be suitable for mixing water-soluble and oil-soluble pesticides in the same formulation. An ME is suitable for dilution into water, either remaining as a microemulsion or forming a conventional oil-in-water emulsion.
Suspension concentrates (SC) may comprise aqueous or non-aqueous suspensions of finely divided insoluble solid particles of a compound of formula (I). SCs may be prepared by ball or bead milling the solid compound of formula (I) in a suitable medium, optionally with one or more dispersing agents, to produce a fine particle suspension of the compound. One or more wetting agents may be included in the composition and a suspending agent may be included to reduce the rate at which the particles settle. Alternatively, a compound of formula (I) may be dry milled and added to water, containing agents hereinbefore described, to produce the desired end product.
Aerosol formulations comprise a compound of formula (I) and a suitable propellant (for example n-butane). A compound of formula (I) may also be dissolved or dispersed in a suitable medium (for example water or a water miscible liquid, such as π-propanol) to provide compositions for use in non-pressurised, hand-actuated spray pumps.
A compound of formula (I) may be mixed in the dry state with a pyrotechnic mixture to form a composition suitable for generating, in an enclosed space, a smoke containing the compound.
Capsule suspensions (CS) may be prepared in a manner similar to the preparation of EW formulations but with an additional polymerisation stage such that an aqueous dispersion of oil droplets is obtained, in which each oil droplet is encapsulated by a polymeric shell and contains a compound of formula (I) and, optionally, a carrier or diluent therefor. The polymeric shell may be produced by either an interfacial polycondensation reaction or by a coacervation procedure. The compositions may provide for controlled release of the compound of formula (I) and they may be used for seed treatment. A compound of formula (I) may also be formulated in a biodegradable polymeric matrix to provide a slow, controlled release of the compound.
A composition may include one or more additives to improve the biological performance of the composition (for example by improving wetting, retention or distribution on surfaces; resistance to rain on treated surfaces; or uptake or mobility of a compound of formula (I)). Such additives include surface active agents, spray additives based on oils, for example certain mineral oils or natural plant oils (such as soy bean and rape seed oil), and blends of these with other bio-enhancing adjuvants (ingredients which may aid or modify the action of a compound of formula (I)).
A compound of formula (I) may also be formulated for use as a seed treatment, for example as a powder composition, including a powder for dry seed treatment (DS), a water soluble powder (SS) or a water dispersible powder for slurry treatment (WS), or as a liquid composition, including a flowable concentrate (FS), a solution (LS) or a capsule suspension (CS). The preparations of DS, SS, WS, FS and LS compositions are very similar to those of, respectively, DP, SP, WP, SC and DC compositions described above. Compositions for treating seed may include an agent for assisting the adhesion of the composition to the seed (for example a mineral oil or a film-forming barrier). Wetting agents, dispersing agents and emulsifying agents may be SFAs of the cationic, anionic, amphoteric or non-ionic type.
Suitable SFAs of the cationic type include quaternary ammonium compounds (for example cetyltrimethyl ammonium bromide), imidazolines and amine salts. Suitable anionic SFAs include alkali metals salts of fatty acids, salts of aliphatic monoesters of sulphuric acid (for example sodium lauryl sulphate), salts of sulphonated aromatic compounds (for example sodium dodecylbenzenesulphonate, calcium dodecylbenzenesulphonate, butylnaphthalene sulphonate and mixtures of sodium di- /sopropyl- and tri-/sopropyl-naphthalene sulphonates), ether sulphates, alcohol ether sulphates (for example sodium laureth-3-sulphate), ether carboxylates (for example sodium laureth-3-carboxylate), phosphate esters (products from the reaction between one or more fatty alcohols and phosphoric acid (predominately mono-esters) or phosphorus pentoxide (predominately di-esters), for example the reaction between lauryl alcohol and tetraphosphoric acid; additionally these products may be ethoxylated), sulphosuccinamates, paraffin or olefin sulphonates, taurates and lignosulphonates. Suitable SFAs of the amphoteric type include betaines, propionates and glycinates. Suitable SFAs of the non-ionic type include condensation products of alkylene oxides, such as ethylene oxide, propylene oxide, butylene oxide or mixtures thereof, with fatty alcohols (such as oleyl alcohol or cetyl alcohol) or with alkylphenols (such as octylphenol, nonylphenol or octylcresol); partial esters derived from long chain fatty acids or hexitol anhydrides; condensation products of said partial esters with ethylene oxide; block polymers (comprising ethylene oxide and propylene oxide); alkanolamides; simple esters (for example fatty acid polyethylene glycol esters); amine oxides (for example lauryl dimethyl amine oxide); and lecithins. Suitable suspending agents include hydrophilic colloids (such as polysaccharides, polyvinylpyrrolidone or sodium carboxymethylcellulose) and swelling clays (such as bentonite or attapulgite).
A compound of formula (I) may be applied by any of the known means of applying fungicidal compounds. For example, it may be applied, formulated or unformulated, to any part of the plant, including the foliage, stems, branches or roots, to the seed before it is planted or to other media in which plants are growing or are to be planted (such as soil surrounding the roots, the soil generally, paddy water or hydroponic culture systems), directly or it may be sprayed on, dusted on, applied by dipping, applied as a cream or paste formulation, applied as a vapour or applied through distribution or incorporation of a composition (such as a granular composition or a composition packed in a water- soluble bag) in soil or an aqueous environment.
A compound of formula (I) may also be injected into plants or sprayed onto vegetation using electrodynamic spraying techniques or other low volume methods, or applied by land or aerial irrigation systems.
Compositions for use as aqueous preparations (aqueous solutions or dispersions) are generally supplied in the form of a concentrate containing a high proportion of the active ingredient, the concentrate being added to water before use. These concentrates, which may include DCs, SCs, ECs, EWs, MEs, SGs, SPs, WPs, WGs and CSs, are often required to withstand storage for prolonged periods and, after such storage, to be capable of addition to water to form aqueous preparations which remain homogeneous for a sufficient time to enable them to be applied by conventional spray equipment. Such aqueous preparations may contain varying amounts of a compound of formula (I) (for example 0.0001 to 10%, by weight) depending upon the purpose for which they are to be used.
A compound of formula (I) may be used in mixtures with fertilisers (for example nitrogen-, potassium- or phosphorus-containing fertilisers). Suitable formulation types include granules of fertiliser. The mixtures suitably contain up to 25% by weight of the compound of formula (I). The invention therefore also provides a fertiliser composition comprising a fertiliser and a compound of formula (I).
The compositions of this invention may contain other compounds having biological activity, for example micronutrients or compounds having similar or complementary fungicidal activity or which possess plant growth regulating, herbicidal, insecticidal, nematicidal or acaricidal activity.
By including another fungicide, the resulting composition may have a broader spectrum of activity or a greater level of intrinsic activity than the compound of formula (I) alone. Further the other fungicide may have a synergistic effect on the fungicidal activity of the compound of formula (I).
The compound of formula (I) may be the sole active ingredient of the composition or it may be admixed with one or more additional active ingredients such as a pesticide, fungicide, synergist, herbicide or plant growth regulator where appropriate. An additional active ingredient may: provide a composition having a broader spectrum of activity or increased persistence at a locus; synergise the activity or complement the activity (for example by increasing the speed of effect or overcoming repellency) of the compound of formula (I); or help to overcome or prevent the development of resistance to individual components. The particular additional active ingredient will depend upon the intended utility of the composition.
Examples of fungicidal compounds which may be included in the composition of the invention are AC 382042 (Λ/-(1 -cyano-1 ,2-dimethylpropyl)-2-(2,4-dichlorophenoxy) pro- pionamide), acibenzolar-S-methyl, alanycarb, aldimorph, anilazine, azaconazole, azafenidin, azoxystrobin, benalaxyl, benomyl, benthiavalicarb, biloxazol, bitertanol, blasticidin S, boscalid (new name for nicobifen), bromuconazole, bupirimate, captafol, captan, carbendazim, carbendazim chlorhydrate, carboxin, carpropamid, carvone, CGA 41396, CGA 41397, chinomethionate, chlorbenzthiazone, chlorothalonil, chlorozolinate, clozylacon, copper containing compounds such as copper oxychloride, copper oxyquinolate, copper sulphate, copper tallate, and Bordeaux mixture, cyamidazosulfamid, cyazofamid (IKF-916), cyflufenamid, cymoxanil, cyproconazole, cyprodinil, debacarb, di-2-pyridyl disulphide 1 ,1 '-dioxide, dichlofluanid, diclocymet, diclomezine, dicloran, diethofencarb, difenoconazole, difenzoquat, diflumetorim,
O,O-di-/so-propyl-S-benzyl thiophosphate, dimefluazole, dimetconazole, dimethirimol, dimethomorph, dimoxystrobin, diniconazole, dinocap, dithianon, dodecyl dimethyl ammonium chloride, dodemorph, dodine, doguadine, edifenphos, epoxiconazole, ethaboxam, ethirimol, ethyl (Z)-Λ/-benzyl-Λ/([methyl(methyl-thioethylideneaminooxy- carbonyl)amino]thio)-β-alaninate, etridiazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fenfuram, fenhexamid, fenoxanil (AC 382042), fenpiclonil, fenpropidin, fenpropimorph, fentin acetate, fentin hydroxide, ferbam, ferimzone, fluazinam, fludioxonil, flumetover, flumorph, fluoroimide, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutolanil, flutriafol, folpet, fosetyl-aluminium, fuberidazole, furalaxyl, furametpyr, guazatine, hexaconazole, hydroxyisoxazole, hymexazole, imazalil, imibenconazole, iminoctadine, iminoctadine triacetate, ipconazole, iprobenfos, iprodione, iprovalicarb, isopropanyl butyl carbamate, isoprothiolane, kasugamycin, kresoxim-methyl, LY186054, LY21 1795, LY 248908, mancozeb, maneb, mefenoxam, mepanipyrim, mepronil, metalaxyl, metalaxyl M, metconazole, metiram, metiram-zinc, metominostrobin, metrafenone, MON65500 (Λ/-allyl-4,5-dimethyl-2- trimethylsilylthiophene-3-carboxamide), myclobutanil, NTN0301 , neoasozin, nickel dimethyldithiocarbamate, nitrothale-isopropyl, nuarimol, ofurace, organomercury compounds, orysastrobin, oxadixyl, oxasulfuron, oxolinic acid, oxpoconazole, oxycarboxin, pefurazoate, penconazole, pencycuron, phenazin oxide, phosphorus acids, phthalide, picoxystrobin, polyoxin D, polyram, probenazole, prochloraz, procymidone, propamocarb, propamocarb hydrochloride, propiconazole, propineb, propionic acid, proquinazid, prothioconazole, pyraclostrobin, pyrazophos, pyrifenox, pyrimethanil, pyroquilon, pyroxyfur, pyrrolnitrin, quaternary ammonium compounds, quinomethionate, quinoxyfen, quintozene, silthiofam (MON 65500), S-imazalil, simeconazole, sipconazole, sodium pentachlorophenate, spiroxamine, streptomycin, sulphur, tebuconazole, tecloftalam, tecnazene, tetraconazole, thiabendazole, thifluzamide, 2-(thiocyano- methylthio)benzothiazole, thiophanate-methyl, thiram, tiadinil, timibenconazole, tolclofos-methyl, tolylfluanid, triadimefon, triadimenol, triazbutil, triazoxide, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin A, vapam, vinclozolin, XRD-563, zineb, ziram, zoxamide and the compounds of the formulae:
Figure imgf000053_0001
The compounds of formula (I) may be mixed with soil, peat or other rooting media for the protection of plants against seed-borne, soil-borne or foliar fungal diseases. Some mixtures may comprise active ingredients, which have significantly different physical, chemical or biological properties such that they do not easily lend themselves to the same conventional formulation type. In these circumstances other formulation types may be prepared. For example, where one active ingredient is a water insoluble solid and the other a water insoluble liquid, it may nevertheless be possible to disperse each active ingredient in the same continuous aqueous phase by dispersing the solid active ingredient as a suspension (using a preparation analogous to that of an SC) but dispersing the liquid active ingredient as an emulsion (using a preparation analogous to that of an EW). The resultant composition is a suspoemulsion (SE) formulation. The invention is illustrated by the following Examples in which the following abbreviations are used: ml = millilitres m.p. = melting point (uncorrected) g = grammes b.p. = boiling point
THF = tetrahydrofuran DMSO = dimethylsulphoxide
M+ = mass ion DMF = N, N- s = singlet dimethylformamide d = doublet
HOBT = 1 -hydroxybenzotriazole HOAT = 7-aza-1 -hydroxybenzotriazole bs = broad singlet NMR = nuclear magnetic resonance t = triplet HPLC = high performance liquid chromatography q = quartet TLC = thin layer chromatography m = multiplet glc = gas-liquid chromatography ppm = parts per million EDC = 1 -ethyl-3-Λ/,Λ/-dimethylamino
M = molar propylcarbodiimide hydrochloride
EXAMPLE 1
This examples illustrates the preparation of 2-(3-Bromo-7-chloro-quinolin-6-yloxy)-N-tert- butyl-2-methylsulfanyl-acetamide (Compound No. 12 of Table 2)
Stage 1. Preparation of 3-bromo-7-chloro-quinolin-6-ol
Step 1
3-Chloro-4-methoxy aniline (1Og) in acetic acid (100ml) was treated with 2,2,3 tribromopropanal (18.8g) and the mixture was stirred at room temperature for 2h after which it was diluted with water and extracted with ethyl acetate. The organic phase was washed with 2N NaOH, dried over sodium sulphate, filtered and evaporated under reduced pressure to give the desired product, S-bromo^-chloro-θ-methoxy-quinoline, as a yellow solid after chromatography (silica; hexane/ethyl acetate) (M+ 274). 1H NMR (CDCI3) δppm: 8.78 (1 H,d); 8.21 (1 H,d); 8.10 (1 H,s); 7.03 (1 H,s). Step 2 A mixture of the product from Step 1 (1.4g) and hydrobromic acid (48 wt% solution in water) (100 ml x2) was refluxed for 62 hours. The mixture was cooled to ambient temperature, diluted with water, treated with sodium hydrogen carbonate and extracted with ethyl acetate. The extract was dried over magnesium sulfate, filtered and evaporated under reduced pressure to give the required product, 3-bromo-7-chloro- quinolin-6-ol (M+ 260). 1H NMR (DMSQ) δ ppm: 7.34 (1 H, s); 7.07 (1 H, s); 8.60 (1 H, d); 8.73 (1 H, d); 11.12 (1 H, s).
Stage 2: Preparation of (S-Bromo^-chloro-quinolin-β-yloxyJ-methylsulfanyl-acetic acid methyl ester Step 1 To a stirred solution of methyl (methylthio)acetate (10.8 ml) in dichloromethane (300ml) cooled to -15°C was added dropwise sulphuryl chloride (8.1ml). The mixture was allowed to warm to room temperature over two hours and then concentrated under reduced pressure to give crude chloro-methylsulfanyl-acetic acid methyl ester as a colourless liquid. The product was used in the next step without further purification. 1H NMR (CDCI3) δ ppm: 2.33 (3H, s); 3.83 (3H, s); 5.49 (1 H1S). Step 2
To a stirred solution of 3-bromo-7-chloro-quinolin-6-ol from Stage 1 , Step 2 (1.1 g) in dry DMF (17ml) containing anhydrous potassium carbonate (3.1g) at ambient temperature was added chloro-methylsulfanyl-acetic acid methyl ester (0.79g) dropwise. The mixture was heated for 1 hour at 60-65°C then cooled to ambient temperature, diluted with water and extracted with ethyl acetate. The extracts were combined, washed with brine, dried over magnesium sulfate, filtered and evaporated under reduced pressure. Purification of the crude material by chromatography (silica; ethyl acetate /hexane 1 :4 by volume) provided the title compound, 3-bromo-7-chloro-quinolin-6-yloxy)-methylsulfanyl-acetic acid methyl ester (M+ 378). 1H NMR (CDCI3) δ ppm: 2.29 (3H1 s); 3.89 (3H, s); 5.74 (1 H, s) 7.18 (1 H.8); 8.16 (1 H, s); 8.23 (1 H, s); 8.82 (1 H, s).
Stage 3: Preparation of (3-Bromo-7-chloro-quinolin-6-yloxy)-methylsulfanyl-acetic acid To a stirred solution of the product from Stage 2, Step 2 (1.1 g) in ethanol (14ml) at ambient temperature was added a solution of 2N sodium hydroxide in water (2.2ml). The mixture was stirred at room temperature for 1 hour and then poured into ice-water and acidified with 2M hydrochloric acid. The resulting precipitate was filtered from solution, washed with cold water and dried in vacuo to give (3-bromo-7-chloro-quinolin-6-yloxy)- methylsulfanyl-acetic acid (M+ 364). 1H NMR (DMSO-d6) δ ppm: 2.20 (3H, s); 6.18 (1 H1 s) 7.57 (1 H, s); 8.19 (1 H, s); 8.28 (1 H, d); 8.88 (1 H, d); 13.7 (1 H1 bs). Stage 4: Preparation of 2-(3-Bromo-7-chloro-quinolin-6-yloxy)-N-tert-butyl-2- methylsulfanyl-acetamide
The product from Stage 3 above, 3-bromo-7-chloro-quinolin-6-yloxy)-methylsulfanyl- acetic acid (85 mg) from in dry N,N-dimethylformamide (2ml) was treated with t- butylamine (17 mg), N-(3-dimethylamino-propyl)-N'-ethyl carbodiimide hydrochloride (45 mg), HOAt (32 mg) and triethylarπine (24 mg) at ambient temperature with stirring for 3 hours. The mixture was poured into water, extracted with ethyl acetate (three times) and the extracts combined, washed with saturated aqueous sodium carbonate solution, water (three times) then dried over magnesium sulfate, filtered and evaporated under reduced pressure to give an oil. The oil was fractionated by chromatography (silica; hexane/ ethyl acetate, 3:1 by volume) to give the required product as a white solid (m.p. 172-174°C, M+ 419). 1H NMR (CDCI3) δ ppm: 1.46 (9H, s); 2.18 (3H, s); 5.63 (1 H, s); 6.89 (1 H, bs); 7.28 (1 H,s); 7.28 (1 H, s); 8.18 (1 H, s), 8.27 (1 H, d); 8.83 (1 H, d). The following amides were prepared using a similar procedure. Compound No. 238 of Table 2: using 1 ,1-dimethyl-prop-2-ynylamine, m.p. 169-171°C; 1H NMR (CDCI3) δ ppm: 1.75 (6H,s); 2.19 (3H, s); 2.41 (1 H, s); 5.69 (1 H, s); 7.16 (1 H, bs); 7.29 (1 H, s); 8.18 (1 H, s); 8.27 (1 H, d); 8.83 (1 H, d).
Compound No. 52 of Table 2: using 2-amino-3-methoxy-2-methyl-propionitrile, 1H NMR (CDCI3) δ ppm: diastereoisomeric mixture (1/1 ); 1.82 and 1 .84 (3H, 2xs); 2.18 and 2.20 (3H, 2xs); 3.52 and 3.53 (3H, 2xs); 3.64-3.84 (2H, 2xdd); 5.76 and 5.77 (1 H, 2xs); 7.29 and 7.30 (1 H, 2xs); 7.59 and 7.61 (1 H, 2xbs); 8.18 (1 H, s); 8.29 (1 H, d); 8.85 (1 H, s). Compound No. 244 of Table 2: using 1 ,1-dimethyl-but-2-ynylamine, m.p. 160-162°C; 1H NMR (CDCI3) δ ppm: 1.71 (6H,s); 1.83 (3H, s); 2.19 (3H, s); 5.66 (1 H, s); 7.15 (1 H, bs); 7.27 (1 H, s); 8.18 (1 H, s); 8.27 (1 H, d); 8.83 (1 H, d).
Compound No. 251 of Table 2: using 4-methoxy-1 ,1 -dimethyl-but-2-ynylamine, m.p. 124-125°C; 1H NMR (CDCI3) δ ppm: 1.75 (6H,s); 2.19 (3H, s); 3.39 (3H, s); 4.13 (2H, s); 5.67 (1 H, s); 7.17 (1 H, bs); 7.28 (1 H, s); 8.18 (1 H, s); 8.28 (1 H, d); 8.84 (1 H, d).
EXAMPLE 2
This examples illustrates the preparation of 2-(3-Bromo-7-methyl-quinolin-6-yloxy)-N- tert-butyl-2-methylsulfanyl-acetamide (Compound No. 12 of Table 13) Stage 1. Preparation of 3-bromo-7-methyl-quinolin-6-ol 4-Amino-2-methyl-phenol (5g) in acetic acid (60ml) was treated with 2,2,3 tribromopropanal (1 1.9g) and the mixture was stirred at room temperature for 3h after which it was diluted with water and extracted with ethyl acetate. The organic phase was washed with aqueous NH4OH, dried over sodium sulphate, filtered and evaporated under reduced pressure to give the required product, 3-bromo-7-methyl-6-quinolin-6-ol which was used as such in the following step (M+ 240), 1H NMR (DMSO-d6) δ ppm: 2.32 (3H, s); 7.12 (1H, s); 7.75 (1H, s); 8.46 (1H, d); 8.64 (1H, d); 10.35 (1H, bs). Stage 2: Preparation of methyl 3-bromo-7-methyl-quinolinyl-6-oxy-2-methylthioacetate In a similar procedure to Stage 2, Step 2 of Example 1 , 3-bromo-7-methyl-quinolin-6-ol was reacted with methyl 2-bromo-2-methylthioacetate to give methyl 3-bromo-7-methyl- quinolinyl-6-oxy-2-methylthio-acetate (M+ 358). 1H NMR (CDCI3) δ ppm: 2.25 (3H, s); 2.50 (3H, s); 3.88 (3H, s); 5.73 (1 H, s); 6.99 (1 H,s); 7.86 (1 H,s); 8.19 (1 H, d), 8.76 (1 H, d). Stage 3: Preparation of (3-Bromo-7-methyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid In a similar procedure to Stage 3 of Example 1 , methyl 3-bromo-7-methyl-quinolinyl-6- oxy-2-methylthio-acetate was hydrolysed to give (3-bromo-7-methyl-quinolin-6-yloxy)- methylsulfanyl-acetic acid (M+ 344). 1H NMR (DMSQ) δ ppm: 2.19 (3H, s); 2.42 (3H, s); 6.07 (1 H, s); 7.42 (1 H, s); 7.86 (1 H, s); 8.52 (1 H, s), 8.78 (1 H1 s), 13.55 (1 H, bs). Stage 4: Preparation of 2-(3-Bromo-7-methyl-ouinolin-6-yloxy)-N-te/t-butyl-2- methylsulfanyl-acetamide
In a similar procedure to Stage 4 of Example 1 , 2-(3-bromo-7-methyl-quinolinyl-6-oxy)-2- methylthioacetic acid was condensed with t-butylamine to give 2-(3-bromo-7-methyl- quinolin-6-yloxy)-N-tert-butyl-2-methylsulfanyl-acetamide (m.p. 132-134°C, M+ 344). 1H NMR (CDCI3) δ ppm: 1.44 (9H, s); 2.19 (3H, s); 2.49 (3H, s); 5.60 (1 H, s); 6.48 (1 H, bs); 7.10 (1 H, s); 7.89 (1 H, s); 8.21 (1 H, d), 8.78 (1 H, d).
The following amides were prepared using a similar procedure.
Compound No. 16 of Table 13: using 1 ,1-dimethyl-propylamine, m.p. 135-137°C; 1H
NMR (CDCI3) δ ppm: 0.88 (3H, t); 1.39 (6H, s); 1.79 (2H, q); 2.20 (3H, s); 2.48 (3H, s); 5.59 (1 H, s); 6.39 (1 H, bs); 7.10 (1 H, s); 7.89 (1 H1 s); 8.21 (1H, d); 8.78 (1H, d).
Compound No. 238 of Table 13: using 1 ,1-dimethyl-prop-2-ynylamine, m.p. 141 -146°C;
1H NMR (CDCI3) δ ppm: 1.74 (6H,s); 2.19 (3H, s); 2.41 (1 H, s); 2.50 (3H, s); 5.65 (1 H, s); 6.77 (1 H, bs); 7.10 (1 H1 s); 7.89 (1 H, s); 8.21 (1 H, d); 8.78 (1 H, d).
Compound No. 52 of Table 13: using 2-amino-3-methoxy-2-methyl-propionitrile, 1H NMR (CDCI3) δ ppm: diastereoisomeric mixture (1/1 ); 1.81 and 1 .83 (3H, 2xs); 2.20 and 2.21 (3H, 2xs); 2.48 (3H, s); 3.50 and 3.53 (3H, 2xs); 3.61-3.82 (2H, 2xdd); 5.72 and 5.75 (1 H, 2xs); 7.1 1 and 7.13 (1 H1 2xs);
7.32 and 7.34 (1 H, 2xbs); 7.90 (1 H, s); 8.23 (1 H, s); 8.79 (1 H, s). Compound No. 221 of Table 13: using 1 ,1-dimethyl-2-prop-2-ynyloxy-ethylamine, m.p. 1 14-1 16°C; 1H NMR (CDCI3) δ ppm: 1 .41 (3H,s); 1 .44 (3H,s); 2.18 (3H, s); 2.50 (1 H1 1); 3.54 (2H, dd); 4.19 (2H, d); 5.61 (1 H, s); 6.92 (1 H, bs); 7.10 (1 H, s); 7.88 (1 H, s); 8.22 (1 H, d); 8.77 (1 H, d).
Compound No. 251 of Table 13: using 4-methoxy-1 ,1-dimethyl-but-2-ynylamine, m.p. 129-132°C; 1H NMR (CDCI3) δ ppm: 1 .73 (6H, s); 2.20 (3H, s); 2.49 (3H, s); 3.37 (3H, s); 4.11 (2H, s); 5.63 (1 H, s); 6.76 (1 H, bs); 7.10 (1 H, s); 7.89 (1H, s); 8.21 (1 H, d); 8.78 (1 H, d).
EXAMPLE 3
This examples illustrates the preparation of 2-(3-Bromo-7-fluoro-quinolin-6-yloxy)-N-tert- butyl-2-methylsulfanyl-acetamide (Compound No. 12 of Table 6)
Stage 1. Preparation of 3-bromo-7-fluoro-quinolin-6-ol
Step i
In a similar procedure to Step 1 , Stage 1 of Example 1 , 3-fluoro-4-methoxy-phenylamine
(2g) in acetic acid (25ml) was treated with 2,2,3 tribromopropanal (4.2g) to give 3- bromo-7-fluoro-6-methoxy-quinoline (M+258). 1H NMR (CDCI3) δ ppm: 4.02 (3H, s); 7.07
(1 H1 d); 7.75 (1 H1 d); 8.23 (1 H, d); 8.78 (1 H, d).
Step 2
In a similar procedure to Step 1 , Stage 2 of Example 1 , 3-bromo-7-fluoro-6-methoxy- quinoline from the previous step was treated with hydrobromic acid to give 3-bromo-7- fluoro-quinolin-6-ol (M+ 244). 1H NMR (DMSO-d6) δ ppm: 7.35 (1 H, d); 7.77 (1 H1 d);
8.59 (1 H, d); 8.74 (1 H1 d), 10.93 (1 H1 s).
Stage 2: Preparation of (3-bromo-7-fluoro-quinolin-6-yloxy)-methylsulfanyl-acetic acid methyl ester
In a similar procedure to Stage 2, Step 2 of Example 1 , 3-bromo-7-fluoro-quinolin-6-ol from the previous step was reacted with methyl 2-bromo-2-methylthioacetate from Stage
2, Stepi of Example 1 , to give methyl 3-bromo-7-fluoro-quinolinyl-6-oxy-2- methylthioacetate (M+ 362). 1H NMR (CDCI3) δ ppm: 2.27 (3H1 s); 3.89 (3H1 s); 5.77
(1 H1 s) 7.26 (1 H, d); 7.77 (1 H, s); 8.23 (1 H1 s); 8.83 (1 H, s).
Stage 3: Preparation of (3-bromo-7-fluoro-quinolin-6-yloxy)-methylsulfanyl-acetic acid In a similar procedure to Stage 3 of Example 1 , methyl 3-bromo-7-fluoro-quinolinyl-6- oxy-2-methylthio-acetate was hydrolysed to give (3-bromo-7-fluoro-quinolin-6-yloxy)- methylsulfanyl-acetic acid (M+ 348). 1H NMR (DMSO-dS) δ ppm: 6.16 (1 H, s); 7.71 (1 H, d) 7.90 (1 H, d); 8.62 (1 H, d), 8.88 (1 H, d), 13.69 (1 H, bs). Stage 4: Preparation of 2-(3-bromo-7-fluoro-quinolin-6-yloxy)-N-fert-butyl-2- methylsulfanyl-acetamide In a similar procedure to Stage 4 of Example 1 , 2-(3-bromo-7-fluoro-quinolinyl-6-oxy)-2- methylthioacetic acid was condensed with t-butylamine to give 2-(3-bromo-7-fluoro- quinolin-6-yloxy)-N-tert-butyl-2-methylsulfanyl-acetamide (m.p. 144-145°C, M+ 403). 1H NMR (CDCI3) δ ppm: 1.45 (9H, s); 2.19 (3H, s); 5.62 (1 H, s); 6.62 (1 H, bs); 7.30 (1 H1 d); 7.79 (1 H, d); 8.26 (1 H1 d), 8.84 (1 H, d).
The following amides were prepared using a similar procedure.
Compound No. 238 of Table 6: using 1 ,1 -dimethyl-prop-2-ynylamine, m.p. 167-169°C;
1H NMR (CDCI3) δ ppm: 1.75 (6H,s); 2.21 (3H, s); 2.41 (1 H, s); 2.50 (3H, s); 5.68 (1 H, s); 6.89 (1 H, bs); 7.33 (1 H, d); 7.79 (1 H, d); 8.26 (1 H, d); 8.84 (1 H, d).
Compound No. 52 of Table 6: using 2-amino-3-methoxy-2-methyl-propionitrile, 1H NMR (CDCI3) δ ppm: diastereoisomeric mixture (1/1 ); 1.81 and 1 .83 (3H, 2xs); 2.21 and 2.22
(3H, 2xs); 3.52 and 3.54 (3H, 2xs); 3.64-3.84 (2H, 2xdd); 5.75 and 5.76 (1 H1 2xs); 7.33-
7.36 (2H, m); 7.80 (1 H, d); 8.28 (1 H, d); 8.85 (1 H, d).
Compound No. 221 of Table 6: using 1 ,1 -Dimethyl-2-prop-2-ynyloxy-ethylamine, m.p.
115-1 17°C; 1H NMR (CDCI3) δ ppm: 1.44 (3H,s); 1.46 (3H,s); 2.20 (3H, s); 2.45 (1 H1 1); 3.61 (2H, dd); 4.20 (2H, d); 5.63 (1 H, s); 6.90 (1 H, bs); 7.28 (1 H, d); 7.78 (1 H, d); 8.26
(1 H, d); 8.83 (1 H, d).
Compound No. 251 of Table 6: using 4-methoxy-1 ,1 -dimethyl-but-2-ynylamine, m.p.
115-117°C; 1H NMR (CDCI3) δ ppm: 1.74 (6H, s); 2.21 (3H, s); 2.49 (3H, s); 3.38 (3H, s); 4.12 (2H, s); 5.65 (1 H, s); 6.88 (1 H, bs); 7.31 (1 H, d); 7.79 (1 H, d); 8.26 (1 H, d); 8.84 (1 H, d).
Compound No. 244 of Table 6: using 1 ,1 -dimethyl-but-2-ynylamine, m.p. 130-132°C; 1H
NMR (CDCI3) δ ppm: 1.70 (6H,s); 1.83 (3H, s); 2.21 (3H, s); 5.65 (1 H, s); 6.86 (1 H, bs);
7.31 (1 H, d); 7.78 (1 H, d); 8.25 (1 H, d); 8.84 (1 H, d).
Compound No. 68 of Table 6: using 2-ethoxy-1 ,1 -dimethyl-ethylamine, m.p. 111 -113°C; 1H NMR (CDCI3) δ ppm: 1.21 (3H, t); 1.43 (H,s); 1.46 (3H,s); 2.20 (3H, s); 3.43 (2H, dd);
3.51-3.58 (2H, m), 5.63 (1 H, s); 7.17 (1 H, bs); 7.28 (1 H, d); 7.78 (1 H, d); 8.25 (1 H, d);
8.83 (1 H1 d).
Compound No. 277 of Table 6: using 5-methoxy-1 ,1 -dimethyl-pent-2-ynylamine, m.p.
104-106°C; 1H NMR (CDCI3) δ ppm: 1.71 (6H, s); 2.20 (3H, s); 2.48 (2H, t); 3.37 (3H, s); 3.50 (2H, t); (5.65 (1 H, s); 6.88 (1 H1 bs); 7.31 (1 H, d); 7.79 (1 H, d); 8.26 (1 H, d); 8.84 (1 H, d).
Compound No. 256 of Table 6: using 6-chloro-1 ,1 -dimethyl-hex-2-ynylamine, m.p. 95- 97°C; 1H NMR (CDCI3) δ ppm: 1.70 (6H, s); 1.96 (2H1 quin),2.20 (3H, s); 2.90 (2H, t); 3.68 (2H, t); 3.50 (2H, t); 5.66 (1 H, s); 6.87 (1 H, bs); 7.31 (1 H, d); 7.79 (1 H, d); 8.26 (1 H, d); 8.84 (1 H, d).
EXAMPLE 4 This examples illustrates the preparation of 2-(3-iodo-7-fluoro-quinolin-6-yloxy)-N-tert- butyl-2-methylsulfanyl-acetamide (Compound No. 12 of Table 7) Stage 1 : Preparation of 3-iodo-6-hydroxyquinoline
To a stirred mixture of 3-bromo-7-fluoro-6-hydroxyquinoline from Example 3, Stage 1 , Step 2 (0.5Og), sodium iodide (0.62g) and copper iodide (0.08g) in dioxane (3.0ml) was added N,N,N',N'-tetramethyl-ethane-1 ,2-diamine (0.07g) in a sealed tube. The mixture was stirred at 120°C for 14h and upon cooling was treated with aqueous ammonia followed by aqueous hydrochloric acid. Extraction with ethyl acetate, drying of the organic phase over magnesium sulphate, filtration and evaporation under reduced pressure gave the required product (M+ 290) as a light brown coloured powder that was used as such in the next step. 1H NMR (CDCI3) δ ppm: 7.30 (1 H, d); 7.72 (1 H, d); 8.02 (1 H,d), 8.73 (1 H,d); 8.83 (1 H, d), 10.88 (1 H, s).
Stage 2: Preparation of N-tert-Butyl-2-(3-iodo-7-fluoro-quinolin-6-yloxy)-2- methylsulfanyl-acetamide
In a similar procedure to Stage 2, Step 1 of Example 1 , 3-iodo-7-fluoro-6-hydroxy- quinoline was reacted with chloromethylsulfanyl-acetic acid ethyl ester to give (3-iodo-7- fluoro-quinolin-6-yloxy)-methylsulfanyl-acetic acid ethyl ester (M+ 408).
In a similar procedure to Stage 3 of Example 1 , (3-iodo-7-fluoror-quinolin-6-yloxy)- methylsulfanyl-acetic acid ethyl ester was hydrolysed to give (3-iodo-7-fluoro-quinolin-6- yloxy)-methylsulfanyl-acetic acid (M+ 394). In a similar procedure to Stage 4 of Example 1 , (3-iodo-7-fluoro-quinolin-6-yloxy)- methylsulfanyl-acetic acid was condensed with t-butylamine to give N-tert-butyl-2-(3- iodo-quinolin-6-yloxy)-2-methylsulfanyl-acetamide as a white solid (m.p. 165-166°C, M+ 449).
1H NMR (CDCI3)δ ppm: 1.44 (9H,s); 2.18 (3H,s); 5.60 (1 H,s); 6.62 (1 H, bs); 7.27 (1 H,d); 7.76 (1 H.dd); 8.47 (1 H, d); 8.97 (1 H, d).
The following amides were prepared using a similar procedure. Compound No. 238 of Table 7: using 1 ,1 -dimethyl-prop-2-ynylamine, m.p. 150-152°C;
1H NMR (CDCI3) δ ppm: 1.75 (6H, s); 2.20 (3H, s); 2.40 (1 H, s); 5.66 (1 H, s); 6.88 (1 H, bs); 7.27 (1 H, s); 7.77 (1 H, s); 8.47 (1 H, d); 8.97 (1 H, d).
Compound No. 52 of Table 7: using 2-amino-3-methoxy-2-methyl-propionitrile, 1H NMR (CDCI3) δ ppm: diastereoisomeric mixture (1/1 ); 1.82 and 1.84 (3H, 2xs); 2.20 and 2.22
(3H, 2xs);
3.53 and 3.54 (3H, 2xs); 3.64-3.84 (2H, 2xdd); 5.73 and 5.75 (1 H1 2xs); 7.27-7.36 (3H, m); 7.77 (1 H, d); 8.49 (1 H1 d); 8.98 (1 H, s).
Compound No. 244 of Table 7: using 1 ,1 -dimethyl-but-2-ynylamine, m.p. 142-145°C; 1H NMR (CDCI3) δ ppm: 1 .70 (6H,s); 1.83 (3H, s); 2.20 (3H, s); 5.64 (1 H, s); 6.87 (1 H, bs);
7.27 (1 H, d); 7.76 (1 H, d); 8.47 (1 H, d); 8.96 (1 H, d).
Compound No. 251 of Table 7: using 4-methoxy-1 ,1 -dimethyl-but-2-ynylamine, m.p.
110-112°C; 1H NMR (CDCI3) δ ppm: 1 .74 (6H,s); 2.20 (3H, s); 3.38 (3H, s); 4.13 (2H, s);
5.65 (1 H, s); 6.89 (1 H, bs); 7.27 (1 H, d); 7.78 (1 H, d); 8.47 (1 H, d); 8.97 (1 H, d).
EXAMPLE 5
This examples illustrates the preparation of N-tert-butyl-2-(7-fluoro-3-thiophen-3-yl- quinolin-6-yloxy)-2-methylsulfanyl-acetamide (Compound No. 12 of Table 30).
Stage 1 : A stirred mixture of 2-(3-bromo-7-fluoro-quino!in-6-yloxy)-N-tert-butyl-2- methylsulfanyl-acetamide from Example 3, Stage 4 (160mg), bis(triphenylphosphine)palladium (II) chloride (1.4 mg), 3-thiophene boronic acid (56mg) and sodium hydrogen carbonate (101 mg)) in dioxane/water (1 :1 mixture, 4.8ml) was heated to 7O°C for 14h. Upon cooling, the reaction mixture was treated with saturated aqueous sodium hydrogen carbonate (5ml). Extraction with ethyl acetate, drying of the organic phase over magnesium sulphate, filtration and evaporation under reduced pressure gave the crude product which was fractionated by chromatography (silica; hexane/ ethyl acetate, 2:1 by volume) to give the required product as a white solid (m.p. 170-173°C, M+ 405). 1H NMR (CDCI3) δ ppm: 1.46 (9H, s); 2.20 (3H, s); 5.64 (1 H, s); 6.66 (1 H, bs); 7.42 (1 H1 d); 7.51 (2H, m); 7.66 (1 H, m), 7.80 (1 H, d), 8.22 (1 H, d); 9.13 (1 H1 d).
The following amide was prepared using a similar procedure. 2-(7-Fluoro-3-thiophen-3- yl-quinolin-6-yloxy)-N-(4-methoxy-1 ,1 -dimethyl-but-2-ynyl)-2-methyl-sulfanyl-acetamide (Compound No. 251 of Table 30) m.p. 132-134°C; 1H NMR (CDCI3) δ ppm: 1.75 (6H, s); 2.22 (3H, s); 3.39 (3H, s); 4.13 (2H, s); 5.68 (1 H, s); 6.93 (1 H, bs); 7.42 (1 H, d); 7.51 (2H, m); 7.66 (1 H, m), 7.82 (1 H1 d), 8.22 (1 H1 d); 9.13 (1 H, d). prepared from 2-(3- Bromo-7-fluoro-quinolin-6-yloxy)-N-(4-methoxy-1 ,1 -dimethyl-but-2-ynyl)-2- methylsulfanyl-acetamide from Example 3, stage 4, above.
EXAMPLE 6
This Example illustrates the fungicidal properties of compounds of formula (I). The compounds were tested in a leaf disk assay, with methods described below. The test compounds were dissolved in DMSO and diluted into water to 200 ppm. In the case of the test on Pythium υltimum, they were dissolved in DMSO and diluted into water to 20 ppm.
Erysiphe graminis f.sp. tritici (wheat powdery mildew): Wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
Puccinia recondita f.sp. tritici (wheat brown rust): Wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed nine days after inoculation as preventive fungicidal activity.
Septoήa nodorυm (wheat glume blotch): Wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
Pyrenophora teres (barley net blotch): Barley leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Pyricularia oryzae (rice blast): Rice leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
Botrytis cinerea (grey mould): Bean leaf disks were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
Phytophthora infestans (late blight of potato on tomato): Tomato leaf disks were placed on water agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
Plasmopara viticola (downy mildew of grapevine): Grapevine leaf disks were placed on agar in a 24-well plate and sprayed a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed seven days after inoculation as preventive fungicidal activity.
Septoria tritici (leaf blotch): Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of the test compounds into a microtiter plate (96-well format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 C and the inhibition of growth was determined photometrically after 72 hrs.
Fusarium culmorum (root rot): Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of the test compounds into a microtiter plate (96-well format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 C and the inhibition of growth was determined photometrically after 48 hrs. Pythium ultimum (Damping off): Mycelial fragments of the fungus, prepared from a fresh liquid culture, were mixed into potato dextrose broth. A solution of the test compound in dimethyl sulphoxide was diluted with water to 20ppm then placed into a 96-well microtiter plate and the nutrient broth containing the fungal spores was added. The test plate was incubated at 24°C and the inhibition of growth was determined photometrically after 48 hours.
The following compounds (number of compound first, followed by table number in brackets) gave at least 60% control of the following fungal infection at 200ppm: Plasmopara viticola, compounds 9 (6), 12 (7), 38 (6), 52 (6), 52 (7), 60 (6), 95 (6), 221 (6), 221 (13), 235 (6), 238 (7), 238 (10), 244 (6), 244 (7), 251 (2), 251 (7), 251 (10), 251 (13), 251 (30), 256 (6), 264 (6), 277 (6), 278 (6), Phytophthora infestans, compounds 12 (6), 12 (10), 52 (7), 52 (13), 221 (6), 221 (13), 238 (7), 238 (10), 238 (13), 244 (6), 244 (7), 251 (7), 251 (10), 256 (6), 275 (7), 277 (6), 278 (6), Erysiphe graminis f.sp. tritici, compounds 9 (6), 12 (6), 12 (13), 28 (6), 38 (6), 52 (6), 52 (7), 52 (13), 68 (6), 86 (6), 181 (6), 189 (6), 221 (6), 221 (13), 235 (6), 238 (6), 238 (7), 238 (10), 238 (13), 244 (6), 251 (6), 251 (7), 251 (13), 251 (30), 256 (6), 264 (6), 268 (6), 275 (6), 275 (7), 277 (6), 278 (6), 281 (6), 284 (6), Pyricularia oryzae, compounds 9 (6), 52 (6), 52 (7), 68 (6), 221 (6), 238 (6), 244 (7), 251 (6), 251 (7), 275 (7), 277 (6), 278 (6), Puccinia recondita f.sp. tritici, compounds 52 (6), 52 (7), 68 (6), 221 (6), 238 (7), 251 (2), 264 (6), Septoria nodorum, compounds 9 (6), 12 (2), 12 (7), 12 (10), 12 (13), 12 (30), 52 (6), 52 (7), 68 (6), 221 (6), 235 (6), 238 (6), 238 (7), 244 (6), 244 (7), 244 (13), 251 (6), 251 (7), 251 (13), 256 (6), 264 (6), 277 (6), 278 (6), 281 (6), Septoria tritici, compounds 9 (6), 12 (6), 12 (7), 12 (13), 16 (13), 38 (6), 52 (2), 52 (6), 52 (7), 52(13), 68 (6), 95 (6), 122 (6), 221 (6), 221 (13), 224 (6), 235 (6), 238 (6), 238 (7), 238 (13), 244 (2), 244 (6), 244 (7), 251 (6), 251 (7), 251 (13), 251 (2), 251 (30), 256 (6), 264 (6), 268 (6), 275 (7), 277 (6), 278 (6), 281 (6), 284 (6), 287 (6), 291 (6), Fusarium culmorum, compounds 9 (6), 12 (6), 12 (7), 221 (6), 238 (6), 238 (7), 244 (6), 244 (7), 251 (6), 251 (7), 251 (13), 284 (6), The following compounds (number of compound first, followed by table number in brackets) gave at least 60% control of the following fungal infection at 20ppm: Pythium ultimum, compounds 9 (6), 12 (10), 52 (6), 52 (13), 221 (6), 221 (13), 235 (6), 238 (6), 244 (6), 251 (6), 251 (10), 251 (13), 251 (30), 264 (6), 275 (7), 278 (6), 281 (6).

Claims

1. A compound of the general formula I
Figure imgf000065_0001
wherein
Q1, Q2 and Q3, independently of each other, are halogen, cyano, nitro, azido, optionally substituted C1-6 alkyl, optionally substituted C3.6 cycloalkyl, optionally substituted C3.6 - heterocyclyl, which contains at least one heteroatom selected from sulphur, oxygen or NR0, where R0 is hydrogen or optionally substituted d.6alkyl, optionally substituted C3.6 cycloalkyl(C1_4)alkyl, optionally substituted C2.6 alkenyl, optionally substituted C2.6 alkynyl, optionally substituted d-6 alkoxy, optionally substituted C2.6 alkenyloxy, optionally substituted C2-6 alkynyloxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted aryl(d-6)alkyl, optionally substituted aryl(d.6)alkoxy, optionally substituted heteroaryl, optionally substituted heteroaryloxy, optionally substituted heteroaryl(d-6)alkyl, optionally substituted heteroaryl(d-6)alkoxy, -SF5 or -S(O)u(Ci-6)alkyl, wherein u is 0, 1 or 2 and the alkyl group is optionally substituted with halogen, or Q1, Q2 and Q3, independently of each other, are -OSO2(d-4)alkyl, wherein the alkyl group is optionally substituted with halogen, or
Q1, Q2 and Q3, independently of each other, are -CONRURV, -CORU, -CO2RU, -CRU=NR\ -NRURV, -NRUCOR\ -NRUCO2RV, -SO2NRURV or -NRUSO2RW, wherein Rw is optionally substituted d-6 alkyl and Ru and Rv, independently of each other, are hydrogen or C1-6 alkyl optionally substituted with halogen, or, in the case of -CONRURV or -SO2NRURV, RURV may join to form a 5- or 6-membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulfur, oxygen and NR0, wherein R0 is hydrogen or optionally substituted d.6alkyl, or, in the case of -CRU=NRV, Rv is hydroxy or optionally substituted d-εalkoxy, optionally substituted aryloxy or optionally substituted heteroaryloxy, or Q1 and Q2, independently of each other, additionally denote hydrogen, R1 is optionally substituted d.4 alkyl, optionally substituted C2^ alkenyl, optionally substituted C2-4 alkynyl or optionally substituted C3.4 cycloalkyl, R2 is hydrogen, C1-8 alkyl, C3-4 cycloalkyl, C2.8 alkenyl, cyano, hydroxy, alkoxy, cyano(C1_4)alkyl, C1^ alkoxy(Ci^)alkyl, C1-4 alkoxy(C1_4)alkoxy(C1^,)alkyl or benzyloxy(C1_4)alkyl, wherein the phenyl ring is optionally substituted with Cv4 alkoxy, R3 is -(CRaRb)p(CRCRd)q(χ)r(CReRf)sR4, wherein
Ra, Rb, Rc, Rd, Re and Rf, independently of each other, are hydrogen, C1-4 alkyl, halogen, cyano, hydroxy, C1-4 alkoxy or C1 -4 alkoxycarbonyl, or RaRb, RcRd or ReRf may join to form a 3 to 8 membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulfur, oxygen and NR0, wherein R0 is hydrogen or optionally substituted d ealkyl,
X is (CO), (CO)O, O(CO), O, S(O),, wherein t is O1 1 or 2, or X is NH or N(C1.6)alkyl, p, r and s, independently of each other, are 0 or 1 , q is O, 1 or 2, R4 is optionally substituted Ci-6 alkyl, optionally substituted C2-6 alkenyl, -CRUU=NRW, wherein Ruu is hydrogen or C1-6 alkyl and Rw is hydroxy or optionally substituted d.6alkoxy, optionally substituted aryloxy or optionally substituted heteroaryloxy, or - CH2-C≡C-R5, wherein R5 is hydrogen, C1-8 alkyl optionally substituted with halogen, hydroxy, C1-6 alkoxy, C,.3 alkoxy(Ci_3)alkoxy, cyano, C1^ alkylcarbonyloxy, aminocarbonyloxy, mono- or di(C1-4)- alkylaminocarbonyloxy, tri(Ci-4)alkylsilyloxy or -S(O)g(d.6)alkyl, wherein g is 0, 1 or 2, or R5 is C3-6 cycloalkyl optionally substituted with halogen, hydroxy, C1-6 alkoxy, C1-3 alkoxy- (C1-3JaIkOXy, cyano, d_4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(d.4)alkyl- aminocarbonyloxy, tri(C1_4)alkylsilyloxy or -S(O)g(Ci-6)alkyl, wherein g is 0, 1 or 2, or R5 is C3-6 cycloalky^d^Jalkyl, wherein the alkyl and/or cycloalkyl moiety is optionally substituted with halogen, hydroxy, C^6 alkoxy, d.3 alkoxy(d.3)alkoxy, cyano, C1-4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(C1_4)alkylaminocarbonyloxy, tri(C1-4)alkyl- silyloxy or -S(O)g(d_6)alkyl, wherein g is 0, 1 or 2, or R5 is optionally substituted aryl, optionally substituted aryl(d-4)alkyl, optionally substituted aryloxy(C1_4)alkyl, optionally substituted heteroaryl or optionally substituted heteroaryl(d.4)alkyl or optionally substituted heteroaryloxy(d.4)alkyl, or R4 is optionally substituted C3.6 cycloalkyl, optionally substituted C5.6 cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl or an optionally substituted 5- to 8-membered ring optionally containing a heteroatom selected from sulfur, oxygen or NR0, wherein R0 is hydrogen or optionally substituted C1-6alkyl, or when R3 is -(CRaRb)p(CRcRd)q(X)r(CReRf)sR4, R2 and R3 may join to form a 5- or 6- membered ring optionally substituted with halogen, C1^ alkyl, mono- or di- (d-^alkylaminocarbonyl, and optionally containing a heteroatom selected from sulphur, oxygen and NR00, wherein R00 is C1-4 alkyl optionally substituted with halogen, C1-6 alkoxy or cyano, or R00 is phenyl optionally substituted with nitro, C1-4 alkyl, halo(C1_4)- alkyl, Ci^ alkylcarbonyl or heteroaryl, or R2 and R3 may join to form an optionally substituted 6,6-membered bicycle, R3 is -(CR30R40)C≡CR50, wherein R30 and R40, independently of each other, are hydrogen, Ci_6 alkyl, halo(C1_4)alkyl, C^ alkoxy(C1.3)alkyl, C2-3 alkenyl or C2-3alkynyl, or
R30 and R40 join with the carbon atom to which they are attached to form a 3 to 6 membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulfur, oxygen or NR000, wherein R000 is hydrogen or Ci-4 alkyl, where the carbocyclic or heterocyclic ring is optionally substituted with halo or C1-4 alkyl, R50 is hydrogen, optionally substituted C1^ alkyl, optionally substituted C3.6cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl containing a heteroatom selected from sulphur, oxygen or NR000, wherein R000 is hydrogen or Ci^alkyl, L is sulfur or oxygen, and n is 0, 1 or 2, and salts and N-oxides of the compounds of the formula I.
2. Compounds according to claim 1 , wherein Q2 is hydrogen, Q1 and Q3 are are as defined in claim 1.
3. Compounds according to claim 1 wherein Q1 is halogen, aryl or heteroaryl, Q2 is hydrogen and Q3 is as defined in claim 1.
4. Compounds according to claim 1 wherein Q1 is aryl, Q2 is hydrogen and Q3 is as defined in claim 1.
5. Compounds according to claim 1 , wherein Q1 is heteroaryl, Q2 is hydrogen and Q3 is as defined in claim 1.
6. Compounds according to claim 1 , wherein Q1 and Q3 are halogen and Q2 is hydrogen.
7. Compounds according to claim 1 wherein, Q1 is aryl or heteroaryl, Q2 is hydrogen and Q3 is halogen.
8. Compounds according to claim 1 , wherein Q1 and Q2 are hydrogen and Q3 is halogen or optionally substituted alkyl.
9. Compounds according to claim 1 , wherein Q1 is halogen, Q2 is hydrogen and Q3 is optionally substituted alkyl.
10. Compounds according to claim 1 , wherein Q1 and Q2 are halogen and Q3 is optionally substituted alkyl.
1 1. Compounds according to claim 1 wherein Q1 is bromo.
12. Compounds according to claim 1 wherein Q1 is iodo.
13. Compounds according to claim 1 wherein Q1 is chloro.
14. Compounds according to claim 1 wherein Q1 is fluoro.
15. Compounds according to claim 1 wherein Q3 is halogen.
16. Compounds according to claim 1 wherein Q3 is fluorine.
17. Compounds according to claim 1 , wherein Q1 is bromo, Q2 is hydrogen and Q3 is fluoro.
18. Compounds according to claim 1 , wherein Q1 is bromo, Q2 is hydrogen and Q3 is chloro.
19. Compounds according to claim 1 , wherein Q1 is iodo, Q2 is hydrogen and Q3 is fluoro.
20. Compounds according to claim 1 , wherein Q1 is iodo, Q2 is hydrogen and Q3 is chloro.
21. Compounds according to claim 1 , wherein Q1 is hydrogen, halogen, aryl or heteroaryl.
22. Compounds according to claim 1 , wherein R1 is C1^ alkyl or halo(C1_4)alkyl.
23. Compounds according to claim 1 , wherein R1 is methyl.
24. Compounds according to claim 1 , wherein R1 is ethyl.
25. Compounds according to claim 1 , wherein R2 is hydrogen or methyl.
26. Compounds according to claim 1 , wherein R2 is hydrogen.
27. Compounds according to claim 1 , wherein Q1, Q2 and Q3 are halogen.
28. Compounds according to claim 1 , wherein Q1is halogen, Q2 is C1_4alkyl and Q3 is halogen.
29. Compounds according to claim 28, wherein Q1is halogen, Q2 is d-4alkyl and Q3 is chloro.
30. Compounds according to claim 28 wherein Q1is halogen, Q2 is Ci-4alkyl and Q3 is fluoro.
31. Compounds according to claim 1 , wherein Q1is halogen, Q2 is methyl and Q3 is halogen.
32. Compounds according to claim 31 , wherein Q1 is halogen, Q2 is methyl and Q3 is chloro.
33. Compounds according to claim 31 , wherein Q1is halogen, Q2 is methyl and Q3 is fluoro.
34. Compounds according to claim 31 , wherein Q1 is bromo, Q2 is methyl and Q3 is chloro.
35. Compounds according to claim 31 , wherein Q1is bromo, Q2 is methyl and Q3 is fluoro.
36. Compounds according to claim 31 , wherein Q1is iodo, Q2 is methyl and Q3 is chloro.
37. Compounds according to claim 31 , wherein Q1is iodo, Q2 is methyl and Q3 is fluoro.
38. Compounds according to claim 1 , wherein Q1 is halogen and Q2 and Q3 are C1-4alkyl.
39. Compounds according to claim 1 , wherein R3 is tert-butyl, 1-halo-2-methylprop-2-yl, 1 , 1 -dihalo-2-methylprop-2-yl , 1 ,1 ,1 -trihalo-2-methylprop-2-yl , 1 -alkoxy-2-methylprop-2-yl , 1 -alkenyloxy^-methylprop^-yl, 1 -alkynyloxy-2-methylprop-2-yl, 1 -cyano-2-methyl-prop- 2-yl, 1 -alkoxyalkoxy-2-methyl-prop-2-yl, 1-halo-3-methylbut-3-yl, 1 ,1 -dihalo-3-methylbut- 3-yl, 1 ,1 ,1 -trihalo-3-methylbut-3-yl, 1 -alkoxy-3-methylbut-3-yl, 1 -alkenyloxy-3-methylbut- 3-yl, 1 -alkynyloxy-3-methylbut-3-yl, 1-cyano-3-methylbut-3-yl, 2-cyanoprop-2-yl, 2- methoxycarbonylprop-2-yl or 2-methylaminocarbonylprop-2-yl, 1 -alkylthio-2-methylprop- 2-yl, 1 -alkylsulphinyl-2-methylprop-2-yl, 1 -alkylsulphonyl-2-methylprop-2-yl, 2-cyano-1 - alkoxyprop-2-yl, 2-methyl-1 -[(E and/or Z)-hydroxyimino]-prop-2-yl, 2-methyl-1 -[(E and/or Z)-alkoxyimino]-prop-2-yl, 2-methyl-1 -[(E and/or Z)-aryloxyimino]-prop-2-yl, 2-methyl-1 - [(E and/or Z)-heteroaryloxyimino]-prop-2-yl, 1 -alkoxy-prop-2-yl, 1-halo-prop-2-yl, 3- methyl-but-1 -yn-3-yl, 1-alkyl-3-methyl-but-1 -yn-3-yl, 4-methyl-pent-2-yn-4-yl, 1-hydroxy- 4-methyl-pent-2-yn-4-yl, 1 -alkoxy-4-methyl-pent-2-yn-4-yl, 1 -alkoxyalkoxy-4-methyl-pent- 2-yn-4-yl, 1 -alkoxyalkoxyalkyl-4-methyl-pent-2-yn-4-yl,1 -cyanoalkyl-3-methylbut-3-yl, 1 - haloalkyl-3-methylbut-3-yl.
40. Compounds according to claim 39, wherein R3 is tert-butyl, 1 -halo-2-methylprop-2- yl, 1-fluoro-2-methylprop-2-yl, 1 -methoxy-2-methylprop-2-yl, 1-ethoxy-2-methylprop-2-yl, 1 -allyloxy-2-methylprop-2-yl, 1 -(prop-2-ynyloxy)-2-methylprop-2-yl, 2-cyano-1 -ethoxy- prop-2-yl, 2-cyano-1 -methoxyprop-2-yl, 1 -halo-3-methylbut-3-yl, 1 -fluoro-3-methylbut-3- yl, 3-methylbut-1 -yn-3-yl, 4-methylpent-2-yn-4-yl, 5-methyl-hex-3-yn-5-yl, 1 -methoxy-4- methyl-pent-2-yn-4-yl, 1 -allyloxy-4-methyl-pent-2-yn-4-yl, 1 -propargyloxy-4-methyl-pent- 2-yn-4-yl, 1 -ethoxy-4-methyl-pent-2-yn-4-yl.
41 . Compounds according to claim 1 , wherein R4 is C1-6alkyl optionally substituted with C1_4alkoxy-(C1_4)alkoxy(C1_4)alkyl, wherein the alkyl group is optionally substituted with halo, mono- or di-(Ci^)alkylamino or tri(Ci-4)alkylsilyl, or R4 is Ci-6 alkyl optionally substituted with benzyloxy(C1_4)alkyl, wherein the alkyl group is optionally substituted with halo, mono- or di-(C1.6)alkylamino or tri(C1_4)alkylsilyl, or R4 is C1-6 alkyl optionally substituted with C2.6 alkenyloxy or -S(O)x(Ci.6)alkyl, wherein x is 0, 1 or 2 and the alkyl group is optionally substituted with halo, mono- or di-(C1.6)alkylamino, - NH(d.4)alkyl=NOR, wherein R is hydrogen or C1 -4alkyl, or wherein the alkyl group is optionally substituted with tri(Ci^)alkylsilyl, or R4 is -CRUU=NRW, wherein Ruu is hydrogen or d-6 alkyl and Rw is hydroxy or optionally substituted d.6alkoxy.
42. Compounds according to claim 1 , wherein the optionally substituted aryl and optionally substituted heteroaryl rings or moieties of the R5 values are optionally substituted with halogen, cyano, nitro, azido, CV6 alkyl, halo(C1.6)alkyl, C3-6 cycloalkyl, C3.6 cycloalkyl(Ci-4)alkyl, C2.6 alkenyl, halo(C2.6)alkenyl, C2.6 alkynyl, halo(C2-6)alkynyl, C1. 6 alkoxy, halo(Ci^)alkoxy, C2-6 alkenyloxy, halo(C2.6)alkenyloxy, C2.6 alkynyloxy, halo(C2-6)alkynyloxy, aryl, aryloxy, aryl(Ci^)alkyl, aryKd^alkoxy, heteroaryl, heteroaryloxy, heteroaryl(d-6)alkyl, heteroaryl(Ci.6)alkoxy, -SF5, -S(O)g(C1_4)alkyl wherein g is 0, 1 or 2 and the alkyl is optionally substituted with halo, or R5 is optionally substituted with -OSO2(C1_4)alkyl, wherein the alkyl group is optionally substituted with halo, or R5 is optionally substituted with -CONR9Rh, -COR9, -CO2R9, -R9=NRh, -NR9Rh, -NR9COR*1, -NR9CO2Rh, -SO2NR9Rh or -NR9SO2R1, wherein R' is d-e alkyl optionally substituted with halogen and R9 and Rh, independently of each other, are hydrogen or Ci-6 alkyl optionally substituted with halogen, or, in the case of -CONR9Rh or - SO2N R9Rh, R9Rh may join to form a 5- or 6-membered carbocyclic or heterocyclic ring containing a heteroatom selected from sulphur, oxygen or NR0, wherein R0 is hydrogen or optionally substituted Ci.6alkyl.
43. Compounds according to claim 1 , wherein the optionally substituted aryl, optionally substituted heteroaryl or optionally substituted 5- to 8-membered ring R4 is optionally substituted with halogen, cyano, nitro, azido, Ci_6 alkyl, halo(C1.6)alkyl, C3.6 cycloalkyl, C3.6 cycloalkyl(C1_4)alkyl, C2.6 alkenyl, halo(C2.6)alkenyl, C2-6 alkynyl, halo(C2.6)alkynyl, d-e alkoxy, halo(Ci.6)alkoxy, C2-6 alkenyloxy, halo(C2^)alkenyloxy, C2-6 alkynyloxy, halo(C2.6)alkynyloxy, -SF5, -S(O)x(Ci-6)alkyl, wherein x is 0, 1 or 2 and the alkyl group is optionally substituted with halo, or R4 is optionally substituted with -OSO2(C1_4)alkyl, wherein the alkyl group is optionally substituted with halogen, -CONRxRy, -CON(ORx)Ry, -CORX, -CO2RX, -CRx=NRy, -NRxRy, -NRxCORy, -NRxCO2Ry, -SO2NRxRy or -NRXSO2RZ, wherein Rz is C1-8 alkyl optionally substituted with halogen and Rx and Ry, independently of each other, are hydrogen or Ci_6 alkyl optionally substituted with halogen.
44. Compounds according to claim 1 , wherein R50 is d.4alkyl optionally substituted with halogen, hydroxy, Ci.6alkoxy, C2-6 alkenyl, C2-6 alkynyl, Ci-4 alkoxy(C1_4)alkoxy, cyano, d^alkylcarbonyloxy, aminocarbonyloxy, mono- or di(C1_4)alkylamino-carbonyloxy, S(O)p(C1.6)-alkyl, wherein p is 0, 1 or 2, triazolyl, pyrazolyl, imidazolyl, In(C1-4)- alkylsilyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienylmethoxy.
45. Compounds according to claim 1 , wherein R50 is C3.6cycloalkyl optionally substituted with halogen, hydroxy, Ci.6alkoxy, C1^ alkoxy(d.4)alkoxy, cyano, Ci^alkylcarbonyloxy, aminocarbonyloxy, mono- or di(C1_4)alkylamino-carbonyloxy, S(O)p(Ci.6)-alkyl, wherein p is 0, 1 or 2, triazolyl, pyrazolyl, imidazolyl, tri(C1_4)-alkylsilyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienylmethoxy,
46. Compounds according to claim 1 , wherein the optionally substituted aryl or the optionally substituted heteroaryl R50 is optionally substituted with halogen, hydroxy, mercapto, C1-4 alkyl, C2.4 alkenyl, C2-4 alkynyl, d-4 alkoxy, C2-A alkenyloxy, C2-4 alkynyloxy, halo(Ci-4)alkyl, halo(C1_4)alkoxy, C1_4 alkylthio, halo(C1-4)-alkylthio, hydroxy(Ci-4)alkyl, C1-4 alkoxy(C1_4)alkyl, C3.6cycloalkyl, C3.6 cycloalkyl-(Ci-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, NRpRq, NHCORP, - NHCONRpRq, CONRpRq, -SO2R0, OSO2R0, CORP, CRp=NRq or N=CRpRq, wherein R0 is Ci-4 alkyl, halo(C1_4)alkyl, d.4alkoxy, halo(d.4)alkoxy, C1_4 alkylthio, C3-6 cycloalkyl, C3. 6cycloalkyl(Ci-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4alkyl or Ci-4 alkoxy, and Rp and Rq are independently hydrogen, C1^ alkyl, halo(d_4)alkyl, Ci^ alkoxy, halo(C1_4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3.6cycloalkyl(d.4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, Ci-4 alkyl or d^alkoxy.
47. Compounds according to claim 1 , wherein L is oxygen.
48. Compounds according to claim 1 , wherein n is 0.
49. A process for preparing a compound of the formula I according to claim 1 as herein described.
50. A fungicidal composition comprising a fungicidally effective amount of a compound according to claim 1 and a suitable carrier or diluent therefor.
51. A method of combating or controlling phytopathogenic fungi which comprises applying a fungicidally effective amount of a compound according to claim 1 to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or any other plant growth medium.
PCT/EP2007/007700 2006-09-06 2007-09-04 Fungicides WO2008028624A1 (en)

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EP2179990A1 (en) 2008-10-24 2010-04-28 Bayer CropScience SA Fungicide oxyalkylamide derivatives
EP2343280A1 (en) 2009-12-10 2011-07-13 Bayer CropScience AG Fungicide quinoline derivatives
WO2011154240A1 (en) * 2010-06-10 2011-12-15 Syngenta Participations Ag Quinoline derivatives as fungicides
US20130065922A1 (en) * 2010-05-21 2013-03-14 Syngenta Crop Protection Llc Novel amides as fungicides
US20140045890A1 (en) * 2011-03-31 2014-02-13 Syngenta Participations Ag Novel compounds

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GB0717256D0 (en) * 2007-09-05 2007-10-17 Syngenta Participations Ag Novel fungicides
US8914462B2 (en) 2009-04-14 2014-12-16 Lg Electronics Inc. Terminal and controlling method thereof
TWI772367B (en) * 2017-02-16 2022-08-01 瑞士商先正達合夥公司 Fungicidal compositions

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WO2004108663A1 (en) * 2003-06-04 2004-12-16 Syngenta Limited N-alkynyl-2- (substituted aryloxy) alkylthioamide derivatives as fungicides

Cited By (9)

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Publication number Priority date Publication date Assignee Title
WO2010015680A1 (en) * 2008-08-07 2010-02-11 Bayer Cropscience Sa Fungicide oxyalkylamide derivatives
EP2179990A1 (en) 2008-10-24 2010-04-28 Bayer CropScience SA Fungicide oxyalkylamide derivatives
EP2343280A1 (en) 2009-12-10 2011-07-13 Bayer CropScience AG Fungicide quinoline derivatives
US20130065922A1 (en) * 2010-05-21 2013-03-14 Syngenta Crop Protection Llc Novel amides as fungicides
WO2011154240A1 (en) * 2010-06-10 2011-12-15 Syngenta Participations Ag Quinoline derivatives as fungicides
EP2397467A1 (en) * 2010-06-10 2011-12-21 Syngenta Participations AG Quinoline derivatives as fungicides
CN102933550A (en) * 2010-06-10 2013-02-13 先正达参股股份有限公司 Quinoline derivatives as fungicides
US20130096156A1 (en) * 2010-06-10 2013-04-18 Syngenta Crop Protection Llc Quinoline derivatives as fungicides
US20140045890A1 (en) * 2011-03-31 2014-02-13 Syngenta Participations Ag Novel compounds

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