WO2008027397A3 - Method for identifying protease inhibitors - Google Patents

Method for identifying protease inhibitors Download PDF

Info

Publication number
WO2008027397A3
WO2008027397A3 PCT/US2007/018945 US2007018945W WO2008027397A3 WO 2008027397 A3 WO2008027397 A3 WO 2008027397A3 US 2007018945 W US2007018945 W US 2007018945W WO 2008027397 A3 WO2008027397 A3 WO 2008027397A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease inhibitors
identifying protease
protease
identifying
screening
Prior art date
Application number
PCT/US2007/018945
Other languages
French (fr)
Other versions
WO2008027397A2 (en
Inventor
William P Taylor
Original Assignee
Vertex Pharma
William P Taylor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma, William P Taylor filed Critical Vertex Pharma
Priority to EP07811572A priority Critical patent/EP2057278A2/en
Priority to AU2007290535A priority patent/AU2007290535A1/en
Priority to NZ575186A priority patent/NZ575186A/en
Priority to JP2009526684A priority patent/JP2010502184A/en
Publication of WO2008027397A2 publication Critical patent/WO2008027397A2/en
Publication of WO2008027397A3 publication Critical patent/WO2008027397A3/en
Priority to US13/294,635 priority patent/US8501426B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Abstract

The invention describes a method for assaying HCV NS3 protease activity using an NS3⋅4A protease molecule. The invention also provides a method for screening and identifying modulators of NS3 protease.
PCT/US2007/018945 2006-08-28 2007-08-28 Method for identifying protease inhibitors WO2008027397A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP07811572A EP2057278A2 (en) 2006-08-28 2007-08-28 Method for identifying protease inhibitors
AU2007290535A AU2007290535A1 (en) 2006-08-28 2007-08-28 Method for identifying protease inhibitors
NZ575186A NZ575186A (en) 2006-08-28 2007-08-28 Method for identifying protease inhibitors
JP2009526684A JP2010502184A (en) 2006-08-28 2007-08-28 Method for identifying protease inhibitors
US13/294,635 US8501426B2 (en) 2006-08-28 2011-11-11 Method for identifying protease inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84057306P 2006-08-28 2006-08-28
US60/840,573 2006-08-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/380,323 Continuation US20100216161A1 (en) 2006-08-28 2009-02-26 Method for identifying protease inhibitors

Publications (2)

Publication Number Publication Date
WO2008027397A2 WO2008027397A2 (en) 2008-03-06
WO2008027397A3 true WO2008027397A3 (en) 2008-05-22

Family

ID=39030878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018945 WO2008027397A2 (en) 2006-08-28 2007-08-28 Method for identifying protease inhibitors

Country Status (5)

Country Link
EP (1) EP2057278A2 (en)
JP (1) JP2010502184A (en)
AU (1) AU2007290535A1 (en)
NZ (1) NZ575186A (en)
WO (1) WO2008027397A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251583B1 (en) * 1998-04-27 2001-06-26 Schering Corporation Peptide substrates for HCV NS3 protease assays
WO2005058821A1 (en) * 2003-12-11 2005-06-30 Schering Corporation Inhibitors of hepatitis c virus ns3/ns4a serine protease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6754196A (en) * 1995-08-25 1997-03-19 Rational Drug Design Laboratories Novel fluorescent substrate for assaying activity of hepatitis c virus ns3 serine protease
BR9712544B1 (en) * 1996-10-18 2013-10-22 SERINE PROTEASE INHIBITORS, PHARMACEUTICAL COMPOSITION UNDERSTANDING THE SAME AND ITS USES
WO1999050230A1 (en) * 1998-03-31 1999-10-07 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
JP2001019699A (en) * 1999-07-06 2001-01-23 Welfide Corp Measurement of ns3 protease activity of hcv
AR055395A1 (en) * 2005-08-26 2007-08-22 Vertex Pharma INHIBITING COMPOUNDS OF THE ACTIVITY OF SERINA PROTEASA NS3-NS4A OF HEPATITIS C VIRUS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251583B1 (en) * 1998-04-27 2001-06-26 Schering Corporation Peptide substrates for HCV NS3 protease assays
WO2005058821A1 (en) * 2003-12-11 2005-06-30 Schering Corporation Inhibitors of hepatitis c virus ns3/ns4a serine protease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2057278A2 *

Also Published As

Publication number Publication date
WO2008027397A2 (en) 2008-03-06
JP2010502184A (en) 2010-01-28
NZ575186A (en) 2012-03-30
AU2007290535A1 (en) 2008-03-06
EP2057278A2 (en) 2009-05-13

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