WO2008026075A3 - Treatment of intracellular bacterial infections with a protein kinase inhibitor or an as160 polypeptide activator - Google Patents

Treatment of intracellular bacterial infections with a protein kinase inhibitor or an as160 polypeptide activator Download PDF

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Publication number
WO2008026075A3
WO2008026075A3 PCT/IB2007/003553 IB2007003553W WO2008026075A3 WO 2008026075 A3 WO2008026075 A3 WO 2008026075A3 IB 2007003553 W IB2007003553 W IB 2007003553W WO 2008026075 A3 WO2008026075 A3 WO 2008026075A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
kinase inhibitor
bacterial infections
treatment
intracellular bacterial
Prior art date
Application number
PCT/IB2007/003553
Other languages
French (fr)
Other versions
WO2008026075A2 (en
Inventor
Jacques Jacobus Neefjes
Herman Steven Overkleeft
Thomas Henricus Maria Ottenhoff
Nigel Denning Leonard Savage
Adriaan Willem Tuin
Marije Marsman
Coenraad Paul Kuijl
Original Assignee
Vereniging Het Nl Kanker I
Academisch Ziekenhuis Leiden
Univ Leiden
Jacques Jacobus Neefjes
Herman Steven Overkleeft
Ottenhoff Thomas Henricus Mari
Nigel Denning Leonard Savage
Adriaan Willem Tuin
Marije Marsman
Coenraad Paul Kuijl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vereniging Het Nl Kanker I, Academisch Ziekenhuis Leiden, Univ Leiden, Jacques Jacobus Neefjes, Herman Steven Overkleeft, Ottenhoff Thomas Henricus Mari, Nigel Denning Leonard Savage, Adriaan Willem Tuin, Marije Marsman, Coenraad Paul Kuijl filed Critical Vereniging Het Nl Kanker I
Publication of WO2008026075A2 publication Critical patent/WO2008026075A2/en
Publication of WO2008026075A3 publication Critical patent/WO2008026075A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Products for treating intracellular bacterial infections comprising a protein kinase inhibitor and/or an activator of AS160 polypeptide-. The protein kinase inhibitor may be a H-89 derivative.
PCT/IB2007/003553 2006-08-31 2007-08-31 Treatment of intracellular bacterial infections with a protein kinase inhibitor or an as160 polypeptide activator WO2008026075A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0617222.5 2006-08-31
GBGB0617222.5A GB0617222D0 (en) 2006-08-31 2006-08-31 Antibiotics

Publications (2)

Publication Number Publication Date
WO2008026075A2 WO2008026075A2 (en) 2008-03-06
WO2008026075A3 true WO2008026075A3 (en) 2009-01-22

Family

ID=37137160

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003553 WO2008026075A2 (en) 2006-08-31 2007-08-31 Treatment of intracellular bacterial infections with a protein kinase inhibitor or an as160 polypeptide activator

Country Status (2)

Country Link
GB (1) GB0617222D0 (en)
WO (1) WO2008026075A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103173529B (en) 2011-12-23 2015-04-29 上海吉凯基因化学技术有限公司 Associated use of human NLK (Neuroleukin) gene and associated medicines
EP3027654B1 (en) * 2013-07-30 2019-09-25 Blueprint Medicines Corporation Pik3c2g fusions
WO2019165067A1 (en) 2018-02-21 2019-08-29 Bristol-Myers Squibb Company Camk2d antisense oligonucleotides and uses thereof
IL296252A (en) * 2020-03-06 2022-11-01 Endolytix Tech Inc Compositions and methods for the treatment of intracellular bacterial infections

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081246A (en) * 1988-12-26 1992-01-14 Hiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
EP0956865A1 (en) * 1996-08-12 1999-11-17 Yoshitomi Pharmaceutical Industries, Ltd. MEDICINES COMPRISING Rho KINASE INHIBITOR
WO2001091754A1 (en) * 2000-05-30 2001-12-06 Peptor Ltd. Protein kinase inhibitors
US20030180830A1 (en) * 2002-02-14 2003-09-25 Pyro Pharmaceuticals, Inc. Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway
WO2004087943A1 (en) * 2003-03-29 2004-10-14 Astrazeneca Ab Method
US20050164323A1 (en) * 2003-12-24 2005-07-28 Wyeth Methods of treating asthma

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081246A (en) * 1988-12-26 1992-01-14 Hiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
EP0956865A1 (en) * 1996-08-12 1999-11-17 Yoshitomi Pharmaceutical Industries, Ltd. MEDICINES COMPRISING Rho KINASE INHIBITOR
WO2001091754A1 (en) * 2000-05-30 2001-12-06 Peptor Ltd. Protein kinase inhibitors
US20030180830A1 (en) * 2002-02-14 2003-09-25 Pyro Pharmaceuticals, Inc. Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway
WO2004087943A1 (en) * 2003-03-29 2004-10-14 Astrazeneca Ab Method
US20050164323A1 (en) * 2003-12-24 2005-07-28 Wyeth Methods of treating asthma

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
KUIJL COENRAAD ET AL: "Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1", NATURE (LONDON), vol. 450, no. 7170, November 2007 (2007-11-01), pages 725, XP002489301, ISSN: 0028-0836 *
KUSNER D J: "Mechanisms of mycobacterial persistence in tuberculosis", CLINICAL IMMUNOLOGY, ACADEMIC PRESS, US, vol. 114, no. 3, 1 March 2005 (2005-03-01), pages 239 - 247, XP004753479, ISSN: 1521-6616 *
LE STUNFF HERVE ET AL: "The roles of protein kinase C and tyrosine kinases in mediating endothelin-1-stimulated phospholipase D activity in rat myometrium: Differential inhibition by ceramides and cyclic AMP", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 292, no. 2, February 2000 (2000-02-01), pages 629 - 637, XP002489300, ISSN: 0022-3565 *
MALIK Z A ET AL: "Mycobacterium tuberculosis phagosomes exhibit altered calmodulin-dependent signal transduction: contribution to inhibition of phagosome-lysosome fusion and intracellular survival in human macrophages.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 MAR 2001, vol. 166, no. 5, 1 March 2001 (2001-03-01), pages 3392 - 3401, XP002502829, ISSN: 0022-1767 *
MARIA-PILAR J D B ET AL: "Cellular bioterrorism: how Brucella corrupts macrophage physiology to promote invasion and proliferation", CLINICAL IMMUNOLOGY, ACADEMIC PRESS, US, vol. 114, no. 3, 1 March 2005 (2005-03-01), pages 227 - 238, XP004753478, ISSN: 1521-6616 *
NAKAMURA S ET AL: "EFFECTS OF ISOQUINOLINESULPHONAMIDE COMPOUNDS ON MULTIDRUG-RESISTANT P388 CELLS", JOURNAL OF PHARMACY AND PHARMACOLOGY, LONDON, vol. 45, no. 4, 1 January 1993 (1993-01-01), pages 268 - 273, XP009011437, ISSN: 0022-3573 *
PENN R B ET AL: "Pharmacological Inhibition of Protein Kinases in Intact Cells: Antagonism of Beta Adrenergic Receptor Ligand Binding by H-89 Reveals Limitations of Usefulness", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, EXPERIMENTAL THERAPEUTICS, BALTIMORE, MD, vol. 288, no. 2, 1 January 1999 (1999-01-01), pages 428 - 437, XP002405317, ISSN: 0022-3565 *
UCHIYA KEI-ICHI ET AL: "Involvement of Salmonella pathogenicity island 2 in the up-regulation of interleukin-10 expression in macrophages: Role of protein kinase a signal pathway", INFECTION AND IMMUNITY, vol. 72, no. 4, April 2004 (2004-04-01), pages 1964 - 1973, XP002489299, ISSN: 0019-9567 *
ZEIGERER ANJA ET AL: "Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.", MOLECULAR BIOLOGY OF THE CELL OCT 2004, vol. 15, no. 10, October 2004 (2004-10-01), pages 4406 - 4415, XP002502830, ISSN: 1059-1524 *

Also Published As

Publication number Publication date
GB0617222D0 (en) 2006-10-11
WO2008026075A2 (en) 2008-03-06

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