WO2008024902A3 - Targeting of fructokinase as therapy for cardiovascular disease, metabolic syndrome, and renal disease - Google Patents

Targeting of fructokinase as therapy for cardiovascular disease, metabolic syndrome, and renal disease Download PDF

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Publication number
WO2008024902A3
WO2008024902A3 PCT/US2007/076624 US2007076624W WO2008024902A3 WO 2008024902 A3 WO2008024902 A3 WO 2008024902A3 US 2007076624 W US2007076624 W US 2007076624W WO 2008024902 A3 WO2008024902 A3 WO 2008024902A3
Authority
WO
WIPO (PCT)
Prior art keywords
fructokinase
metabolic syndrome
targeting
disease
therapy
Prior art date
Application number
PCT/US2007/076624
Other languages
French (fr)
Other versions
WO2008024902A2 (en
Inventor
Richard J Johnson
Takahiko Nakagawa
Mark S Segal
Yuri Y Sautin
Original Assignee
Univ Florida
Richard J Johnson
Takahiko Nakagawa
Mark S Segal
Yuri Y Sautin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, Richard J Johnson, Takahiko Nakagawa, Mark S Segal, Yuri Y Sautin filed Critical Univ Florida
Publication of WO2008024902A2 publication Critical patent/WO2008024902A2/en
Publication of WO2008024902A3 publication Critical patent/WO2008024902A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/321—Arterial hypertension
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed herein are methods of treating and/or preventing hypertension, metabolic syndrome, and/or renal disease that involve the targeting of Fructokinase (ketohexokinase). Also disclosed herein are methods of screening for inhibitors of Fructokinase. Further disclosed herein are methods of formulating a prescriptive regimen for hypertension, metabolic syndrome, and/or renal disease that comprises evaluating the level of ketohexokinase activity in an individual.
PCT/US2007/076624 2006-08-23 2007-08-23 Targeting of fructokinase as therapy for cardiovascular disease, metabolic syndrome, and renal disease WO2008024902A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82337606P 2006-08-23 2006-08-23
US60/823,376 2006-08-23
US86299706P 2006-10-26 2006-10-26
US60/862,997 2006-10-26

Publications (2)

Publication Number Publication Date
WO2008024902A2 WO2008024902A2 (en) 2008-02-28
WO2008024902A3 true WO2008024902A3 (en) 2008-11-20

Family

ID=39107675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/076624 WO2008024902A2 (en) 2006-08-23 2007-08-23 Targeting of fructokinase as therapy for cardiovascular disease, metabolic syndrome, and renal disease

Country Status (1)

Country Link
WO (1) WO2008024902A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8822447B2 (en) * 2010-04-22 2014-09-02 Janssen Pharmaceutica Nv Indazole compounds useful as ketohexokinase inhibitors
WO2012019188A2 (en) * 2010-08-06 2012-02-09 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for the inhibition of fructokinase
US20130195886A1 (en) * 2011-11-27 2013-08-01 The Regents Of The University Of Colorado, A Body Corporate Methods for Fructanase and Fructokinase Inhibition
EA201691587A1 (en) * 2014-02-11 2017-01-30 Элнилэм Фармасьютикалз, Инк. COMPOSITIONS BASED ON iRNA FOR KETOGEXOKINASE (KHK) AND METHODS OF THEIR APPLICATION
EP3291693A4 (en) * 2015-05-06 2019-04-03 University of Southern California Fasting mimicking and enhancing diet for treating hypertension and lipid disorders
RS61896B1 (en) 2015-12-29 2021-06-30 Pfizer Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
US20210332367A1 (en) * 2018-09-18 2021-10-28 Alnylam Pharmaceuticals, Inc. KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
KR20230150844A (en) 2021-02-26 2023-10-31 알닐람 파마슈티칼스 인코포레이티드 Ketohexokinase (KHK) iRNA compositions and methods of using the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAIS, R. ET AL.: "The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol", BIOCHEM. JOURNAL, vol. 230, no. 1, 15 August 1985 (1985-08-15), pages 53 - 60, XP055353007, DOI: doi:10.1042/bj2300053 *
HAYWARD, B. ET AL.: "Structure and alternative splicing of the ketohexokinase gene", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 257, no. 1, 1 October 1998 (1998-10-01), pages 85 - 91, XP055353008 *
SCHREUDER, M. ET AL.: "Immobilizing proteins on the surface of yeast cells", TRENDS BIOTECHNOL., vol. 14, no. 4, April 1996 (1996-04-01), pages 115 - 120, XP004035795 *

Also Published As

Publication number Publication date
WO2008024902A2 (en) 2008-02-28

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