WO2008021725A3 - Chemical compounds - Google Patents

Chemical compounds Download PDF

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Publication number
WO2008021725A3
WO2008021725A3 PCT/US2007/074913 US2007074913W WO2008021725A3 WO 2008021725 A3 WO2008021725 A3 WO 2008021725A3 US 2007074913 W US2007074913 W US 2007074913W WO 2008021725 A3 WO2008021725 A3 WO 2008021725A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical compounds
pyridone
compositions
isoquinoline derivatives
medicaments
Prior art date
Application number
PCT/US2007/074913
Other languages
French (fr)
Other versions
WO2008021725A2 (en
Inventor
David Harold Drewry
Robert Neil Hunter Iii
James Andrew Linn
Original Assignee
Smithkline Beecham Corp
David Harold Drewry
Robert Neil Hunter Iii
James Andrew Linn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, David Harold Drewry, Robert Neil Hunter Iii, James Andrew Linn filed Critical Smithkline Beecham Corp
Publication of WO2008021725A2 publication Critical patent/WO2008021725A2/en
Publication of WO2008021725A3 publication Critical patent/WO2008021725A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention encompasses pyridone isoquinoline derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. The pyridone isoquinoline derivatives are useful in the treatment of diseases associated with inappropriate SGK1 activity.
PCT/US2007/074913 2006-08-11 2007-08-01 Chemical compounds WO2008021725A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82210706P 2006-08-11 2006-08-11
US60/822,107 2006-08-11

Publications (2)

Publication Number Publication Date
WO2008021725A2 WO2008021725A2 (en) 2008-02-21
WO2008021725A3 true WO2008021725A3 (en) 2008-10-16

Family

ID=39082874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074913 WO2008021725A2 (en) 2006-08-11 2007-08-01 Chemical compounds

Country Status (1)

Country Link
WO (1) WO2008021725A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013261128B2 (en) 2012-05-15 2015-11-12 Novartis Ag Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
EP2861576B1 (en) 2012-05-15 2018-01-10 Novartis AG Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
WO2013171641A1 (en) 2012-05-15 2013-11-21 Novartis Ag Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1
MY169377A (en) 2012-05-15 2019-03-26 Novartis Ag Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
ES2894333T3 (en) 2013-09-26 2022-02-14 Beth Israel Deaconess Medical Ct Inc SGK1 inhibitors in the treatment of Long QT syndrome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329678B2 (en) * 2003-01-28 2008-02-12 Smithkline Beecham Corporation Chemical compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329678B2 (en) * 2003-01-28 2008-02-12 Smithkline Beecham Corporation Chemical compounds

Also Published As

Publication number Publication date
WO2008021725A2 (en) 2008-02-21

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