WO2008021163A3 - Kits and methods for determining risk for primary liver cancer - Google Patents

Kits and methods for determining risk for primary liver cancer Download PDF

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Publication number
WO2008021163A3
WO2008021163A3 PCT/US2007/017690 US2007017690W WO2008021163A3 WO 2008021163 A3 WO2008021163 A3 WO 2008021163A3 US 2007017690 W US2007017690 W US 2007017690W WO 2008021163 A3 WO2008021163 A3 WO 2008021163A3
Authority
WO
WIPO (PCT)
Prior art keywords
kits
methods
protein
hepatocellular carcinoma
liver cancer
Prior art date
Application number
PCT/US2007/017690
Other languages
French (fr)
Other versions
WO2008021163A2 (en
Inventor
Claus Fimmel
Yie-Hwa Chang
Original Assignee
Univ Saint Louis
Claus Fimmel
Yie-Hwa Chang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Saint Louis, Claus Fimmel, Yie-Hwa Chang filed Critical Univ Saint Louis
Publication of WO2008021163A2 publication Critical patent/WO2008021163A2/en
Publication of WO2008021163A3 publication Critical patent/WO2008021163A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Methods and kits for diagnosing hepatocellular carcinoma are disclosed. The methods comprise detecting in a serum sample from a subject the quantity of at least one serum protein which is upregulated in patients with hepatocellular carcinoma. Kits of the present teachings include a capture antibody directed against a first epitope of a serum protein which is upregulated in patients with hepatocellular carcinoma, a detection antibody against a second epitope of the protein, and a labeled secondary protein directed against the detection antibody. The capture antibody can be immobilized on a solid support, such as a multiwell plate or a plastic bead.
PCT/US2007/017690 2006-08-09 2007-08-09 Kits and methods for determining risk for primary liver cancer WO2008021163A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82192106P 2006-08-09 2006-08-09
US60/821,921 2006-08-09

Publications (2)

Publication Number Publication Date
WO2008021163A2 WO2008021163A2 (en) 2008-02-21
WO2008021163A3 true WO2008021163A3 (en) 2009-04-16

Family

ID=39082591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017690 WO2008021163A2 (en) 2006-08-09 2007-08-09 Kits and methods for determining risk for primary liver cancer

Country Status (1)

Country Link
WO (1) WO2008021163A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102081100B (en) * 2010-07-20 2015-06-24 李伯安 Liver cancer multi-marker micro-array kit as well as preparation method and application thereof
WO2015020242A1 (en) * 2013-08-06 2015-02-12 Kim Hyun Kee Composition for diagnosing small hepatocellular carcinoma and hepatocellular carcinoma latent in cirrhotic liver
ES2939841T3 (en) 2016-02-26 2023-04-27 Univ Drexel Early detection of hepatocellular carcinoma
CN107942055A (en) * 2017-11-22 2018-04-20 南宁科城汇信息科技有限公司 The ELISA method of transcript profile and protein science in a kind of liver cancer biological process

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030190689A1 (en) * 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies
US20050112711A1 (en) * 2003-09-05 2005-05-26 Thomas Jefferson University Diagnosis and monitoring of hepatocellular carcinoma

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030190689A1 (en) * 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies
US20050112711A1 (en) * 2003-09-05 2005-05-26 Thomas Jefferson University Diagnosis and monitoring of hepatocellular carcinoma

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JIANG ET AL.: "Influence of liver cancer on lipid and lipoprotein metabolism.", LIPIDS IN HEALTH AND DISEASE, vol. 5, March 2006 (2006-03-01), pages 1 - 7 *
SEKIDO ET AL.: "Preferential expression of c-kit protooncogene transcripts in small cell lung cancer.", CANCER RESEARCH, vol. 51, May 1991 (1991-05-01), pages 2416 - 2419 *
YOKOYAMA ET AL.: "Protein level of apolipoprotein E increased in human hepatocellular carcinoma.", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 28, March 2006 (2006-03-01), pages 625 - 631, XP055008717 *

Also Published As

Publication number Publication date
WO2008021163A2 (en) 2008-02-21

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