WO2008021048A3 - Procédés et compositions fondés sur l'adp-ribosyltransférase - Google Patents

Procédés et compositions fondés sur l'adp-ribosyltransférase Download PDF

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Publication number
WO2008021048A3
WO2008021048A3 PCT/US2007/017461 US2007017461W WO2008021048A3 WO 2008021048 A3 WO2008021048 A3 WO 2008021048A3 US 2007017461 W US2007017461 W US 2007017461W WO 2008021048 A3 WO2008021048 A3 WO 2008021048A3
Authority
WO
WIPO (PCT)
Prior art keywords
adp
ribosyltransferase
compositions
based methods
methods
Prior art date
Application number
PCT/US2007/017461
Other languages
English (en)
Other versions
WO2008021048A2 (fr
Inventor
David A Sinclair
Ron Firestein
Basil Hubbard
Original Assignee
Harvard College
David A Sinclair
Ron Firestein
Basil Hubbard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, David A Sinclair, Ron Firestein, Basil Hubbard filed Critical Harvard College
Publication of WO2008021048A2 publication Critical patent/WO2008021048A2/fr
Publication of WO2008021048A3 publication Critical patent/WO2008021048A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91142—Pentosyltransferases (2.4.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des procédés permettant d'identifier des agents qui modulent l'activité des ADP-ribosyltransférases de type sirtuine, notamment la Sirt4 et la Sirt6. L'invention concerne également des procédés permettant de traiter une maladie hyperproliférative, consistant, par exemple, à administrer à un sujet nécessitant des soins un agent qui réduit l'activité ou le niveau protéique d'une ADP-ribosyltransférase, notamment la Sirt6.
PCT/US2007/017461 2006-08-07 2007-08-06 Procédés et compositions fondés sur l'adp-ribosyltransférase WO2008021048A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83600806P 2006-08-07 2006-08-07
US83603506P 2006-08-07 2006-08-07
US60/836,035 2006-08-07
US60/836,008 2006-08-07

Publications (2)

Publication Number Publication Date
WO2008021048A2 WO2008021048A2 (fr) 2008-02-21
WO2008021048A3 true WO2008021048A3 (fr) 2008-09-04

Family

ID=39082544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017461 WO2008021048A2 (fr) 2006-08-07 2007-08-06 Procédés et compositions fondés sur l'adp-ribosyltransférase

Country Status (1)

Country Link
WO (1) WO2008021048A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008138943A2 (fr) * 2007-05-14 2008-11-20 Universite Libre De Bruxelles Utilisation prophylactique et thérapeutique d'inhibiteurs de la sirtuine dans des pathologies à médiation par tnf-alpha
KR102043303B1 (ko) * 2013-03-08 2019-11-12 한국화학연구원 Sirt7단백질의 탈아세틸화 활성을 정량분석하는 방법 및 상기 방법을 이용한 활성을 저해하는 억제제의 스크리닝 방법
US8962779B2 (en) 2013-07-16 2015-02-24 Dow Global Technologies Llc Method of forming polyaryl polymers
US9410016B2 (en) 2013-07-16 2016-08-09 Dow Global Technologies Llc Aromatic polyacetals and articles comprising them
US8933239B1 (en) 2013-07-16 2015-01-13 Dow Global Technologies Llc Bis(aryl)acetal compounds
US9063420B2 (en) 2013-07-16 2015-06-23 Rohm And Haas Electronic Materials Llc Photoresist composition, coated substrate, and method of forming electronic device

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRYE ET AL.: "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity", BIOCHEM. BIPHYS. RES. COMMUN., vol. 260, no. 1, 24 June 1999 (1999-06-24), pages 273 - 279, XP002963940 *
HONES ET AL.: "Studies of enzyme-ligand complexes using dynamic fluorescence anisotropy. II. The coenzyme-binding site of malate dehydrogenase", BIOL. CHEM. HOPPE SEYLER, vol. 367, no. 2, February 1986 (1986-02-01), pages 103 - 108 *

Also Published As

Publication number Publication date
WO2008021048A2 (fr) 2008-02-21

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