WO2008017859A3 - Ligand for the g6b receptor on blood platelets - Google Patents

Ligand for the g6b receptor on blood platelets Download PDF

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Publication number
WO2008017859A3
WO2008017859A3 PCT/GB2007/003048 GB2007003048W WO2008017859A3 WO 2008017859 A3 WO2008017859 A3 WO 2008017859A3 GB 2007003048 W GB2007003048 W GB 2007003048W WO 2008017859 A3 WO2008017859 A3 WO 2008017859A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligand
receptor
blood platelets
platelets
blood
Prior art date
Application number
PCT/GB2007/003048
Other languages
French (fr)
Other versions
WO2008017859A2 (en
Inventor
Duncan R Campbell
Stephen Newland
Nicolas Watkins
Iain Macaulay
Paul Lyons
Original Assignee
Isis Innovation
Medical Res Council
Univ Cambridge Tech
Duncan R Campbell
Stephen Newland
Nicolas Watkins
Iain Macaulay
Paul Lyons
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0615845A external-priority patent/GB0615845D0/en
Priority claimed from GB0702359A external-priority patent/GB0702359D0/en
Application filed by Isis Innovation, Medical Res Council, Univ Cambridge Tech, Duncan R Campbell, Stephen Newland, Nicolas Watkins, Iain Macaulay, Paul Lyons filed Critical Isis Innovation
Publication of WO2008017859A2 publication Critical patent/WO2008017859A2/en
Publication of WO2008017859A3 publication Critical patent/WO2008017859A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

We disclose a ligand that binds to and modulates the activity of a receptor G6B, expressed by blood platelets.
PCT/GB2007/003048 2006-08-10 2007-08-10 Ligand for the g6b receptor on blood platelets WO2008017859A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0615845.5 2006-08-10
GB0615845A GB0615845D0 (en) 2006-08-10 2006-08-10 Ligand
GB0702359A GB0702359D0 (en) 2007-02-07 2007-02-07 Ligand
GB0702359.1 2007-02-07

Publications (2)

Publication Number Publication Date
WO2008017859A2 WO2008017859A2 (en) 2008-02-14
WO2008017859A3 true WO2008017859A3 (en) 2008-07-03

Family

ID=38984214

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/003048 WO2008017859A2 (en) 2006-08-10 2007-08-10 Ligand for the g6b receptor on blood platelets

Country Status (1)

Country Link
WO (1) WO2008017859A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090202534A1 (en) * 2007-10-30 2009-08-13 Levin Steven D Compositions and methods for modulating immune responses
WO2019178364A2 (en) * 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
GB201902590D0 (en) * 2019-02-26 2019-04-10 Univ Birmingham Antibodies and uses thereof
EP4399228A1 (en) 2021-09-07 2024-07-17 Etablissement Français du Sang Targeted regulation of platelet and megakaryocyte activation by heteroreceptor co-clustering

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056575A2 (en) * 2003-12-03 2005-06-23 The Scripps Research Institute INTEGRIN αIIbβ3 SPECIFIC ANTIBODIES AND PEPTIDES
EP1647596A2 (en) * 2003-07-18 2006-04-19 Mochida Pharmaceutical Co., Ltd. Monoclonal antibody against platelet membrane glycoprotein vi

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1647596A2 (en) * 2003-07-18 2006-04-19 Mochida Pharmaceutical Co., Ltd. Monoclonal antibody against platelet membrane glycoprotein vi
WO2005056575A2 (en) * 2003-12-03 2005-06-23 The Scripps Research Institute INTEGRIN αIIbβ3 SPECIFIC ANTIBODIES AND PEPTIDES

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
E. DE VET ET AL.: "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 45, 9 November 2001 (2001-11-09), Baltimore, MD, USA, pages 42070 - 42076, XP002469604 *
G. RIBAS ET AL.: "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and a N omega-N omega-dimethylarginine dimethylaminohydrolase homologue....etc.", THE JOURNAL OF IMMUNOLOGY, vol. 163, no. 1, 1 July 1999 (1999-07-01), Baltimore, MD, USA, pages 278 - 287, XP002469605 *
J. MOEBIUS ET AL.: "The human platelet membrane proteome reveals several new potential membrane proteins.", MOLECULAR & CELLULAR PROTEOMICS, vol. 4, no. 11, November 2005 (2005-11-01), USA, pages 1754 - 1761, XP008088384 *
S. NEWLAND ET AL.: "The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro.", BLOOD, vol. 109, no. 11, 1 June 2007 (2007-06-01), pages 4806 - 4809, XP002469606 *

Also Published As

Publication number Publication date
WO2008017859A2 (en) 2008-02-14

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