WO2008016660A3 - Imidazoacridine compounds for treating leukemias - Google Patents

Imidazoacridine compounds for treating leukemias Download PDF

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Publication number
WO2008016660A3
WO2008016660A3 PCT/US2007/017222 US2007017222W WO2008016660A3 WO 2008016660 A3 WO2008016660 A3 WO 2008016660A3 US 2007017222 W US2007017222 W US 2007017222W WO 2008016660 A3 WO2008016660 A3 WO 2008016660A3
Authority
WO
WIPO (PCT)
Prior art keywords
imidazoacridine
compounds
treating leukemias
treating
leukemias
Prior art date
Application number
PCT/US2007/017222
Other languages
French (fr)
Other versions
WO2008016660A2 (en
Inventor
Alfred M Ajami
Robert L Capizzi
Original Assignee
Xanthus Pharmaceuticals Inc
Alfred M Ajami
Robert L Capizzi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xanthus Pharmaceuticals Inc, Alfred M Ajami, Robert L Capizzi filed Critical Xanthus Pharmaceuticals Inc
Publication of WO2008016660A2 publication Critical patent/WO2008016660A2/en
Publication of WO2008016660A3 publication Critical patent/WO2008016660A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

A method of treating a patient suffering from certain types of leukemia, comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided therein.
PCT/US2007/017222 2006-08-02 2007-08-02 Imidazoacridine compounds for treating leukemias WO2008016660A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83502806P 2006-08-02 2006-08-02
US83506406P 2006-08-02 2006-08-02
US60/835,064 2006-08-02
US60/835,028 2006-08-02
US87385006P 2006-12-08 2006-12-08
US60/873,850 2006-12-08

Publications (2)

Publication Number Publication Date
WO2008016660A2 WO2008016660A2 (en) 2008-02-07
WO2008016660A3 true WO2008016660A3 (en) 2008-04-24

Family

ID=38792006

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017222 WO2008016660A2 (en) 2006-08-02 2007-08-02 Imidazoacridine compounds for treating leukemias

Country Status (1)

Country Link
WO (1) WO2008016660A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2428508T3 (en) * 2009-05-08 2016-05-31 Astellas Pharma Inc Diamino heterocyclic carboxamide compound
CN116425828A (en) * 2023-04-03 2023-07-14 浙江大学 Small molecule compound for degrading HDAC7 protein, and preparation and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0502668A1 (en) * 1991-03-05 1992-09-09 Btg International Limited Imidazoacridines and their antineoplastic use
WO2001066545A2 (en) * 2000-03-07 2001-09-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 1,8-NAPHTHALIMIDE IMIDAZO[4,5,1-de]ACRIDONES WITH ANTI-TUMOR ACTIVITY
WO2007016338A2 (en) * 2005-07-29 2007-02-08 Goverment Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Use of chk2 kinase inhibitors for cancer treatment
WO2007092436A2 (en) * 2006-02-08 2007-08-16 Xanthus Pharmaceuticals, Inc. Compounds for treating inflammatory disorders, demyelinating disorders and cancers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0502668A1 (en) * 1991-03-05 1992-09-09 Btg International Limited Imidazoacridines and their antineoplastic use
WO2001066545A2 (en) * 2000-03-07 2001-09-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 1,8-NAPHTHALIMIDE IMIDAZO[4,5,1-de]ACRIDONES WITH ANTI-TUMOR ACTIVITY
WO2007016338A2 (en) * 2005-07-29 2007-02-08 Goverment Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Use of chk2 kinase inhibitors for cancer treatment
WO2007092436A2 (en) * 2006-02-08 2007-08-16 Xanthus Pharmaceuticals, Inc. Compounds for treating inflammatory disorders, demyelinating disorders and cancers

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AUGUSTIN E ET AL: "Imidazoacridinones arrest cell-cycle progression in the G2 phase of L1210 cells", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 38, no. 1, 1996, pages 39 - 44, XP008085895, ISSN: 0344-5704 *
CHOLODY WIESLAW M ET AL: "Structure-activity relationship for antineoplastic imidazoacridinones: Synthesis and antileukemic activity in vivo", JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, no. 5, 1996, pages 1028 - 1032, XP002468996, ISSN: 0022-2623 *
CHOLODY, WIESLAW M. ET AL: "Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias", JOURNAL OF MEDICINAL CHEMISTRY , 35(2), 378-82 CODEN: JMCMAR; ISSN: 0022-2623, 1992, XP002468995 *
MAZERSKA Z ET AL: "QSAR of acridines, III. Structure-activity relationship for antitumor imidazoacridinones and intercorrelations between in vivo and in vitro tests", ANTI-CANCER DRUG DESIGN, BASINGSTOKE, GB, vol. 11, no. 1, 1996, pages 73 - 88, XP008085898, ISSN: 0266-9536 *
MAZERSKA ZOFIA ET AL: "C-1311: Atineoplastic", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 23, no. 7, July 1998 (1998-07-01), pages 702 - 706, XP002459524, ISSN: 0377-8282 *
MYDOANH CHAU ET AL: "Imidazoacridinones are bifunctional targeting agents active in leukemia cells", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 108, no. 11, PART 1, November 2006 (2006-11-01), pages 658A, XP008088583, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
WO2008016660A2 (en) 2008-02-07

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