WO2008016604A3 - Utilisation de la colostrinine, peptides constitutifs de celle-ci, et leurs analogues comme agents anti-mutagéniques - Google Patents

Utilisation de la colostrinine, peptides constitutifs de celle-ci, et leurs analogues comme agents anti-mutagéniques Download PDF

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Publication number
WO2008016604A3
WO2008016604A3 PCT/US2007/017112 US2007017112W WO2008016604A3 WO 2008016604 A3 WO2008016604 A3 WO 2008016604A3 US 2007017112 W US2007017112 W US 2007017112W WO 2008016604 A3 WO2008016604 A3 WO 2008016604A3
Authority
WO
WIPO (PCT)
Prior art keywords
colostrinin
analogs
mutagenic agents
constituent peptides
agents
Prior art date
Application number
PCT/US2007/017112
Other languages
English (en)
Other versions
WO2008016604A2 (fr
Inventor
Marian Kruzel
Istvan Boldogh
Original Assignee
Univ Texas
Regen Therapeutics Plc
Marian Kruzel
Istvan Boldogh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Regen Therapeutics Plc, Marian Kruzel, Istvan Boldogh filed Critical Univ Texas
Publication of WO2008016604A2 publication Critical patent/WO2008016604A2/fr
Publication of WO2008016604A3 publication Critical patent/WO2008016604A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des procédés pour diminuer la fréquence de mutation dans une cellule, le procédé comprenant la mise en contact de cellules avec de la colostrinine, un peptide constitutif de celle-ci, un analogue actif de ceux-ci ou une combinaison de ceux-ci. Les fréquences de mutation diminuées par le présent procédé comprennent les mutations spontanées et les mutations induites par les espèces à oxygène réactif (ROS), le rayonnement UVA, le rayonnement UVB, les agents chimiques et les agents physiques.
PCT/US2007/017112 2006-07-31 2007-07-31 Utilisation de la colostrinine, peptides constitutifs de celle-ci, et leurs analogues comme agents anti-mutagéniques WO2008016604A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83443306P 2006-07-31 2006-07-31
US60/834,433 2006-07-31

Publications (2)

Publication Number Publication Date
WO2008016604A2 WO2008016604A2 (fr) 2008-02-07
WO2008016604A3 true WO2008016604A3 (fr) 2008-06-26

Family

ID=38997678

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017112 WO2008016604A2 (fr) 2006-07-31 2007-07-31 Utilisation de la colostrinine, peptides constitutifs de celle-ci, et leurs analogues comme agents anti-mutagéniques

Country Status (1)

Country Link
WO (1) WO2008016604A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009138762A2 (fr) * 2008-05-15 2009-11-19 Regen Therapeutics Plc Utilisation thérapeutique de peptides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037851A2 (fr) * 2002-10-22 2004-05-06 Board Of Regents The University Of Texas System Utilisation de colostrinine, peptides constitutifs de celle-ci, et analogues de celle-ci utilises en tant que modulateurs de molecules de signalisation intracellulaire et inhibiteurs de l'apoptose

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037851A2 (fr) * 2002-10-22 2004-05-06 Board Of Regents The University Of Texas System Utilisation de colostrinine, peptides constitutifs de celle-ci, et analogues de celle-ci utilises en tant que modulateurs de molecules de signalisation intracellulaire et inhibiteurs de l'apoptose

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 2006, BACSI ATTILA ET AL: "Colostrinin decreases spontaneous and induced mutation frequencies at the hprt locus in Chinese hamster V79 cells.", XP002477053, Database accession no. NLM17024966 *
GLADKEVICH ET AL: "Proline-rich polypeptides in Alzheimer's disease and neurodegenerative disorders - Therapeutic potential or a mirage?", PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, OXFORD, GB, vol. 31, no. 7, 28 August 2007 (2007-08-28), pages 1347 - 1355, XP022215883, ISSN: 0278-5846 *
JOURNAL OF EXPERIMENTAL THERAPEUTICS & ONCOLOGY 2006, vol. 5, no. 4, 2006, pages 249 - 259, ISSN: 1359-4117 *

Also Published As

Publication number Publication date
WO2008016604A2 (fr) 2008-02-07

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