WO2008016385A3 - Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof - Google Patents

Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof Download PDF

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Publication number
WO2008016385A3
WO2008016385A3 PCT/US2007/001290 US2007001290W WO2008016385A3 WO 2008016385 A3 WO2008016385 A3 WO 2008016385A3 US 2007001290 W US2007001290 W US 2007001290W WO 2008016385 A3 WO2008016385 A3 WO 2008016385A3
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WO
WIPO (PCT)
Prior art keywords
deacylase
present
methods
polypeptides
invention further
Prior art date
Application number
PCT/US2007/001290
Other languages
French (fr)
Other versions
WO2008016385A2 (en
Inventor
Richard P Darveau
Stephen R Coats
Original Assignee
Univ Washington
Richard P Darveau
Stephen R Coats
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington, Richard P Darveau, Stephen R Coats filed Critical Univ Washington
Publication of WO2008016385A2 publication Critical patent/WO2008016385A2/en
Publication of WO2008016385A3 publication Critical patent/WO2008016385A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides isolated deacylase polypeptides; and deacylase nucleic acids. The present invention further provides methods for identifying inhibitors of a bacterial deacylase and that are candidates for treating a periodontal disease. The present invention further provides antibodies specific for a subject deacylase polypeptide. The present invention further provides diagnostic methods for detecting silent bacterial infections of the gum tissues; diagnostic methods for detecting conditions and disorders that are sequelae of periodontitis; and diagnostic methods for monitoring a patient's response to treatment for a periodontal disease.
PCT/US2007/001290 2006-01-20 2007-01-18 Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof WO2008016385A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76055606P 2006-01-20 2006-01-20
US60/760,556 2006-01-20

Publications (2)

Publication Number Publication Date
WO2008016385A2 WO2008016385A2 (en) 2008-02-07
WO2008016385A3 true WO2008016385A3 (en) 2009-01-08

Family

ID=38997606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/001290 WO2008016385A2 (en) 2006-01-20 2007-01-18 Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2008016385A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO652897A0 (en) 1997-04-30 1997-05-29 University Of Melbourne, The Synthetic peptide constructs for the diagnosis and treatment of periodontitis
US8129500B2 (en) 1997-12-10 2012-03-06 Csl Limited Porphyromonas gingivalis polypeptides and nucleotides
AU2007264402B2 (en) 2006-06-27 2012-09-20 Oral Health Australia Pty Ltd Porphyromonas gingivalis polypeptides useful in the prevention of periodontal disease
PL2175851T3 (en) 2007-07-12 2013-11-29 Oral Health Australia Pty Ltd Biofilm treatment
NZ595378A (en) * 2007-07-12 2013-04-26 Immunology treatment for biofilms
AU2013203250B2 (en) * 2007-07-12 2014-11-13 Oral Health Australia Pty Ltd Immunology treatment for biofilms
AU2009287340B2 (en) 2008-08-29 2015-03-19 Oral Health Australia Pty Ltd Prevention, treatment and diagnosis of P.gingivalis infection
WO2020139784A1 (en) * 2018-12-29 2020-07-02 Weinberg Assa Method to prevent and treat gingival recession by calcium channel blockers, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712102A (en) * 1993-11-10 1998-01-27 Bristol-Myers Squibb Company Method of screening compounds which inhibit P. gingivalis lipopolysaccharide from inhibiting the extravasation of leukocytes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712102A (en) * 1993-11-10 1998-01-27 Bristol-Myers Squibb Company Method of screening compounds which inhibit P. gingivalis lipopolysaccharide from inhibiting the extravasation of leukocytes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] NELSON ET AL., Database accession no. (NP_906066) *

Also Published As

Publication number Publication date
WO2008016385A2 (en) 2008-02-07

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