WO2008015693A3 - Process for the preparation of mycophenolate mofetil - Google Patents

Process for the preparation of mycophenolate mofetil Download PDF

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Publication number
WO2008015693A3
WO2008015693A3 PCT/IN2007/000192 IN2007000192W WO2008015693A3 WO 2008015693 A3 WO2008015693 A3 WO 2008015693A3 IN 2007000192 W IN2007000192 W IN 2007000192W WO 2008015693 A3 WO2008015693 A3 WO 2008015693A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
mycophenolate mofetil
provides
improved process
mycophenolic acid
Prior art date
Application number
PCT/IN2007/000192
Other languages
French (fr)
Other versions
WO2008015693A2 (en
WO2008015693A8 (en
Inventor
Pardeep Narula
Bhautik Patel
Sudhir Vaid
Original Assignee
Concord Biotech Ltd
Pardeep Narula
Bhautik Patel
Sudhir Vaid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concord Biotech Ltd, Pardeep Narula, Bhautik Patel, Sudhir Vaid filed Critical Concord Biotech Ltd
Publication of WO2008015693A2 publication Critical patent/WO2008015693A2/en
Publication of WO2008015693A8 publication Critical patent/WO2008015693A8/en
Publication of WO2008015693A3 publication Critical patent/WO2008015693A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Invention provides an improved process for the preparation of Mycophenolate mofetil by reacting Mycophenolic acid with morpholino ethanol in presence of Dipyridyl carbonate.
PCT/IN2007/000192 2006-06-02 2007-05-10 Process for the preparation of mycophenolate mofetil WO2008015693A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1489MU2006 2006-06-02
IN1489/MUM/2005 2006-06-02

Publications (3)

Publication Number Publication Date
WO2008015693A2 WO2008015693A2 (en) 2008-02-07
WO2008015693A8 WO2008015693A8 (en) 2008-03-27
WO2008015693A3 true WO2008015693A3 (en) 2009-04-16

Family

ID=38997573

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000192 WO2008015693A2 (en) 2006-06-02 2007-05-10 Process for the preparation of mycophenolate mofetil

Country Status (1)

Country Link
WO (1) WO2008015693A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS accession no. STN Database accession no. 1985:77975 *
KIM ET AL.: "Di-2-pyridyl carbonate: a new eficient coupling agent for the direct esterificaiton of carboxylic acids.", TETRAHEDRON LETTERS, vol. 25, no. 43, 1984, pages 4943 - 4946 *
SMITH ET AL.: "March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure", pages: 1414 *

Also Published As

Publication number Publication date
WO2008015693A2 (en) 2008-02-07
WO2008015693A8 (en) 2008-03-27

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