WO2008015634A3 - Method for the determination of phospholipids in amniotic fluid samples - Google Patents

Method for the determination of phospholipids in amniotic fluid samples Download PDF

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Publication number
WO2008015634A3
WO2008015634A3 PCT/IB2007/053011 IB2007053011W WO2008015634A3 WO 2008015634 A3 WO2008015634 A3 WO 2008015634A3 IB 2007053011 W IB2007053011 W IB 2007053011W WO 2008015634 A3 WO2008015634 A3 WO 2008015634A3
Authority
WO
WIPO (PCT)
Prior art keywords
phospholipids
determination
amniotic fluid
fluid samples
novative
Prior art date
Application number
PCT/IB2007/053011
Other languages
French (fr)
Other versions
WO2008015634A2 (en
Inventor
Oliveira Monteiro Jesus Reb De
Santos Patricio Belmiro Dos
Original Assignee
Univ Do Porto
Oliveira Monteiro Jesus Reb De
Santos Patricio Belmiro Dos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Do Porto, Oliveira Monteiro Jesus Reb De, Santos Patricio Belmiro Dos filed Critical Univ Do Porto
Priority to US12/159,768 priority Critical patent/US20090081796A1/en
Priority to EP07825973A priority patent/EP2047281A2/en
Publication of WO2008015634A2 publication Critical patent/WO2008015634A2/en
Publication of WO2008015634A3 publication Critical patent/WO2008015634A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Abstract

The present invention refers to a fast method for the determination of phospholipids in amniotic fluid samples by HPTLC (high performance thin layer chromatography). This in- novative method presents high sensitivity, reproducibility and resolution. It has also the advantage of being of easy laboratorial interpretation, allowing the elimination of false results due to the contamination of the sample with blood or meconium.
PCT/IB2007/053011 2006-07-31 2007-07-31 Method for the determination of phospholipids in amniotic fluid samples WO2008015634A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/159,768 US20090081796A1 (en) 2006-07-31 2007-07-31 Method for the determination of phospholipids in amniotic fluid samples
EP07825973A EP2047281A2 (en) 2006-07-31 2007-07-31 Method for the determination of phospholipids in amniotic fluid samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT103547 2006-07-31
PT10354706A PT103547B (en) 2006-07-31 2006-07-31 METHOD FOR THE DETERMINATION OF PHOSPHOLIDES IN A SAMPLE OF AMMYTIC LIQUID

Publications (2)

Publication Number Publication Date
WO2008015634A2 WO2008015634A2 (en) 2008-02-07
WO2008015634A3 true WO2008015634A3 (en) 2008-07-03

Family

ID=38997550

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/053011 WO2008015634A2 (en) 2006-07-31 2007-07-31 Method for the determination of phospholipids in amniotic fluid samples

Country Status (3)

Country Link
EP (1) EP2047281A2 (en)
PT (1) PT103547B (en)
WO (1) WO2008015634A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101379289B1 (en) * 2013-08-02 2014-03-28 라인호(주) Method and equipment transfering ship movement efficiency is excellent

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010917A1 (en) * 1978-10-23 1980-05-14 The University Of Sydney Method of assessing foetal lung maturity
US5443989A (en) * 1993-10-25 1995-08-22 Beth Israel Hospital Association Method for assessing fetal lung maturity using amniotic fluid samples

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010917A1 (en) * 1978-10-23 1980-05-14 The University Of Sydney Method of assessing foetal lung maturity
US5443989A (en) * 1993-10-25 1995-08-22 Beth Israel Hospital Association Method for assessing fetal lung maturity using amniotic fluid samples

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GLUCK L ET AL: "DIAGNOSIS OF THE RESPIRATORY DISTRESS SYNDROME BY AMNIOCENTESIS", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 109, no. 3, 1971, pages 440 - 445, XP009028231, ISSN: 0002-9378 *
IWAMORI MASAO ET AL: "Sensitive method for the determination of pulmonary surfactant phospholipid/sphingomyelin ratio in human amniotic fluids for the diagnosis of respiratory distress syndrome by thin-layer chromatography-immunostaining", 1996, ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, PAGE(S) 29-33, ISSN: 0003-2697, XP002240317 *
MACKENZIE J R ET AL: "RADIAL HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY USED TO ASSESS FETAL LUNG MATURITY", 1990, CLINICAL CHEMISTRY, VOL. 36, NR. 5, PAGE(S) 728-731, ISSN: 0009-9147, XP002470519 *
TOUCHSTONE J C ET AL: "IMPROVED SEPARATION OF PHOSPHO LIPIDS IN THIN LAYER CHROMATOGRAPHY", January 1980, LIPIDS, CHAMPAIGN, IL, US, PAGE(S) 61-62, ISSN: 0024-4201, XP009095908 *

Also Published As

Publication number Publication date
WO2008015634A2 (en) 2008-02-07
PT103547B (en) 2011-05-09
PT103547A (en) 2008-01-31
EP2047281A2 (en) 2009-04-15

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