WO2008013955A3 - Sustained release formulations for pulmonary delivery - Google Patents
Sustained release formulations for pulmonary delivery Download PDFInfo
- Publication number
- WO2008013955A3 WO2008013955A3 PCT/US2007/016939 US2007016939W WO2008013955A3 WO 2008013955 A3 WO2008013955 A3 WO 2008013955A3 US 2007016939 W US2007016939 W US 2007016939W WO 2008013955 A3 WO2008013955 A3 WO 2008013955A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sustained release
- release formulations
- pulmonary delivery
- dry powder
- pharmacologically active
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Abstract
Compositions comprising at least one pharmacologically active protein, and at least one charged polymer; wherein the composition comprises insoluble complexes of the charged polymer and precipitated pharmacologically active protein; and wherein the composition is in dry powder form and the dry powder comprises particles in which at least an outermost portion is amorphous. Methods of making and using are also provided.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83373206P | 2006-07-27 | 2006-07-27 | |
US60/833,732 | 2006-07-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008013955A2 WO2008013955A2 (en) | 2008-01-31 |
WO2008013955A3 true WO2008013955A3 (en) | 2008-12-31 |
Family
ID=38662682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/016939 WO2008013955A2 (en) | 2006-07-27 | 2007-07-27 | Sustained release formulations for pulmonary delivery |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008013955A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008013938A2 (en) * | 2006-07-27 | 2008-01-31 | Nektar Therapeutics | Aerosolizable formulation comprising insulin for pulmonary delivery |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
US10806770B2 (en) | 2014-10-31 | 2020-10-20 | Monash University | Powder formulation |
TW201630622A (en) | 2014-12-16 | 2016-09-01 | 美國禮來大藥廠 | Rapid-acting insulin compositions |
IL302567A (en) * | 2020-11-09 | 2023-07-01 | Realta Life Sciences Inc | Peptide formulations and methods of use |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030068277A1 (en) * | 1997-09-15 | 2003-04-10 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
WO2005067898A2 (en) * | 2004-01-07 | 2005-07-28 | Nektar Therapeutics | Improved sustained release compositions for pulmonary administration of insulin |
-
2007
- 2007-07-27 WO PCT/US2007/016939 patent/WO2008013955A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030068277A1 (en) * | 1997-09-15 | 2003-04-10 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
WO2005067898A2 (en) * | 2004-01-07 | 2005-07-28 | Nektar Therapeutics | Improved sustained release compositions for pulmonary administration of insulin |
Non-Patent Citations (2)
Title |
---|
MAO SHIRUI ET AL: "Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin.", JOURNAL OF PHARMACEUTICAL SCIENCES MAY 2006, vol. 95, no. 5, May 2006 (2006-05-01), pages 1035 - 1048, XP002501783, ISSN: 0022-3549 * |
SR ELLIOTT: "digital Encyclopedia of Applied Physics. Amorphous materials, structure of", 15 April 2003, WILEY-VHC VERLAG GMBH, XP002501784 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008013955A2 (en) | 2008-01-31 |
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