WO2008012047A1 - Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol - Google Patents
Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol Download PDFInfo
- Publication number
- WO2008012047A1 WO2008012047A1 PCT/EP2007/006515 EP2007006515W WO2008012047A1 WO 2008012047 A1 WO2008012047 A1 WO 2008012047A1 EP 2007006515 W EP2007006515 W EP 2007006515W WO 2008012047 A1 WO2008012047 A1 WO 2008012047A1
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- WO
- WIPO (PCT)
- Prior art keywords
- process according
- ethyl
- acid
- general formula
- tetrahydropyranyl
- Prior art date
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- 0 CC[C@]([C@@](C)CN(C)C)c1cccc(O*)c1 Chemical compound CC[C@]([C@@](C)CN(C)C)c1cccc(O*)c1 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J25/00—Catalysts of the Raney type
- B01J25/02—Raney nickel
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
- C07C225/08—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
- C07C225/10—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms not being part of rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
Claims
Priority Applications (32)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200731545T SI2046724T1 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
BRPI0714558A BRPI0714558B8 (en) | 2006-07-24 | 2007-07-23 | process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
DK07786260.5T DK2046724T3 (en) | 2006-07-24 | 2007-07-23 | Process for Preparation of (1R, 2R) -3- (3-Dimethylamino-1-ethyl-2-methyl-propyl) -phenol |
EP17161440.7A EP3210965B1 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
ES07786260.5T ES2524252T3 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1R, 2R) -3- (3-dimethylamino-1-ethyl-2-methylpropyl) phenol |
PL07786260T PL2046724T3 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
MX2009000667A MX2009000667A (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl -2-methyl-propyl)-phenol. |
EP21163457.1A EP3868739B1 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
JP2009521156A JP5612308B2 (en) | 2006-07-24 | 2007-07-23 | Method for producing (1R, 2R) -3- (3-dimethylamino-1-ethyl-2-methyl-propyl) -phenol |
EP07786260.5A EP2046724B1 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
CA2657104A CA2657104C (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
KR1020097003831A KR101423996B1 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
CN2007800278848A CN101495445B (en) | 2006-07-24 | 2007-07-23 | Process for preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
AU2007278464A AU2007278464C1 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
NZ573911A NZ573911A (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
PL17161440T PL3210965T3 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
US12/374,874 US8877974B2 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropy1)-phenol |
IL196049A IL196049A (en) | 2006-07-24 | 2008-12-18 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
ZA2009/00136A ZA200900136B (en) | 2006-07-24 | 2009-01-07 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
NO20090376A NO341939B1 (en) | 2006-07-24 | 2009-01-26 | Process for Preparation of (1R, 2R) -3- (3-Dimethylamino-1-ethyl-2-methylpropyl) -phenol |
HK09109087.6A HK1130246A1 (en) | 2006-07-24 | 2009-09-30 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol (1r2r)-3-(3--1--2--) |
US14/478,797 US20140378706A1 (en) | 2006-07-24 | 2014-09-05 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
HRP20140891TT HRP20140891T1 (en) | 2006-07-24 | 2014-09-17 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
US15/096,986 US20160221928A1 (en) | 2006-07-24 | 2016-04-12 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
IL249748A IL249748B (en) | 2006-07-24 | 2016-12-25 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
US15/488,888 US20170217875A1 (en) | 2006-07-24 | 2017-04-17 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
IL255201A IL255201B (en) | 2006-07-24 | 2017-10-22 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
NO20171811A NO343951B1 (en) | 2006-07-24 | 2017-11-15 | Process for Preparation of (1R, 2R) -3- (3-Dimethylamino-1-ethyl-2-methyl-propyl) -phenol |
US16/409,910 US20190263747A1 (en) | 2006-07-24 | 2019-05-13 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
US16/896,754 US20200299225A1 (en) | 2006-07-24 | 2020-06-09 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
US17/142,325 US11739049B2 (en) | 2006-07-24 | 2021-01-06 | Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
CY20211101129T CY1124873T1 (en) | 2006-07-24 | 2021-12-22 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06015338.4 | 2006-07-24 | ||
EP06015338 | 2006-07-24 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/374,874 A-371-Of-International US8877974B2 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropy1)-phenol |
US14/478,797 Division US20140378706A1 (en) | 2006-07-24 | 2014-09-05 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008012047A1 true WO2008012047A1 (en) | 2008-01-31 |
Family
ID=37198995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/006515 WO2008012047A1 (en) | 2006-07-24 | 2007-07-23 | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
Country Status (27)
Country | Link |
---|---|
US (7) | US8877974B2 (en) |
EP (4) | EP3868739B1 (en) |
JP (1) | JP5612308B2 (en) |
KR (1) | KR101423996B1 (en) |
CN (1) | CN101495445B (en) |
AU (1) | AU2007278464C1 (en) |
BR (1) | BRPI0714558B8 (en) |
CA (1) | CA2657104C (en) |
CO (1) | CO6160221A2 (en) |
CY (3) | CY1115651T1 (en) |
DK (3) | DK2046724T3 (en) |
ES (4) | ES2629342T3 (en) |
HK (2) | HK1130246A1 (en) |
HR (3) | HRP20211902T1 (en) |
HU (2) | HUE034253T2 (en) |
IL (3) | IL196049A (en) |
LT (2) | LT2368871T (en) |
MX (1) | MX2009000667A (en) |
NO (2) | NO341939B1 (en) |
NZ (1) | NZ573911A (en) |
PL (3) | PL2046724T3 (en) |
PT (3) | PT2368871T (en) |
RU (1) | RU2466124C2 (en) |
SI (3) | SI2046724T1 (en) |
TW (2) | TWI448447B (en) |
WO (1) | WO2008012047A1 (en) |
ZA (1) | ZA200900136B (en) |
Cited By (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20092110A1 (en) * | 2009-12-01 | 2011-06-02 | Archimica Srl | NEW PROCESS FOR THE PREPARATION OF TAPENTADOL AND ITS INTERMEDIATES. |
WO2011080736A1 (en) | 2009-12-29 | 2011-07-07 | Mapi Pharma Hk Limited | Intermediate compounds and processes for the preparation of tapentadol and related compounds |
WO2011107876A2 (en) | 2010-03-05 | 2011-09-09 | Actavis Group Ptc Ehf | Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
WO2011128784A2 (en) | 2010-04-05 | 2011-10-20 | Actavis Group Ptc Ehf | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
EP2383255A1 (en) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
ITMI20100924A1 (en) * | 2010-05-21 | 2011-11-22 | Fidia Farmaceutici | NEW METHOD OF SYNTHESIS OF THE TWO TAPENTADOL ENANTIOMERIC FORMS |
WO2011157390A2 (en) | 2010-06-15 | 2011-12-22 | Grünenthal GmbH | Process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds |
ITMI20101224A1 (en) * | 2010-07-02 | 2012-01-03 | Archimica Srl | NEW PROCESS FOR THE PREPARATION OF TAPENTADOL AND ITS INTERMEDIATES. |
WO2012023147A1 (en) | 2010-08-16 | 2012-02-23 | Indoco Remedies Limited | Process for the preparation of tapentadol |
CZ303115B6 (en) * | 2010-12-30 | 2012-04-11 | Zentiva, K.S. | Process for preparing (2R,3R)-N,N-dimethyl-3-(3-hydroxyphenyl)-2-methylpentylamine |
WO2012089177A1 (en) * | 2010-12-30 | 2012-07-05 | Zentiva, K.S. | Method of producing (2r,3r)-na-dimethyl-3-(3-hydroxyphenyi)-2-methylpentylamine (tapentadol) |
CN102557851A (en) * | 2011-12-13 | 2012-07-11 | 安徽省新星药物开发有限责任公司 | New method for synthesizing tapentadol hydrochloride and analogue of tapentadol hydrochloride |
CN102617501A (en) * | 2011-01-31 | 2012-08-01 | 中国科学院上海药物研究所 | Substituted valeramide compound, preparation method and application thereof |
US8288592B2 (en) | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
WO2012146978A2 (en) | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
CN103159633A (en) * | 2012-07-06 | 2013-06-19 | 江苏恩华药业股份有限公司 | Preparation method of tapentadol hydrochloride and compounds for preparation of tapentadol hydrochloride |
WO2013090161A1 (en) | 2011-12-12 | 2013-06-20 | Boehringer Ingelheim International Gmbh | Stereoselective synthesis of tapentadol and its salts |
WO2013105109A1 (en) | 2011-11-09 | 2013-07-18 | Indoco Remedies Limited | Process for the preparation of tapentadol |
WO2013120466A1 (en) | 2012-02-17 | 2013-08-22 | Zentiva, K.S. | A new solid form of tapentadol and a method of its preparation |
CN103553940A (en) * | 2013-11-07 | 2014-02-05 | 南京艾德凯腾生物医药有限责任公司 | Preparation method of new crystal form tapentadol hydrochloride |
WO2015075678A1 (en) | 2013-11-21 | 2015-05-28 | Unimark Remedies Ltd. | A novel process for the preparation of 1-phenyl-3-aminopropane derivatives |
WO2015091068A1 (en) | 2013-12-16 | 2015-06-25 | Farma Grs, D.O.O. | Crystalline forms of tapentadol intermediate |
WO2015117576A1 (en) | 2014-02-04 | 2015-08-13 | Zentiva, K.S. | A solid form of tapentadol maleate and a method of its preparation |
EP3210965A1 (en) | 2006-07-24 | 2017-08-30 | Grünenthal GmbH | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
WO2019035775A1 (en) | 2017-08-18 | 2019-02-21 | Saneca Pharmaceuticals A.S. | Method for the preparation of tapentadol and its intermediates |
WO2019238267A1 (en) | 2018-06-15 | 2019-12-19 | Pharmathen S.A. | A novel process for the preparation of tapentadol |
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EP3656765B1 (en) | 2010-07-23 | 2021-04-14 | Grünenthal GmbH | Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
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EP4269384A1 (en) | 2022-04-26 | 2023-11-01 | KRKA, d.d., Novo mesto | Method for crystallizing tapentadol intermediate, tapentadol intermediate of high purity, method of making tapentadol and tapentadol of high purity |
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US20100272815A1 (en) * | 2009-04-28 | 2010-10-28 | Actavis Group Ptc Ehf | Amorphous form of tapentadol hydrochloride |
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WO2011080756A1 (en) * | 2009-12-29 | 2011-07-07 | Ind-Swift Laboratories Limited | Process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives |
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EP2545028A4 (en) | 2011-01-27 | 2013-07-03 | Symed Labs Ltd | A novel stereospecific synthesis of (-) (2s,3s)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol |
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