WO2008011073A3 - Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof - Google Patents

Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof Download PDF

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Publication number
WO2008011073A3
WO2008011073A3 PCT/US2007/016312 US2007016312W WO2008011073A3 WO 2008011073 A3 WO2008011073 A3 WO 2008011073A3 US 2007016312 W US2007016312 W US 2007016312W WO 2008011073 A3 WO2008011073 A3 WO 2008011073A3
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WO
WIPO (PCT)
Prior art keywords
analogs
derivatives
androgen receptor
receptor modulators
selective androgen
Prior art date
Application number
PCT/US2007/016312
Other languages
French (fr)
Other versions
WO2008011073A2 (en
Inventor
James T Dalton
Duane D Miller
Igor Rakov
Casey Bohl
Michael L Mohler
Original Assignee
Osurf
Univ Tennessee Res Foundation
James T Dalton
Duane D Miller
Igor Rakov
Casey Bohl
Michael L Mohler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osurf, Univ Tennessee Res Foundation, James T Dalton, Duane D Miller, Igor Rakov, Casey Bohl, Michael L Mohler filed Critical Osurf
Priority to AU2007275737A priority Critical patent/AU2007275737A1/en
Priority to JP2009520822A priority patent/JP2009543872A/en
Priority to CA002658098A priority patent/CA2658098A1/en
Priority to BRPI0713200-0A priority patent/BRPI0713200A2/en
Priority to EP07810587A priority patent/EP2040709A2/en
Priority to EA200900203A priority patent/EA200900203A1/en
Priority to MX2009000714A priority patent/MX2009000714A/en
Publication of WO2008011073A2 publication Critical patent/WO2008011073A2/en
Publication of WO2008011073A3 publication Critical patent/WO2008011073A3/en
Priority to IL196534A priority patent/IL196534A0/en

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    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

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Abstract

This invention provides nuclear hormone receptor binding compounds, compositions comprising the same and methods of uses thereof in treating a variety of diseases or conditions in a subject, including, inter-alia, prostate cancer and/or diseases or disorders of bone and muscle.
PCT/US2007/016312 2006-07-19 2007-07-19 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof WO2008011073A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2007275737A AU2007275737A1 (en) 2006-07-19 2007-07-19 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
JP2009520822A JP2009543872A (en) 2006-07-19 2007-07-19 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
CA002658098A CA2658098A1 (en) 2006-07-19 2007-07-19 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
BRPI0713200-0A BRPI0713200A2 (en) 2006-07-19 2007-07-19 selective androgen receptor modulators, their analogues and derivatives, and their uses
EP07810587A EP2040709A2 (en) 2006-07-19 2007-07-19 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
EA200900203A EA200900203A1 (en) 2006-07-19 2007-07-19 ELECTORAL MODULATORS OF ANDROGENS RECEPTOR, THEIR ANALOGUES, DERIVATIVES AND APPLICATIONS
MX2009000714A MX2009000714A (en) 2006-07-19 2007-07-19 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof.
IL196534A IL196534A0 (en) 2006-07-19 2009-01-15 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83198806P 2006-07-19 2006-07-19
US83188006P 2006-07-19 2006-07-19
US60/831,988 2006-07-19
US60/831,880 2006-07-19

Publications (2)

Publication Number Publication Date
WO2008011073A2 WO2008011073A2 (en) 2008-01-24
WO2008011073A3 true WO2008011073A3 (en) 2008-10-23

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/016312 WO2008011073A2 (en) 2006-07-19 2007-07-19 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
PCT/US2007/016311 WO2008011072A2 (en) 2006-07-19 2007-07-19 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016311 WO2008011072A2 (en) 2006-07-19 2007-07-19 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof

Country Status (12)

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US (2) US8110562B2 (en)
EP (2) EP2041077A2 (en)
JP (2) JP2009543872A (en)
KR (2) KR20090035707A (en)
AR (1) AR063208A1 (en)
AU (2) AU2007275737A1 (en)
BR (2) BRPI0713200A2 (en)
CA (2) CA2658096A1 (en)
EA (2) EA200900203A1 (en)
IL (2) IL196533A0 (en)
MX (2) MX2009000714A (en)
WO (2) WO2008011073A2 (en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2824517A1 (en) * 2005-11-28 2007-05-31 Gtx, Inc. Nuclear receptor binding agents
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8158828B2 (en) * 2005-11-28 2012-04-17 Gtx, Inc. Nuclear receptor binding agents
US8546451B2 (en) * 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8637706B2 (en) 2005-11-28 2014-01-28 Gtx, Inc. Nuclear receptor binding agents
US7550505B2 (en) * 2006-07-24 2009-06-23 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US7834051B2 (en) 2007-08-07 2010-11-16 Takeda Pharmaceutical Company Limited Cyclic amine compounds
AU2008296136A1 (en) 2007-09-07 2009-03-12 Bionovo. Inc. Estrogenic extracts of Scuttelaria barbata D. Don of the Labiatae Family and uses thereof
EP2222323A4 (en) 2007-11-19 2012-07-25 Bionovo Inc A process of making purified extract of scutellaria barbata d. don
EP2260028B1 (en) 2008-02-22 2014-05-07 Radius Health, Inc. Selective androgen receptor modulators
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
US20110105608A1 (en) * 2008-03-21 2011-05-05 Northeastern University Modulators of nuclear receptor co-regulatory protein binding
ITBO20090078A1 (en) * 2009-02-13 2010-08-14 Consiglio Nazionale Ricerche COMPOUNDS FOR TREATING TUMOR TO THE PROSTATE AND PROCEDURES FOR THEIR SYNTHESIS
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
EP2424853B1 (en) * 2009-04-10 2018-09-19 Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori (I.R.S.T.) S.R.L. Non-steroidal compounds for androgen receptor modulation, processes for the preparation and uses thereof
ITBO20090235A1 (en) * 2009-04-10 2010-10-11 Consiglio Nazionale Ricerche COMPOUNDS FOR TREATING TUMOR TO THE PROSTATE AND PROCEDURES FOR THEIR SYNTHESIS
US8450374B2 (en) * 2009-06-29 2013-05-28 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
US8791158B2 (en) * 2010-01-11 2014-07-29 Gtx, Inc. Methods of treating meibomian gland dysfunction
GB201000685D0 (en) 2010-01-15 2010-03-03 Glaxo Group Ltd Novel compounds
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
EP2531029B1 (en) 2010-02-04 2016-10-19 Radius Health, Inc. Selective androgen receptor modulators
AU2011223706A1 (en) * 2010-03-05 2012-09-20 Baylor Research Institute Involvement of androgen/androgen receptor pathway in Fabry disease
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
SI2568806T1 (en) 2010-05-12 2016-09-30 Radius Health, Inc. Therapeutic regimens
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
FI20105806A0 (en) 2010-07-15 2010-07-15 Medeia Therapeutics Ltd New arylamide derivatives with antiandrogenic properties
AU2011312490B2 (en) 2010-09-28 2015-06-25 Radius Pharmaceuticals, Inc. Selective androgen receptor modulators
WO2013104829A1 (en) 2012-01-13 2013-07-18 Medeia Therapeutics Ltd Novel arylamide derivatives having antiandrogenic properties
WO2013104831A1 (en) 2012-01-13 2013-07-18 Medeia Therapeutics Ltd Arylamide derivatives having antiandrogenic properties
EP2802563B1 (en) 2012-01-13 2017-06-07 Aranda Pharma Ltd Novel heteroarylamide derivatives having antiandrogenic properties
ES2668300T3 (en) 2012-05-02 2018-05-17 Boehringer Ingelheim International Gmbh 3-haloamidine substituted SSAO inhibitors and uses thereof
JP6401702B2 (en) 2012-09-07 2018-10-10 ザ・ガバナーズ・オブ・ザ・ユニバーシティー オブ・アルバータ Methods and compositions for diagnosis of inflammatory liver disease
US20140274979A1 (en) * 2013-03-13 2014-09-18 Golden Biotechnology Corporation Method for the treatment of fatty liver disease
WO2015102996A1 (en) * 2013-12-31 2015-07-09 Grasso Frank J Extremely high loading dose
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
SI3122426T1 (en) 2014-03-28 2023-04-28 Duke University Treating breast cancer using selective estrogen receptor modulators
KR101597327B1 (en) 2014-04-24 2016-02-24 동아에스티 주식회사 Oxazolidine-based compound and selective androgen receptor agonists comprising the same
JOP20180072A1 (en) 2014-09-11 2019-01-30 Lilly Co Eli Treatment of androgen deprivation therapy associated symptoms
US10441570B2 (en) 2015-04-21 2019-10-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) Ligands and methods of use thereof
US10865184B2 (en) 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10654809B2 (en) 2016-06-10 2020-05-19 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
MX2017013565A (en) 2015-04-21 2018-02-19 Gtx Inc Selective androgen receptor degrader (sard) ligands and methods of use thereof.
US10035763B2 (en) 2015-04-21 2018-07-31 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10017471B2 (en) 2015-04-21 2018-07-10 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10806720B2 (en) 2015-04-21 2020-10-20 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
KR20170140291A (en) 2015-04-21 2017-12-20 지티엑스, 인코포레이티드 Selective androgen receptor dissociation (SARD) ligands and methods for their use
US9834507B2 (en) 2015-04-21 2017-12-05 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10093613B2 (en) 2015-04-21 2018-10-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US11230523B2 (en) 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
DK3474841T3 (en) 2016-06-22 2022-05-09 Ellipses Pharma Ltd PROCEDURES FOR THE TREATMENT OF AR + BREAST CANCER
US11167007B2 (en) 2016-08-04 2021-11-09 City Of Hope FOXM1 modulators and uses thereof
KR20230109795A (en) 2017-01-05 2023-07-20 래디어스 파마슈티컬스, 인코포레이티드 Polymorphic forms of rad1901-2hcl
WO2019025153A1 (en) 2017-07-31 2019-02-07 Bayer Cropscience Aktiengesellschaft Use of substituted n-sulfonyl-n'-aryl diaminoalkanes and n-sulfonyl-n'-heteroaryl diaminoalkanes or salts thereof for increasing the stress tolerance in plants
US11707449B2 (en) 2017-10-27 2023-07-25 St. Jude Children's Research Hospital, Inc. Methods and formulations for treatment of spinobulbar muscular atrophy
US20200392103A1 (en) 2017-11-23 2020-12-17 Basf Se Herbicidal pyridylethers
BR112020008084B1 (en) 2017-11-23 2023-11-14 Basf Se PHENYL ETHERS, HERBICIDAL COMPOSITION, PROCESS FOR PREPARING ACTIVE COMPOSITIONS, METHOD FOR CONTROLLING UNWANTED VEGETATION AND USE OF PHENYL ETHERS
EP3817821A1 (en) 2018-07-04 2021-05-12 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
WO2023011596A1 (en) * 2021-08-05 2023-02-09 中国药科大学 Amide compound and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2684965A (en) * 1950-08-10 1954-07-27 Abbott Lab Aminoalkylpiperidines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB798410A (en) 1956-01-18 1958-07-23 Bofors Ab N-alkyl-tetrahydroquinaldinic acid amides
US6995284B2 (en) * 2000-08-24 2006-02-07 The University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
ITMI20012060A1 (en) 2001-10-05 2003-04-05 Recordati Chem Pharm NEW N-ACYLATED HETEROCYCLES

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2684965A (en) * 1950-08-10 1954-07-27 Abbott Lab Aminoalkylpiperidines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BEADLE C.D.: "1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, nove ard selective norepinephrine re-uptake inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, no. 20, 2005, pages 4432 - 4437, XP005064624 *

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