WO2008010235A3 - An improved process for the preparation of donepezil - Google Patents

An improved process for the preparation of donepezil Download PDF

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Publication number
WO2008010235A3
WO2008010235A3 PCT/IN2007/000293 IN2007000293W WO2008010235A3 WO 2008010235 A3 WO2008010235 A3 WO 2008010235A3 IN 2007000293 W IN2007000293 W IN 2007000293W WO 2008010235 A3 WO2008010235 A3 WO 2008010235A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
donepezil
preparation
benzyl
mixture
Prior art date
Application number
PCT/IN2007/000293
Other languages
French (fr)
Other versions
WO2008010235A2 (en
Inventor
Attanti V V Srinivasrao
Yadla Venkateshwarlu
Original Assignee
Torrent Pharmaceuticals Ltd
Attanti V V Srinivasrao
Yadla Venkateshwarlu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd, Attanti V V Srinivasrao, Yadla Venkateshwarlu filed Critical Torrent Pharmaceuticals Ltd
Publication of WO2008010235A2 publication Critical patent/WO2008010235A2/en
Publication of WO2008010235A3 publication Critical patent/WO2008010235A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Abstract

An improved, novel and simple industrial process for the preparation of Donepezil of formula (I) and its pharmaceutically acceptable salts manufactured by the condensation of 5,6-dimethoxy indanone of formula (III) with 1-benzyl-4-piperidine carboxaldehyde of formula (IV) to give 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidenyl] methyl piperidine in the presence of base in organic solvents or an aqueous solvent or mixture thereof followed by the reduction carried out using at least one metal borohydride in the presence of catalytic amount of cobalt salts and suitable solvent or mixture thereof.
PCT/IN2007/000293 2006-07-19 2007-07-17 An improved process for the preparation of donepezil WO2008010235A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1655/DEL/2006 2006-07-19
IN1655DE2006 2006-07-19

Publications (2)

Publication Number Publication Date
WO2008010235A2 WO2008010235A2 (en) 2008-01-24
WO2008010235A3 true WO2008010235A3 (en) 2009-04-16

Family

ID=38957204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000293 WO2008010235A2 (en) 2006-07-19 2007-07-17 An improved process for the preparation of donepezil

Country Status (1)

Country Link
WO (1) WO2008010235A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7994328B2 (en) 2006-02-16 2011-08-09 Aurobindo Pharma Ltd. Process for the preparation of donepezil hydrochloride
JP5746965B2 (en) * 2008-03-25 2015-07-08 シプラ・リミテッド Method for producing donepezil hydrochloride
CN101628889B (en) * 2008-07-20 2013-12-25 浙江华海药业股份有限公司 Method for preparing improved donepezil hydrochloride key intermediate
WO2011051957A2 (en) * 2009-10-30 2011-05-05 Neuland Laboratories Ltd. A process for the preparation of donepezil hydrochloride
US20140128613A1 (en) * 2011-03-25 2014-05-08 Piramal Enterprises Limited A process for preparation of intermediates of donepezil hydrochloride
EP2557077B1 (en) * 2011-08-08 2013-10-16 Taiwan Biotech Co., Ltd. Method for making donepezil

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100901A (en) * 1987-06-22 1992-03-31 Eisai Co., Ltd. Cyclic amine compounds and pharmaceutical use
WO1993013095A1 (en) * 1991-12-20 1993-07-08 The Upjohn Company A reduction method for substituted 5-methylene-thiazolidinediones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100901A (en) * 1987-06-22 1992-03-31 Eisai Co., Ltd. Cyclic amine compounds and pharmaceutical use
WO1993013095A1 (en) * 1991-12-20 1993-07-08 The Upjohn Company A reduction method for substituted 5-methylene-thiazolidinediones

Also Published As

Publication number Publication date
WO2008010235A2 (en) 2008-01-24

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