WO2008010231A3 - A process for the purification of topiramate - Google Patents

A process for the purification of topiramate Download PDF

Info

Publication number
WO2008010231A3
WO2008010231A3 PCT/IN2007/000211 IN2007000211W WO2008010231A3 WO 2008010231 A3 WO2008010231 A3 WO 2008010231A3 IN 2007000211 W IN2007000211 W IN 2007000211W WO 2008010231 A3 WO2008010231 A3 WO 2008010231A3
Authority
WO
WIPO (PCT)
Prior art keywords
topiramate
purification
aqueous alkali
alkali solution
solution
Prior art date
Application number
PCT/IN2007/000211
Other languages
French (fr)
Other versions
WO2008010231A2 (en
Inventor
Pandurang Balwant Deshpande
Parven Kumar Luthra
Anand Kumar Pandey
Dinesh Jayantibhai Paghdar
Bhavinkumar Prafulbha Hamirani
Original Assignee
Alembic Ltd
Pandurang Balwant Deshpande
Parven Kumar Luthra
Anand Kumar Pandey
Dinesh Jayantibhai Paghdar
Bhavinkumar Prafulbha Hamirani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Ltd, Pandurang Balwant Deshpande, Parven Kumar Luthra, Anand Kumar Pandey, Dinesh Jayantibhai Paghdar, Bhavinkumar Prafulbha Hamirani filed Critical Alembic Ltd
Publication of WO2008010231A2 publication Critical patent/WO2008010231A2/en
Publication of WO2008010231A3 publication Critical patent/WO2008010231A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides a process for the purification of Topiramate comprising treating Topiramate with aqueous alkali solution followed by washing the aqueous alkali solution of Topiramate with water immiscible solvent and neutralizing this solution to obtain Topiramate having purity at least 99% impurity of formula (II) less than 0.1%.
PCT/IN2007/000211 2006-05-26 2007-05-23 A process for the purification of topiramate WO2008010231A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN810/MUM/2006 2006-05-26
IN810MU2006 2006-05-26

Publications (2)

Publication Number Publication Date
WO2008010231A2 WO2008010231A2 (en) 2008-01-24
WO2008010231A3 true WO2008010231A3 (en) 2008-05-29

Family

ID=38957201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000211 WO2008010231A2 (en) 2006-05-26 2007-05-23 A process for the purification of topiramate

Country Status (1)

Country Link
WO (1) WO2008010231A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
CN106632530A (en) * 2016-12-08 2017-05-10 陕西大生制药科技有限公司 Preparation method of high-purity topiramate
CN110655542A (en) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 Crystal form of 2,3:4, 5-bis-O- (1-methylethylidene) -beta-D-fructopyranose chlorosulfonate
CN113651861A (en) * 2020-05-12 2021-11-16 鲁南制药集团股份有限公司 Topiramate impurity
CN113999228B (en) * 2021-11-08 2022-11-04 南京卓康医药科技有限公司 Synthesis method of tadalafil

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138441A2 (en) * 1983-09-26 1985-04-24 McNeilab, Inc. Anticonvulsant sulfamate derivatives
WO2004078769A1 (en) * 2003-03-04 2004-09-16 Ortho-Mcneil Pharmaceutical Inc. Process for the preparation of anticonvulsant derivatives of topiramate
WO2004108732A1 (en) * 2003-05-12 2004-12-16 Sun Pharmaceutical Industries Limited PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138441A2 (en) * 1983-09-26 1985-04-24 McNeilab, Inc. Anticonvulsant sulfamate derivatives
WO2004078769A1 (en) * 2003-03-04 2004-09-16 Ortho-Mcneil Pharmaceutical Inc. Process for the preparation of anticonvulsant derivatives of topiramate
WO2004108732A1 (en) * 2003-05-12 2004-12-16 Sun Pharmaceutical Industries Limited PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE

Also Published As

Publication number Publication date
WO2008010231A2 (en) 2008-01-24

Similar Documents

Publication Publication Date Title
WO2008010231A3 (en) A process for the purification of topiramate
WO2011048148A3 (en) Glycoside derivative and uses thereof
WO2010078512A4 (en) Production of substituted phenylene aromatic diesters
TN2012000109A1 (en) Glycoside derivatives and uses thereof
WO2010043682A3 (en) Process for the preparation of compounds useful as inhibitors of sglt
NZ594077A (en) Process for production of delta-9-tetrahydrocannabinol
WO2007103105A3 (en) Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
EP2465823A3 (en) Washing system for nitroaromatic compounds
WO2007011951A3 (en) Purification of paricalcitol
WO2009004643A3 (en) An improved process for preparation of (s)-pregabalin and intermediates thereof
WO2009138847A3 (en) An improved process for the preparation of cefozopran
BR0011403A (en) Processes for the purification and preparation of acrylic acid or methacrylic acid
EP2374807A3 (en) An improved process for the isolation of temozolomide
TNSN08030A1 (en) PROCESS FOR THE PREPARATION OF 4B-AMINO-4'-DEMETHYL-4-DESOXYPODOPHYLLOTOXIN
IL195622A0 (en) Process for the purification of montelukast
WO2007108011A3 (en) Process for the preparation of highly pure donepezil
MX2007013872A (en) Process for production of 4-biphenylyazetidin-2-ones.
WO2007039914A3 (en) Novel polymorphs of telithromycin
WO2009056483A3 (en) Process for preparing chlorocyan
WO2007149305A3 (en) Improved oxidation process with enhanced safety useful in the manufacture of moxidectin by means of stabilised 2-iodoxybenzoic acid (sibx)
BRPI0415019A (en) mesotrione purification process
WO2007083243A3 (en) An improved process for the preparation of risedronate sodium hemi-pentahydrate
ITMI20051115A1 (en) PROCEDURE FOR OBTAINING CEFOTETAN WITH HIGH YIELD
MX2010007923A (en) Crystalline form of abacavir that is essentially free of solvent.
WO2009057137A3 (en) A process for the purification of levetiracetam

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07827503

Country of ref document: EP

Kind code of ref document: A2