WO2008009977A3 - Methods and compositions for modulating socs3 - Google Patents

Methods and compositions for modulating socs3 Download PDF

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Publication number
WO2008009977A3
WO2008009977A3 PCT/GB2007/002798 GB2007002798W WO2008009977A3 WO 2008009977 A3 WO2008009977 A3 WO 2008009977A3 GB 2007002798 W GB2007002798 W GB 2007002798W WO 2008009977 A3 WO2008009977 A3 WO 2008009977A3
Authority
WO
WIPO (PCT)
Prior art keywords
socs3
expression
foxp3
activity
modulating
Prior art date
Application number
PCT/GB2007/002798
Other languages
French (fr)
Other versions
WO2008009977A2 (en
Inventor
Susan Marie Metcalfe
Poorni Muthukumarana
Original Assignee
Susan Marie Metcalfe
Poorni Muthukumarana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Susan Marie Metcalfe, Poorni Muthukumarana filed Critical Susan Marie Metcalfe
Publication of WO2008009977A2 publication Critical patent/WO2008009977A2/en
Publication of WO2008009977A3 publication Critical patent/WO2008009977A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The expression of suppressor of cytokine signalling 3 (SOCS3) in mammalian cells is controlled via modulating the expression and/or activity of Foxp3 in the cell. Modulation of Foxp3 homodimer formation or activity allows for control of SOCS3 expression. SOCS3 is an inhibitor of several intracellular signal transduction pathways, including the LIF signalling pathway. Modulators of Foxp3 homodimer activity and/or expression that are able to control the expression of SOCS3 in a cell are useful as immunomodulators.
PCT/GB2007/002798 2006-07-21 2007-07-23 Methods and compositions for modulating socs3 WO2008009977A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0614536A GB0614536D0 (en) 2006-07-21 2006-07-21 Methods of controlling cellular response to LIF
GB0614536.1 2006-07-21

Publications (2)

Publication Number Publication Date
WO2008009977A2 WO2008009977A2 (en) 2008-01-24
WO2008009977A3 true WO2008009977A3 (en) 2008-05-02

Family

ID=36998510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002798 WO2008009977A2 (en) 2006-07-21 2007-07-23 Methods and compositions for modulating socs3

Country Status (2)

Country Link
GB (1) GB0614536D0 (en)
WO (1) WO2008009977A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008154399A1 (en) * 2007-06-08 2008-12-18 The Trustees Of The University Of Pennsylvania Foxp3 oligomerization and intermolecular interactions
WO2013151490A1 (en) * 2012-04-02 2013-10-10 John Andersson Methods and compounds for treating diseases
WO2018080541A1 (en) 2016-10-31 2018-05-03 Seattle Children's Hospital (dba Seattle Children's Research Institute) Method for treating autoimmune disease using cd4 t-cells with engineered stabilization of expression of endogennous foxp3 gene
US11713459B2 (en) 2018-04-27 2023-08-01 Seattle Children's Hospital Expression of FOXP3 in edited CD34+ cells
TW202028222A (en) 2018-11-14 2020-08-01 美商Ionis製藥公司 Modulators of foxp3 expression

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090600A2 (en) * 2001-05-08 2002-11-14 Darwin Molecular Corporation A method for regulating immune function in primates using the foxp3 protein
WO2005074973A2 (en) * 2004-01-29 2005-08-18 Susan Marie Metcalfe Method of inducing or modulating immune response

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090600A2 (en) * 2001-05-08 2002-11-14 Darwin Molecular Corporation A method for regulating immune function in primates using the foxp3 protein
WO2005074973A2 (en) * 2004-01-29 2005-08-18 Susan Marie Metcalfe Method of inducing or modulating immune response

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHAE WOOK-JIN ET AL: "The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 20 JUN 2006, vol. 103, no. 25, 20 June 2006 (2006-06-20), pages 9631 - 9636, XP002457358, ISSN: 0027-8424 *
CHANG XING ET AL: "The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis.", THE JOURNAL OF EXPERIMENTAL MEDICINE 17 OCT 2005, vol. 202, no. 8, 17 October 2005 (2005-10-17), pages 1141 - 1151, XP002457359, ISSN: 0022-1007 *
HEINRICH PETER C ET AL: "Principles of interleukin (IL)-6-type cytokine signalling and its regulation.", THE BIOCHEMICAL JOURNAL 15 AUG 2003, vol. 374, no. Pt 1, 15 August 2003 (2003-08-15), pages 1 - 20, XP002457360, ISSN: 0264-6021 *
METCALFE SU M ET AL: "Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance.", FEBS LETTERS 31 JAN 2005, vol. 579, no. 3, 31 January 2005 (2005-01-31), pages 609 - 614, XP002457362, ISSN: 0014-5793 *
METCALFE SU M ET AL: "Leukemia inhibitory factor is linked to regulatory transplantation tolerance.", TRANSPLANTATION 27 MAR 2005, vol. 79, no. 6, 27 March 2005 (2005-03-27), pages 726 - 730, XP002457361, ISSN: 0041-1337 *
MUTHUKUMARANA POORNI A D S ET AL: "Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance.", INTERNATIONAL IMMUNOPHARMACOLOGY 20 DEC 2006, vol. 6, no. 13-14, 20 December 2006 (2006-12-20), pages 1993 - 2001, XP002457363, ISSN: 1567-5769 *
MUTHUKUMARANA POORNI ET AL: "Regulatory transplantation tolerance and "stemness": evidence that Foxp3 may play a regulatory role in SOCS-3 gene transcription.", TRANSPLANTATION 15 JUL 2007, vol. 84, no. 1 Suppl, 15 July 2007 (2007-07-15), pages S6 - 11, XP008085394, ISSN: 0041-1337 *

Also Published As

Publication number Publication date
WO2008009977A2 (en) 2008-01-24
GB0614536D0 (en) 2006-08-30

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