WO2008009823A3 - Dispositif microfluidique pour la cristallisation et l'analyse cristallographique de molecules - Google Patents

Dispositif microfluidique pour la cristallisation et l'analyse cristallographique de molecules Download PDF

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Publication number
WO2008009823A3
WO2008009823A3 PCT/FR2007/001243 FR2007001243W WO2008009823A3 WO 2008009823 A3 WO2008009823 A3 WO 2008009823A3 FR 2007001243 W FR2007001243 W FR 2007001243W WO 2008009823 A3 WO2008009823 A3 WO 2008009823A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystallization
microfluidic device
chrystallographic
molecules
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2007/001243
Other languages
English (en)
Other versions
WO2008009823A2 (fr
Inventor
Claude Sauter
Bernard Lorber
Richard Giege
Anne Theobald-Dietrich
Chantal Kahn-Malek
Bernard Gauthier-Manuel
Gael Thuillier
Rosaria Ferrigno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Original Assignee
Centre National de la Recherche Scientifique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique filed Critical Centre National de la Recherche Scientifique
Priority to JP2009520013A priority Critical patent/JP2009543573A/ja
Priority to EP07823305A priority patent/EP2040809A2/fr
Priority to CA002658403A priority patent/CA2658403A1/fr
Priority to US12/374,201 priority patent/US20090311666A1/en
Publication of WO2008009823A2 publication Critical patent/WO2008009823A2/fr
Publication of WO2008009823A3 publication Critical patent/WO2008009823A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/06—Crystallising dishes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0077—Screening for crystallisation conditions or for crystal forms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components

Landscapes

  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Thermal Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne un dispositif microfluidique comprenant au moins une chambre de cristallisation susceptible de comprendre une solution dans laquelle au moins un composé est présent selon un gradient de concentration et dans lequel la géométrie de ladite chambre de cristallisation permet de limiter les phénomènes de convection. Elle concerne également l'utilisation dudit dispositif notamment pour la cristallisation par contre- diffusion et un procédé de cristallisation.
PCT/FR2007/001243 2006-07-19 2007-07-19 Dispositif microfluidique pour la cristallisation et l'analyse cristallographique de molecules Ceased WO2008009823A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009520013A JP2009543573A (ja) 2006-07-19 2007-07-19 分子の結晶化および結晶解析用のマイクロ流体デバイス
EP07823305A EP2040809A2 (fr) 2006-07-19 2007-07-19 Dispositif microfluidique pour la cristallisation et l'analyse cristallographique de molecules
CA002658403A CA2658403A1 (fr) 2006-07-19 2007-07-19 Dispositif microfluidique pour la cristallisation et l'analyse cristallographique de molecules
US12/374,201 US20090311666A1 (en) 2006-07-19 2007-07-19 Microfluidic device for crystallization and crystallographic analysis of molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0606583 2006-07-19
FR0606583A FR2903916B1 (fr) 2006-07-19 2006-07-19 Dispositif microfluidique pour la cristallisation et l'analyse cristallographique de molecules

Publications (2)

Publication Number Publication Date
WO2008009823A2 WO2008009823A2 (fr) 2008-01-24
WO2008009823A3 true WO2008009823A3 (fr) 2008-03-27

Family

ID=37909556

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001243 Ceased WO2008009823A2 (fr) 2006-07-19 2007-07-19 Dispositif microfluidique pour la cristallisation et l'analyse cristallographique de molecules

Country Status (6)

Country Link
US (1) US20090311666A1 (fr)
EP (1) EP2040809A2 (fr)
JP (1) JP2009543573A (fr)
CA (1) CA2658403A1 (fr)
FR (1) FR2903916B1 (fr)
WO (1) WO2008009823A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110195515A1 (en) * 2008-06-20 2011-08-11 Universitat Zurich Capillary Plate and Method for Growth and Analysis of Macromolecular Crystals
CN109634062A (zh) * 2018-07-18 2019-04-16 上海应用技术大学 基于整形x射线移动曝光的微台阶加工装置及方法
CN115138402A (zh) * 2021-03-31 2022-10-04 中国科学院深圳先进技术研究院 一种能够设置化学浓度梯度的微流控芯片及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106592A (en) * 1989-12-13 1992-04-21 Dornier Gmbh Manipulating liquids for growing crystals in outer space
WO2002012597A1 (fr) * 2000-07-28 2002-02-14 Consejo Superior De Investigaciones Cientificas Dispositif et procede de croissance de cristaux par contre-diffusion
US20030061687A1 (en) * 2000-06-27 2003-04-03 California Institute Of Technology, A California Corporation High throughput screening of crystallization materials
US20040115731A1 (en) * 2001-04-06 2004-06-17 California Institute Of Technology Microfluidic protein crystallography

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106592A (en) * 1989-12-13 1992-04-21 Dornier Gmbh Manipulating liquids for growing crystals in outer space
US20030061687A1 (en) * 2000-06-27 2003-04-03 California Institute Of Technology, A California Corporation High throughput screening of crystallization materials
WO2002012597A1 (fr) * 2000-07-28 2002-02-14 Consejo Superior De Investigaciones Cientificas Dispositif et procede de croissance de cristaux par contre-diffusion
US20040115731A1 (en) * 2001-04-06 2004-06-17 California Institute Of Technology Microfluidic protein crystallography

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GARCIA-RUIZ, J.M., NOVELLA, M.L., OTALORA, F.: "Supersaturation patterns in counter-diffusion crystallisation methods followed by Mach-Zehnder interferometry", JOUNRAL OF CRYSTAL GROWTH, vol. 196, 1999, pages 703 - 710, XP002429953 *

Also Published As

Publication number Publication date
FR2903916A1 (fr) 2008-01-25
WO2008009823A2 (fr) 2008-01-24
EP2040809A2 (fr) 2009-04-01
FR2903916B1 (fr) 2009-04-03
US20090311666A1 (en) 2009-12-17
JP2009543573A (ja) 2009-12-10
CA2658403A1 (fr) 2008-01-24

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