WO2008008288A3 - Charged oligo(poly(ethylene glycol) fumarate) hydrogels for nerve growth - Google Patents

Charged oligo(poly(ethylene glycol) fumarate) hydrogels for nerve growth Download PDF

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Publication number
WO2008008288A3
WO2008008288A3 PCT/US2007/015612 US2007015612W WO2008008288A3 WO 2008008288 A3 WO2008008288 A3 WO 2008008288A3 US 2007015612 W US2007015612 W US 2007015612W WO 2008008288 A3 WO2008008288 A3 WO 2008008288A3
Authority
WO
WIPO (PCT)
Prior art keywords
charged
reactant
fumarate
poly
ethylene glycol
Prior art date
Application number
PCT/US2007/015612
Other languages
French (fr)
Other versions
WO2008008288A2 (en
Inventor
Mahrokh Dadsentan
Michael J Yaszemski
Lichun Lu
Original Assignee
Mayo Foundation
Mahrokh Dadsentan
Michael J Yaszemski
Lichun Lu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation, Mahrokh Dadsentan, Michael J Yaszemski, Lichun Lu filed Critical Mayo Foundation
Publication of WO2008008288A2 publication Critical patent/WO2008008288A2/en
Publication of WO2008008288A3 publication Critical patent/WO2008008288A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction

Abstract

A biodegradable material for improving the regeneration of nerve cells is disclosed. The material includes a copolymer formed by reacting a first reactant selected from monomers, oligomers and polymers and a second charged reactant selected from charged monomers, charged oligomers and charged polymers. Nerve cells are contained within or attracted to the copolymer. The first reactant can be oligo(poly( ethylene glycol) fumarate). The charged reactant can be selected from unsaturated quaternary ammonium compounds. The material can include a photoinitiator such that the material is photocrosslinkable. The material can include a bioactive agent such as a nerve growth factor. In one form, the material is a hydrogel that can be injected as a fluid into a patient's body via minimally invasive arthroscopic techniques to form a scaffold for nerve tissue regeneration.
PCT/US2007/015612 2006-07-11 2007-07-06 Charged oligo(poly(ethylene glycol) fumarate) hydrogels for nerve growth WO2008008288A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81984606P 2006-07-11 2006-07-11
US60/819,846 2006-07-11

Publications (2)

Publication Number Publication Date
WO2008008288A2 WO2008008288A2 (en) 2008-01-17
WO2008008288A3 true WO2008008288A3 (en) 2008-11-20

Family

ID=38923808

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/015612 WO2008008288A2 (en) 2006-07-11 2007-07-06 Charged oligo(poly(ethylene glycol) fumarate) hydrogels for nerve growth

Country Status (1)

Country Link
WO (1) WO2008008288A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063878A2 (en) * 2006-11-06 2008-05-29 Bonwrx, Inc. Nerve regeneration device
US9050252B2 (en) 2010-05-25 2015-06-09 3M Innovative Properties Company Method of surface treating inorganic oxide particles, hardenable dental compositions, surface treated particles, and surface treatment compounds
ES2634244T3 (en) 2010-10-27 2017-09-27 3M Innovative Properties Company Dental compositions comprising semi-crystalline resin and nano-aggregate filler
US11129693B2 (en) 2016-09-06 2021-09-28 3M Innovative Properties Company Methods of improving dental restoration margins and articles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840338A (en) * 1994-07-18 1998-11-24 Roos; Eric J. Loading of biologically active solutes into polymer gels

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840338A (en) * 1994-07-18 1998-11-24 Roos; Eric J. Loading of biologically active solutes into polymer gels

Also Published As

Publication number Publication date
WO2008008288A2 (en) 2008-01-17

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