WO2008005845A3 - Mitigation of sample-introduction decompression effects in high-pressure liquid chromatography - Google Patents

Mitigation of sample-introduction decompression effects in high-pressure liquid chromatography Download PDF

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Publication number
WO2008005845A3
WO2008005845A3 PCT/US2007/072498 US2007072498W WO2008005845A3 WO 2008005845 A3 WO2008005845 A3 WO 2008005845A3 US 2007072498 W US2007072498 W US 2007072498W WO 2008005845 A3 WO2008005845 A3 WO 2008005845A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
mitigation
introduction
valve unit
liquid chromatography
Prior art date
Application number
PCT/US2007/072498
Other languages
French (fr)
Other versions
WO2008005845A2 (en
Inventor
James E Usowicz
Peyton C Beals
Miguel Soares
Original Assignee
Waters Investments Ltd
James E Usowicz
Peyton C Beals
Miguel Soares
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waters Investments Ltd, James E Usowicz, Peyton C Beals, Miguel Soares filed Critical Waters Investments Ltd
Priority to JP2009518573A priority Critical patent/JP2009543068A/en
Priority to EP07812485A priority patent/EP2035788A2/en
Publication of WO2008005845A2 publication Critical patent/WO2008005845A2/en
Publication of WO2008005845A3 publication Critical patent/WO2008005845A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/202—Injection using a sampling valve rotary valves

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

A method for processing a fluid is applied to systems that include a valve unit that has a sample-loading state and a sample-injecting state. The sample-loading state disposes a sample loop in fluidic communication with a sample conduit. The sample-injecting state disposes the sample loop in fluidic communication with a process conduit. The method involves transferring a sample through both the sample conduit and the valve unit so that a leading end of the sample exits the valve unit. After transitioning the valve unit to the sample-loading state and allowing the sample loop to decompress, at least some of the transferred sample is loaded into the sample loop. A fluid-processing instrument includes a value unit and a control unit that manages operation of the instrument. The control unit is configured, for example, to implement the above-described method.
PCT/US2007/072498 2006-06-30 2007-06-29 Mitigation of sample-introduction decompression effects in high-pressure liquid chromatography WO2008005845A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009518573A JP2009543068A (en) 2006-06-30 2007-06-29 Reduction of pressure reduction during sample introduction in high pressure liquid chromatography
EP07812485A EP2035788A2 (en) 2006-06-30 2007-06-29 Mitigation of sample-introduction decompression effects in high-pressure liquid chromatography

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81799006P 2006-06-30 2006-06-30
US60/817,990 2006-06-30

Publications (2)

Publication Number Publication Date
WO2008005845A2 WO2008005845A2 (en) 2008-01-10
WO2008005845A3 true WO2008005845A3 (en) 2008-07-31

Family

ID=38895362

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/072498 WO2008005845A2 (en) 2006-06-30 2007-06-29 Mitigation of sample-introduction decompression effects in high-pressure liquid chromatography

Country Status (3)

Country Link
EP (1) EP2035788A2 (en)
JP (1) JP2009543068A (en)
WO (1) WO2008005845A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008006266B4 (en) 2008-01-25 2011-06-09 Dionex Softron Gmbh Sampler for liquid chromatography, in particular for high performance liquid chromatography
EP2196801B1 (en) 2008-12-11 2017-08-23 Spark Holland B.V. Method and apparatus for injecting a liquid sample in an HPLC analyzing device, and valve assembly for use therein.
CN102460145B (en) 2009-06-03 2015-04-29 安捷伦科技有限公司 Sample injector with metering device balancing pressure differences in an intermediate valve state
JP5471846B2 (en) * 2010-05-31 2014-04-16 株式会社島津製作所 Liquid sample introduction apparatus and liquid sample introduction method
DE202016100451U1 (en) 2015-06-25 2016-02-16 Dionex Softron Gmbh Sampler for liquid chromatography, in particular for high performance liquid chromatography
EP3617701B1 (en) 2018-08-27 2024-10-23 F. Hoffmann-La Roche AG Sample injector with sample loop and buffer loop

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957009A (en) * 1988-09-23 1990-09-18 Spectra-Physics, Inc. Pushloop liquid sampling method
US5010921A (en) * 1989-07-17 1991-04-30 Spectra-Physics, Inc. Nonsymmetrical valve

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957009A (en) * 1988-09-23 1990-09-18 Spectra-Physics, Inc. Pushloop liquid sampling method
US5010921A (en) * 1989-07-17 1991-04-30 Spectra-Physics, Inc. Nonsymmetrical valve

Also Published As

Publication number Publication date
JP2009543068A (en) 2009-12-03
WO2008005845A2 (en) 2008-01-10
EP2035788A2 (en) 2009-03-18

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