WO2008004028A3 - Systems and methods for radioisotope generation - Google Patents

Systems and methods for radioisotope generation Download PDF

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Publication number
WO2008004028A3
WO2008004028A3 PCT/IB2006/004294 IB2006004294W WO2008004028A3 WO 2008004028 A3 WO2008004028 A3 WO 2008004028A3 IB 2006004294 W IB2006004294 W IB 2006004294W WO 2008004028 A3 WO2008004028 A3 WO 2008004028A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
methods
fluid communication
column
exit port
Prior art date
Application number
PCT/IB2006/004294
Other languages
French (fr)
Other versions
WO2008004028A2 (en
Inventor
Daniel Tartaglia
Carlo Coppola
Vince Teoli
Alain Guy Bournival
Original Assignee
Draxis Specialty Pharmaceutica
Daniel Tartaglia
Carlo Coppola
Vince Teoli
Alain Guy Bournival
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Draxis Specialty Pharmaceutica, Daniel Tartaglia, Carlo Coppola, Vince Teoli, Alain Guy Bournival filed Critical Draxis Specialty Pharmaceutica
Priority to CA2631712A priority Critical patent/CA2631712C/en
Priority to AU2006345883A priority patent/AU2006345883A1/en
Priority to EP06851254A priority patent/EP2011126B1/en
Publication of WO2008004028A2 publication Critical patent/WO2008004028A2/en
Publication of WO2008004028A3 publication Critical patent/WO2008004028A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/283—Porous sorbents based on silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/284—Porous sorbents based on alumina
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems

Abstract

Systems and methods are disclosed for producing customized, predictable. and reproducible supplies of radioisotopes using, for example, a reactor housing that is fabricated from a radioactive shielding material and has both an internal volume and a surface that comprises an entry port and an exit port, a chromatographic column that is positioned within said internal volume such that a first end of said column is in fluid communication with said entry port and a second end of said column is in fluid communication with said exit port, and a changeable filter module that is disposed external to said reactor housing and in fluid communication with said exit port.
PCT/IB2006/004294 2006-01-12 2006-12-16 Systems and methods for radioisotope generation WO2008004028A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2631712A CA2631712C (en) 2006-01-12 2006-12-16 Systems and methods for radioisotope generation
AU2006345883A AU2006345883A1 (en) 2006-01-12 2006-12-16 Systems and methods for radioisotope generation
EP06851254A EP2011126B1 (en) 2006-01-12 2006-12-16 Systems and methods for radioisotope generation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75841906P 2006-01-12 2006-01-12
US60/758,419 2006-01-12
US11/610,574 2006-12-14
US11/610,574 US20070158271A1 (en) 2006-01-12 2006-12-14 Systems and Methods for Radioisotope Generation

Publications (2)

Publication Number Publication Date
WO2008004028A2 WO2008004028A2 (en) 2008-01-10
WO2008004028A3 true WO2008004028A3 (en) 2008-07-24

Family

ID=38231739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/004294 WO2008004028A2 (en) 2006-01-12 2006-12-16 Systems and methods for radioisotope generation

Country Status (5)

Country Link
US (1) US20070158271A1 (en)
EP (2) EP2011126B1 (en)
AU (1) AU2006345883A1 (en)
CA (1) CA2631712C (en)
WO (1) WO2008004028A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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US7700926B2 (en) * 2006-01-12 2010-04-20 Draximage General Partnership Systems and methods for radioisotope generation
US9597053B2 (en) 2008-06-11 2017-03-21 Bracco Diagnostics Inc. Infusion systems including computer-facilitated maintenance and/or operation and methods of use
US7862534B2 (en) 2008-06-11 2011-01-04 Bracco Diagnostics Inc. Infusion circuit subassemblies
US9607722B2 (en) 2008-06-11 2017-03-28 Bracco Diagnostics Inc. Infusion systems including computer-facilitated maintenance and/or operation and methods of use
US8708352B2 (en) 2008-06-11 2014-04-29 Bracco Diagnostics Inc. Cabinet structure configurations for infusion systems
US8317674B2 (en) 2008-06-11 2012-11-27 Bracco Diagnostics Inc. Shielding assemblies for infusion systems
JP5300679B2 (en) 2009-09-30 2013-09-25 住友ゴム工業株式会社 Polymer composition for inner liner and pneumatic tire using the same
EP3117240A1 (en) 2014-03-13 2017-01-18 Bracco Diagnostics Inc. Real time nuclear isotope detection
CA2973636C (en) 2015-01-29 2024-03-26 Areva Gmbh Irradiation target for radioisotope production, method for preparing and use of the irradiation target
CN105845188B (en) * 2016-03-24 2017-11-17 浙江大学 A kind of method of adsorbing separation strontium
EP3516664B1 (en) 2016-09-20 2020-11-04 Bracco Diagnostics Inc. Systems and techniques for generating, infusing, and controlling radioisotope delivery
US20180209921A1 (en) * 2017-01-20 2018-07-26 Mallinckrodt Nuclear Medicine Llc Systems and methods for assaying an eluate of a radionuclide generator
EP3776599B1 (en) 2018-03-28 2023-09-13 Bracco Diagnostics Inc. Early detection of radioisotope generator end life
CN110917658B (en) * 2019-10-28 2021-04-06 清华大学 Automatic strontium-90 discharging and separating device

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CA1093223A (en) * 1977-06-20 1981-01-06 Alfred K. Thornton Rechargeable su99 xxmo/ su99m xxtc generator system
US4280053A (en) * 1977-06-10 1981-07-21 Australian Atomic Energy Commission Technetium-99m generators
US4286169A (en) * 1978-10-20 1981-08-25 Byk-Mallinckrodt Cil B.V. Screening device for a generator producing radio-isotopes
US4782231A (en) * 1984-05-18 1988-11-01 Ustav Jaderneho Vyzkumu Standard component 99m Tc elution generator and method
US6998052B2 (en) * 2002-04-12 2006-02-14 Pg Research Foundation Multicolumn selectivity inversion generator for production of ultrapure radionuclides

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US3774035A (en) * 1971-07-12 1973-11-20 New England Nuclear Corp Method and system for generating and collecting a radionuclide eluate
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GB2386743B (en) * 2002-04-11 2004-02-11 Amersham Plc Radioisotope generator
GB2382453B (en) * 2002-04-11 2004-05-19 Amersham Plc Radioisotope generator and method of construction thereof
US7087206B2 (en) * 2002-04-12 2006-08-08 Pg Research Foundation Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
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US7700926B2 (en) * 2006-01-12 2010-04-20 Draximage General Partnership Systems and methods for radioisotope generation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576998A (en) * 1966-11-16 1971-05-04 Nen Picker Radiopharmaceutical Self-contained, closed system and method for generating and collecting a short-lived daughter radionuclide from a long-lived parent radionuclide
US4280053A (en) * 1977-06-10 1981-07-21 Australian Atomic Energy Commission Technetium-99m generators
CA1093223A (en) * 1977-06-20 1981-01-06 Alfred K. Thornton Rechargeable su99 xxmo/ su99m xxtc generator system
US4286169A (en) * 1978-10-20 1981-08-25 Byk-Mallinckrodt Cil B.V. Screening device for a generator producing radio-isotopes
US4782231A (en) * 1984-05-18 1988-11-01 Ustav Jaderneho Vyzkumu Standard component 99m Tc elution generator and method
US6998052B2 (en) * 2002-04-12 2006-02-14 Pg Research Foundation Multicolumn selectivity inversion generator for production of ultrapure radionuclides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2011126A4 *

Also Published As

Publication number Publication date
CA2631712A1 (en) 2008-01-10
EP2492920A3 (en) 2012-12-12
WO2008004028A2 (en) 2008-01-10
EP2492920A2 (en) 2012-08-29
AU2006345883A1 (en) 2008-01-10
CA2631712C (en) 2014-04-29
EP2011126A4 (en) 2010-03-03
US20070158271A1 (en) 2007-07-12
EP2011126B1 (en) 2012-05-23
EP2011126A2 (en) 2009-01-07

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