WO2008002319A3 - Compositions and methods for inhibition of retroviral infection - Google Patents

Compositions and methods for inhibition of retroviral infection Download PDF

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Publication number
WO2008002319A3
WO2008002319A3 PCT/US2006/038626 US2006038626W WO2008002319A3 WO 2008002319 A3 WO2008002319 A3 WO 2008002319A3 US 2006038626 W US2006038626 W US 2006038626W WO 2008002319 A3 WO2008002319 A3 WO 2008002319A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
retroviral
inhibition
compositions
retroviral infection
Prior art date
Application number
PCT/US2006/038626
Other languages
French (fr)
Other versions
WO2008002319A2 (en
Inventor
Robert A Weldon
Original Assignee
Univ Nebraska
Robert A Weldon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nebraska, Robert A Weldon filed Critical Univ Nebraska
Publication of WO2008002319A2 publication Critical patent/WO2008002319A2/en
Publication of WO2008002319A3 publication Critical patent/WO2008002319A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed are a method for identifying a compound for inhibiting retrovirus infectivity by selectively inhibiting or disrupting the interaction between a retroviral Gag protein and a Ubc9 protein, a therapeutic compound that selectively inhibits or disrupts the interaction between a retroviral Gag protein and a Ubc9 protein, a method to inhibit retroviral infectivity in a patient, a retroviral vaccine, and methods of use thereof.
PCT/US2006/038626 2005-09-30 2006-10-02 Compositions and methods for inhibition of retroviral infection WO2008002319A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72269305P 2005-09-30 2005-09-30
US60/722,693 2005-09-30

Publications (2)

Publication Number Publication Date
WO2008002319A2 WO2008002319A2 (en) 2008-01-03
WO2008002319A3 true WO2008002319A3 (en) 2008-07-24

Family

ID=38846138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/038626 WO2008002319A2 (en) 2005-09-30 2006-10-02 Compositions and methods for inhibition of retroviral infection

Country Status (1)

Country Link
WO (1) WO2008002319A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12059413B2 (en) 2016-11-02 2024-08-13 The Research Foundation For The State University Of New York Methods of inhibiting viruses using compositions targeting TSG101-ubiquitin interaction

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GURER C. ET AL.: "Covalent Modification of Human Immunodeficiency Virus Type 1 p6 by SUMO-1", JOURNAL OF VIROLOGY, vol. 79, no. 2, January 2005 (2005-01-01), pages 910 - 917 *
WELDON R.A. ET AL.: "Mason-Pfizer monkey virus Gag proteins interact with the human sumo conjugating enzyme", HUBC9, VIROLOGY, vol. 314, 2003, pages 62 - 73 *

Also Published As

Publication number Publication date
WO2008002319A2 (en) 2008-01-03

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