WO2008001360A3 - Compositions and methods for treating and preventing gastro esophageal reflux disease - Google Patents

Compositions and methods for treating and preventing gastro esophageal reflux disease Download PDF

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Publication number
WO2008001360A3
WO2008001360A3 PCT/IL2007/000773 IL2007000773W WO2008001360A3 WO 2008001360 A3 WO2008001360 A3 WO 2008001360A3 IL 2007000773 W IL2007000773 W IL 2007000773W WO 2008001360 A3 WO2008001360 A3 WO 2008001360A3
Authority
WO
WIPO (PCT)
Prior art keywords
gerd
compositions
treating
reflux disease
esophageal reflux
Prior art date
Application number
PCT/IL2007/000773
Other languages
French (fr)
Other versions
WO2008001360A2 (en
Inventor
Said Omar
Khalil Khaled
Uyad Khamaysi
Original Assignee
Lycored Ltd
Said Omar
Khalil Khaled
Uyad Khamaysi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lycored Ltd, Said Omar, Khalil Khaled, Uyad Khamaysi filed Critical Lycored Ltd
Priority to EP07766804A priority Critical patent/EP2043669A4/en
Priority to CA002656220A priority patent/CA2656220A1/en
Publication of WO2008001360A2 publication Critical patent/WO2008001360A2/en
Publication of WO2008001360A3 publication Critical patent/WO2008001360A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to methods and compositions effective in treating, preventing, reducing the severity of, or relieving the symptoms of, Gastro Esophageal Reflux Disease (GERD). The compositions comprise, as an active ingredient, an extract from the plant genus Conyza Less, preferably from the species Conyza bonariensis (L) Cronq. The composition comprises only natural ingredients and has been demonstrated to be safe for use, while still providing a beneficial therapeutic effect. The composition can also be administered in combination with traditional anti-GERD medicines, either over-the-counter or prescription medicines such as antacids, H2-receptor agonists, proton pump inhibitors, promotility agents and Sucralfate. The compositions are particularly effective in treating and preventing GERD, the symptoms or GERD and conditions associated with GERD, including heartburn, regurgitation, esophagitis, Non-Erosive Esophageal Reflux Disease (NERD), Barrett's Esophagus, and any combination thereof.
PCT/IL2007/000773 2006-06-28 2007-06-26 Compositions and methods for treating and preventing gastro esophageal reflux disease WO2008001360A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07766804A EP2043669A4 (en) 2006-06-28 2007-06-26 Compositions and methods for treating and preventing gastro esophageal reflux disease
CA002656220A CA2656220A1 (en) 2006-06-28 2007-06-26 Compositions and methods for treating and preventing gastro esophageal reflux disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL176608 2006-06-28
IL176608A IL176608A0 (en) 2006-06-28 2006-06-28 Compositions and methods for treating and preventing gastro esophageal reflux disease

Publications (2)

Publication Number Publication Date
WO2008001360A2 WO2008001360A2 (en) 2008-01-03
WO2008001360A3 true WO2008001360A3 (en) 2009-04-30

Family

ID=38846091

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/000773 WO2008001360A2 (en) 2006-06-28 2007-06-26 Compositions and methods for treating and preventing gastro esophageal reflux disease

Country Status (4)

Country Link
EP (1) EP2043669A4 (en)
CA (1) CA2656220A1 (en)
IL (1) IL176608A0 (en)
WO (1) WO2008001360A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108578654A (en) * 2018-05-22 2018-09-28 中国中医科学院西苑医院 A kind of Chinese medicine composition and preparation method thereof for treating Non-erosive reflux disease

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201700090582A1 (en) * 2017-08-04 2019-02-04 Neilos S R L Composition for use in the prevention and / or treatment of gastric or gastroesophageal disorders.
CN110353271B (en) * 2019-06-13 2022-07-22 陕西科技大学 Special medical food thickening component for inhibiting esophagus reflux and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101032333A (en) * 2007-04-11 2007-09-12 朱西杰 Herbal meal of gastrointestinal sustained release particle for protecting gastrointestinal mucosa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1340356A (en) * 2000-08-28 2002-03-20 黄兴 Chinese medicine for treating enterogastric disease
FR2843125B1 (en) * 2002-08-02 2012-11-16 Coletica ACTIVE PRINCIPLES STIMULATING HUMAN BETA-DEFENSIVE TYPE 2 AND / OR TYPE 3, AND COSMETIC OR PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101032333A (en) * 2007-04-11 2007-09-12 朱西杰 Herbal meal of gastrointestinal sustained release particle for protecting gastrointestinal mucosa

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KONG, L. D. ET AL.: "Glycosides and Xanthine Oxidase Inhibitors from Conyza bonariensis", vol. 58, no. 4, October 2001 (2001-10-01), pages 645 - 651, XP004306136 *
SOUZA, M.C. ET AL.: "Evaluation of Anti-Inflammatory Activity of Essential Oils from two Asteraceae Species.", PHARMAZIE., vol. 58, no. 8, August 2003 (2003-08-01), pages 582 - 586, XP001537158 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108578654A (en) * 2018-05-22 2018-09-28 中国中医科学院西苑医院 A kind of Chinese medicine composition and preparation method thereof for treating Non-erosive reflux disease
CN108578654B (en) * 2018-05-22 2021-11-12 中国中医科学院西苑医院 Traditional Chinese medicine composition for treating non-erosive reflux disease and preparation method thereof

Also Published As

Publication number Publication date
WO2008001360A2 (en) 2008-01-03
EP2043669A4 (en) 2011-06-22
EP2043669A2 (en) 2009-04-08
CA2656220A1 (en) 2008-01-03
IL176608A0 (en) 2006-10-31

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