WO2007149548A3 - Treatment of erectile dysfunction by stem cell therapy - Google Patents

Treatment of erectile dysfunction by stem cell therapy Download PDF

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Publication number
WO2007149548A3
WO2007149548A3 PCT/US2007/014525 US2007014525W WO2007149548A3 WO 2007149548 A3 WO2007149548 A3 WO 2007149548A3 US 2007014525 W US2007014525 W US 2007014525W WO 2007149548 A3 WO2007149548 A3 WO 2007149548A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
erectile dysfunction
cell therapy
stem cell
stem cells
Prior art date
Application number
PCT/US2007/014525
Other languages
French (fr)
Other versions
WO2007149548A2 (en
Inventor
Thomas E Ichim
Original Assignee
Medistem Lab Inc
Thomas E Ichim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medistem Lab Inc, Thomas E Ichim filed Critical Medistem Lab Inc
Priority to US12/305,589 priority Critical patent/US8372797B2/en
Publication of WO2007149548A2 publication Critical patent/WO2007149548A2/en
Publication of WO2007149548A3 publication Critical patent/WO2007149548A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Abstract

Methods, cells and compositions of matter are provided for treatment of erectile dysfunction using stem cell therapy. In particular, various stem cells are modified or administered freshly isolated in order to induce smooth muscle regeneration, neural regeneration, and restoration of endothelial function. In some embodiments endogenous stem cells are mobilized or activated to achieve therapeutic benefit. In other embodiments compositions derived from stem cells are utilized for treatment of erectile dysfunction.
PCT/US2007/014525 2006-06-22 2007-06-22 Treatment of erectile dysfunction by stem cell therapy WO2007149548A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/305,589 US8372797B2 (en) 2006-06-22 2007-06-22 Treatment of erectile dysfunction by stem cell therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81617006P 2006-06-22 2006-06-22
US60/816,170 2006-06-22

Publications (2)

Publication Number Publication Date
WO2007149548A2 WO2007149548A2 (en) 2007-12-27
WO2007149548A3 true WO2007149548A3 (en) 2008-12-24

Family

ID=38740372

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/014525 WO2007149548A2 (en) 2006-06-22 2007-06-22 Treatment of erectile dysfunction by stem cell therapy

Country Status (2)

Country Link
US (1) US8372797B2 (en)
WO (1) WO2007149548A2 (en)

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US8440617B2 (en) * 2007-03-22 2013-05-14 The Trustees Of The University Of Pennsylvania Hyperbaric treatment in wound healing
US11224635B2 (en) 2007-03-27 2022-01-18 Venturis Thereuptics, Inc. Therapeutic angiogenesis for treatment of the spine and other tissues
US8983570B2 (en) 2007-03-27 2015-03-17 Cardiovascular Biotherapeutics, Inc. Therapeutic angiogenesis for treatment of the spine
ATE548080T1 (en) * 2007-06-13 2012-03-15 Univ Wake Forest Health Sciences METHOD FOR RESTORING ERECTILE FUNCTION
WO2010000011A1 (en) * 2008-07-04 2010-01-07 The Heart Research Institute Ltd The use of androgens for vascular regeneration and endothelial repair
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CN102176919A (en) 2008-08-22 2011-09-07 人类起源公司 Methods and compositions for treatment of bone defects with placental cell populations
GB0818725D0 (en) * 2008-10-13 2008-11-19 Habib Nagy A Pharmaceutical composition
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WO2011043147A1 (en) * 2009-10-06 2011-04-14 国立大学法人名古屋大学 Cell preparation for erectile dysfunction or urinary incontinence containing adipose tissue derived mesenchymal stem cells
US8727965B2 (en) * 2010-03-05 2014-05-20 Tissue Genesis, Inc. Methods and compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells
KR20130092394A (en) 2010-04-08 2013-08-20 안트로제네시스 코포레이션 Treatment of sarcoidosis using placental stem cells
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US20120093764A1 (en) * 2010-10-19 2012-04-19 Dipnarine Maharaj Treatment of diabetes using g-csf and hyperbaric oxygen
AR093183A1 (en) 2010-12-31 2015-05-27 Anthrogenesis Corp INCREASE IN THE POWER OF PLACENTA MOTHER CELLS USING MODULATING RNA MOLECULES
EP2526961A1 (en) * 2011-05-26 2012-11-28 Mario Sargentini Treating or ameliorating some neuroendocrine disorders in male with help of prolactin
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US10751374B2 (en) 2012-01-30 2020-08-25 Michael P. Zahalsky Methods and compositions for treatment of penile defects
US20180028575A1 (en) * 2012-01-30 2018-02-01 Michael Zahalsky Methods and compositions for treatment of penile defects
WO2016127153A1 (en) * 2015-02-06 2016-08-11 Zahalsky Michael Methods and compositions for treatment of penile defects
KR20150009528A (en) * 2012-03-28 2015-01-26 가부시키가이샤 쿠오리맨 Immortalized stem cells and medicinal composition and medicinal preparation comprising product thereof as active ingredient
RU2514639C1 (en) * 2012-12-13 2014-04-27 Михаил Евгеньевич Чалый Method of treating erectile dysfunction
CN103861087B (en) * 2012-12-14 2016-04-20 广州暨南大学医药生物技术研究开发中心 Nerve growth factor is for the preparation of the purposes in treatment middle-aging male sexual disorder syndromic medicine
CA2906654A1 (en) * 2013-03-15 2014-09-18 Cardiovascular Biotherapeutics, Inc. Angiogenic compositions for wounds, articular joints and graft materials
US9795639B1 (en) 2013-03-16 2017-10-24 BioDlogics, LLC Methods for the treatment of erectile dysfunction by human birth tissue material compostion
KR101516763B1 (en) * 2014-01-07 2015-05-04 주식회사 강스템바이오텍 Pharmaceutical composition comprising stem cells treated with DNA methyltransferase or culture thereof for prevention and treatment of immune diseases and inflammatory diseases
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Also Published As

Publication number Publication date
WO2007149548A2 (en) 2007-12-27
US8372797B2 (en) 2013-02-12
US20090311223A1 (en) 2009-12-17

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