WO2007147397A3 - PROCESS FOR PREPARING N-ACYL-α-AMINO NITRILES - Google Patents

PROCESS FOR PREPARING N-ACYL-α-AMINO NITRILES Download PDF

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Publication number
WO2007147397A3
WO2007147397A3 PCT/DE2007/001088 DE2007001088W WO2007147397A3 WO 2007147397 A3 WO2007147397 A3 WO 2007147397A3 DE 2007001088 W DE2007001088 W DE 2007001088W WO 2007147397 A3 WO2007147397 A3 WO 2007147397A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkenyl
aryl
formula
alkyl
alkynyl group
Prior art date
Application number
PCT/DE2007/001088
Other languages
German (de)
French (fr)
Other versions
WO2007147397A2 (en
Inventor
Benjamin List
Subhas Chandra Pan
Original Assignee
Studiengesellschaft Kohle Mbh
Benjamin List
Subhas Chandra Pan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Studiengesellschaft Kohle Mbh, Benjamin List, Subhas Chandra Pan filed Critical Studiengesellschaft Kohle Mbh
Publication of WO2007147397A2 publication Critical patent/WO2007147397A2/en
Publication of WO2007147397A3 publication Critical patent/WO2007147397A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A process for preparing N-acyl-α-amino nitriles having the formula (I), where R1, R2 and R3 are each, independently of one another, hydrogen or an alkyl, aryl, alkenyl or alkynyl group which may optionally be substituted, R4 is hydrogen or an alkyl, aryl, alkenyl or alkynyl group which may optionally be substituted, in which an imine having the formula (Il) or compounds which form the imine having the formula (Il) in situ, where R1, R2 and R3 are as defined above, is reacted in the presence of a catalyst with a nitrile compound of the formula (III), where R4 is an alkyl, aryl, alkenyl or alkynyl group which may optionally be substituted or is -OR5, -SR6 or -NR7R8, where R5, R6, R7 and R8 are each, independently of one another, hydrogen or an optionally substituted alkyl, aryl, alkenyl or alkynyl group, is claimed. The nitriles obtained can be converted in a manner known per se into the corresponding amino acids.
PCT/DE2007/001088 2006-06-21 2007-06-18 PROCESS FOR PREPARING N-ACYL-α-AMINO NITRILES WO2007147397A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200610028451 DE102006028451A1 (en) 2006-06-21 2006-06-21 Process for the preparation of N-acyl-α-aminonitriles
DE102006028451.8 2006-06-21

Publications (2)

Publication Number Publication Date
WO2007147397A2 WO2007147397A2 (en) 2007-12-27
WO2007147397A3 true WO2007147397A3 (en) 2008-02-14

Family

ID=38670743

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2007/001088 WO2007147397A2 (en) 2006-06-21 2007-06-18 PROCESS FOR PREPARING N-ACYL-α-AMINO NITRILES

Country Status (2)

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DE (1) DE102006028451A1 (en)
WO (1) WO2007147397A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016116130A1 (en) * 2016-08-30 2018-03-01 Universität Bielefeld Process for the preparation of chiral aminonitriles

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2849477A (en) * 1956-06-12 1958-08-26 Dornow Alfred Preparation of alpha-acylamino-nitriles
GB807606A (en) * 1956-06-12 1959-01-21 Alfred Dornow A process for the preparation of -a-acylamino-nitriles
WO1999051546A1 (en) * 1998-04-02 1999-10-14 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
WO2004094374A2 (en) * 2003-04-23 2004-11-04 Rhodia Pharma Solutions Inc. (Formally Rhodia Chirex Inc.) Preparation of (s)-clopidogrel and related compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2849477A (en) * 1956-06-12 1958-08-26 Dornow Alfred Preparation of alpha-acylamino-nitriles
GB807606A (en) * 1956-06-12 1959-01-21 Alfred Dornow A process for the preparation of -a-acylamino-nitriles
WO1999051546A1 (en) * 1998-04-02 1999-10-14 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
WO2004094374A2 (en) * 2003-04-23 2004-11-04 Rhodia Pharma Solutions Inc. (Formally Rhodia Chirex Inc.) Preparation of (s)-clopidogrel and related compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
S. C. PAN ET AL.: "Catalytic Asymmetric Acylcyanation of Imines", ANGEW CHEM INT ED, vol. 46, 15 January 2007 (2007-01-15), pages 612 - 614, XP002459325 *

Also Published As

Publication number Publication date
DE102006028451A1 (en) 2008-01-10
WO2007147397A2 (en) 2007-12-27

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