WO2007147141A3 - Methods for detecting molecular complexes - Google Patents

Methods for detecting molecular complexes Download PDF

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Publication number
WO2007147141A3
WO2007147141A3 PCT/US2007/071382 US2007071382W WO2007147141A3 WO 2007147141 A3 WO2007147141 A3 WO 2007147141A3 US 2007071382 W US2007071382 W US 2007071382W WO 2007147141 A3 WO2007147141 A3 WO 2007147141A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
antibody
detecting
protein
molecular complexes
Prior art date
Application number
PCT/US2007/071382
Other languages
French (fr)
Other versions
WO2007147141A2 (en
Inventor
Brian B Haab
Original Assignee
Van Andel Res Inst
Brian B Haab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Van Andel Res Inst, Brian B Haab filed Critical Van Andel Res Inst
Priority to EP07798658A priority Critical patent/EP2044437A4/en
Priority to AU2007260649A priority patent/AU2007260649A1/en
Priority to CA002655563A priority patent/CA2655563A1/en
Publication of WO2007147141A2 publication Critical patent/WO2007147141A2/en
Publication of WO2007147141A3 publication Critical patent/WO2007147141A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention includes methods for analyzing copies of an antibody microarray for a protein complexed with another molecule. In this method, one biological sample is divided and then incubated with copies of an antibody microarray. Each capture antibody is paired with a detection antibody, and only one detection antibody is incubated with each copy of the antibody microarray. The invention further includes methods to compare protein complexes under different conditions, methods of detecting an auto-immune response, and methods of detecting interaction between a protein and a small molecule.
PCT/US2007/071382 2006-06-15 2007-06-15 Methods for detecting molecular complexes WO2007147141A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07798658A EP2044437A4 (en) 2006-06-15 2007-06-15 Methods for detecting molecular complexes
AU2007260649A AU2007260649A1 (en) 2006-06-15 2007-06-15 Methods for detecting molecular complexes
CA002655563A CA2655563A1 (en) 2006-06-15 2007-06-15 Methods for detecting molecular complexes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81383806P 2006-06-15 2006-06-15
US60/813,838 2006-06-15

Publications (2)

Publication Number Publication Date
WO2007147141A2 WO2007147141A2 (en) 2007-12-21
WO2007147141A3 true WO2007147141A3 (en) 2008-02-07

Family

ID=38832921

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/071382 WO2007147141A2 (en) 2006-06-15 2007-06-15 Methods for detecting molecular complexes

Country Status (4)

Country Link
EP (1) EP2044437A4 (en)
AU (1) AU2007260649A1 (en)
CA (1) CA2655563A1 (en)
WO (1) WO2007147141A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2443459B1 (en) * 2009-06-19 2018-12-26 The Arizona Board of Regents, A Body Corporate Of the State of Arizona acting for and on behalf Of Arizona State University Compound arrays for sample profiling
US10758886B2 (en) 2015-09-14 2020-09-01 Arizona Board Of Regents On Behalf Of Arizona State University Conditioned surfaces for in situ molecular array synthesis
KR20190020106A (en) 2016-06-20 2019-02-27 헬스텔 인크. Differential diagnosis method of autoimmune disease
CN109790203A (en) 2016-06-20 2019-05-21 健康之语公司 The diagnostic and therapeutic method of autoimmune disease
EP3538893A4 (en) 2016-11-11 2020-09-23 Healthtell Inc. Methods for identifying candidate biomarkers
US12025615B2 (en) 2017-09-15 2024-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
US20050042623A1 (en) * 2002-10-30 2005-02-24 Dana Ault-Riche Systems for capture and analysis of biological particles and methods using the systems

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042623A1 (en) * 2002-10-30 2005-02-24 Dana Ault-Riche Systems for capture and analysis of biological particles and methods using the systems
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOOS ET AL.: "A microarray enzyme-linked immunosorbent assay for autoimmune diagnostics", ELECTROPHORESIS, vol. 21, no. 13, July 2000 (2000-07-01), pages 2641 - 2650, XP002294714 *
See also references of EP2044437A4 *

Also Published As

Publication number Publication date
AU2007260649A1 (en) 2007-12-21
CA2655563A1 (en) 2007-12-21
EP2044437A2 (en) 2009-04-08
EP2044437A4 (en) 2009-11-25
WO2007147141A2 (en) 2007-12-21

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