WO2007146232A3 - Compositions et procédés destinés à régénérer des tissus - Google Patents

Compositions et procédés destinés à régénérer des tissus Download PDF

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Publication number
WO2007146232A3
WO2007146232A3 PCT/US2007/013691 US2007013691W WO2007146232A3 WO 2007146232 A3 WO2007146232 A3 WO 2007146232A3 US 2007013691 W US2007013691 W US 2007013691W WO 2007146232 A3 WO2007146232 A3 WO 2007146232A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissues
repair
compositions
methods
growth factor
Prior art date
Application number
PCT/US2007/013691
Other languages
English (en)
Other versions
WO2007146232A2 (fr
Inventor
D Daniel Carson
Mary C Farach-Carson
Weidong William Yang
Original Assignee
Univ Delaware
D Daniel Carson
Mary C Farach-Carson
Weidong William Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Delaware, D Daniel Carson, Mary C Farach-Carson, Weidong William Yang filed Critical Univ Delaware
Publication of WO2007146232A2 publication Critical patent/WO2007146232A2/fr
Publication of WO2007146232A3 publication Critical patent/WO2007146232A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des biomatériaux assurant une libération prolongée de facteur de croissance pour la régénération de tissus tels que les os et les cartilages. Les biomatériaux contiennent un protéoglycane dérivé du domaine I du perlecane et un facteur de croissance, et, éventuellement, du collagène.
PCT/US2007/013691 2006-06-14 2007-06-11 Compositions et procédés destinés à régénérer des tissus WO2007146232A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81353706P 2006-06-14 2006-06-14
US60/813,537 2006-06-14
US11/811,378 2007-06-07
US11/811,378 US20090162436A1 (en) 2006-06-14 2007-06-07 Compositions and methods for repair of tissues

Publications (2)

Publication Number Publication Date
WO2007146232A2 WO2007146232A2 (fr) 2007-12-21
WO2007146232A3 true WO2007146232A3 (fr) 2009-04-09

Family

ID=38832456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/013691 WO2007146232A2 (fr) 2006-06-14 2007-06-11 Compositions et procédés destinés à régénérer des tissus

Country Status (2)

Country Link
US (2) US20090162436A1 (fr)
WO (1) WO2007146232A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009105624A2 (fr) * 2008-02-21 2009-08-27 Massachusetts Institute Of Technology Transfert simultané de récepteurs et/ou de co-récepteurs pour la stabilité et l'activité de facteurs de croissance
US8846003B2 (en) 2008-03-27 2014-09-30 Symic Biomedical, Inc. Collagen-binding synthetic peptidoglycans, preparation, and methods of use
MX357440B (es) * 2009-05-13 2018-07-10 Medipost Co Ltd Trombospondina 1 (tsp-1), trombospondina 2 (tsp-2), receptor de interleucina 17b (il-17br) y factor de crecimiento tipo factor de crecimiento epidermico de union a heparina (hb-egf) asociados con actividades de celulas madre y aplicaciones de los mismos.
US20150335400A1 (en) * 2009-06-17 2015-11-26 The Trustees Of Columbia University In The City Of New York Tooth scaffolds
WO2011031637A2 (fr) * 2009-09-08 2011-03-17 Musculoskeletal Transplant Foundation Inc. Composition pour réparation de ménisque à base d'une technique de tissu
US20110060412A1 (en) * 2009-09-08 2011-03-10 Musculoskeletal Transplant Foundation Inc. Tissue Engineered Meniscus Repair Composition
US8735116B2 (en) 2010-09-13 2014-05-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High-density spot seeding for tissue model formation
US9597412B2 (en) 2011-03-16 2017-03-21 University Of Delaware Injectable delivery system for heparan-binding growth factors
BR112013030086A2 (pt) 2011-05-24 2022-03-03 Purdue Research Foundation Peptideoglicanos sintéticos que se ligam ao ácido hialurônico, matriz de colágeno engenheirada e seus usos
WO2013090924A1 (fr) * 2011-12-16 2013-06-20 William Marsh Rice University Hydrogel modulaire implantable pour restauration des glandes salivaires
MX2015012608A (es) 2013-03-15 2016-07-06 Symic Biomedical Inc Peptidos sinteticos de union a matriz extracelular.
US10772931B2 (en) 2014-04-25 2020-09-15 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
EP3648774A4 (fr) 2017-07-07 2021-04-21 Symic IP, LLC Bioconjugués synthétiques

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US20040064193A1 (en) * 2002-06-13 2004-04-01 Evans Douglas G. Devices and methods for treating defects in the tissue of a living being

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010016646A1 (en) * 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
AU2001288392A1 (en) * 2000-08-30 2002-03-13 University Of Delaware Delivery system for heparin-binding growth factors
WO2002067978A1 (fr) * 2001-02-23 2002-09-06 Wyeth Utilisation des protéines bmp pour potentialiser la chondrogenèse par les cellules cd105+ tirées de la moelle osseuse humaine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US20040064193A1 (en) * 2002-06-13 2004-04-01 Evans Douglas G. Devices and methods for treating defects in the tissue of a living being

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GOMES ET AL.: "Perlecan: an important component of the cartilage pericellular matrix.", J. MUSCULOSKELET. NEURONAL INTERACT., vol. 2, no. 6, December 2002 (2002-12-01), pages 511 - 516 *

Also Published As

Publication number Publication date
US20090162436A1 (en) 2009-06-25
WO2007146232A2 (fr) 2007-12-21
US20110082081A1 (en) 2011-04-07

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