WO2007145661A3 - Differentially fluorescent yeast biosensors for the detection and biodegradation of chemical agents - Google Patents

Differentially fluorescent yeast biosensors for the detection and biodegradation of chemical agents Download PDF

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Publication number
WO2007145661A3
WO2007145661A3 PCT/US2006/045761 US2006045761W WO2007145661A3 WO 2007145661 A3 WO2007145661 A3 WO 2007145661A3 US 2006045761 W US2006045761 W US 2006045761W WO 2007145661 A3 WO2007145661 A3 WO 2007145661A3
Authority
WO
WIPO (PCT)
Prior art keywords
biodegradation
detection
chemical agents
biosensors
differentially fluorescent
Prior art date
Application number
PCT/US2006/045761
Other languages
French (fr)
Other versions
WO2007145661A2 (en
Inventor
David Alexander Schofield
Augustine Anthony Dinovo
Original Assignee
Guild Ass Inc
David Alexander Schofield
Augustine Anthony Dinovo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guild Ass Inc, David Alexander Schofield, Augustine Anthony Dinovo filed Critical Guild Ass Inc
Priority to JP2008543437A priority Critical patent/JP2009518006A/en
Priority to EP06851299A priority patent/EP1963538A2/en
Publication of WO2007145661A2 publication Critical patent/WO2007145661A2/en
Publication of WO2007145661A3 publication Critical patent/WO2007145661A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

The present disclosure provides methods, devices, systems and compositions for detecting and/or modifying chemical agents. In some embodiments, a biosensor may be configured to detect a chemical agent, modify that agent to a form with reduced toxicity, and and/or detect the modified form of the chemical agent.
PCT/US2006/045761 2005-11-30 2006-11-29 Differentially fluorescent yeast biosensors for the detection and biodegradation of chemical agents WO2007145661A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008543437A JP2009518006A (en) 2005-11-30 2006-11-29 Differential fluorescence yeast biosensor for chemical detection and biodegradation
EP06851299A EP1963538A2 (en) 2005-11-30 2006-11-29 Differentially fluorescent yeast biosensors for the detection and biodegradation of chemical agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74088705P 2005-11-30 2005-11-30
US60/740,887 2005-11-30

Publications (2)

Publication Number Publication Date
WO2007145661A2 WO2007145661A2 (en) 2007-12-21
WO2007145661A3 true WO2007145661A3 (en) 2008-04-10

Family

ID=38832244

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/045761 WO2007145661A2 (en) 2005-11-30 2006-11-29 Differentially fluorescent yeast biosensors for the detection and biodegradation of chemical agents

Country Status (3)

Country Link
EP (1) EP1963538A2 (en)
JP (1) JP2009518006A (en)
WO (1) WO2007145661A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100221817A1 (en) * 2007-04-25 2010-09-02 Technische Universitaet Dresden Whole-Cell Sensor
EP2441834A1 (en) 2007-10-01 2012-04-18 Guild Associates, Inc. Differentially Fluorescent Yeast Biosensors for the Detection and Biodegration of Chemical Agents
PL3118311T3 (en) * 2014-03-12 2019-09-30 Nippon Shinyaku Co., Ltd. Antisense nucleic acid
US10988759B2 (en) 2016-01-15 2021-04-27 University Of Washington High throughput protein-protein interaction screening in yeast liquid culture
US20220380754A1 (en) 2020-05-11 2022-12-01 A-Alpha Bio, Inc. High-Throughput Screening Methods to Identify Small Molecule Targets
CA3180716A1 (en) 2020-06-01 2021-12-09 David Younger Methods for characterizing and engineering protein-protein interactions
CN115753714B (en) * 2022-11-21 2024-06-04 清华大学 Biosensor, nucleic acid molecule, expression vector and application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999027351A1 (en) * 1997-11-25 1999-06-03 Lockheed Martin Energy Research Corporation Bioluminescent bioreporter integrated circuit
WO2000065081A2 (en) * 1999-04-26 2000-11-02 U.S. Army Medical Research And Materiel Command Immobilized enzymes as biosensors for chemical toxins
WO2005069738A2 (en) * 2004-01-27 2005-08-04 Ramot At Tel Aviv University Ltd. Populations of cells and devices and systems including same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999027351A1 (en) * 1997-11-25 1999-06-03 Lockheed Martin Energy Research Corporation Bioluminescent bioreporter integrated circuit
WO2000065081A2 (en) * 1999-04-26 2000-11-02 U.S. Army Medical Research And Materiel Command Immobilized enzymes as biosensors for chemical toxins
WO2005069738A2 (en) * 2004-01-27 2005-08-04 Ramot At Tel Aviv University Ltd. Populations of cells and devices and systems including same

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIRAN I ET AL: "ONLINE AND IN SITU MONITORING OF ENVIRONMENTAL POLLUTANTS: ELECTROCHEMICAL BIOSENSING OF CADMIUM", ENVIRONMENTAL MICROBIOLOGY, BLACKWELL SCIENCE, OXFORD, GB, vol. 3, no. 2, 2000, pages 285 - 290, XP001058094, ISSN: 1462-2912 *
DAVID A SCHOFIELD ET AL: "Development of a yeast biosensor-biocatalyst for the detection and biodegradation of the organophosphate paraoxon", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER-VERLAG, BE, vol. 76, no. 6, 31 July 2007 (2007-07-31), pages 1383 - 1394, XP019538768, ISSN: 1432-0614 *
KITAGAWA E ET AL: "EFFECTS OF THE PESTICIDE THIURAM: GENOME-WIDE SCREENING OF INDICATOR GENES BY YEAST DNA MICROARRAY", ENVIRONMENTAL SCIENCE AND TECHNOLOGY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 36, no. 18, 15 September 2002 (2002-09-15), pages 3908 - 3915, XP001205322, ISSN: 0013-936X *
See also references of EP1963538A2 *
TAKAHASHI JUNKO ET AL: "Multiple reporter gene assays for the assessment and estimation of chemical toxicity.", ENVIRONMENTAL SCIENCES : AN INTERNATIONAL JOURNAL OF ENVIRONMENTAL PHYSIOLOGY AND TOXICOLOGY 2004, vol. 11, no. 5, 2004, pages 269 - 282, XP009096272, ISSN: 0915-955X *

Also Published As

Publication number Publication date
EP1963538A2 (en) 2008-09-03
JP2009518006A (en) 2009-05-07
WO2007145661A2 (en) 2007-12-21

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