WO2007143862A1 - Apparatus and method for preventing and treating vitamin d deficiency of an infant - Google Patents

Apparatus and method for preventing and treating vitamin d deficiency of an infant Download PDF

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Publication number
WO2007143862A1
WO2007143862A1 PCT/CH2006/000330 CH2006000330W WO2007143862A1 WO 2007143862 A1 WO2007143862 A1 WO 2007143862A1 CH 2006000330 W CH2006000330 W CH 2006000330W WO 2007143862 A1 WO2007143862 A1 WO 2007143862A1
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WO
WIPO (PCT)
Prior art keywords
lamp
infant
deficiency
preventing
phototherapy
Prior art date
Application number
PCT/CH2006/000330
Other languages
French (fr)
Inventor
Peter Edwin Hartmann
Original Assignee
Medela Holding Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medela Holding Ag filed Critical Medela Holding Ag
Priority to PCT/CH2006/000330 priority Critical patent/WO2007143862A1/en
Publication of WO2007143862A1 publication Critical patent/WO2007143862A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0621—Hyperbilirubinemia, jaundice treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0654—Lamps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0664—Details
    • A61N2005/0667—Filters

Definitions

  • This invention relates to an apparatus and a method for preventing and treating vitamin D deficiency of an infant.
  • Vitamin D is essential for the absorption of Calcium in the intestines. Calcium is important for bone and tooth development as well as for nervous and muscle action. Deficiency of vitamin D can therefore cause rickets.
  • Vitamin D in the body is derived primarily from the skin and secondarily from the diet. Vitamin D is synthesized in the skin by the action of UV-B. The precursor molecule is the provitamin 7-DHC or 7-dehydrocholesterol which occurs in the strata granulosum and basale of the epidermis.
  • the UV-B exposure causes a photochemical conversion of 7-DHC into previtamin D which is then further transformed to vitamin D and, assisted by liver and kidney, into an active form of vitamin D.
  • the conversion of 7DHC into vitamin D requires ultraviolet (UV) irradiation between 275 - 310 nm. Vitamin D is susceptible to degradation from UV irradiation between 260 - 290 nm.
  • the optimal wavelengths for vitamin D production are between 290 and 300 nm.
  • sunlight exposure is difficult to measure.
  • infants are given vitamin D supplements and care is taken that they are exposed sufficiently to the sun.
  • the following babies are still especially at risk for vitamin D deficiency:
  • the mother is deficient in vitamin D and is breastfeeding the infant.
  • the general treatment with these infants is to increase the doses of vitamin D supplements.
  • hyperbilirubinemia For another disease, namely the neonatal hyperbilirubinemia, another treatment is known. This hyperbilirubinemia is treated by irradiating the affected infant with therapeutic levels of light within a given wavelength range, namely between 420 run and 480 nm.
  • US 5 792 214 and US 6253 380 describe an apparatus for treating neonatal hyperbilirubinemia, this apparatus being known on the market since several years as BiliBed.
  • This apparatus includes a frame for supporting the infant and a source of radiation positioned below the frame and the infant.
  • the frame includes a fully transparent section for allowing the radiation to pass therethrough to the infant.
  • the irradiation unit can be placed into an infant's cot instead of a mattress.
  • the infant may be treated in his cot and in close proximity to its mother which makes the infant feel comfortable and aids in mother/infant bonding.
  • This apparatus can also be used in incubators and other equipment to be used for infants with other pressing medical conditions. No light sources above the affected infants crib is needed. The infant does not need eye patches.
  • the treatment apparatus provides light that is precisely directed at a minimum distance to the affected infant, which results in superb therapeutic performance. Summary of the invention
  • an apparatus for preventing and treating vitamin D deficiency of an infant comprising an irradiation unit with at least one phototherapy lamp and a support unit suitable to support the infant above the irradiation unit and operable to allow radiation of the at least one phototherapy lamp to pass therethrough, wherein at least one of said at least one lamp is a lamp suitable for preventing or treating vitamin D deficiency.
  • the at least one lamp suitable for preventing or treating vitamin D deficiency emits a main light spectrum in the range of 275 to 310 nm, preferably in the range of 290 to 300 nm.
  • the irradiation unit comprises a recess, wherein the at least one lamp is arranged in said recess.
  • the support unit comprises a support frame and a blanket and/or a foil attachable to the frame.
  • one single lamp is arranged in the recess, preferably approximately in the middle of the recess.
  • said lamp suitable for preventing or treating vitamin D deficiency is arranged perpendicular to a second lamp, wherein this second lamp is suitable for treating bilirubinemia.
  • no phototherapy lamps are positioned above the infant.
  • no phototherapy lamps are positioned sideways or in any other position except underneath the plane or surface where the infant is lying or resting on.
  • the inventive method for preventing or treating vitamin D deficiency comprises the steps of : providing an irradiation unit with at least one phototherapy lamp and providing a support unit suitable to support the infant above the irradiation unit and operable to allow radiation of the at least one phototherapy lamp to pass therethrough, placing the infant on this support unit activating at least one of said phototherapy lamps with a main light sprectrum in the range of 275 to 310 nm and exposing the infant to the light of this at least one activated phototherapy lamp.
  • the apparatus is identical with the known BiliBed but using at least one lamp being different from the ones used in BiliBed.
  • the inventive apparatus has the same advantages as the ones described above for the BiliBed.
  • the infant can stay in the same room as the mother.
  • the apparatus can be used in a cot or crib.
  • the infant does not need to wear eye patches.
  • the apparatus can also be used in an incubator or in other medical equipments.
  • an inventive apparatus which can be taken home so that the infant can be treated at home.
  • the apparatus can also be used for treatment or for preventing other diseases by using the same and/or other lamps than the ones described above, i.e. other wavelengths or other light intensities..
  • Figure 2 shows a first perspective view of the irradiation unit shown in figure 1 ;
  • Figure 3 shows a second perspective view of the irradiation unit shown in figure 1 and
  • Figure 4 shows a perspective view of the inventive apparatus according to a second preferred embodiment.
  • the vitamin D deficiency treatment apparatus of the present invention is intended to be inserted in, and thereby used with conventional infant hospital cribs or cots. Specifically it is contemplated that the treatment apparatus shown and described herein can be placed on a hospital crib or cot that has had its mattress removed.
  • FIG. 1 shows an exploded view of the main components of the preferred embodiment of the apparatus.
  • the apparatus comprises an irradiation unit 1 and a support unit 2, 3 to support the infant above the irradiation unit 1.
  • the support unit in this embodiment comprises an infant support therapy frame 2 and a therapy blanket 3 which is comfortable enough to support the infant lying on it but through which light from the irradiation unit can pass through.
  • the frame 2 can comprise a foil which can also support the infants body and which is also transparent for the light emitted by the irradiation unit 1.
  • the blanket 3 and the foil can be detachably connected to the support frame 2 by mating connectors.
  • the apparatus is working with electricity, the power plug bears the reference number 19.
  • the irradiation unit 1 comprises a base 10 having a recess 11, in which are housed the main components of the irradiation unit 1.
  • the recess 11 is covered by a plate 18, which is shown in figure 1.
  • the recess 11 contains a light reflector 12, usually a high polished metal device; a cover 17 for the electronics; the electronics themselves, which are not shown since they are covered by the cover 17; a fan, which is not shown either since it is also covered by the cover 17; a fan grill 16 arranged in the cover 17 and facing the recess 11; at lamp connector 15 connected with the electronics and arranged near the cover 17 and the fan grill 16 and at least one lamp support 13 arranged on a spacer 14 on or above the reflector 12.
  • the lamp 5 is connected to connector 15 and is hold by the lamp support 13.
  • the lamp 5 extends into the recess 11 and lays preferably approximately parallel to the bottom of the recess 11.
  • the apparatus corresponds insofar to the BiliBed described in US 5 792 214 and US 6 253 380.
  • the disclosure of these two prior art references are included in this application by reference.
  • the lamp 5 however is different to the one used in the BiliBed.
  • the lamp 5 is suitable for producing vitamin D in the body of the infants laying on the blanket.
  • the lamp 5 preferably emits a main light spectrum in the range of 275 to 310 nm, preferably with a main peak in the region of 290 to 300 nm. Different kind of lamps can be used.
  • the lamp can have a main light emittance in this range of wavelength
  • the lamp or the environment of the lamp can include a filter which only transmits light in the above mentioned range of wavelength or the lamp comprises a coating which works as a filter transmitting only in the preferred range.
  • the apparatus includes a sensor to quantify the exposure of the infant to this light and/or a timer to avoid over-exposure, wherein the timer switches off the lamp when a preset exposure period has passed.
  • This quantity of exposure and/or the time the infant was exposed is preferably displayed and/or stored in a memory.
  • the data can also be directly transmitted to a control system which records the data into the infants personal record.
  • the apparatus comprises a control unit to control the light intensity level of the lamp in order to avoid an irradiation above a preset maximum level and in order to inform the user that the intensity has dropped under a minimum level, so that the lamp can be exchanged with a new one.
  • FIG 4 another embodiment of the inventive apparatus is shown.
  • a lamp 4 for treating bilirubinemia is arranged in the recess 11.
  • This light of this second lamp 4 is within another range, namely between 420 nm and 480 nm.
  • the first lamp 5 for treating or preventing the vitamin D deficiency is arranged also in the recess 11 but perpendicular to the second lamp 4.
  • the electronics used for both lamps can be the same or they can have different electronics.
  • there is a switch so that the user can choose if the first, the second or both lamps shall be switched on.
  • This embodiment has the advantage that infants who have to lay in this BiliBed for bilirubinemia treatment also can be treated with this first lamp in order to avoid vitamin D deficiency.
  • the arrangement of the lamps can be different.
  • More than one phototherapy lamp of each kind can be used as well.
  • the shape and the contents of the irradiation unit can be different as well.
  • the reflector can be omitted in case only the first lamp but not the second lamp is used. List of reference numbers

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

An apparatus for preventing or treating vitamin D deficiency of an infant comprising an irradiation unit with at least one phototherapy lamp and a support unit suitable to support the infant above the irradiation unit and operable to allow radiation of the at least one phototherapy lamp to pass therethrough, wherein at least one of said at least one lamp is a lamp suitable for preventing or treating vitamin D deficiency.

Description

Apparatus and method for preventing and treating vitamin D deficiency of an infant
Field of the invention
This invention relates to an apparatus and a method for preventing and treating vitamin D deficiency of an infant.
Background of the invention
All infants need vitamin D for their optimal development. Vitamin D is essential for the absorption of Calcium in the intestines. Calcium is important for bone and tooth development as well as for nervous and muscle action. Deficiency of vitamin D can therefore cause rickets.
Vitamin D in the body is derived primarily from the skin and secondarily from the diet. Vitamin D is synthesized in the skin by the action of UV-B. The precursor molecule is the provitamin 7-DHC or 7-dehydrocholesterol which occurs in the strata granulosum and basale of the epidermis. The UV-B exposure causes a photochemical conversion of 7-DHC into previtamin D which is then further transformed to vitamin D and, assisted by liver and kidney, into an active form of vitamin D. The conversion of 7DHC into vitamin D requires ultraviolet (UV) irradiation between 275 - 310 nm. Vitamin D is susceptible to degradation from UV irradiation between 260 - 290 nm. Therefore the optimal wavelengths for vitamin D production are between 290 and 300 nm. However sunlight exposure is difficult to measure. Usually infants are given vitamin D supplements and care is taken that they are exposed sufficiently to the sun. However, the following babies are still especially at risk for vitamin D deficiency:
- babies who have little exposure to sunlight, because they live in a far northern latitude or because they live in an area with tall buildings or high pollution
- both the mother and the baby have a dark skin and thus require more sun exposure to generate an adequate amount of vitamin D
- the mother is deficient in vitamin D and is breastfeeding the infant.
The general treatment with these infants is to increase the doses of vitamin D supplements.
For another disease, namely the neonatal hyperbilirubinemia, another treatment is known. This hyperbilirubinemia is treated by irradiating the affected infant with therapeutic levels of light within a given wavelength range, namely between 420 run and 480 nm.
US 5 792 214 and US 6253 380 describe an apparatus for treating neonatal hyperbilirubinemia, this apparatus being known on the market since several years as BiliBed. This apparatus includes a frame for supporting the infant and a source of radiation positioned below the frame and the infant. The frame includes a fully transparent section for allowing the radiation to pass therethrough to the infant. The irradiation unit can be placed into an infant's cot instead of a mattress. The infant may be treated in his cot and in close proximity to its mother which makes the infant feel comfortable and aids in mother/infant bonding. This apparatus can also be used in incubators and other equipment to be used for infants with other pressing medical conditions. No light sources above the affected infants crib is needed. The infant does not need eye patches. In addition the treatment apparatus provides light that is precisely directed at a minimum distance to the affected infant, which results in superb therapeutic performance. Summary of the invention
It is therefore an object of the invention to provide an apparatus and a method for preventing and treating vitamin D deficiency of an infant.
This object is achieved by an apparatus for preventing and treating vitamin D deficiency of an infant comprising an irradiation unit with at least one phototherapy lamp and a support unit suitable to support the infant above the irradiation unit and operable to allow radiation of the at least one phototherapy lamp to pass therethrough, wherein at least one of said at least one lamp is a lamp suitable for preventing or treating vitamin D deficiency.
Preferably the at least one lamp suitable for preventing or treating vitamin D deficiency emits a main light spectrum in the range of 275 to 310 nm, preferably in the range of 290 to 300 nm.
In a preferred embodiment the irradiation unit comprises a recess, wherein the at least one lamp is arranged in said recess. Preferably the support unit comprises a support frame and a blanket and/or a foil attachable to the frame.
In a preferred embodiment one single lamp is arranged in the recess, preferably approximately in the middle of the recess.
In another preferred embodiment, said lamp suitable for preventing or treating vitamin D deficiency is arranged perpendicular to a second lamp, wherein this second lamp is suitable for treating bilirubinemia.
In a preferred embodiment, no phototherapy lamps are positioned above the infant. Preferably, no phototherapy lamps are positioned sideways or in any other position except underneath the plane or surface where the infant is lying or resting on.
The inventive method for preventing or treating vitamin D deficiency comprises the steps of : providing an irradiation unit with at least one phototherapy lamp and providing a support unit suitable to support the infant above the irradiation unit and operable to allow radiation of the at least one phototherapy lamp to pass therethrough, placing the infant on this support unit activating at least one of said phototherapy lamps with a main light sprectrum in the range of 275 to 310 nm and exposing the infant to the light of this at least one activated phototherapy lamp.
In a preferred embodiment the apparatus is identical with the known BiliBed but using at least one lamp being different from the ones used in BiliBed. The inventive apparatus has the same advantages as the ones described above for the BiliBed. The infant can stay in the same room as the mother. The apparatus can be used in a cot or crib. The infant does not need to wear eye patches. The apparatus can also be used in an incubator or in other medical equipments. However it is also possible to use an inventive apparatus which can be taken home so that the infant can be treated at home. Furthermore the apparatus can also be used for treatment or for preventing other diseases by using the same and/or other lamps than the ones described above, i.e. other wavelengths or other light intensities..
Further preferred embodiments of the invention and variants of the inventive method are described in the dependent claims.
Brief description of the drawings
The present invention will be more clearly understood with reference to the following detailed description of preferred embodiments, taken in conjunction with the accompanying drawings, in which Figure 1 shows an exploded perspective view of a first preferred embodiment of the inventive apparatus;
Figure 2 shows a first perspective view of the irradiation unit shown in figure 1 ;
Figure 3 shows a second perspective view of the irradiation unit shown in figure 1 and
Figure 4 shows a perspective view of the inventive apparatus according to a second preferred embodiment.
Description of the preferred embodiments
The vitamin D deficiency treatment apparatus of the present invention is intended to be inserted in, and thereby used with conventional infant hospital cribs or cots. Specifically it is contemplated that the treatment apparatus shown and described herein can be placed on a hospital crib or cot that has had its mattress removed.
Figure 1 shows an exploded view of the main components of the preferred embodiment of the apparatus. The apparatus comprises an irradiation unit 1 and a support unit 2, 3 to support the infant above the irradiation unit 1. The support unit in this embodiment comprises an infant support therapy frame 2 and a therapy blanket 3 which is comfortable enough to support the infant lying on it but through which light from the irradiation unit can pass through. The frame 2 can comprise a foil which can also support the infants body and which is also transparent for the light emitted by the irradiation unit 1. The blanket 3 and the foil can be detachably connected to the support frame 2 by mating connectors. The apparatus is working with electricity, the power plug bears the reference number 19.
As can be seen in figures 1 to 3, the irradiation unit 1 comprises a base 10 having a recess 11, in which are housed the main components of the irradiation unit 1. The recess 11 is covered by a plate 18, which is shown in figure 1.
The recess 11 contains a light reflector 12, usually a high polished metal device; a cover 17 for the electronics; the electronics themselves, which are not shown since they are covered by the cover 17; a fan, which is not shown either since it is also covered by the cover 17; a fan grill 16 arranged in the cover 17 and facing the recess 11; at lamp connector 15 connected with the electronics and arranged near the cover 17 and the fan grill 16 and at least one lamp support 13 arranged on a spacer 14 on or above the reflector 12.
The lamp 5 is connected to connector 15 and is hold by the lamp support 13. The lamp 5 extends into the recess 11 and lays preferably approximately parallel to the bottom of the recess 11.
The apparatus corresponds insofar to the BiliBed described in US 5 792 214 and US 6 253 380. The disclosure of these two prior art references are included in this application by reference. The lamp 5 however is different to the one used in the BiliBed. According to the invention the lamp 5 is suitable for producing vitamin D in the body of the infants laying on the blanket. The lamp 5 preferably emits a main light spectrum in the range of 275 to 310 nm, preferably with a main peak in the region of 290 to 300 nm. Different kind of lamps can be used. In the following, just a few examples are given but other solutions are possible as well: The lamp can have a main light emittance in this range of wavelength, the lamp or the environment of the lamp can include a filter which only transmits light in the above mentioned range of wavelength or the lamp comprises a coating which works as a filter transmitting only in the preferred range.
Preferably the apparatus includes a sensor to quantify the exposure of the infant to this light and/or a timer to avoid over-exposure, wherein the timer switches off the lamp when a preset exposure period has passed. This quantity of exposure and/or the time the infant was exposed is preferably displayed and/or stored in a memory. The data can also be directly transmitted to a control system which records the data into the infants personal record. Preferably the apparatus comprises a control unit to control the light intensity level of the lamp in order to avoid an irradiation above a preset maximum level and in order to inform the user that the intensity has dropped under a minimum level, so that the lamp can be exchanged with a new one.
Furthermore the electronics and the apparatus as such can have the same features as incorporated in the BiliBed and/or described in the prior art patents mentioned above.
In figure 4 another embodiment of the inventive apparatus is shown. Instead of the above mentioned lamp 5 with the main peak in the region of 290 to 300 nm, a lamp 4 for treating bilirubinemia is arranged in the recess 11. This light of this second lamp 4 is within another range, namely between 420 nm and 480 nm. According to this embodiment the first lamp 5 for treating or preventing the vitamin D deficiency is arranged also in the recess 11 but perpendicular to the second lamp 4. The electronics used for both lamps can be the same or they can have different electronics. In a preferred embodiment there is a switch so that the user can choose if the first, the second or both lamps shall be switched on. This embodiment has the advantage that infants who have to lay in this BiliBed for bilirubinemia treatment also can be treated with this first lamp in order to avoid vitamin D deficiency.
In this description two preferred embodiments were given. However the invention can be modified in different ways. Changes to the embodiments mentioned above can be made without departing from the spirit of invention. For example: the arrangement of the lamps can be different. There can be used only one single lamp having two main peaks in the region of 420 nm to 480 nm and 290 nm to 300 nm. More than one phototherapy lamp of each kind can be used as well. The shape and the contents of the irradiation unit can be different as well. There can be used an irradiation unit with a support unit suitable to support an infant wherein the unit can not be used in a crib or a cot. Furthermore the reflector can be omitted in case only the first lamp but not the second lamp is used. List of reference numbers
1 irradiation unit
10 base
11 recess
12 reflector
13 lamp support
14 spacer
15 connector
16 fan grill
17 cover for the electronics
18 plate
19 power plug
2 support therapy frame
3 therapy blanket
4 first lamp
5 second lamp

Claims

Claims
1. An apparatus for preventing and treating vitamin D deficiency of an infant comprising an irradiation unit with at least one phototherapy lamp and a support unit suitable to support the infant above the irradiation unit and operable to allow radiation of the at least one phototherapy lamp to pass therethrough, wherein at least one of said at least one lamp is a lamp suitable for preventing or treating vitamin D deficiency.
2. The apparatus of claim 1, wherein the at least one lamp suitable for preventing or treating vitamin D deficiency emits a main light spectrum in the range of 275 to 310 nm.
3. The apparatus of claim 1, wherein the at least one lamp suitable for preventing or treating vitamin D deficiency emits a main light spectrum in the range of 290 to 300 nm.
4. The apparatus of claim 1, wherein the irradiation unit comprises a recess and wherein the at least one lamp is arranged in said recess.
5. The apparatus of claim 1, wherein no phototherapy lamp is positioned above the infant.
6. The apparatus of claim 1 , wherein no phototherapy lamp is positioned in any other position except underneath a plane or surface where the infant is lying on.
7. The apparatus of claim 1, wherein the support unit comprises a support frame and a blanket and/or a foil attachable to the frame.
8. The apparatus of claim 1 , wherein one single lamp is arranged in the recess.
9. The apparatus of claim 8, wherein this lamp is arranged approximately in the middle of the recess.
10. The apparatus of claim 1 wherein said lamp suitable for preventing or treating vitamin D deficiency is arranged perpendicular to a second lamp, wherein this second lamp is suitable to treat bilirubinemia.
11. An apparatus for preventing and treating a deficiency of an infant comprising an irradiation unit with at least one phototherapy lamp and a support unit suitable to support the infant above the irradiation unit and operable to allow radiation of the at least one phototherapy lamp to pass therethrough, wherein no phototherapy lamp is positioned above the infant.
12. A method for preventing or treating vitamin D deficiency wherein the method comprises: providing an irradiation unit with at least one phototherapy lamp and providing a support unit suitable to support the infant above the irradiation unit and operable to allow radiation of the at least one phototherapy lamp to pass therethrough, placing the infant on this support unit activating at least one of said phototherapy lamps with a main light spectrum in the range of 275 to 310 ran and exposing the infant to the light of this at least one activated phototherapy lamp.
PCT/CH2006/000330 2006-06-16 2006-06-16 Apparatus and method for preventing and treating vitamin d deficiency of an infant WO2007143862A1 (en)

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Cited By (5)

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JP2015503406A (en) * 2012-01-03 2015-02-02 ウィリアム エー． モファット， Phototherapy device for focused UVB radiation and vitamin D synthesis, and related systems and methods
WO2015061773A1 (en) 2013-10-25 2015-04-30 Benesol, Inc. Systems and methods for increased vitamin d3 production
CN109200475A (en) * 2017-07-05 2019-01-15 上海健康医学院 A kind of baby health-care bed
US11311744B2 (en) 2017-12-15 2022-04-26 Benesol, Inc. Dynamic dosing systems for phototherapy and associated devices, systems, and methods
CN109200475B (en) * 2017-07-05 2024-06-07 上海健康医学院 Baby health care bed

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US4177384A (en) * 1975-08-26 1979-12-04 Friedrich Wolff Apparatus for producing ultraviolet radiation
EP0812604A2 (en) * 1996-06-13 1997-12-17 Hamamatsu Photonics K.K. Bed preventing osteoporose and bedsore
DE19644525A1 (en) * 1996-10-26 1998-05-07 Gosbert Dr Med Dr Rer Nat Weth Energy saving lamp for medical therapies
US5792214A (en) * 1995-01-31 1998-08-11 Medela, Inc. Apparatus and method for treating neonatal hyperbilirubinemia

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US4177384A (en) * 1975-08-26 1979-12-04 Friedrich Wolff Apparatus for producing ultraviolet radiation
US5792214A (en) * 1995-01-31 1998-08-11 Medela, Inc. Apparatus and method for treating neonatal hyperbilirubinemia
EP0812604A2 (en) * 1996-06-13 1997-12-17 Hamamatsu Photonics K.K. Bed preventing osteoporose and bedsore
DE19644525A1 (en) * 1996-10-26 1998-05-07 Gosbert Dr Med Dr Rer Nat Weth Energy saving lamp for medical therapies

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2800605B1 (en) 2012-01-03 2017-10-25 BeneSol, Inc. Phototherapeutic apparatus for focused uvb radiation and vitamin d synthesis and associated systems
US11007376B2 (en) 2012-01-03 2021-05-18 Benesol, Inc. Phototherapeutic apparatus for focused UVB radiation and vitamin D synthesis and associated systems and methods
EP2800605A4 (en) * 2012-01-03 2015-06-10 Benesol Inc Phototherapeutic apparatus for focused uvb radiation and vitamin d synthesis and associated systems and methods
US10226641B2 (en) 2012-01-03 2019-03-12 Benesol, Inc. Phototherapeutic apparatus for focused UVB radiation and vitamin D synthesis and associated systems and methods
JP2015503406A (en) * 2012-01-03 2015-02-02 ウィリアム エー． モファット， Phototherapy device for focused UVB radiation and vitamin D synthesis, and related systems and methods
AU2018200369B2 (en) * 2012-01-03 2019-02-21 William A. Moffat Phototherapeutic apparatus for focused UVB radiation and vitamin D synthesis and associated systems and methods
CN107029357A (en) * 2012-01-03 2017-08-11 贝那索尔公司 UVB for focusing radiates the phototherapy device and related systems approach to the synthesis of vitamin D
EP3345653A1 (en) * 2012-01-03 2018-07-11 BeneSol, Inc. Phototherapeutic apparatus for focused uvb radiation and vitamin d synthesis and associated systems and methods
JP2017148533A (en) * 2012-01-03 2017-08-31 ウィリアム エー． モファット， Phototherapeutic apparatus for focused uvb radiation and vitamin d synthesis and associated systems and methods
AU2013206887B2 (en) * 2012-01-03 2017-10-19 William A. Moffat Phototherapeutic apparatus for focused UVB radiation and vitamin D synthesis and associated systems and methods
EP3060301A1 (en) * 2013-10-25 2016-08-31 BeneSol, Inc. Systems and methods for increased vitamin d3 production
EP3060301A4 (en) * 2013-10-25 2017-08-30 BeneSol, Inc. Systems and methods for increased vitamin d3 production
JP2016533866A (en) * 2013-10-25 2016-11-04 ベネソル， インコーポレイテッド System and method for increased vitamin D3 production
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