WO2007142929A3 - Novel pde4 inhibitors - Google Patents

Novel pde4 inhibitors Download PDF

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Publication number
WO2007142929A3
WO2007142929A3 PCT/US2007/012668 US2007012668W WO2007142929A3 WO 2007142929 A3 WO2007142929 A3 WO 2007142929A3 US 2007012668 W US2007012668 W US 2007012668W WO 2007142929 A3 WO2007142929 A3 WO 2007142929A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
pde4 inhibitors
compounds
disorders
arthritis
Prior art date
Application number
PCT/US2007/012668
Other languages
French (fr)
Other versions
WO2007142929A2 (en
Inventor
Ke Hengming
Gurpreet Kaur
Binghe Wang
Shi-Long Zheng
Original Assignee
Univ North Carolina
Univ Georgia State Res Found
Ke Hengming
Gurpreet Kaur
Binghe Wang
Shi-Long Zheng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Univ Georgia State Res Found, Ke Hengming, Gurpreet Kaur, Binghe Wang, Shi-Long Zheng filed Critical Univ North Carolina
Publication of WO2007142929A2 publication Critical patent/WO2007142929A2/en
Publication of WO2007142929A3 publication Critical patent/WO2007142929A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PDE4 inhibitors, pharmaceutical compositions including the inhibitors, and methods of treatment using the inhibitors are disclosed. The compounds are illustrated by Formulas 1-9 in the specification. The compounds can be used to treat a variety of disorders mediated by phosphodiesterase, and TNF-α, including asthma, chronic bronchitis, chronic obstructive pulmonary disease, arthritis, respiratory distress syndrome, allergic rhinitis, neurogenic inflammation, pain, rheumatoid arthritis, central nervous system disorders, cardiovascular disorders, and tumor progression.
PCT/US2007/012668 2006-05-31 2007-05-29 Novel pde4 inhibitors WO2007142929A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80975106P 2006-05-31 2006-05-31
US60/809,751 2006-05-31

Publications (2)

Publication Number Publication Date
WO2007142929A2 WO2007142929A2 (en) 2007-12-13
WO2007142929A3 true WO2007142929A3 (en) 2008-04-24

Family

ID=38801992

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/012668 WO2007142929A2 (en) 2006-05-31 2007-05-29 Novel pde4 inhibitors

Country Status (2)

Country Link
CN (1) CN101495454A (en)
WO (1) WO2007142929A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013155123A1 (en) 2012-04-10 2013-10-17 Georgia State University Research Foundation, Inc. Compositions and methods for treating otitis media and other conditions with inhibitors of cyld
US11446398B2 (en) 2016-04-11 2022-09-20 Obsidian Therapeutics, Inc. Regulated biocircuit systems
CN107714686B (en) * 2016-08-10 2020-01-14 广州华真医药科技有限公司 Application of phosphodiesterase 4 inhibitor ZL-n-91 in preparation of drugs for treating prostatic cancer hyperplasia and metastasis
MX2019014960A (en) 2017-06-12 2020-08-06 Obsidian Therapeutics Inc Pde5 compositions and methods for immunotherapy.
US11891634B2 (en) 2017-06-23 2024-02-06 The Board Of Trustees Of The Leland Stanford Junior University PDE5A destabilizing domains
JP2021535180A (en) * 2018-09-05 2021-12-16 ユニベルシテイト ファン アムステルダム Use of PDE11 or PDE2 inhibitors for the treatment of Parkinson's disease
CN109908139B (en) * 2018-12-28 2022-02-22 南京市儿童医院 Use of cilomilast for the preparation of a medicament for the treatment of a disorder associated with acute kidney injury
CN110003102B (en) * 2019-05-16 2022-03-22 河南师范大学 (R) -2- (alpha-deuterium-alpha-alkyl-alpha-aromatic) nitrogen heteroaryl compound and preparation method and application thereof
CN110279686A (en) * 2019-08-01 2019-09-27 汪海涛 A kind of phosphodiesterase 4 inhibitors are preventing and are treating the application in Parkinson's disease
MX2022002747A (en) 2019-09-10 2022-04-06 Obsidian Therapeutics Inc Ca2-il15 fusion proteins for tunable regulation.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4838930A (en) * 1985-04-01 1989-06-13 Ciba-Geigy Corporation 3-fuoropyridyl-2-oxy-phenoxy derivatives having herbicidal activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4838930A (en) * 1985-04-01 1989-06-13 Ciba-Geigy Corporation 3-fuoropyridyl-2-oxy-phenoxy derivatives having herbicidal activity

Also Published As

Publication number Publication date
CN101495454A (en) 2009-07-29
WO2007142929A2 (en) 2007-12-13

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