WO2007140989A3 - Process for the manufacture of 2-butyl-3- (4-methoxybenzoyl) -5-nitrobenzofurane and use thereof in the production of of medicaments - Google Patents

Process for the manufacture of 2-butyl-3- (4-methoxybenzoyl) -5-nitrobenzofurane and use thereof in the production of of medicaments Download PDF

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Publication number
WO2007140989A3
WO2007140989A3 PCT/EP2007/004984 EP2007004984W WO2007140989A3 WO 2007140989 A3 WO2007140989 A3 WO 2007140989A3 EP 2007004984 W EP2007004984 W EP 2007004984W WO 2007140989 A3 WO2007140989 A3 WO 2007140989A3
Authority
WO
WIPO (PCT)
Prior art keywords
butyl
nitrobenzofurane
methoxybenzoyl
production
medicaments
Prior art date
Application number
PCT/EP2007/004984
Other languages
French (fr)
Other versions
WO2007140989A2 (en
Inventor
Lars Eklund
Original Assignee
Cambrex Karlskoga Ab
Lars Eklund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambrex Karlskoga Ab, Lars Eklund filed Critical Cambrex Karlskoga Ab
Publication of WO2007140989A2 publication Critical patent/WO2007140989A2/en
Publication of WO2007140989A3 publication Critical patent/WO2007140989A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

A process for the production of 2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofurane by reaction of 2-butyl-5-nitrobenzofuran, characterised by the exclusive use of non-halogenated solvents in the reaction and/or extraction by crystallisation of the product. There is also proidde a method of making Dronedarone including the step of making the intermediate 2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofurane in the presence of non-halogenated solvents.
PCT/EP2007/004984 2006-06-07 2007-06-05 Process for the manufacture of 2-butyl-3- (4-methoxybenzoyl) -5-nitrobenzofurane and use thereof in the production of of medicaments WO2007140989A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0611210A GB0611210D0 (en) 2006-06-07 2006-06-07 Process
GB0611210.6 2006-06-07

Publications (2)

Publication Number Publication Date
WO2007140989A2 WO2007140989A2 (en) 2007-12-13
WO2007140989A3 true WO2007140989A3 (en) 2008-07-17

Family

ID=36745397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/004984 WO2007140989A2 (en) 2006-06-07 2007-06-05 Process for the manufacture of 2-butyl-3- (4-methoxybenzoyl) -5-nitrobenzofurane and use thereof in the production of of medicaments

Country Status (2)

Country Link
GB (1) GB0611210D0 (en)
WO (1) WO2007140989A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0719180D0 (en) 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
KR20100135909A (en) 2008-04-17 2010-12-27 사노피-아벤티스 Use of dronedarone for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or of mortality
EP2116239A1 (en) * 2008-04-29 2009-11-11 Sanofi-Aventis Method for managing the risks associated with an increase in serum creatinine during dronedarone treatment
CA2737092A1 (en) * 2008-10-10 2010-04-15 Lonza Ltd Process for preparing 2-alkyl-3-aroyl-5-nitro-benzofurans
PL2417099T3 (en) * 2009-04-08 2016-06-30 Cambrex Karlskoga Ab New process for preparing hydroxylamines and medicaments
UY32657A (en) * 2009-05-27 2010-12-31 Sanofi Aventis PROCEDURE FOR THE MANUFACTURE OF DRONEDARONA INTERMEDIATE PRODUCTS
UY32656A (en) 2009-05-27 2010-12-31 Sanofi Aventis PROCEDURE TO PRODUCE BENZOFURANS
FR2958290B1 (en) 2010-03-30 2012-10-19 Sanofi Aventis PROCESS FOR THE PREPARATION OF SULFONAMIDO-BENZOFURAN DERIVATIVES
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
WO2012120544A2 (en) 2011-03-10 2012-09-13 Sun Pharmaceutical Industries Ltd. PROCESS FOR N-[2-n-BUTYL-3-[4-[3-(DI-n-BUTYLAMINO) PROPOXY]ENZOYL]BENZOFURAN-5-YL]METHANESULFONAMIDE HYDROCHLORIDE
FR2973027A1 (en) * 2011-03-24 2012-09-28 Sanofi Aventis PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (en) 2011-11-29 2013-11-15 Sanofi Sa PROCESS FOR THE PREPARATION OF 5-AMINO-BENZOYL-BENZOFURAN DERIVATIVES
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223510A (en) * 1990-08-06 1993-06-29 Sanofi Alkylaminoalkyl derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation and compositions containing them
US5854282A (en) * 1994-08-11 1998-12-29 Karo Bio Ab 3-benzoyl benzofuran derivatives as thyroid hormone antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223510A (en) * 1990-08-06 1993-06-29 Sanofi Alkylaminoalkyl derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation and compositions containing them
US5854282A (en) * 1994-08-11 1998-12-29 Karo Bio Ab 3-benzoyl benzofuran derivatives as thyroid hormone antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHELLHAMMER, C.-W.: "METHODEN DER ORGANISCHEN CHEMIE (HOUBEN-WEYL), VOL. VII/2A: Ketone", 28 June 1973, EUGEN MÜLLER, GEORG THIEME VERLAG, STUTTGART; DE, XP002479753 *

Also Published As

Publication number Publication date
WO2007140989A2 (en) 2007-12-13
GB0611210D0 (en) 2006-07-19

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