WO2007136818A8 - Method and apparatus for simultaneously measuring a three dimensional postion of a particle in a flow - Google Patents

Method and apparatus for simultaneously measuring a three dimensional postion of a particle in a flow

Info

Publication number
WO2007136818A8
WO2007136818A8 PCT/US2007/012047 US2007012047W WO2007136818A8 WO 2007136818 A8 WO2007136818 A8 WO 2007136818A8 US 2007012047 W US2007012047 W US 2007012047W WO 2007136818 A8 WO2007136818 A8 WO 2007136818A8
Authority
WO
WIPO (PCT)
Prior art keywords
particle
location
knowledge
exact
light scattering
Prior art date
Application number
PCT/US2007/012047
Other languages
French (fr)
Other versions
WO2007136818A3 (en
WO2007136818A2 (en
Inventor
William D Herzog
Antonio Sanchez-Rubio
Gregory G Cappiello
Ronald H Hoffeld
Shane M Tysk
Thomas H Jeys
Vincenzo Daneu
Original Assignee
Massachusetts Inst Technology
William D Herzog
Antonio Sanchez-Rubio
Gregory G Cappiello
Ronald H Hoffeld
Shane M Tysk
Thomas H Jeys
Vincenzo Daneu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, William D Herzog, Antonio Sanchez-Rubio, Gregory G Cappiello, Ronald H Hoffeld, Shane M Tysk, Thomas H Jeys, Vincenzo Daneu filed Critical Massachusetts Inst Technology
Publication of WO2007136818A2 publication Critical patent/WO2007136818A2/en
Publication of WO2007136818A8 publication Critical patent/WO2007136818A8/en
Publication of WO2007136818A3 publication Critical patent/WO2007136818A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/019—Biological contaminants; Fouling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1027—Determining speed or velocity of a particle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1447—Spatial selection
    • G01N2015/145—Spatial selection by pattern of light, e.g. fringe pattern

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Length Measuring Devices By Optical Means (AREA)

Abstract

Particle detection systems without knowledge of a location and velocity of a particle passing through a volume of space, are less efficient than if knowledge of the particle location is known. An embodiment of a particle position detection system capable of determining an exact location of a particle in a fluid stream is discussed. The detection system may employ a patterned illuminating beam, such that once a particle passes through the various portions of the patterned illuminating beam, a light scattering is produced. The light scattering defines a temporal profile that contains measurement information indicative of an exact particle location. However, knowledge of the exact particle location has several advantages. These advantages include correction of systematic particle measurement errors due to variability of the particle position within the sample volume, targeting of particles based on position, capture of particles based on position, reduced system energy consumption and reduced system complexity.
PCT/US2007/012047 2006-05-18 2007-05-18 Method and apparatus for simultaneously measuring a three dimensional postion of a particle in a flow WO2007136818A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80208706P 2006-05-18 2006-05-18
US60/802,087 2006-05-18
US92783207P 2007-05-04 2007-05-04
US60/927,832 2007-05-04

Publications (3)

Publication Number Publication Date
WO2007136818A2 WO2007136818A2 (en) 2007-11-29
WO2007136818A8 true WO2007136818A8 (en) 2008-04-17
WO2007136818A3 WO2007136818A3 (en) 2008-07-03

Family

ID=38723887

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/012047 WO2007136818A2 (en) 2006-05-18 2007-05-18 Method and apparatus for simultaneously measuring a three dimensional postion of a particle in a flow

Country Status (1)

Country Link
WO (1) WO2007136818A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008010870A2 (en) 2006-05-18 2008-01-24 Massachusetts Institute Of Technology Method and apparatus for measuring a position of a particle in a flow
AT505522B1 (en) * 2007-08-09 2011-04-15 Univ Graz Tech DEVICE FOR DETERMINING FLOW PARAMETERS OF A PARTICLE FLUIDUM FLOW
US7920261B2 (en) 2008-02-11 2011-04-05 Massachusetts Institute Of Technology Method and apparatus for detecting and discriminating particles in a fluid
WO2009102299A1 (en) * 2008-02-11 2009-08-20 Massachusetts Institute Of Technology Particle detection and discrimination
WO2014086375A1 (en) * 2012-12-07 2014-06-12 Aarhus Universitet Optical particle detector
CN113238075B (en) * 2021-04-22 2023-02-14 哈尔滨工程大学 Flow velocity meter based on optical fiber tweezers technology

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931119C1 (en) * 1989-09-18 1991-04-11 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De Simultaneously measuring size and speed of particles and bubbles - applying pair of crossing beams of different wavelengths and intensity distribution to multiphase carrying stream
EP0829726B1 (en) * 1996-09-05 2003-04-16 Robert Bosch Gmbh Method and apparatus for determining three dimensional flow structures
US5793478A (en) * 1996-11-19 1998-08-11 Sandia Corporation Apparatus for measuring particle properties
US5999250A (en) * 1997-03-17 1999-12-07 Tsi Corporation System for detecting fluorescing components in aerosols
DE19954702A1 (en) * 1999-11-13 2001-05-17 Nils Damaschke Arrangement to measure particle, drop or bubble size or other characteristic in fluid flow; has light source and detectors for defocused imaging of interference pattern, and particles in bright points
US20010040214A1 (en) * 2000-03-13 2001-11-15 Friedman Jacob A. Method and apparatus for extending particle image velocimetry to determine particle size and three dimensional velocity

Also Published As

Publication number Publication date
WO2007136818A3 (en) 2008-07-03
WO2007136818A2 (en) 2007-11-29

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