WO2007136782A3 - Kits et procédés destinés à évaluer des potéines incorrectement repliées - Google Patents

Kits et procédés destinés à évaluer des potéines incorrectement repliées Download PDF

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Publication number
WO2007136782A3
WO2007136782A3 PCT/US2007/011960 US2007011960W WO2007136782A3 WO 2007136782 A3 WO2007136782 A3 WO 2007136782A3 US 2007011960 W US2007011960 W US 2007011960W WO 2007136782 A3 WO2007136782 A3 WO 2007136782A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
misfolded proteins
kits
evaluating
cell
Prior art date
Application number
PCT/US2007/011960
Other languages
English (en)
Other versions
WO2007136782A2 (fr
Inventor
Eric Anderson
Marisa Dolled-Filhart
Original Assignee
Historx Inc
Eric Anderson
Marisa Dolled-Filhart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Historx Inc, Eric Anderson, Marisa Dolled-Filhart filed Critical Historx Inc
Publication of WO2007136782A2 publication Critical patent/WO2007136782A2/fr
Publication of WO2007136782A3 publication Critical patent/WO2007136782A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des procédés destinés à identifier des protéines incorrectement repliées à l'intérieur d'une cellule. En particulier, l'invention concerne des procédés destinés à diagnostiquer une maladie de protéines de réserve lysosomales par localisation et quantification d'au moins un marqueur de maladie à l'intérieur d'une cellule. L'invention concerne également des procédés destinés à identifier des traitements appropriés destinés à des patients présentant des troubles au niveau des protéines de réserve lysosomales et à déterminer la réactivité d'un patient par rapport à des options de traitement variées.
PCT/US2007/011960 2006-05-19 2007-05-21 Kits et procédés destinés à évaluer des potéines incorrectement repliées WO2007136782A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80175306P 2006-05-19 2006-05-19
US60/801,753 2006-05-19

Publications (2)

Publication Number Publication Date
WO2007136782A2 WO2007136782A2 (fr) 2007-11-29
WO2007136782A3 true WO2007136782A3 (fr) 2008-11-27

Family

ID=38723870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/011960 WO2007136782A2 (fr) 2006-05-19 2007-05-21 Kits et procédés destinés à évaluer des potéines incorrectement repliées

Country Status (1)

Country Link
WO (1) WO2007136782A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201114909D0 (en) * 2011-08-30 2011-10-12 San Raffaele Centro Fond Biomarkers for lysosomal storage disorders
CN111297902A (zh) * 2020-04-14 2020-06-19 南开大学 一种溶酶体作为制备治疗蛋白错误折叠或加工类疾病药物领域的应用
AU2022327748A1 (en) * 2021-08-09 2024-02-15 Neuroquest Ltd. Compositions, kits, and methods for detecting preclinical alzheimer's disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759189B1 (en) * 1996-05-17 2004-07-06 Women's And Children's Hopital Early detection of lysosomal storage disorders
US20050191710A1 (en) * 2004-03-01 2005-09-01 Hanrahan John W. Method for labeling a membrane-localized protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759189B1 (en) * 1996-05-17 2004-07-06 Women's And Children's Hopital Early detection of lysosomal storage disorders
US20050191710A1 (en) * 2004-03-01 2005-09-01 Hanrahan John W. Method for labeling a membrane-localized protein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KARTNER ET AL.: "Mislocalization of deltaF508 CFTR in cystic fibrosis sweat gland", NATURE GENETICS, vol. 1, August 1992 (1992-08-01), pages 321 - 327 *

Also Published As

Publication number Publication date
WO2007136782A2 (fr) 2007-11-29

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