WO2007134262A3 - Crystal structure of prostasin and uses thereof - Google Patents
Crystal structure of prostasin and uses thereof Download PDFInfo
- Publication number
- WO2007134262A3 WO2007134262A3 PCT/US2007/068822 US2007068822W WO2007134262A3 WO 2007134262 A3 WO2007134262 A3 WO 2007134262A3 US 2007068822 W US2007068822 W US 2007068822W WO 2007134262 A3 WO2007134262 A3 WO 2007134262A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- prostasin
- crystal structure
- coordinates
- studying
- crystallized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention provides a crystallized prostasin molecule. The three-dimensional coordinates of the crystal structure of prostasin are obtained by X-ray diffraction. The coordinates can be used for studying the prostasin structure and designing, screening and developing compounds that modulate prostasin activity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79983906P | 2006-05-11 | 2006-05-11 | |
US60/799,839 | 2006-05-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007134262A2 WO2007134262A2 (en) | 2007-11-22 |
WO2007134262A3 true WO2007134262A3 (en) | 2009-02-12 |
Family
ID=38694749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/068822 WO2007134262A2 (en) | 2006-05-11 | 2007-05-11 | Crystal structure of prostasin and uses thereof |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007134262A2 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002021133A2 (en) * | 2000-09-07 | 2002-03-14 | The Brigham And Women's Hospital, Inc. | Methods of detecting cancer based on prostasin |
-
2007
- 2007-05-11 WO PCT/US2007/068822 patent/WO2007134262A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002021133A2 (en) * | 2000-09-07 | 2002-03-14 | The Brigham And Women's Hospital, Inc. | Methods of detecting cancer based on prostasin |
Non-Patent Citations (4)
Title |
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BLUNDELL T L ET AL: "HIGH-THROUGHPUT CRYSTALLOGRAPHY FOR LEAD DISCOVERY IN DRUG DESIGN", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, BASINGSTOKE, GB, vol. 1, no. 1, 1 January 2002 (2002-01-01), pages 45 - 54, XP009023187, ISSN: 1474-1784 * |
CHEN L-M ET AL: "DOWN-REGULATION OF PROSTASIN SERINE PROTEASE: A POTENTIAL INVASION SUPPRESSOR IN PROSTATE CANCER", PROSTATE, WILEY-LISS, NEW YORK, NY, US, vol. 48, no. 2, 1 July 2001 (2001-07-01), pages 93 - 103, XP001106415, ISSN: 0270-4137 * |
TULLY DAVID C ET AL: "Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 NOV 2008, vol. 18, no. 22, 15 November 2008 (2008-11-15), pages 5895 - 5899, XP002506250, ISSN: 1464-3405 * |
YU JACK X ET AL: "Prostasin is a novel human serine proteinase from seminal fluid: Purification, tissue distribution, and localization in prostate gland", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 29, 1994, pages 18843 - 18848, XP002506249, ISSN: 0021-9258 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007134262A2 (en) | 2007-11-22 |
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