WO2007134262A3 - Crystal structure of prostasin and uses thereof - Google Patents

Crystal structure of prostasin and uses thereof Download PDF

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Publication number
WO2007134262A3
WO2007134262A3 PCT/US2007/068822 US2007068822W WO2007134262A3 WO 2007134262 A3 WO2007134262 A3 WO 2007134262A3 US 2007068822 W US2007068822 W US 2007068822W WO 2007134262 A3 WO2007134262 A3 WO 2007134262A3
Authority
WO
WIPO (PCT)
Prior art keywords
prostasin
crystal structure
coordinates
studying
crystallized
Prior art date
Application number
PCT/US2007/068822
Other languages
French (fr)
Other versions
WO2007134262A2 (en
Inventor
Glen Spraggon
Jennifer L Harris
Michael J Hornsby
Original Assignee
Irm Llc
Glen Spraggon
Jennifer L Harris
Michael J Hornsby
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc, Glen Spraggon, Jennifer L Harris, Michael J Hornsby filed Critical Irm Llc
Publication of WO2007134262A2 publication Critical patent/WO2007134262A2/en
Publication of WO2007134262A3 publication Critical patent/WO2007134262A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides a crystallized prostasin molecule. The three-dimensional coordinates of the crystal structure of prostasin are obtained by X-ray diffraction. The coordinates can be used for studying the prostasin structure and designing, screening and developing compounds that modulate prostasin activity.
PCT/US2007/068822 2006-05-11 2007-05-11 Crystal structure of prostasin and uses thereof WO2007134262A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79983906P 2006-05-11 2006-05-11
US60/799,839 2006-05-11

Publications (2)

Publication Number Publication Date
WO2007134262A2 WO2007134262A2 (en) 2007-11-22
WO2007134262A3 true WO2007134262A3 (en) 2009-02-12

Family

ID=38694749

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/068822 WO2007134262A2 (en) 2006-05-11 2007-05-11 Crystal structure of prostasin and uses thereof

Country Status (1)

Country Link
WO (1) WO2007134262A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002021133A2 (en) * 2000-09-07 2002-03-14 The Brigham And Women's Hospital, Inc. Methods of detecting cancer based on prostasin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002021133A2 (en) * 2000-09-07 2002-03-14 The Brigham And Women's Hospital, Inc. Methods of detecting cancer based on prostasin

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLUNDELL T L ET AL: "HIGH-THROUGHPUT CRYSTALLOGRAPHY FOR LEAD DISCOVERY IN DRUG DESIGN", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, BASINGSTOKE, GB, vol. 1, no. 1, 1 January 2002 (2002-01-01), pages 45 - 54, XP009023187, ISSN: 1474-1784 *
CHEN L-M ET AL: "DOWN-REGULATION OF PROSTASIN SERINE PROTEASE: A POTENTIAL INVASION SUPPRESSOR IN PROSTATE CANCER", PROSTATE, WILEY-LISS, NEW YORK, NY, US, vol. 48, no. 2, 1 July 2001 (2001-07-01), pages 93 - 103, XP001106415, ISSN: 0270-4137 *
TULLY DAVID C ET AL: "Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 NOV 2008, vol. 18, no. 22, 15 November 2008 (2008-11-15), pages 5895 - 5899, XP002506250, ISSN: 1464-3405 *
YU JACK X ET AL: "Prostasin is a novel human serine proteinase from seminal fluid: Purification, tissue distribution, and localization in prostate gland", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 29, 1994, pages 18843 - 18848, XP002506249, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2007134262A2 (en) 2007-11-22

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