WO2007131488A3 - Utilisation de dérivés de quinolone comme agents antiprotozoaires et dans des associations médicamenteuses - Google Patents

Utilisation de dérivés de quinolone comme agents antiprotozoaires et dans des associations médicamenteuses Download PDF

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Publication number
WO2007131488A3
WO2007131488A3 PCT/DE2007/000879 DE2007000879W WO2007131488A3 WO 2007131488 A3 WO2007131488 A3 WO 2007131488A3 DE 2007000879 W DE2007000879 W DE 2007000879W WO 2007131488 A3 WO2007131488 A3 WO 2007131488A3
Authority
WO
WIPO (PCT)
Prior art keywords
quinoline derivatives
protozoal
combination preparations
protozoal agent
relates
Prior art date
Application number
PCT/DE2007/000879
Other languages
German (de)
English (en)
Other versions
WO2007131488A2 (fr
Inventor
Wolfgang Bohne
Uwe Gross
Original Assignee
Univ Goettingen Georg August
Wolfgang Bohne
Uwe Gross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Goettingen Georg August, Wolfgang Bohne, Uwe Gross filed Critical Univ Goettingen Georg August
Publication of WO2007131488A2 publication Critical patent/WO2007131488A2/fr
Publication of WO2007131488A3 publication Critical patent/WO2007131488A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne l'utilisation de certains dérivés de quinolone comme agents pharmaceutiques antiprotozoaires sur les êtres humains et les animaux. Cette invention concerne plus précisément l'utilisation de ces dérivés de quinolone dans la prophylaxie et/ou le traitement d'une maladie causée, en particulier, par des protozoaires appartenant à la famille des apicomplexes ou des flagellés. Ladite invention se rapporte enfin à des associations médicamenteuses contenant les dérivés de quinolone selon l'invention et au moins un autre principe actif antiprotozoaire ainsi que leur utilisation dans la prophylaxie et le traitement d'infections à protozoaires.
PCT/DE2007/000879 2006-05-15 2007-05-15 Utilisation de dérivés de quinolone comme agents antiprotozoaires et dans des associations médicamenteuses WO2007131488A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006022908.8 2006-05-15
DE102006022908A DE102006022908A1 (de) 2006-05-15 2006-05-15 Verwendung von Chinolonderivaten als antiprotozoäre Mittel und in Kombinationspräparaten

Publications (2)

Publication Number Publication Date
WO2007131488A2 WO2007131488A2 (fr) 2007-11-22
WO2007131488A3 true WO2007131488A3 (fr) 2008-01-31

Family

ID=38607850

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2007/000879 WO2007131488A2 (fr) 2006-05-15 2007-05-15 Utilisation de dérivés de quinolone comme agents antiprotozoaires et dans des associations médicamenteuses

Country Status (2)

Country Link
DE (1) DE102006022908A1 (fr)
WO (1) WO2007131488A2 (fr)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIAGINI GIANCARLO A ET AL: "Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 50, no. 5, May 2006 (2006-05-01), pages 1841 - 1851, XP002458398, ISSN: 0066-4804 *
BIAVATTI, MAIQUE W. ET AL: "Biological activity of quinoline alkaloids from Raulinoa echinata and X-ray structure of flindersiamine", JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY , 13(1), 66-70 CODEN: JOCSET; ISSN: 0103-5053, 2002, XP002458397 *
CASEY A C: "4(1H) quinolones. 2. Antimalarial effect of some 2 methyl 3 (1' alkenyl) or 3 alkyl 4(1H) quinolones", JOURNAL OF MEDICINAL CHEMISTRY 1974, vol. 17, no. 2, 1974, pages 255 - 256, XP002458400, ISSN: 0022-2623 *
ESCHEMANN ANDREA ET AL: "HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 5, 4 February 2005 (2005-02-04), pages 3138 - 3142, XP002458399, ISSN: 0021-9258 *
MUNSON H R ET AL: "ANTIMALARIALS.10.SUBSTITUTED 3-HALO- AND 3-METHOXY-2-ARYL-4- QUINOLINE (DI-N-BUTYLAMINOMETHYL)METHANOLS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 18, no. 12, 1 December 1975 (1975-12-01), pages 1232 - 1236, XP000645380, ISSN: 0022-2623 *
SALEH AHMAD ET AL: "Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 51, no. 4, April 2007 (2007-04-01), pages 1217 - 1222, XP002458401, ISSN: 0066-4804 *

Also Published As

Publication number Publication date
WO2007131488A2 (fr) 2007-11-22
DE102006022908A1 (de) 2007-11-22

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